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Hypersensitivity reaction disease

MedGen UID:
759636
•Concept ID:
C3532523
•
Disease or Syndrome
Synonyms: hypersensitive; hypersensitivity; Hypersensitivity condition; hypersensitivity reaction; hypersensitivity reaction disease
SNOMED CT: Hypersensitivity condition (473010000)
 
Monarch Initiative: MONDO:0000605

Definition

The disposition to develop an allergic or pseudoallergic reaction, the reaction itself or its consequences. [from SNOMEDCT_US]

Professional guidelines

PubMed

International consensus statement on allergy and rhinology: Allergic rhinitis - 2023.
Wise SK, Damask C, Roland LT, Ebert C, Levy JM, Lin S, Luong A, Rodriguez K, Sedaghat AR, Toskala E, Villwock J, Abdullah B, Akdis C, Alt JA, Ansotegui IJ, Azar A, Baroody F, Benninger MS, Bernstein J, Brook C, Campbell R, Casale T, Chaaban MR, Chew FT, Chambliss J, Cianferoni A, Custovic A, Davis EM, DelGaudio JM, Ellis AK, Flanagan C, Fokkens WJ, Franzese C, Greenhawt M, Gill A, Halderman A, Hohlfeld JM, Incorvaia C, Joe SA, Joshi S, Kuruvilla ME, Kim J, Klein AM, Krouse HJ, Kuan EC, Lang D, Larenas-Linnemann D, Laury AM, Lechner M, Lee SE, Lee VS, Loftus P, Marcus S, Marzouk H, Mattos J, McCoul E, Melen E, Mims JW, Mullol J, Nayak JV, Oppenheimer J, Orlandi RR, Phillips K, Platt M, Ramanathan M Jr, Raymond M, Rhee CS, Reitsma S, Ryan M, Sastre J, Schlosser RJ, Schuman TA, Shaker MS, Sheikh A, Smith KA, Soyka MB, Takashima M, Tang M, Tantilipikorn P, Taw MB, Tversky J, Tyler MA, Veling MC, Wallace D, Wang Y, White A, Zhang L
Int Forum Allergy Rhinol 2023 Apr;13(4):293-859. Epub 2023 Mar 6 doi: 10.1002/alr.23090. PMID: 36878860
Neurosarcoidosis: Pathophysiology, Diagnosis, and Treatment.
Bradshaw MJ, Pawate S, Koth LL, Cho TA, Gelfand JM
Neurol Neuroimmunol Neuroinflamm 2021 Nov;8(6) Epub 2021 Oct 4 doi: 10.1212/NXI.0000000000001084. PMID: 34607912Free PMC Article
European consensus-based recommendations for diagnosis and treatment of immunoglobulin A vasculitis-the SHARE initiative.
Ozen S, Marks SD, Brogan P, Groot N, de Graeff N, Avcin T, Bader-Meunier B, Dolezalova P, Feldman BM, Kone-Paut I, Lahdenne P, McCann L, Pilkington C, Ravelli A, van Royen A, Uziel Y, Vastert B, Wulffraat N, Kamphuis S, Beresford MW
Rheumatology (Oxford) 2019 Sep 1;58(9):1607-1616. doi: 10.1093/rheumatology/kez041. PMID: 30879080

Recent clinical studies

Etiology

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part I. Epidemiology, pathogenesis, clinicopathological features, and prognosis.
Wei BM, Fox LP, Kaffenberger BH, Korman AM, Micheletti RG, Mostaghimi A, Noe MH, Rosenbach M, Shinkai K, Kwah JH, Phillips EJ, Bolognia JL, Damsky W, Nelson CA
J Am Acad Dermatol 2024 May;90(5):885-908. Epub 2023 Jul 27 doi: 10.1016/j.jaad.2023.02.072. PMID: 37516359
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part II diagnosis and management.
Wei BM, Fox LP, Kaffenberger BH, Korman AM, Micheletti RG, Mostaghimi A, Noe MH, Rosenbach M, Shinkai K, Kwah JH, Phillips EJ, Bolognia JL, Damsky W, Nelson CA
J Am Acad Dermatol 2024 May;90(5):911-926. Epub 2023 Jul 28 doi: 10.1016/j.jaad.2023.02.073. PMID: 37516356
Drug Hypersensitivity Reactions.
Wilkerson RG
Immunol Allergy Clin North Am 2023 Aug;43(3):473-489. doi: 10.1016/j.iac.2022.10.005. PMID: 37394254
Drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS): An update in 2019.
Shiohara T, Mizukawa Y
Allergol Int 2019 Jul;68(3):301-308. Epub 2019 Apr 16 doi: 10.1016/j.alit.2019.03.006. PMID: 31000444
Asthma transition from childhood into adulthood.
Fuchs O, Bahmer T, Rabe KF, von Mutius E
Lancet Respir Med 2017 Mar;5(3):224-234. Epub 2016 Sep 22 doi: 10.1016/S2213-2600(16)30187-4. PMID: 27666650

