MeSH

An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.

Year introduced: NUX VOMICA was heading 1963-1978

Substances that act in the brain stem or spinal cord to produce tonic or clonic convulsions, often by removing normal inhibitory tone. They were formerly used to stimulate respiration or as antidotes to barbiturate overdose. They are now most commonly used as experimental tools.

Year introduced: 1975

Substances which, when ingested, inhaled, or absorbed, or when applied to, injected into, or developed within the body in relatively small amounts may, by their chemical action, cause damage to structure or disturbance of function. (From Dorland, 27th ed)

Substances used for their pharmacological actions on glycinergic systems. Glycinergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function.

Year introduced: 1995

Multiple ring heterocyclic compounds containing two or more rings that share two atoms and one bond in common.

Year introduced: 2017

Saturated indolizines that are fused six and five-membered rings with a nitrogen atom at the ring fusion. They are biosynthesized in PLANTS by cyclization of a LYSINE coupled to ACETYL COENZYME A. Many of them are naturally occurring ALKALOIDS.

Year introduced: 2008

Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant and Hackh's Chemical Dictionary, 5th ed)

Cyclic compounds that include atoms other than carbon in their ring structure.

A class of heterocyclic compounds that include a two-ring fused structure. Both aromatic and non-aromatic ring structures are included in this category.

Year introduced: 1998

Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.

Year introduced: 1966

Group of alkaloids containing a benzylpyrrole group (derived from TRYPTOPHAN).

Year introduced: 2002

Compounds formed by condensation of secologanin with tryptamine resulting in a tetrahydro-beta-carboline which is processed further to a number of bioactive compounds. These are especially found in plants of the APOCYNACEAE; LOGANIACEAE; and RUBIACEAE families.

Year introduced: 2005

Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.

Year introduced: 1998

A group of pharmacologic activities, effects on living systems and the environment, and modes of employment of drugs and chemicals. They are broken into actions, which describe their effects, and uses, which describe how they are employed.

Year introduced: 1999

Agents capable of exerting a harmful effect on the body.

Year introduced: 1998

A broad category of chemical actions and uses that result in the prevention, treatment, cure or diagnosis of disease. Included here are drugs and chemicals that act by altering normal body functions, such as the REPRODUCTIVE CONTROL AGENTS and ANESTHETICS. Effects of chemicals on the environment are also included.

Year introduced: 2004(1999)

Uses of chemicals in a research, industrial, or household setting. This does not include PHARMACOLOGIC ACTIONS.

Year introduced: 2004(1999)

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY.

Year introduced: 2008(2004)

A broad category of chemical actions with harmful or deadly effect on living organisms.

Year introduced: 2004(1998)