LOCUS NM_001433305 7119 bp mRNA linear ROD 09-AUG-2024
DEFINITION Rattus norvegicus transcription factor Dp-2 (Tfdp2), transcript
variant 12, mRNA.
ACCESSION NM_001433305
VERSION NM_001433305.1
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 7119)
AUTHORS Zaragoza,K., Begay,V., Schuetz,A., Heinemann,U. and Leutz,A.
TITLE Repression of transcriptional activity of C/EBPalpha by
E2F-dimerization partner complexes
JOURNAL Mol Cell Biol 30 (9), 2293-2304 (2010)
PUBMED 20176812
REFERENCE 2 (bases 1 to 7119)
AUTHORS Rubin,S.M., Gall,A.L., Zheng,N. and Pavletich,N.P.
TITLE Structure of the Rb C-terminal domain bound to E2F1-DP1: a
mechanism for phosphorylation-induced E2F release
JOURNAL Cell 123 (6), 1093-1106 (2005)
PUBMED 16360038
REFERENCE 3 (bases 1 to 7119)
AUTHORS Vara,D., Bicknell,K.A., Coxon,C.H. and Brooks,G.
TITLE Inhibition of E2F abrogates the development of cardiac myocyte
hypertrophy
JOURNAL J Biol Chem 278 (24), 21388-21394 (2003)
PUBMED 12682052
REFERENCE 4 (bases 1 to 7119)
AUTHORS Nili,E., Cojocaru,G.S., Kalma,Y., Ginsberg,D., Copeland,N.G.,
Gilbert,D.J., Jenkins,N.A., Berger,R., Shaklai,S., Amariglio,N.,
Brok-Simoni,F., Simon,A.J. and Rechavi,G.
TITLE Nuclear membrane protein LAP2beta mediates transcriptional
repression alone and together with its binding partner GCL
(germ-cell-less)
JOURNAL J Cell Sci 114 (Pt 18), 3297-3307 (2001)
PUBMED 11591818
REFERENCE 5 (bases 1 to 7119)
AUTHORS Trimarchi,J.M., Fairchild,B., Verona,R., Moberg,K., Andon,N. and
Lees,J.A.
TITLE E2F-6, a member of the E2F family that can behave as a
transcriptional repressor
JOURNAL Proc Natl Acad Sci U S A 95 (6), 2850-2855 (1998)
PUBMED 9501179
REFERENCE 6 (bases 1 to 7119)
AUTHORS Wu,C.L., Zukerberg,L.R., Ngwu,C., Harlow,E. and Lees,J.A.
TITLE In vivo association of E2F and DP family proteins
JOURNAL Mol Cell Biol 15 (5), 2536-2546 (1995)
PUBMED 7739537
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000008.1.
##Evidence-Data-START##
Transcript exon combination :: SRR26360190.1048303.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA5760475, SAMEA5760494
[ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-180 JAXUCZ010000008.1 105706415-105706594
181-284 JAXUCZ010000008.1 105728268-105728371
285-406 JAXUCZ010000008.1 105745234-105745355
407-454 JAXUCZ010000008.1 105748259-105748306
455-617 JAXUCZ010000008.1 105752132-105752294
618-761 JAXUCZ010000008.1 105754484-105754627
762-830 JAXUCZ010000008.1 105757273-105757341
831-982 JAXUCZ010000008.1 105763697-105763848
983-1149 JAXUCZ010000008.1 105767662-105767828
1150-1255 JAXUCZ010000008.1 105774835-105774940
