Segmental glomerulosclerosis [Supplementary Concept]
A pathologic finding in several renal disorders that manifest clinically as PROTEINURIA and progressive decline in renal function. Some patients develop NEPHROTIC SYNDROME (OMIM: 256300), but others may only have proteinuria in the nephrotic syndrome range. Autosomal dominant mutations in the ACTN4 gene have been identified in some cases. OMIM: 603278
Date introduced: August 25, 2010
MeSH Unique ID: C538457
Heading Mapped to:
Entry Terms:
- Focal sclerosis with hyalinosis
- Glomerulosclerosis, Focal Segmental, 1
- FSGS1
- Focal segmental glomerulosclerosis 1