LOCUS NM_005572 2077 bp mRNA linear PRI 29-MAR-2020
DEFINITION Homo sapiens lamin A/C (LMNA), transcript variant 2, mRNA.
ACCESSION NM_005572
VERSION NM_005572.3
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2077)
AUTHORS McClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS
and Djabali K.
TITLE The mutant form of lamin A that causes Hutchinson-Gilford progeria
is a biomarker of cellular aging in human skin
JOURNAL PLoS ONE 2 (12), e1269 (2007)
PUBMED 18060063
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 2077)
AUTHORS Scaffidi P and Misteli T.
TITLE Lamin A-dependent nuclear defects in human aging
JOURNAL Science 312 (5776), 1059-1063 (2006)
PUBMED 16645051
REMARK GeneRIF: observations implicate lamin A in physiological aging
REFERENCE 3 (bases 1 to 2077)
AUTHORS De Sandre-Giovannoli A, Bernard R, Cau P, Navarro C, Amiel J,
Boccaccio I, Lyonnet S, Stewart CL, Munnich A, Le Merrer M and Levy
N.
TITLE Lamin a truncation in Hutchinson-Gilford progeria
JOURNAL Science 300 (5628), 2055 (2003)
PUBMED 12702809
REMARK GeneRIF: Hutchinson-Gilford progeria appears to represent a novel
laminopathy, caused by a single heterozygous splicing mutation in
the LMNA gene, leading to a major loss of Lamin A expression,
intimately associated to nuclear alterations
REFERENCE 4 (bases 1 to 2077)
AUTHORS Hershberger,R.E. and Morales,A.
TITLE LMNA-Related Dilated Cardiomyopathy
JOURNAL (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
K and Amemiya A (Eds.);
GENEREVIEWS((R));
(1993)
PUBMED 20301717
REFERENCE 5 (bases 1 to 2077)
AUTHORS Bonne,G., Leturcq,F. and Ben Yaou,R.
TITLE Emery-Dreifuss Muscular Dystrophy
JOURNAL (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
K and Amemiya A (Eds.);
GENEREVIEWS((R));
(1993)
PUBMED 20301609
REFERENCE 6 (bases 1 to 2077)
AUTHORS Pegoraro,E. and Hoffman,E.P.
TITLE Limb-Girdle Muscular Dystrophy Overview - ARCHIVED CHAPTER, FOR
HISTORICAL REFERENCE ONLY
JOURNAL (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
K and Amemiya A (Eds.);
GENEREVIEWS((R));
(1993)
PUBMED 20301582
REFERENCE 7 (bases 1 to 2077)
AUTHORS Bird,T.D.
TITLE Charcot-Marie-Tooth (CMT) Hereditary Neuropathy Overview
JOURNAL (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
K and Amemiya A (Eds.);
GENEREVIEWS((R));
(1993)
PUBMED 20301532
REFERENCE 8 (bases 1 to 2077)
AUTHORS Hershberger,R.E. and Morales,A.
TITLE Dilated Cardiomyopathy Overview
JOURNAL (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
K and Amemiya A (Eds.);
GENEREVIEWS((R));
(1993)
PUBMED 20301486
REFERENCE 9 (bases 1 to 2077)
AUTHORS Sparks,S.E., Quijano-Roy,S., Harper,A., Rutkowski,A., Gordon,E.,
Hoffman,E.P. and Pegoraro,E.
TITLE Congenital Muscular Dystrophy Overview - ARCHIVED CHAPTER, FOR
HISTORICAL REFERENCE ONLY
JOURNAL (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
K and Amemiya A (Eds.);
GENEREVIEWS((R));
(1993)
PUBMED 20301468
REFERENCE 10 (bases 1 to 2077)
AUTHORS Bird,T.D.
TITLE Charcot-Marie-Tooth Neuropathy Type 2 - ARCHIVED CHAPTER, FOR
HISTORICAL REFERENCE ONLY
JOURNAL (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
K and Amemiya A (Eds.);
GENEREVIEWS((R));
(1993)
PUBMED 20301462
REFERENCE 11 (bases 1 to 2077)
AUTHORS Gordon,L.B., Brown,W.T. and Collins,F.S.
TITLE Hutchinson-Gilford Progeria Syndrome
JOURNAL (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
K and Amemiya A (Eds.);
GENEREVIEWS((R));
(1993)
PUBMED 20301300
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA421696.1, X03445.1 and
AA558657.1.
