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Homo sapiens lamin A/C (LMNA), transcript variant 2, mRNA

NCBI Reference Sequence: NM_005572.3

FASTA Graphics 

LOCUS       NM_005572               2077 bp    mRNA    linear   PRI 29-MAR-2020
DEFINITION  Homo sapiens lamin A/C (LMNA), transcript variant 2, mRNA.
ACCESSION   NM_005572
VERSION     NM_005572.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2077)
  AUTHORS   McClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS
            and Djabali K.
  TITLE     The mutant form of lamin A that causes Hutchinson-Gilford progeria
            is a biomarker of cellular aging in human skin
  JOURNAL   PLoS ONE 2 (12), e1269 (2007)
   PUBMED   18060063
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2077)
  AUTHORS   Scaffidi P and Misteli T.
  TITLE     Lamin A-dependent nuclear defects in human aging
  JOURNAL   Science 312 (5776), 1059-1063 (2006)
   PUBMED   16645051
  REMARK    GeneRIF: observations implicate lamin A in physiological aging
REFERENCE   3  (bases 1 to 2077)
  AUTHORS   De Sandre-Giovannoli A, Bernard R, Cau P, Navarro C, Amiel J,
            Boccaccio I, Lyonnet S, Stewart CL, Munnich A, Le Merrer M and Levy
            N.
  TITLE     Lamin a truncation in Hutchinson-Gilford progeria
  JOURNAL   Science 300 (5628), 2055 (2003)
   PUBMED   12702809
  REMARK    GeneRIF: Hutchinson-Gilford progeria appears to represent a novel
            laminopathy, caused by a single heterozygous splicing mutation in
            the LMNA gene, leading to a major loss of Lamin A expression,
            intimately associated to nuclear alterations
REFERENCE   4  (bases 1 to 2077)
  AUTHORS   Hershberger,R.E. and Morales,A.
  TITLE     LMNA-Related Dilated Cardiomyopathy
  JOURNAL   (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
            K and Amemiya A (Eds.);
            GENEREVIEWS((R));
            (1993)
   PUBMED   20301717
REFERENCE   5  (bases 1 to 2077)
  AUTHORS   Bonne,G., Leturcq,F. and Ben Yaou,R.
  TITLE     Emery-Dreifuss Muscular Dystrophy
  JOURNAL   (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
            K and Amemiya A (Eds.);
            GENEREVIEWS((R));
            (1993)
   PUBMED   20301609
REFERENCE   6  (bases 1 to 2077)
  AUTHORS   Pegoraro,E. and Hoffman,E.P.
  TITLE     Limb-Girdle Muscular Dystrophy Overview - ARCHIVED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
            K and Amemiya A (Eds.);
            GENEREVIEWS((R));
            (1993)
   PUBMED   20301582
REFERENCE   7  (bases 1 to 2077)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth (CMT) Hereditary Neuropathy Overview
  JOURNAL   (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
            K and Amemiya A (Eds.);
            GENEREVIEWS((R));
            (1993)
   PUBMED   20301532
REFERENCE   8  (bases 1 to 2077)
  AUTHORS   Hershberger,R.E. and Morales,A.
  TITLE     Dilated Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
            K and Amemiya A (Eds.);
            GENEREVIEWS((R));
            (1993)
   PUBMED   20301486
REFERENCE   9  (bases 1 to 2077)
  AUTHORS   Sparks,S.E., Quijano-Roy,S., Harper,A., Rutkowski,A., Gordon,E.,
            Hoffman,E.P. and Pegoraro,E.
  TITLE     Congenital Muscular Dystrophy Overview - ARCHIVED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
            K and Amemiya A (Eds.);
            GENEREVIEWS((R));
            (1993)
   PUBMED   20301468
REFERENCE   10 (bases 1 to 2077)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Neuropathy Type 2 - ARCHIVED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
            K and Amemiya A (Eds.);
            GENEREVIEWS((R));
            (1993)
   PUBMED   20301462
REFERENCE   11 (bases 1 to 2077)
  AUTHORS   Gordon,L.B., Brown,W.T. and Collins,F.S.
