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Rattus norvegicus transcription factor Dp-2 (Tfdp2), transcript variant 12, mRNA

NCBI Reference Sequence: NM_001433305.1

FASTA Graphics 

LOCUS       NM_001433305            7119 bp    mRNA    linear   ROD 09-AUG-2024
DEFINITION  Rattus norvegicus transcription factor Dp-2 (Tfdp2), transcript
            variant 12, mRNA.
ACCESSION   NM_001433305
VERSION     NM_001433305.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7119)
  AUTHORS   Zaragoza,K., Begay,V., Schuetz,A., Heinemann,U. and Leutz,A.
  TITLE     Repression of transcriptional activity of C/EBPalpha by
            E2F-dimerization partner complexes
  JOURNAL   Mol Cell Biol 30 (9), 2293-2304 (2010)
   PUBMED   20176812
REFERENCE   2  (bases 1 to 7119)
  AUTHORS   Rubin,S.M., Gall,A.L., Zheng,N. and Pavletich,N.P.
  TITLE     Structure of the Rb C-terminal domain bound to E2F1-DP1: a
            mechanism for phosphorylation-induced E2F release
  JOURNAL   Cell 123 (6), 1093-1106 (2005)
   PUBMED   16360038
REFERENCE   3  (bases 1 to 7119)
  AUTHORS   Vara,D., Bicknell,K.A., Coxon,C.H. and Brooks,G.
  TITLE     Inhibition of E2F abrogates the development of cardiac myocyte
            hypertrophy
  JOURNAL   J Biol Chem 278 (24), 21388-21394 (2003)
   PUBMED   12682052
REFERENCE   4  (bases 1 to 7119)
  AUTHORS   Nili,E., Cojocaru,G.S., Kalma,Y., Ginsberg,D., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Berger,R., Shaklai,S., Amariglio,N.,
            Brok-Simoni,F., Simon,A.J. and Rechavi,G.
  TITLE     Nuclear membrane protein LAP2beta mediates transcriptional
            repression alone and together with its binding partner GCL
            (germ-cell-less)
  JOURNAL   J Cell Sci 114 (Pt 18), 3297-3307 (2001)
   PUBMED   11591818
REFERENCE   5  (bases 1 to 7119)
  AUTHORS   Trimarchi,J.M., Fairchild,B., Verona,R., Moberg,K., Andon,N. and
            Lees,J.A.
  TITLE     E2F-6, a member of the E2F family that can behave as a
            transcriptional repressor
  JOURNAL   Proc Natl Acad Sci U S A 95 (6), 2850-2855 (1998)
   PUBMED   9501179
REFERENCE   6  (bases 1 to 7119)
  AUTHORS   Wu,C.L., Zukerberg,L.R., Ngwu,C., Harlow,E. and Lees,J.A.
  TITLE     In vivo association of E2F and DP family proteins
  JOURNAL   Mol Cell Biol 15 (5), 2536-2546 (1995)
   PUBMED   7739537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1048303.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               JAXUCZ010000008.1  105706415-105706594
            181-284             JAXUCZ010000008.1  105728268-105728371
            285-406             JAXUCZ010000008.1  105745234-105745355
            407-454             JAXUCZ010000008.1  105748259-105748306
            455-617             JAXUCZ010000008.1  105752132-105752294
            618-761             JAXUCZ010000008.1  105754484-105754627
            762-830             JAXUCZ010000008.1  105757273-105757341
            831-982             JAXUCZ010000008.1  105763697-105763848
            983-1149            JAXUCZ010000008.1  105767662-105767828