1256-7119 JAXUCZ010000008.1 105775163-105781026
FEATURES Location/Qualifiers
source 1..7119
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="8"
/map="8q31"
gene 1..7119
/gene="Tfdp2"
/gene_synonym="Tcfdp2"
/note="transcription factor Dp-2"
/db_xref="GeneID:300947"
/db_xref="RGD:1305814"
exon 1..180
/gene="Tfdp2"
/gene_synonym="Tcfdp2"
/inference="alignment:Splign:2.1.0"
misc_feature 123..125
/gene="Tfdp2"
/gene_synonym="Tcfdp2"
/note="upstream in-frame stop codon"
exon 181..284
/gene="Tfdp2"
/gene_synonym="Tcfdp2"
/inference="alignment:Splign:2.1.0"
CDS 282..1439
/gene="Tfdp2"
/gene_synonym="Tcfdp2"
/note="isoform 6 is encoded by transcript variant 12;
transcription factor Dp-2 (E2F dimerization partner 2)"
/codon_start=1
/product="transcription factor Dp-2 isoform 6"
/protein_id="NP_001420234.1"
/db_xref="GeneID:300947"
/db_xref="RGD:1305814"
/translation="MIISTPQRITNSGSVLIGSPYTPAPAMVTQTHIAEAAGWVPSDR
KRAREFIDSDFSESKRSKKGDKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVSEFT
NASNHLAADSAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLE
IEKQRRIERIKQKRAQLQELLLQQIAFKNLVQRNRQNEQQNQGPPAVNSTIQLPFIVI
NTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRMGMSFGLESGKCSLEDLKIA
KSLVPKALEGYITDVSTGPSWLNQGLLLNSTQSVSNLDPTTGATVPQSSVNQGLCLDA
EVALATGQFLAPNSHQSSTAASQFSESRGETPCSFNDEEEEDEEEDPSSPE"
exon 285..406
/gene="Tfdp2"
/gene_synonym="Tcfdp2"
/inference="alignment:Splign:2.1.0"
exon 407..454
/gene="Tfdp2"
/gene_synonym="Tcfdp2"
/inference="alignment:Splign:2.1.0"
exon 455..617
/gene="Tfdp2"
/gene_synonym="Tcfdp2"
/inference="alignment:Splign:2.1.0"
exon 618..761
/gene="Tfdp2"
/gene_synonym="Tcfdp2"
/inference="alignment:Splign:2.1.0"
exon 762..830
/gene="Tfdp2"
/gene_synonym="Tcfdp2"
/inference="alignment:Splign:2.1.0"
exon 831..982
/gene="Tfdp2"
/gene_synonym="Tcfdp2"
/inference="alignment:Splign:2.1.0"
exon 983..1149
/gene="Tfdp2"
/gene_synonym="Tcfdp2"
/inference="alignment:Splign:2.1.0"
exon 1150..1255
/gene="Tfdp2"
/gene_synonym="Tcfdp2"
/inference="alignment:Splign:2.1.0"
exon 1256..7119
/gene="Tfdp2"
/gene_synonym="Tcfdp2"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 agtttcacca agctcagaaa gctctgagca gtttttcagg agtttctcct cccctttttc
61 tgggaaattc atggtgcatt tgctctgctt tcaaaatgca gtaaggtcct ctgctttgtg
121 actgactgcc ttggagcccg cagacagtcg gacatgtaca attccaacta tgcaggtctt
181 gtaacatttc acttgtggcc tttccagttt caagcaccaa ctcaccaaca aagattttac
241 cgaaaacctt agggccagta aatgtgaatg ttggacccca aatgattata agcacaccac
301 agagaattac caattcagga agtgttctga ttgggagtcc atatacccct gcaccagcaa
361 tggtcactca gactcacata gctgaggctg ctggctgggt tcccagtgat agaaaacgag
421 ctagagaatt tatagactcc gatttttcag aaagtaaacg aagcaaaaaa ggggacaaaa