This sequence is a reference standard in the RefSeqGene project.
[WARNING] On Apr 9, 2020 this sequence was replaced by NM_005572.4.
On Jul 24, 2007 this sequence version replaced NM_005572.2.
Summary: The nuclear lamina consists of a two-dimensional matrix of
proteins located next to the inner nuclear membrane. The lamin
family of proteins make up the matrix and are highly conserved in
evolution. During mitosis, the lamina matrix is reversibly
disassembled as the lamin proteins are phosphorylated. Lamin
proteins are thought to be involved in nuclear stability, chromatin
structure and gene expression. Vertebrate lamins consist of two
types, A and B. Alternative splicing results in multiple transcript
variants. Mutations in this gene lead to several diseases:
Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy,
limb girdle muscular dystrophy, dilated cardiomyopathy,
Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria
syndrome. [provided by RefSeq, Apr 2012].
Transcript Variant: This variant (2) uses an alternate splice site
in the 3' coding region, compared to variant 1. This results in a
shorter isoform (C) with a distinct C-terminus when compared to
isoform prelamin A. Both variants 2 and 6 encode the same isoform
(C).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1163657.305657.1, X03445.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682
[ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-104 DA421696.1 43-146
105-1857 X03445.1 66-1818
1858-2077 AA558657.1 1-220 c
FEATURES Location/Qualifiers
source 1..2077
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q22"
gene 1..2077
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/note="lamin A/C"
/db_xref="GeneID:4000"
/db_xref="HGNC:HGNC:6636"
/db_xref="MIM:150330"
exon 1..605
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/inference="alignment:Splign:2.1.0"
misc_feature 13..15
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/note="upstream in-frame stop codon"
CDS 250..1968
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/note="isoform C is encoded by transcript variant 2; lamin
A/C-like 1; 70 kDa lamin; prelamin-A/C; renal carcinoma
antigen NY-REN-32; mandibuloacral dysplasia type A;
epididymis secretory sperm binding protein"
/codon_start=1
/product="lamin isoform C"
/protein_id="NP_005563.1"
/db_xref="CCDS:CCDS1131.1"
/db_xref="GeneID:4000"
/db_xref="HGNC:HGNC:6636"
/db_xref="MIM:150330"
/translation="METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAV
YIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARL
QLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEG
ELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRET
KRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQ
SAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTS
RRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPS
PTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEGK
FVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSP
PTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHH
VSGSRR"
misc_feature 250..639
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02545.1);
Region: Interaction with MLIP.
{ECO:0000269|PubMed:21498514}"
misc_feature 250..348
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02545.1);
Region: Head"
misc_feature 250..252
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylmethionine. {ECO:0000244|PubMed:20068231};
propagated from UniProtKB/Swiss-Prot (P02545.1);
acetylation site"
misc_feature 256..258
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine. {ECO:0000244|PubMed:20068231};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 283..285
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}; propagated from
UniProtKB/Swiss-Prot (P02545.1); phosphorylation site"
misc_feature 301..303
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:18669648};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 304..306
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine. {ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163, ECO:0000244|PubMed:24275569};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 313..315
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163, ECO:0000244|PubMed:24275569,
ECO:0000269|Ref.9}; propagated from UniProtKB/Swiss-Prot
(P02545.1); phosphorylation site"
misc_feature 343..345
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine, alternate.
{ECO:0000250|UniProtKB:P48678}; propagated from
UniProtKB/Swiss-Prot (P02545.1); acetylation site"
misc_feature 343..345
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-succinyllysine, alternate.
{ECO:0000250|UniProtKB:P48678}; propagated from
UniProtKB/Swiss-Prot (P02545.1); modified site"
misc_feature 349..459
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02545.1);
Region: Coil 1A"
misc_feature 400..402
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 445..447
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 460..489
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02545.1);
Region: Linker 1"
misc_feature 460..462
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 490..903
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02545.1);
Region: Coil 1B"
misc_feature 568..570
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 571..573
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine. {ECO:0000244|PubMed:19608861};
propagated from UniProtKB/Swiss-Prot (P02545.1);
acetylation site"
misc_feature 616..618
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine. {ECO:0000250|UniProtKB:P48678};
propagated from UniProtKB/Swiss-Prot (P02545.1);
acetylation site"
misc_feature 652..654
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine. {ECO:0000250|UniProtKB:P48678};
propagated from UniProtKB/Swiss-Prot (P02545.1);
acetylation site"
misc_feature 712..714
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine. {ECO:0000250|UniProtKB:P48678};
propagated from UniProtKB/Swiss-Prot (P02545.1);
acetylation site"
misc_feature 760..762
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine, alternate.
