U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from PMC

Pulmonary hypertension, neonatal, susceptibility to(PHN)

MedGen UID:
811528
•Concept ID:
C3714958
•
Finding
Synonym: PHN
 
Gene (location): CPS1 (2q34)
 
Monarch Initiative: MONDO:0014151
OMIM®: 615371

Professional guidelines

PubMed

Impact of Changes in Early Respiratory Support Management on Respiratory Outcomes of Preterm Infants.
Xie L, Luo X, Li B, Du L, Wang Z, Liu Y, Chen J, Duan S, Yan L, Gao W
Respir Care 2022 Oct;67(10):1310-1319. Epub 2022 Jun 28 doi: 10.4187/respcare.09963. PMID: 35764345
Characteristics and treatment outcomes of patients with MDR and XDR tuberculosis in a TB referral hospital in Beijing: a 13-year experience.
Liu CH, Li L, Chen Z, Wang Q, Hu YL, Zhu B, Woo PC
PLoS One 2011 Apr 29;6(4):e19399. doi: 10.1371/journal.pone.0019399. PMID: 21559362Free PMC Article
Pathophysiology and treatment of bronchopulmonary dysplasia. Current issues.
Abman SH, Groothius JR
Pediatr Clin North Am 1994 Apr;41(2):277-315. doi: 10.1016/s0031-3955(16)38726-0. PMID: 8139877

Recent clinical studies

Etiology

Vascular Disorders of Pregnancy Increase Susceptibility to Neonatal Pulmonary Hypertension in High-Altitude Populations.
Heath-Freudenthal A, Toledo-Jaldin L, von Alvensleben I, Lazo-Vega L, Mizutani R, Stalker M, Yasini H, Mendizabal F, Dorado Madera J, Mundo W, Castro-Monrroy M, Houck JA, Moreno-Aramayo A, Miranda-Garrido V, Su EJ, Giussani DA, Abman SH, Moore LG, Julian CG
Hypertension 2022 Jun;79(6):1286-1296. Epub 2022 Apr 19 doi: 10.1161/HYPERTENSIONAHA.122.19078. PMID: 35437031Free PMC Article
Short- and Long-Term Complications of Bronchopulmonary Dysplasia.
Homan TD, Nayak RP
Respir Care 2021 Oct;66(10):1618-1629. doi: 10.4187/respcare.08401. PMID: 34552015
Cardiovascular impact and sequelae of bronchopulmonary dysplasia.
Yallapragada SG, Savani RC, Goss KN
Pediatr Pulmonol 2021 Nov;56(11):3453-3463. Epub 2021 Mar 23 doi: 10.1002/ppul.25370. PMID: 33756045
The COVID-19 pandemic: a global health crisis.
Pollard CA, Morran MP, Nestor-Kalinoski AL
Physiol Genomics 2020 Nov 1;52(11):549-557. Epub 2020 Sep 29 doi: 10.1152/physiolgenomics.00089.2020. PMID: 32991251Free PMC Article
Pathogenesis of bronchopulmonary dysplasia.
Hayes D Jr, Feola DJ, Murphy BS, Shook LA, Ballard HO
Respiration 2010;79(5):425-36. Epub 2009 Sep 25 doi: 10.1159/000242497. PMID: 19786727

Diagnosis

Pulmonary Hypertension in Established Bronchopulmonary Dysplasia: Physiologic Approaches to Clinical Care.
Abman SH, Lakshminrusimha S
Clin Perinatol 2024 Mar;51(1):195-216. Epub 2024 Jan 9 doi: 10.1016/j.clp.2023.12.002. PMID: 38325941
Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia.
Sun F, Wang G, Pradhan A, Xu K, Gomez-Arroyo J, Zhang Y, Kalin GT, Deng Z, Vagnozzi RJ, He H, Dunn AW, Wang Y, York AJ, Hegde RS, Woods JC, Kalin TV, Molkentin JD, Kalinichenko VV
Circulation 2021 Aug 17;144(7):539-555. Epub 2021 Jun 11 doi: 10.1161/CIRCULATIONAHA.121.053980. PMID: 34111939Free PMC Article
Epigenetic regulation of insulin-like growth factor signaling: A novel insight into the pathophysiology of neonatal pulmonary hypertension.
Madonna R, De Caterina R, Geng YJ
Vascul Pharmacol 2015 Oct;73:4-7. Epub 2015 Aug 5 doi: 10.1016/j.vph.2015.08.002. PMID: 26254106
Pulmonary arterial hypertension in women.
Sanchez O, Marié E, Lerolle U, Wermert D, Israël-Biet D, Meyer G
Rev Mal Respir 2010 Oct;27(8):e79-87. Epub 2010 May 13 doi: 10.1016/j.rmr.2009.12.001. PMID: 20965396
Perinatal asphyxia, hypoxia, ischemia and hearing loss. An overview.
Borg E
Scand Audiol 1997;26(2):77-91. doi: 10.3109/01050399709074979. PMID: 9187000

