Asialoglycoproteins

Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS.

Year introduced: 1985

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Tree Number(s): D09.400.430.657, D12.776.395.140

MeSH Unique ID: D001212

Entry Terms:

• Asialoglycoprotein
• Desialylated Glycoproteins
• Glycoproteins, Desialylated

Previous Indexing:

• Glycoproteins (1966-1984)

See Also:

• Asialoglycoprotein Receptor

All MeSH Categories
Chemicals and Drugs Category
Carbohydrates
Glycoconjugates
Glycoproteins
Asialoglycoproteins

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Glycoproteins
Asialoglycoproteins