            1150-1255           JAXUCZ010000008.1  105774835-105774940
            1256-7119           JAXUCZ010000008.1  105775163-105781026
FEATURES             Location/Qualifiers
     source          1..7119
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..7119
                     /gene="Tfdp2"
                     /gene_synonym="Tcfdp2"
                     /note="transcription factor Dp-2"
                     /db_xref="GeneID:300947"
                     /db_xref="RGD:1305814"
     exon            1..180
                     /gene="Tfdp2"
                     /gene_synonym="Tcfdp2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    123..125
                     /gene="Tfdp2"
                     /gene_synonym="Tcfdp2"
                     /note="upstream in-frame stop codon"
     exon            181..284
                     /gene="Tfdp2"
                     /gene_synonym="Tcfdp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1439
                     /gene="Tfdp2"
                     /gene_synonym="Tcfdp2"
                     /note="isoform 6 is encoded by transcript variant 12;
                     transcription factor Dp-2 (E2F dimerization partner 2)"
                     /codon_start=1
                     /product="transcription factor Dp-2 isoform 6"
                     /protein_id="NP_001420234.1"
                     /db_xref="GeneID:300947"
                     /db_xref="RGD:1305814"
                     /translation="MIISTPQRITNSGSVLIGSPYTPAPAMVTQTHIAEAAGWVPSDR
                     KRAREFIDSDFSESKRSKKGDKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVSEFT
                     NASNHLAADSAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLE
                     IEKQRRIERIKQKRAQLQELLLQQIAFKNLVQRNRQNEQQNQGPPAVNSTIQLPFIVI
                     NTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRMGMSFGLESGKCSLEDLKIA
                     KSLVPKALEGYITDVSTGPSWLNQGLLLNSTQSVSNLDPTTGATVPQSSVNQGLCLDA
                     EVALATGQFLAPNSHQSSTAASQFSESRGETPCSFNDEEEEDEEEDPSSPE"
     exon            285..406
                     /gene="Tfdp2"
                     /gene_synonym="Tcfdp2"
                     /inference="alignment:Splign:2.1.0"
     exon            407..454
                     /gene="Tfdp2"
                     /gene_synonym="Tcfdp2"
                     /inference="alignment:Splign:2.1.0"
     exon            455..617
                     /gene="Tfdp2"
                     /gene_synonym="Tcfdp2"
                     /inference="alignment:Splign:2.1.0"
     exon            618..761
                     /gene="Tfdp2"
                     /gene_synonym="Tcfdp2"
                     /inference="alignment:Splign:2.1.0"
     exon            762..830
                     /gene="Tfdp2"
                     /gene_synonym="Tcfdp2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..982
                     /gene="Tfdp2"
                     /gene_synonym="Tcfdp2"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1149
                     /gene="Tfdp2"
                     /gene_synonym="Tcfdp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1255