481 atgggaaagg cttgagacat ttttcaatga aggtgtgtga gaaagttcaa cggaaaggca
541 caacatcata caatgaagta gctgatgaac tggtgtctga gtttaccaat gcgagtaacc
601 atctggcagc tgactcggct tatgatcaga agaacattag acgaagagtt tatgatgctc
661 tgaatgtgct aatggcaatg aacataattt caaaggagaa aaaagaaatc aagtggattg
721 ggctgcctac caactccgcc caggagtgcc agaacctgga aatagagaag caaaggcgga
781 tagaacggat aaagcagaag cgggcccagc tacaagaact tctccttcag caaattgctt
841 ttaaaaacct ggtacagaga aatcgacaaa atgaacaaca aaaccagggc cctccagctg
901 tgaattccac cattcagctg ccatttatag tcattaatac aagcaggaaa acagtcatag
961 actgcagcat ctccagtgac aagtttgaat acctctttaa ttttgataac acctttgaga
1021 tccatgatga catagaggta ctgaagcgga tgggaatgtc ctttggtctg gagtcaggca
1081 aatgctctct ggaggatctg aaaatcgcaa aatccctggt tccaaaagct ttagaaggct
1141 atatcacaga cgtctctaca ggaccttctt ggttaaatca gggactactt ttgaactcta
1201 cccaatcagt ttcaaattta gacccgacca ccggtgccac tgtaccccaa tcaagtgtaa
1261 accaagggtt gtgcttggat gctgaagtgg ccttagcaac tgggcagttc cttgccccaa
1321 acagtcacca gtccagcact gcagcctctc agttttcgga gtcccgaggt gagaccccct
1381 gttcattcaa cgatgaagag gaggaagatg aagaggagga cccctcctcc cctgaataaa
1441 gacaggagag aactcatgtt taatatttga tgctcatgtg tgtctttagt gtgagctctt
1501 gtgttttgaa atgattgctt cagtctttgc ctttgtttgc atttgtgttt agtgaaaact
1561 agagaaacac aataagcaaa ttacacgcag gctgagatga ttgagatgac agttcccata
1621 gtgtggatga agcggagctg cagagctgtg gacatcgcca acagagcaag ctttctgagg
1681 aggtagaggc cgatctgaag agcagtgcgg tgaagttcat ttgttttcag ggaggtgggg
1741 attaaaggcc cacagtgtga gcatttagac ctcaggtggc tgcaaggagc agtatgcagt
1801 gatgacagct tctccctcgc ctgcccgccc actgtccttg gtaggcaaga gtgaacttgg
1861 aagtcacagt gggggtctgt tgtcgcctgc gcggagcggt gaactgctga gctggtccag
1921 gtttagctga gcgcctcttg catctgctgc cttagcttct gaagggagca agcgctaatc
1981 tttaagtacc taggtgacac gtaggaaatt ttacactaaa ctgaggtgag catctgtcag
2041 tgcgttggtg cataggagtt actaggacta cttctggaag ccaaagtaga atagcatttc
2101 catgtgcatt aaaaacttcg ccagcactgc cttttgccag cattctaagt ttggagtttt
2161 actgagagag aaactgtttt tatagtttta atcaaagcta tgcattcata cagcttttta
2221 atttacaatg agacaaagaa atcaattcct ttgaccaaat tgcttgtcta cagttgtctg
2281 cagtactgtg tgattttacc catgtgcaat ttgtaaaaat gaaccaaatg tcattacttt
2341 tgtctttatt tcaagaatat ggccatcatt gttatcttat acatcttatc ttttccatat
2401 tttaattatc aaaatgacct tacagattta ttcctgggta aattgcattt caaactaact
2461 caatattcat acttttgtta aaaccgtgaa cactccagct gcctgcatcc atgccagtgt
2521 ggcatgtcat atgtgatctt aaagccaaag atgccgtgaa aatcccgcgg tatgtgtgtg
2581 attgctgctt ctccacgtag aggagcatga gacatccact gccaagccac actcaactta
2641 ctaatccgtt aaggcctgaa agggggcaga gagtggctgc agactcagtt ccacgaccag
