Helix-Turn-Helix Motifs
The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were originally identified in bacterial proteins but have since been found in hundreds of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the turn. The two helices are held at a fixed angle, primarily through interactions between the two helices. (From Alberts et al., Molecular Biology of the Cell, 3d ed, p408-9)
Year introduced: 1996
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Subheadings:
Tree Number(s): G02.111.570.820.709.275.500.360.360
MeSH Unique ID: D019077
Entry Terms:
- Helix-Turn-Helix Motif
- Helix Turn Helix Motifs
- Motif, Helix-Turn-Helix
- HTH Motifs
- HTH Motif
- Motif, HTH
- Motifs, HTH
- Motifs, Helix-Turn-Helix
- Motifs, Helix Turn Helix
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