{ECO:0000250|UniProtKB:P48678}; propagated from
UniProtKB/Swiss-Prot (P02545.1); acetylation site"
misc_feature 760..762
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-succinyllysine, alternate.
{ECO:0000250|UniProtKB:P48678}; propagated from
UniProtKB/Swiss-Prot (P02545.1); modified site"
misc_feature 850..852
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine, alternate.
{ECO:0000250|UniProtKB:P48678}; propagated from
UniProtKB/Swiss-Prot (P02545.1); acetylation site"
misc_feature 883..885
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163, ECO:0000244|PubMed:24275569};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 904..975
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02545.1);
Region: Linker 2"
misc_feature 976..1398
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02545.1);
Region: Coil 2"
misc_feature 1027..1029
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine, alternate.
{ECO:0000250|UniProtKB:P48678}; propagated from
UniProtKB/Swiss-Prot (P02545.1); acetylation site"
misc_feature 1045..1047
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Heptad change of phase; propagated from
UniProtKB/Swiss-Prot (P02545.1); other site"
misc_feature 1057..1059
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine, alternate.
{ECO:0000244|PubMed:19608861}; propagated from
UniProtKB/Swiss-Prot (P02545.1); acetylation site"
misc_feature 1078..1080
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:17081983,
ECO:0000244|PubMed:20068231}; propagated from
UniProtKB/Swiss-Prot (P02545.1); phosphorylation site"
misc_feature 1150..1152
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}; propagated from
UniProtKB/Swiss-Prot (P02545.1); phosphorylation site"
misc_feature 1168..1170
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:24275569};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 1180..1182
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine, alternate.
{ECO:0000244|PubMed:19608861}; propagated from
UniProtKB/Swiss-Prot (P02545.1); acetylation site"
misc_feature 1222..1224
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Stutter. {ECO:0000250}; propagated from
UniProtKB/Swiss-Prot (P02545.1); other site"
misc_feature 1237..1239
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Heptad change of phase; propagated from
UniProtKB/Swiss-Prot (P02545.1); other site"
misc_feature 1417..1419
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}; propagated from
UniProtKB/Swiss-Prot (P02545.1); phosphorylation site"
misc_feature 1423..1425
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 1432..1434
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:24275569}; propagated from
UniProtKB/Swiss-Prot (P02545.1); phosphorylation site"
misc_feature 1441..1443
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 1456..1458
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:24275569};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 1459..1461
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:24275569};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 1468..1470
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000250|UniProtKB:P48678};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 1489..1491
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:24275569};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 1498..1515
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02545.1);
Region: Nuclear localization signal. {ECO:0000255}"
misc_feature 1534..1536
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 1540..1542
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:20068231};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 1597..1599
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine, alternate.
{ECO:0000244|PubMed:19608861}; propagated from
UniProtKB/Swiss-Prot (P02545.1); acetylation site"
misc_feature 1618..1620
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine. {ECO:0000250|UniProtKB:P48678};
propagated from UniProtKB/Swiss-Prot (P02545.1);
acetylation site"
misc_feature 1621..1623
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163, ECO:0000244|PubMed:24275569};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 1636..1638
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163, ECO:0000244|PubMed:24275569};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 1735..1737
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine. {ECO:0000250|UniProtKB:P48679};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 1762..1764