2701 gtaaagccag ggccgtctga atctgctctc tgtgagccct gcaccaagtt cagtccaaat
2761 gctcttttca gtcctgtggt tcggggagca caggctctat tccatgatgc ctttctgaga
2821 cttgaccatt atgagctgag caaaaagctt tggctggctt acataggtta ttgaggccat
2881 taacactgat aagtatgagt atacagatgt ggcttaggtt tcttcaggag caaactcatt
2941 ctgtcaggag gaaactgtag aacgagccca gagtgttcaa ggggcataac ggtcctggca
3001 ggtttcaaag ggctttgtgt tgacatgagt tctagaacac attcaggctc tcagagcaaa
3061 gtgactcaga atgcaacagg agctacctcc tgttatcatt gtcggccttt gggaacgtag
3121 gaagacatgg agattagaga catcaagggc cacaaaatgc tttttcagtc ttcaaaatac
3181 tgagctactg gtcctaagat gtttcagaac ttaaagcaaa tgcatgtgtt acacccatcc
3241 cacttactag actgcaaaat ccttgcagta attttcaagg aactgtttcc cattatctgc
3301 gcccctgctg ccgtatgatt tacattgaca aaacttgggc tttaaattgg cagacatgtt
3361 gggcatgttg tgtggctcta atcccagctt ttgggaaata gagcagaaaa gtcaatcttg
3421 gctacatagt gagttcaagg ccagcttggg ctacatgtga ccctgtccag gggaaagagc
3481 tggggagcta accaaagact taatctttgt gtgccccacc cctgaacatt ctaactacca
3541 ctgccctgca ctgcccagtg taaccctgtt cctcctctgt gatgtactgc tgagggcatc
3601 tgcatactag accaagccag gagtggtggt aacactcgta atcctagaca ggcaaaaggt
3661 caccagaggc ttgaagccag cccgggctac attagattag ccctgacata cacgcacgca
3721 tgccccaaag gttgaggtgg ggtgagagag gagcctaaat tgagatgttg aaaaagatga
3781 actctgatct tcattcacta tgtttatatt gctctgggtc cagcaacact gaatcacagt
3841 ttaacacaga gatcaaaatc aaaggggcgg ggagttaaac tgtggtcata gcatctgggt
3901 ttctttgtag gagggcactt aggttccttg cacatagcca ttccctaccc tcaaggtgct
3961 ggtcactgct tagcgaggag ctgaggcgga tttcccctct caagggtcag tttgctattt
4021 ctcaagggta cagcacccat gtcactcccc tgatgacatg tgcagctgcc tgcgccctcc
4081 atgtgaagaa caggtccagc aggctacaca gaggtgctca gccctcacgc ttagcacgct
4141 tcccgtcatg tgtccctgct ggaagtctag tcggtcttta tatttattgt gccttacata
4201 ggaagaaggg actgaatctt tccctatgaa cagtcatcca gaaaacaggc tgtggtggcc
4261 acacactttg catctttctt atttgattct tttaaagaag tgtggggagg aaaacctgtc
4321 atctttgttg ttttaccaga atgaagacag ctcctcctgt tagcaaaacc tatacttaga
4381 gcagcagcag aacgctaccc attttagaag gtaattccca ggtctgtcct cagaaagttc
4441 cccttttgga tagtccagat gaagaaatgt ctcactgtat cccttcgtag attcctaact
4501 cggccatttc taaatctaaa ccgatatctt aagtcagagg cagtgaagct gttcaagaac
4561 agtgtgattt gtgccctgtg acagtctgaa cagtgtgtgt gcatgacaga cagacagaca
4621 gactgactaa gcagatgaca ggaatggcgt cagcagttta tgccgtaacc acgcccagag
4681 caaaaaacct actcagtttt ataagctcct ttcccaacca aaatgggttg tcctcattca
4741 aaaaacctgt gacatagacc ttagaatttt gctcctttag tggtgagcat gggacatggt
4801 ttgttttgga gcgagaatgt tgaaatgctg aacttagcta gctttaggac ctgaaaggca
4861 ggcggggact gcagcaaggc cctgaagttc tcagtgagtc gcattcccct gagctgaacc
