Aldo-Keto Reductase Family 1 Member C2
Aldo-keto reductase that functions with 5-alpha and 5-beta-steroid reductases to convert steroid hormones into the 3-alpha or 5-alpha and 3-alpha or 5-beta-tetrahydrosteroid, including 5-ALPHA-DIHYDROTESTOSTERONE to ANDROSTANE-3,17-DIOL. It also binds to BILE ACIDS. Mutations in the AKR1C2 gene are associated with Type 8 DISORDER OF SEX DEVELOPMENT, 46,XY (SRXY8).
Year introduced: 2018
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Subheadings:
Tree Number(s): D08.811.682.047.150.700.156.750, D08.811.682.047.820.284.875
MeSH Unique ID: D000074422
Registry Number: EC 1.1.1.357
Entry Terms:
- Aldo Keto Reductase Family 1 Member C2
- Dihydrodiol Dehydrogenase 2
- AKR1C2 Protein
- Dihydrodiol Dehydrogenase-Bile Acid Binding Protein
- Dihydrodiol Dehydrogenase Bile Acid Binding Protein
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