Serotonin Syndrome

An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.

Year introduced: 1999

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Tree Number(s): C25.100.875

MeSH Unique ID: D020230

Entry Terms:

• Serotonin Syndromes
• Syndrome, Serotonin
• Syndromes, Serotonin

Previous Indexing:

• Serotonin (1980-1992)
• Serotonin Uptake Inhibitors/adverse effects (1993-1998)

See Also:

• Monoamine Oxidase Inhibitors
• Serotonin
• Selective Serotonin Reuptake Inhibitors

All MeSH Categories
Diseases Category
Chemically-Induced Disorders
Drug-Related Side Effects and Adverse Reactions
Serotonin Syndrome