                     /gene="Tfdp2"
                     /gene_synonym="Tcfdp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..7119
                     /gene="Tfdp2"
                     /gene_synonym="Tcfdp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtttcacca agctcagaaa gctctgagca gtttttcagg agtttctcct cccctttttc
       61 tgggaaattc atggtgcatt tgctctgctt tcaaaatgca gtaaggtcct ctgctttgtg
      121 actgactgcc ttggagcccg cagacagtcg gacatgtaca attccaacta tgcaggtctt
      181 gtaacatttc acttgtggcc tttccagttt caagcaccaa ctcaccaaca aagattttac
      241 cgaaaacctt agggccagta aatgtgaatg ttggacccca aatgattata agcacaccac
      301 agagaattac caattcagga agtgttctga ttgggagtcc atatacccct gcaccagcaa
      361 tggtcactca gactcacata gctgaggctg ctggctgggt tcccagtgat agaaaacgag
      421 ctagagaatt tatagactcc gatttttcag aaagtaaacg aagcaaaaaa ggggacaaaa
      481 atgggaaagg cttgagacat ttttcaatga aggtgtgtga gaaagttcaa cggaaaggca
      541 caacatcata caatgaagta gctgatgaac tggtgtctga gtttaccaat gcgagtaacc
      601 atctggcagc tgactcggct tatgatcaga agaacattag acgaagagtt tatgatgctc
      661 tgaatgtgct aatggcaatg aacataattt caaaggagaa aaaagaaatc aagtggattg
      721 ggctgcctac caactccgcc caggagtgcc agaacctgga aatagagaag caaaggcgga
      781 tagaacggat aaagcagaag cgggcccagc tacaagaact tctccttcag caaattgctt
      841 ttaaaaacct ggtacagaga aatcgacaaa atgaacaaca aaaccagggc cctccagctg
      901 tgaattccac cattcagctg ccatttatag tcattaatac aagcaggaaa acagtcatag
      961 actgcagcat ctccagtgac aagtttgaat acctctttaa ttttgataac acctttgaga
     1021 tccatgatga catagaggta ctgaagcgga tgggaatgtc ctttggtctg gagtcaggca
     1081 aatgctctct ggaggatctg aaaatcgcaa aatccctggt tccaaaagct ttagaaggct
     1141 atatcacaga cgtctctaca ggaccttctt ggttaaatca gggactactt ttgaactcta
     1201 cccaatcagt ttcaaattta gacccgacca ccggtgccac tgtaccccaa tcaagtgtaa
     1261 accaagggtt gtgcttggat gctgaagtgg ccttagcaac tgggcagttc cttgccccaa
     1321 acagtcacca gtccagcact gcagcctctc agttttcgga gtcccgaggt gagaccccct
     1381 gttcattcaa cgatgaagag gaggaagatg aagaggagga cccctcctcc cctgaataaa
     1441 gacaggagag aactcatgtt taatatttga tgctcatgtg tgtctttagt gtgagctctt
     1501 gtgttttgaa atgattgctt cagtctttgc ctttgtttgc atttgtgttt agtgaaaact
     1561 agagaaacac aataagcaaa ttacacgcag gctgagatga ttgagatgac agttcccata
     1621 gtgtggatga agcggagctg cagagctgtg gacatcgcca acagagcaag ctttctgagg
     1681 aggtagaggc cgatctgaag agcagtgcgg tgaagttcat ttgttttcag ggaggtgggg
     1741 attaaaggcc cacagtgtga gcatttagac ctcaggtggc tgcaaggagc agtatgcagt
     1801 gatgacagct tctccctcgc ctgcccgccc actgtccttg gtaggcaaga gtgaacttgg
     1861 aagtcacagt gggggtctgt tgtcgcctgc gcggagcggt gaactgctga gctggtccag
     1921 gtttagctga gcgcctcttg catctgctgc cttagcttct gaagggagca agcgctaatc
     1981 tttaagtacc taggtgacac gtaggaaatt ttacactaaa ctgaggtgag catctgtcag
     2041 tgcgttggtg cataggagtt actaggacta cttctggaag ccaaagtaga atagcatttc
     2101 catgtgcatt aaaaacttcg ccagcactgc cttttgccag cattctaagt ttggagtttt
     2161 actgagagag aaactgtttt tatagtttta atcaaagcta tgcattcata cagcttttta
     2221 atttacaatg agacaaagaa atcaattcct ttgaccaaat tgcttgtcta cagttgtctg