  TITLE     Hutchinson-Gilford Progeria Syndrome
  JOURNAL   (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
            K and Amemiya A (Eds.);
            GENEREVIEWS((R));
            (1993)
   PUBMED   20301300
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA421696.1, X03445.1 and
            AA558657.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            [WARNING] On Apr 9, 2020 this sequence was replaced by NM_005572.4.
            
            On Jul 24, 2007 this sequence version replaced NM_005572.2.
            
            Summary: The nuclear lamina consists of a two-dimensional matrix of
            proteins located next to the inner nuclear membrane. The lamin
            family of proteins make up the matrix and are highly conserved in
            evolution. During mitosis, the lamina matrix is reversibly
            disassembled as the lamin proteins are phosphorylated. Lamin
            proteins are thought to be involved in nuclear stability, chromatin
            structure and gene expression. Vertebrate lamins consist of two
            types, A and B. Alternative splicing results in multiple transcript
            variants. Mutations in this gene lead to several diseases:
            Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy,
            limb girdle muscular dystrophy, dilated cardiomyopathy,
            Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria
            syndrome. [provided by RefSeq, Apr 2012].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, compared to variant 1. This results in a
            shorter isoform (C) with a distinct C-terminus when compared to
            isoform prelamin A. Both variants 2 and 6 encode the same isoform
            (C).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.305657.1, X03445.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               DA421696.1         43-146
            105-1857            X03445.1           66-1818
            1858-2077           AA558657.1         1-220               c
FEATURES             Location/Qualifiers
     source          1..2077
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2077
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /note="lamin A/C"
                     /db_xref="GeneID:4000"
                     /db_xref="HGNC:HGNC:6636"
                     /db_xref="MIM:150330"
     exon            1..605
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    13..15
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /note="upstream in-frame stop codon"
     CDS             250..1968
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /note="isoform C is encoded by transcript variant 2; lamin
                     A/C-like 1; 70 kDa lamin; prelamin-A/C; renal carcinoma
                     antigen NY-REN-32; mandibuloacral dysplasia type A;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="lamin isoform C"
                     /protein_id="NP_005563.1"
                     /db_xref="CCDS:CCDS1131.1"
                     /db_xref="GeneID:4000"
                     /db_xref="HGNC:HGNC:6636"
                     /db_xref="MIM:150330"
                     /translation="METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAV
                     YIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARL
                     QLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEG
                     ELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRET
                     KRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQ
                     SAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTS
                     RRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPS
                     PTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEGK
                     FVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSP
                     PTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHH
                     VSGSRR"
     misc_feature    250..639
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P02545.1);
                     Region: Interaction with MLIP.
                     {ECO:0000269|PubMed:21498514}"
     misc_feature    250..348
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P02545.1);
                     Region: Head"
     misc_feature    250..252
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N-acetylmethionine. {ECO:0000244|PubMed:20068231};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     acetylation site"
     misc_feature    256..258
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000244|PubMed:20068231};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    283..285
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:23186163,
                     ECO:0000244|PubMed:24275569}; propagated from
                     UniProtKB/Swiss-Prot (P02545.1); phosphorylation site"
     misc_feature    301..303
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    304..306
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000244|PubMed:16964243,
                     ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:20068231,
                     ECO:0000244|PubMed:23186163, ECO:0000244|PubMed:24275569};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    313..315
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:16964243,
                     ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:20068231,
                     ECO:0000244|PubMed:23186163, ECO:0000244|PubMed:24275569,
                     ECO:0000269|Ref.9}; propagated from UniProtKB/Swiss-Prot
                     (P02545.1); phosphorylation site"
     misc_feature    343..345
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000250|UniProtKB:P48678}; propagated from
                     UniProtKB/Swiss-Prot (P02545.1); acetylation site"
     misc_feature    343..345
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000250|UniProtKB:P48678}; propagated from
                     UniProtKB/Swiss-Prot (P02545.1); modified site"
     misc_feature    349..459
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P02545.1);
                     Region: Coil 1A"
     misc_feature    400..402
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    445..447
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    460..489
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P02545.1);
                     Region: Linker 1"
     misc_feature    460..462
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    490..903
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P02545.1);
                     Region: Coil 1B"
     misc_feature    568..570
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    571..573
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000244|PubMed:19608861};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     acetylation site"
     misc_feature    616..618
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000250|UniProtKB:P48678};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     acetylation site"
     misc_feature    652..654
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000250|UniProtKB:P48678};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     acetylation site"
     misc_feature    712..714
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000250|UniProtKB:P48678};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     acetylation site"
     misc_feature    760..762
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000250|UniProtKB:P48678}; propagated from
                     UniProtKB/Swiss-Prot (P02545.1); acetylation site"
     misc_feature    760..762
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-succinyllysine, alternate.
