Depressive Disorder, Major

Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every day; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)

Year introduced: 1981

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Subheadings:

Restrict to MeSH Major Topic.

Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): F03.600.300.375

MeSH Unique ID: D003865

Entry Terms:

• Depressive Disorders, Major
• Major Depressive Disorders
• Clinical Depression
• Major Depressive Disorder
• Depression, Involutional
• Involutional Depression
• Melancholia, Involutional
• Involutional Melancholia
• Psychosis, Involutional
• Involutional Psychoses
• Involutional Psychosis
• Psychoses, Involutional
• Paraphrenia, Involutional
• Involutional Paraphrenia
• Involutional Paraphrenias
• Paraphrenias, Involutional

All MeSH Categories
Psychiatry and Psychology Category
Mental Disorders
Mood Disorders
Depressive Disorder
Depressive Disorder, Major