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine. {ECO:0000244|PubMed:20068231};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 1777..1779
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine. {ECO:0000250|UniProtKB:P48679};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 1846..1848
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 1885..1887
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000250|UniProtKB:P48678};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 1891..1893
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine. {ECO:0000250|UniProtKB:P48678};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
misc_feature 1951..1953
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000250|UniProtKB:P48678};
propagated from UniProtKB/Swiss-Prot (P02545.1);
phosphorylation site"
exon 606..762
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/inference="alignment:Splign:2.1.0"
exon 763..888
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/inference="alignment:Splign:2.1.0"
exon 889..1059
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/inference="alignment:Splign:2.1.0"
exon 1060..1185
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/inference="alignment:Splign:2.1.0"
exon 1186..1406
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/inference="alignment:Splign:2.1.0"
exon 1407..1629
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/inference="alignment:Splign:2.1.0"
exon 1630..1737
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/inference="alignment:Splign:2.1.0"
exon 1738..1857
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/inference="alignment:Splign:2.1.0"
exon 1858..2070
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
/inference="alignment:Splign:2.1.0"
regulatory 2047..2052
/regulatory_class="polyA_signal_sequence"
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
polyA_site 2068
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
polyA_site 2070
/gene="LMNA"
/gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
LMNL1; MADA; PRO1"
ORIGIN
1 aggaggacct attagagcct ttgccccggc gtcggtgact cagtgttcgc gggagcgccg
61 cacctacacc agccaaccca gatcccgagg tccgacagcg cccggcccag atccccacgc
121 ctgccaggag caagccgaga gccagccggc cggcgcactc cgactccgag cagtctctgt
181 ccttcgaccc gagccccgcg ccctttccgg gacccctgcc ccgcgggcag cgctgccaac
241 ctgccggcca tggagacccc gtcccagcgg cgcgccaccc gcagcggggc gcaggccagc
301 tccactccgc tgtcgcccac ccgcatcacc cggctgcagg agaaggagga cctgcaggag
361 ctcaatgatc gcttggcggt ctacatcgac cgtgtgcgct cgctggaaac ggagaacgca
421 gggctgcgcc ttcgcatcac cgagtctgaa gaggtggtca gccgcgaggt gtccggcatc
481 aaggccgcct acgaggccga gctcggggat gcccgcaaga cccttgactc agtagccaag
541 gagcgcgccc gcctgcagct ggagctgagc aaagtgcgtg aggagtttaa ggagctgaaa
601 gcgcgcaata ccaagaagga gggtgacctg atagctgctc aggctcggct gaaggacctg
661 gaggctctgc tgaactccaa ggaggccgca ctgagcactg ctctcagtga gaagcgcacg
721 ctggagggcg agctgcatga tctgcggggc caggtggcca agcttgaggc agccctaggt
781 gaggccaaga agcaacttca ggatgagatg ctgcggcggg tggatgctga gaacaggctg
841 cagaccatga aggaggaact ggacttccag aagaacatct acagtgagga gctgcgtgag
901 accaagcgcc gtcatgagac ccgactggtg gagattgaca atgggaagca gcgtgagttt
961 gagagccggc tggcggatgc gctgcaggaa ctgcgggccc agcatgagga ccaggtggag
1021 cagtataaga aggagctgga gaagacttat tctgccaagc tggacaatgc caggcagtct
1081 gctgagagga acagcaacct ggtgggggct gcccacgagg agctgcagca gtcgcgcatc
1141 cgcatcgaca gcctctctgc ccagctcagc cagctccaga agcagctggc agccaaggag
1201 gcgaagcttc gagacctgga ggactcactg gcccgtgagc gggacaccag ccggcggctg
1261 ctggcggaaa aggagcggga gatggccgag atgcgggcaa ggatgcagca gcagctggac
1321 gagtaccagg agcttctgga catcaagctg gccctggaca tggagatcca cgcctaccgc
1381 aagctcttgg agggcgagga ggagaggcta cgcctgtccc ccagccctac ctcgcagcgc
1441 agccgtggcc gtgcttcctc tcactcatcc cagacacagg gtgggggcag cgtcaccaaa
1501 aagcgcaaac tggagtccac tgagagccgc agcagcttct cacagcacgc acgcactagc
1561 gggcgcgtgg ccgtggagga ggtggatgag gagggcaagt ttgtccggct gcgcaacaag
1621 tccaatgagg accagtccat gggcaattgg cagatcaagc gccagaatgg agatgatccc
1681 ttgctgactt accggttccc accaaagttc accctgaagg ctgggcaggt ggtgacgatc
1741 tgggctgcag gagctggggc cacccacagc ccccctaccg acctggtgtg gaaggcacag
1801 aacacctggg gctgcgggaa cagcctgcgt acggctctca tcaactccac tggggaagaa
1861 gtggccatgc gcaagctggt gcgctcagtg actgtggttg aggacgacga ggatgaggat
1921 ggagatgacc tgctccatca ccaccacgtg agtggtagcc gccgctgagg ccgagcctgc
1981 actggggcca cccagccagg cctgggggca gcctctcccc agcctccccg tgccaaaaat
2041 cttttcatta aagaatgttt tggaacttta aaaaaaa
//