Therapy

Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia.
Sun F, Wang G, Pradhan A, Xu K, Gomez-Arroyo J, Zhang Y, Kalin GT, Deng Z, Vagnozzi RJ, He H, Dunn AW, Wang Y, York AJ, Hegde RS, Woods JC, Kalin TV, Molkentin JD, Kalinichenko VV
Circulation 2021 Aug 17;144(7):539-555. Epub 2021 Jun 11 doi: 10.1161/CIRCULATIONAHA.121.053980. PMID: 34111939Free PMC Article
The COVID-19 pandemic: a global health crisis.
Pollard CA, Morran MP, Nestor-Kalinoski AL
Physiol Genomics 2020 Nov 1;52(11):549-557. Epub 2020 Sep 29 doi: 10.1152/physiolgenomics.00089.2020. PMID: 32991251Free PMC Article
Pulmonary arterial hypertension in children after neonatal arterial switch operation.
Zijlstra WM, Elmasry O, Pepplinkhuizen S, Ivy DD, Bonnet D, Luijendijk P, Lévy M, Gavilan JL, Torrent-Vernetta A, Mendoza A, Del Cerro MJ, Moledina S, Berger RM
Heart 2017 Aug;103(16):1244-1249. Epub 2017 Jan 23 doi: 10.1136/heartjnl-2016-310624. PMID: 28115472
Pulmonary arterial hypertension in women.
Sanchez O, Marié E, Lerolle U, Wermert D, Israël-Biet D, Meyer G
Rev Mal Respir 2010 Oct;27(8):e79-87. Epub 2010 May 13 doi: 10.1016/j.rmr.2009.12.001. PMID: 20965396
Pathogenesis of bronchopulmonary dysplasia.
Hayes D Jr, Feola DJ, Murphy BS, Shook LA, Ballard HO
Respiration 2010;79(5):425-36. Epub 2009 Sep 25 doi: 10.1159/000242497. PMID: 19786727

Prognosis

Pulmonary Hypertension in Established Bronchopulmonary Dysplasia: Physiologic Approaches to Clinical Care.
Abman SH, Lakshminrusimha S
Clin Perinatol 2024 Mar;51(1):195-216. Epub 2024 Jan 9 doi: 10.1016/j.clp.2023.12.002. PMID: 38325941
Pulmonary arterial hypertension in children after neonatal arterial switch operation.
Zijlstra WM, Elmasry O, Pepplinkhuizen S, Ivy DD, Bonnet D, Luijendijk P, Lévy M, Gavilan JL, Torrent-Vernetta A, Mendoza A, Del Cerro MJ, Moledina S, Berger RM
Heart 2017 Aug;103(16):1244-1249. Epub 2017 Jan 23 doi: 10.1136/heartjnl-2016-310624. PMID: 28115472
Epigenetic regulation of insulin-like growth factor signaling: A novel insight into the pathophysiology of neonatal pulmonary hypertension.
Madonna R, De Caterina R, Geng YJ
Vascul Pharmacol 2015 Oct;73:4-7. Epub 2015 Aug 5 doi: 10.1016/j.vph.2015.08.002. PMID: 26254106
Developmental and genetic aspects of congenital diaphragmatic hernia.
Veenma DC, de Klein A, Tibboel D
Pediatr Pulmonol 2012 Jun;47(6):534-45. Epub 2012 Mar 29 doi: 10.1002/ppul.22553. PMID: 22467525
Pulmonary arterial hypertension in women.
Sanchez O, Marié E, Lerolle U, Wermert D, Israël-Biet D, Meyer G
Rev Mal Respir 2010 Oct;27(8):e79-87. Epub 2010 May 13 doi: 10.1016/j.rmr.2009.12.001. PMID: 20965396

Clinical prediction guides

Vascular Disorders of Pregnancy Increase Susceptibility to Neonatal Pulmonary Hypertension in High-Altitude Populations.
Heath-Freudenthal A, Toledo-Jaldin L, von Alvensleben I, Lazo-Vega L, Mizutani R, Stalker M, Yasini H, Mendizabal F, Dorado Madera J, Mundo W, Castro-Monrroy M, Houck JA, Moreno-Aramayo A, Miranda-Garrido V, Su EJ, Giussani DA, Abman SH, Moore LG, Julian CG
Hypertension 2022 Jun;79(6):1286-1296. Epub 2022 Apr 19 doi: 10.1161/HYPERTENSIONAHA.122.19078. PMID: 35437031Free PMC Article
Short- and Long-Term Complications of Bronchopulmonary Dysplasia.
Homan TD, Nayak RP
Respir Care 2021 Oct;66(10):1618-1629. doi: 10.4187/respcare.08401. PMID: 34552015
Sex and Gender Differences in Lung Disease.
Silveyra P, Fuentes N, Rodriguez Bauza DE
Adv Exp Med Biol 2021;1304:227-258. doi: 10.1007/978-3-030-68748-9_14. PMID: 34019273Free PMC Article
EDN1 Gene Variant is Associated with Neonatal Persistent Pulmonary Hypertension.
Mei M, Cheng G, Sun B, Yang L, Wang H, Sun J, Zhou W
Sci Rep 2016 Jul 18;6:29877. doi: 10.1038/srep29877. PMID: 27425626Free PMC Article
Developmental and genetic aspects of congenital diaphragmatic hernia.
Veenma DC, de Klein A, Tibboel D
Pediatr Pulmonol 2012 Jun;47(6):534-45. Epub 2012 Mar 29 doi: 10.1002/ppul.22553. PMID: 22467525

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...