     2281 cagtactgtg tgattttacc catgtgcaat ttgtaaaaat gaaccaaatg tcattacttt
     2341 tgtctttatt tcaagaatat ggccatcatt gttatcttat acatcttatc ttttccatat
     2401 tttaattatc aaaatgacct tacagattta ttcctgggta aattgcattt caaactaact
     2461 caatattcat acttttgtta aaaccgtgaa cactccagct gcctgcatcc atgccagtgt
     2521 ggcatgtcat atgtgatctt aaagccaaag atgccgtgaa aatcccgcgg tatgtgtgtg
     2581 attgctgctt ctccacgtag aggagcatga gacatccact gccaagccac actcaactta
     2641 ctaatccgtt aaggcctgaa agggggcaga gagtggctgc agactcagtt ccacgaccag
     2701 gtaaagccag ggccgtctga atctgctctc tgtgagccct gcaccaagtt cagtccaaat
     2761 gctcttttca gtcctgtggt tcggggagca caggctctat tccatgatgc ctttctgaga
     2821 cttgaccatt atgagctgag caaaaagctt tggctggctt acataggtta ttgaggccat
     2881 taacactgat aagtatgagt atacagatgt ggcttaggtt tcttcaggag caaactcatt
     2941 ctgtcaggag gaaactgtag aacgagccca gagtgttcaa ggggcataac ggtcctggca
     3001 ggtttcaaag ggctttgtgt tgacatgagt tctagaacac attcaggctc tcagagcaaa
     3061 gtgactcaga atgcaacagg agctacctcc tgttatcatt gtcggccttt gggaacgtag
     3121 gaagacatgg agattagaga catcaagggc cacaaaatgc tttttcagtc ttcaaaatac
     3181 tgagctactg gtcctaagat gtttcagaac ttaaagcaaa tgcatgtgtt acacccatcc
     3241 cacttactag actgcaaaat ccttgcagta attttcaagg aactgtttcc cattatctgc
     3301 gcccctgctg ccgtatgatt tacattgaca aaacttgggc tttaaattgg cagacatgtt
     3361 gggcatgttg tgtggctcta atcccagctt ttgggaaata gagcagaaaa gtcaatcttg
     3421 gctacatagt gagttcaagg ccagcttggg ctacatgtga ccctgtccag gggaaagagc
     3481 tggggagcta accaaagact taatctttgt gtgccccacc cctgaacatt ctaactacca
     3541 ctgccctgca ctgcccagtg taaccctgtt cctcctctgt gatgtactgc tgagggcatc
     3601 tgcatactag accaagccag gagtggtggt aacactcgta atcctagaca ggcaaaaggt
     3661 caccagaggc ttgaagccag cccgggctac attagattag ccctgacata cacgcacgca
     3721 tgccccaaag gttgaggtgg ggtgagagag gagcctaaat tgagatgttg aaaaagatga
     3781 actctgatct tcattcacta tgtttatatt gctctgggtc cagcaacact gaatcacagt
     3841 ttaacacaga gatcaaaatc aaaggggcgg ggagttaaac tgtggtcata gcatctgggt
     3901 ttctttgtag gagggcactt aggttccttg cacatagcca ttccctaccc tcaaggtgct
     3961 ggtcactgct tagcgaggag ctgaggcgga tttcccctct caagggtcag tttgctattt
     4021 ctcaagggta cagcacccat gtcactcccc tgatgacatg tgcagctgcc tgcgccctcc
     4081 atgtgaagaa caggtccagc aggctacaca gaggtgctca gccctcacgc ttagcacgct
     4141 tcccgtcatg tgtccctgct ggaagtctag tcggtcttta tatttattgt gccttacata
     4201 ggaagaaggg actgaatctt tccctatgaa cagtcatcca gaaaacaggc tgtggtggcc
     4261 acacactttg catctttctt atttgattct tttaaagaag tgtggggagg aaaacctgtc
     4321 atctttgttg ttttaccaga atgaagacag ctcctcctgt tagcaaaacc tatacttaga
     4381 gcagcagcag aacgctaccc attttagaag gtaattccca ggtctgtcct cagaaagttc
     4441 cccttttgga tagtccagat gaagaaatgt ctcactgtat cccttcgtag attcctaact
     4501 cggccatttc taaatctaaa ccgatatctt aagtcagagg cagtgaagct gttcaagaac
     4561 agtgtgattt gtgccctgtg acagtctgaa cagtgtgtgt gcatgacaga cagacagaca
     4621 gactgactaa gcagatgaca ggaatggcgt cagcagttta tgccgtaacc acgcccagag
     4681 caaaaaacct actcagtttt ataagctcct ttcccaacca aaatgggttg tcctcattca