                     {ECO:0000250|UniProtKB:P48678}; propagated from
                     UniProtKB/Swiss-Prot (P02545.1); modified site"
     misc_feature    850..852
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000250|UniProtKB:P48678}; propagated from
                     UniProtKB/Swiss-Prot (P02545.1); acetylation site"
     misc_feature    883..885
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:20068231,
                     ECO:0000244|PubMed:23186163, ECO:0000244|PubMed:24275569};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    904..975
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P02545.1);
                     Region: Linker 2"
     misc_feature    976..1398
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P02545.1);
                     Region: Coil 2"
     misc_feature    1027..1029
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000250|UniProtKB:P48678}; propagated from
                     UniProtKB/Swiss-Prot (P02545.1); acetylation site"
     misc_feature    1045..1047
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Heptad change of phase; propagated from
                     UniProtKB/Swiss-Prot (P02545.1); other site"
     misc_feature    1057..1059
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000244|PubMed:19608861}; propagated from
                     UniProtKB/Swiss-Prot (P02545.1); acetylation site"
     misc_feature    1078..1080
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:17081983,
                     ECO:0000244|PubMed:20068231}; propagated from
                     UniProtKB/Swiss-Prot (P02545.1); phosphorylation site"
     misc_feature    1150..1152
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:23186163,
                     ECO:0000244|PubMed:24275569}; propagated from
                     UniProtKB/Swiss-Prot (P02545.1); phosphorylation site"
     misc_feature    1168..1170
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:24275569};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    1180..1182
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000244|PubMed:19608861}; propagated from
                     UniProtKB/Swiss-Prot (P02545.1); acetylation site"
     misc_feature    1222..1224
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Stutter. {ECO:0000250}; propagated from
                     UniProtKB/Swiss-Prot (P02545.1); other site"
     misc_feature    1237..1239
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Heptad change of phase; propagated from
                     UniProtKB/Swiss-Prot (P02545.1); other site"
     misc_feature    1417..1419
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:16964243,
                     ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:20068231,
                     ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:23186163,
                     ECO:0000244|PubMed:24275569}; propagated from
                     UniProtKB/Swiss-Prot (P02545.1); phosphorylation site"
     misc_feature    1423..1425
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:16964243,
                     ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:20068231,
                     ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    1432..1434
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:16964243,
                     ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:20068231,
                     ECO:0000244|PubMed:24275569}; propagated from
                     UniProtKB/Swiss-Prot (P02545.1); phosphorylation site"
     misc_feature    1441..1443
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    1456..1458
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:24275569};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    1459..1461
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:20068231,
                     ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:24275569};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    1468..1470
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:P48678};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    1489..1491
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:20068231,
                     ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:24275569};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    1498..1515
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P02545.1);
                     Region: Nuclear localization signal. {ECO:0000255}"
     misc_feature    1534..1536
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    1540..1542
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:20068231};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    1597..1599
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine, alternate.