4921 taccctgcag gcgggagagc tgagatcaca tgatctgtaa gctgctaata cataaagaga
4981 gataatgtat aagctcatga attgagcgca cgaagagtga ccctcatgct gcacatagac
5041 ttcgtctttg ttggaaggtg gactggatag ctaagagcta gcttcccaat ggcattccaa
5101 tttgtgtacg ccttgggccg gtgcctctgg gcactaatgt tcatcgatac acagtctctg
5161 aagaccgggg cacatgcccg gagcctgcag cacggcactt aaatgagcct cagaaatgtc
5221 ccttccagct cacgaagtca gttcactcac gctctgttga cctgtacttg agcccagcac
5281 tgtcattcag aaggggaggc taatgtgaca attcttcctt taattctttt tgttaacgtt
5341 agtgctaaaa ggctgtgata agttagaaca agcctcagga aatagcctct tacctattag
5401 cggagtacct gaaaaatatc catctgtagg gtccagtttt cctacataca tctttgatca
5461 cagtatgcta aggggaaaaa attaggacac aaaactggca ttttatgttt ccttggagtc
5521 cttggcagat actgacactg atgtgggtag ccgtccctca cggtgtctcg agaggaaagc
5581 tacgtgttta cactgtctgt tctgcgcagt ctctcagcta agatgatatc ctggatcttt
5641 ttttaatgta caaaaccctg tagaaccagt gctttggctg ctttctatcc tagcagagag
5701 gaccttggtc ctctctactt agaaagctac ttcagaagct attgggaagt caaggtttgt
5761 gtcttctcta ctgaggtctc agaaagggag agagcatctc tgggagccgg gcctcgggca
5821 ggaagtaccc agagcctcat gtgtggccca gcagccttcg cctctatagc agtgagctca
5881 acagtctggc ctgccacctc cctcagggca tcattgctta ctgcaaagca caccttcacc
5941 atgctccagc cagacagctc cagtctcgcc aacaagtgcc aaaagtctga ggaacacagg
6001 ggatctcttc tcgaaagccc catcaagtag tgccatcttg gggcttccca ggacttccag
6061 tataggtggt tacgatcaca agaaacctcc aggcaagggt ccattcagtc tgtacattgg
6121 tagggacacg agaggtggga ttgccatctg ggcctcagtg gcttgtctcc aaccaaatta
6181 ttggacttca gaagccatcc ctctgctgtg cttgacttca gactcagttg ctgcaccttg
6241 gtcatgatct gagtacaaaa gctgtaccag tttcccatgc tcagaccctc tgtctgtctg
6301 tcctcgtgat actgaagtgt ctccactcgc ccagcggctt ctctgtggaa gtggcttctc
6361 tccaggctgc taatctgttt tttccgggcg gtactaggac agcatcctga gaaacgggac
6421 cagttctcca cccgctctga ctgctcagga ggcctgggtc ccgtttaccc tgtcactctt
6481 tactggaagg gaggttgctc agtcaccagg tcgctcactt tccattcaga gacgctttgc
6541 tctgcttgtg tgccgcgagt ttctgtctcc agaaaagtgt aactttgccc tttttctgca
6601 tgacgcacgt acccatgtcg cgcactaagt agtttaaatg aggtaaagga aaacgcagag
6661 cacatcttgc ttgcctctta gagtttcctc cctaaattga agtccatagg ctaatatatt
6721 attttgtagt atctcagact ttgcataaat actattattt ttgtatggaa ttttttatag
6781 aagagctatt tctgtatact tatttgtggt ttttgaaatg ccttccagta ggtaaccgac
6841 aagtcttaag cagtgtccac taagggtagc tcagggacca cctacccaga ataggcaggg
6901 aatttaaatt ttcttactcc ctgtacccac tccagacaga agctcaggtt gtgtctagga
6961 agcagtttta ataagctctg agtgattttc ttcatcaacc cacacatatt tgtccatgct
7021 gtaagagaag acatctggaa tgagtatgtt gagctggaga ataattgtat catatactct
7081 gtgatttgag atacaaaata aagaaataat ttaaaataa
//