     4741 aaaaacctgt gacatagacc ttagaatttt gctcctttag tggtgagcat gggacatggt
     4801 ttgttttgga gcgagaatgt tgaaatgctg aacttagcta gctttaggac ctgaaaggca
     4861 ggcggggact gcagcaaggc cctgaagttc tcagtgagtc gcattcccct gagctgaacc
     4921 taccctgcag gcgggagagc tgagatcaca tgatctgtaa gctgctaata cataaagaga
     4981 gataatgtat aagctcatga attgagcgca cgaagagtga ccctcatgct gcacatagac
     5041 ttcgtctttg ttggaaggtg gactggatag ctaagagcta gcttcccaat ggcattccaa
     5101 tttgtgtacg ccttgggccg gtgcctctgg gcactaatgt tcatcgatac acagtctctg
     5161 aagaccgggg cacatgcccg gagcctgcag cacggcactt aaatgagcct cagaaatgtc
     5221 ccttccagct cacgaagtca gttcactcac gctctgttga cctgtacttg agcccagcac
     5281 tgtcattcag aaggggaggc taatgtgaca attcttcctt taattctttt tgttaacgtt
     5341 agtgctaaaa ggctgtgata agttagaaca agcctcagga aatagcctct tacctattag
     5401 cggagtacct gaaaaatatc catctgtagg gtccagtttt cctacataca tctttgatca
     5461 cagtatgcta aggggaaaaa attaggacac aaaactggca ttttatgttt ccttggagtc
     5521 cttggcagat actgacactg atgtgggtag ccgtccctca cggtgtctcg agaggaaagc
     5581 tacgtgttta cactgtctgt tctgcgcagt ctctcagcta agatgatatc ctggatcttt
     5641 ttttaatgta caaaaccctg tagaaccagt gctttggctg ctttctatcc tagcagagag
     5701 gaccttggtc ctctctactt agaaagctac ttcagaagct attgggaagt caaggtttgt
     5761 gtcttctcta ctgaggtctc agaaagggag agagcatctc tgggagccgg gcctcgggca
     5821 ggaagtaccc agagcctcat gtgtggccca gcagccttcg cctctatagc agtgagctca
     5881 acagtctggc ctgccacctc cctcagggca tcattgctta ctgcaaagca caccttcacc
     5941 atgctccagc cagacagctc cagtctcgcc aacaagtgcc aaaagtctga ggaacacagg
     6001 ggatctcttc tcgaaagccc catcaagtag tgccatcttg gggcttccca ggacttccag
     6061 tataggtggt tacgatcaca agaaacctcc aggcaagggt ccattcagtc tgtacattgg
     6121 tagggacacg agaggtggga ttgccatctg ggcctcagtg gcttgtctcc aaccaaatta
     6181 ttggacttca gaagccatcc ctctgctgtg cttgacttca gactcagttg ctgcaccttg
     6241 gtcatgatct gagtacaaaa gctgtaccag tttcccatgc tcagaccctc tgtctgtctg
     6301 tcctcgtgat actgaagtgt ctccactcgc ccagcggctt ctctgtggaa gtggcttctc
     6361 tccaggctgc taatctgttt tttccgggcg gtactaggac agcatcctga gaaacgggac
     6421 cagttctcca cccgctctga ctgctcagga ggcctgggtc ccgtttaccc tgtcactctt
     6481 tactggaagg gaggttgctc agtcaccagg tcgctcactt tccattcaga gacgctttgc
     6541 tctgcttgtg tgccgcgagt ttctgtctcc agaaaagtgt aactttgccc tttttctgca
     6601 tgacgcacgt acccatgtcg cgcactaagt agtttaaatg aggtaaagga aaacgcagag
     6661 cacatcttgc ttgcctctta gagtttcctc cctaaattga agtccatagg ctaatatatt
     6721 attttgtagt atctcagact ttgcataaat actattattt ttgtatggaa ttttttatag
     6781 aagagctatt tctgtatact tatttgtggt ttttgaaatg ccttccagta ggtaaccgac
     6841 aagtcttaag cagtgtccac taagggtagc tcagggacca cctacccaga ataggcaggg
     6901 aatttaaatt ttcttactcc ctgtacccac tccagacaga agctcaggtt gtgtctagga
     6961 agcagtttta ataagctctg agtgattttc ttcatcaacc cacacatatt tgtccatgct
     7021 gtaagagaag acatctggaa tgagtatgtt gagctggaga ataattgtat catatactct
     7081 gtgatttgag atacaaaata aagaaataat ttaaaataa
//
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