                     {ECO:0000244|PubMed:19608861}; propagated from
                     UniProtKB/Swiss-Prot (P02545.1); acetylation site"
     misc_feature    1618..1620
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine. {ECO:0000250|UniProtKB:P48678};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     acetylation site"
     misc_feature    1621..1623
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:21406692,
                     ECO:0000244|PubMed:23186163, ECO:0000244|PubMed:24275569};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    1636..1638
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:20068231,
                     ECO:0000244|PubMed:23186163, ECO:0000244|PubMed:24275569};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    1735..1737
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000250|UniProtKB:P48679};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    1762..1764
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000244|PubMed:20068231};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    1777..1779
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000250|UniProtKB:P48679};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    1846..1848
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    1885..1887
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:P48678};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    1891..1893
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000250|UniProtKB:P48678};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     misc_feature    1951..1953
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:P48678};
                     propagated from UniProtKB/Swiss-Prot (P02545.1);
                     phosphorylation site"
     exon            606..762
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            763..888
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1059
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1185
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1406
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1629
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1737
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1857
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..2070
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2047..2052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
     polyA_site      2068
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
     polyA_site      2070
                     /gene="LMNA"
                     /gene_synonym="CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL;
                     FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
                     LMNL1; MADA; PRO1"
ORIGIN      
        1 aggaggacct attagagcct ttgccccggc gtcggtgact cagtgttcgc gggagcgccg
       61 cacctacacc agccaaccca gatcccgagg tccgacagcg cccggcccag atccccacgc
      121 ctgccaggag caagccgaga gccagccggc cggcgcactc cgactccgag cagtctctgt
      181 ccttcgaccc gagccccgcg ccctttccgg gacccctgcc ccgcgggcag cgctgccaac
      241 ctgccggcca tggagacccc gtcccagcgg cgcgccaccc gcagcggggc gcaggccagc
      301 tccactccgc tgtcgcccac ccgcatcacc cggctgcagg agaaggagga cctgcaggag
      361 ctcaatgatc gcttggcggt ctacatcgac cgtgtgcgct cgctggaaac ggagaacgca
      421 gggctgcgcc ttcgcatcac cgagtctgaa gaggtggtca gccgcgaggt gtccggcatc
      481 aaggccgcct acgaggccga gctcggggat gcccgcaaga cccttgactc agtagccaag
      541 gagcgcgccc gcctgcagct ggagctgagc aaagtgcgtg aggagtttaa ggagctgaaa
      601 gcgcgcaata ccaagaagga gggtgacctg atagctgctc aggctcggct gaaggacctg
      661 gaggctctgc tgaactccaa ggaggccgca ctgagcactg ctctcagtga gaagcgcacg
      721 ctggagggcg agctgcatga tctgcggggc caggtggcca agcttgaggc agccctaggt
      781 gaggccaaga agcaacttca ggatgagatg ctgcggcggg tggatgctga gaacaggctg
      841 cagaccatga aggaggaact ggacttccag aagaacatct acagtgagga gctgcgtgag
      901 accaagcgcc gtcatgagac ccgactggtg gagattgaca atgggaagca gcgtgagttt
      961 gagagccggc tggcggatgc gctgcaggaa ctgcgggccc agcatgagga ccaggtggag
     1021 cagtataaga aggagctgga gaagacttat tctgccaagc tggacaatgc caggcagtct
     1081 gctgagagga acagcaacct ggtgggggct gcccacgagg agctgcagca gtcgcgcatc
     1141 cgcatcgaca gcctctctgc ccagctcagc cagctccaga agcagctggc agccaaggag
     1201 gcgaagcttc gagacctgga ggactcactg gcccgtgagc gggacaccag ccggcggctg
     1261 ctggcggaaa aggagcggga gatggccgag atgcgggcaa ggatgcagca gcagctggac
     1321 gagtaccagg agcttctgga catcaagctg gccctggaca tggagatcca cgcctaccgc
     1381 aagctcttgg agggcgagga ggagaggcta cgcctgtccc ccagccctac ctcgcagcgc
     1441 agccgtggcc gtgcttcctc tcactcatcc cagacacagg gtgggggcag cgtcaccaaa
     1501 aagcgcaaac tggagtccac tgagagccgc agcagcttct cacagcacgc acgcactagc
     1561 gggcgcgtgg ccgtggagga ggtggatgag gagggcaagt ttgtccggct gcgcaacaag
     1621 tccaatgagg accagtccat gggcaattgg cagatcaagc gccagaatgg agatgatccc
     1681 ttgctgactt accggttccc accaaagttc accctgaagg ctgggcaggt ggtgacgatc
     1741 tgggctgcag gagctggggc cacccacagc ccccctaccg acctggtgtg gaaggcacag
     1801 aacacctggg gctgcgggaa cagcctgcgt acggctctca tcaactccac tggggaagaa
     1861 gtggccatgc gcaagctggt gcgctcagtg actgtggttg aggacgacga ggatgaggat
     1921 ggagatgacc tgctccatca ccaccacgtg agtggtagcc gccgctgagg ccgagcctgc
     1981 actggggcca cccagccagg cctgggggca gcctctcccc agcctccccg tgccaaaaat
     2041 cttttcatta aagaatgttt tggaacttta aaaaaaa
//
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