Diagnosis

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part I. Epidemiology, pathogenesis, clinicopathological features, and prognosis.
Wei BM, Fox LP, Kaffenberger BH, Korman AM, Micheletti RG, Mostaghimi A, Noe MH, Rosenbach M, Shinkai K, Kwah JH, Phillips EJ, Bolognia JL, Damsky W, Nelson CA
J Am Acad Dermatol 2024 May;90(5):885-908. Epub 2023 Jul 27 doi: 10.1016/j.jaad.2023.02.072. PMID: 37516359
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part II diagnosis and management.
Wei BM, Fox LP, Kaffenberger BH, Korman AM, Micheletti RG, Mostaghimi A, Noe MH, Rosenbach M, Shinkai K, Kwah JH, Phillips EJ, Bolognia JL, Damsky W, Nelson CA
J Am Acad Dermatol 2024 May;90(5):911-926. Epub 2023 Jul 28 doi: 10.1016/j.jaad.2023.02.073. PMID: 37516356
Drug Hypersensitivity Reactions.
Wilkerson RG
Immunol Allergy Clin North Am 2023 Aug;43(3):473-489. doi: 10.1016/j.iac.2022.10.005. PMID: 37394254
Allergy, Anaphylaxis, and Nonallergic Hypersensitivity: IgE, Mast Cells, and Beyond.
Vitte J, Vibhushan S, Bratti M, Montero-Hernandez JE, Blank U
Med Princ Pract 2022;31(6):501-515. Epub 2022 Oct 11 doi: 10.1159/000527481. PMID: 36219943Free PMC Article
Perioperative Anaphylaxis.
Pitlick MM, Volcheck GW
Immunol Allergy Clin North Am 2022 Feb;42(1):145-159. doi: 10.1016/j.iac.2021.09.002. PMID: 34823744

Therapy

Hypersensitivity reactions to proton pump inhibitors. An EAACI position paper.
Bavbek S, Kepil Özdemir S, Bonadonna P, Atanaskovic-Markovic M, Barbaud A, Brockow K, Laguna Martinez J, Nakonechna A, Pagani M, Arcolacı A, Lombardo C, Torres MJ
Allergy 2024 Mar;79(3):552-564. Epub 2023 Nov 27 doi: 10.1111/all.15961. PMID: 38013608
Cow's Milk Protein Allergy.
Malik R, Kaul S
Indian J Pediatr 2024 May;91(5):499-506. Epub 2023 Oct 18 doi: 10.1007/s12098-023-04866-5. PMID: 37851326
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part I. Epidemiology, pathogenesis, clinicopathological features, and prognosis.
Wei BM, Fox LP, Kaffenberger BH, Korman AM, Micheletti RG, Mostaghimi A, Noe MH, Rosenbach M, Shinkai K, Kwah JH, Phillips EJ, Bolognia JL, Damsky W, Nelson CA
J Am Acad Dermatol 2024 May;90(5):885-908. Epub 2023 Jul 27 doi: 10.1016/j.jaad.2023.02.072. PMID: 37516359
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part II diagnosis and management.
Wei BM, Fox LP, Kaffenberger BH, Korman AM, Micheletti RG, Mostaghimi A, Noe MH, Rosenbach M, Shinkai K, Kwah JH, Phillips EJ, Bolognia JL, Damsky W, Nelson CA
J Am Acad Dermatol 2024 May;90(5):911-926. Epub 2023 Jul 28 doi: 10.1016/j.jaad.2023.02.073. PMID: 37516356
Perioperative Anaphylaxis.
Pitlick MM, Volcheck GW
Immunol Allergy Clin North Am 2022 Feb;42(1):145-159. doi: 10.1016/j.iac.2021.09.002. PMID: 34823744

Prognosis

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part I. Epidemiology, pathogenesis, clinicopathological features, and prognosis.
Wei BM, Fox LP, Kaffenberger BH, Korman AM, Micheletti RG, Mostaghimi A, Noe MH, Rosenbach M, Shinkai K, Kwah JH, Phillips EJ, Bolognia JL, Damsky W, Nelson CA
J Am Acad Dermatol 2024 May;90(5):885-908. Epub 2023 Jul 27 doi: 10.1016/j.jaad.2023.02.072. PMID: 37516359
Updates on the immunopathology and genomics of severe cutaneous adverse drug reactions.
Gibson A, Deshpande P, Campbell CN, Krantz MS, Mukherjee E, Mockenhaupt M, Pirmohamed M, Palubinsky AM, Phillips EJ
J Allergy Clin Immunol 2023 Feb;151(2):289-300.e4. doi: 10.1016/j.jaci.2022.12.005. PMID: 36740326Free PMC Article
Research Progress in Atopic March.
Yang L, Fu J, Zhou Y
Front Immunol 2020;11:1907. Epub 2020 Aug 27 doi: 10.3389/fimmu.2020.01907. PMID: 32973790Free PMC Article
Clinical Phenotypes of Severe Cutaneous Drug Hypersensitivity Reactions.
Guvenir H, Arikoglu T, Vezir E, Misirlioglu ED
Curr Pharm Des 2019;25(36):3840-3854. doi: 10.2174/1381612825666191107162921. PMID: 31696807
Drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS): An update in 2019.
Shiohara T, Mizukawa Y
Allergol Int 2019 Jul;68(3):301-308. Epub 2019 Apr 16 doi: 10.1016/j.alit.2019.03.006. PMID: 31000444

Clinical prediction guides

Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma.
Breiteneder H, Peng YQ, Agache I, Diamant Z, Eiwegger T, Fokkens WJ, Traidl-Hoffmann C, Nadeau K, O'Hehir RE, O'Mahony L, Pfaar O, Torres MJ, Wang DY, Zhang L, Akdis CA
Allergy 2020 Dec;75(12):3039-3068. Epub 2020 Sep 30 doi: 10.1111/all.14582. PMID: 32893900Free PMC Article
Drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS): An update in 2019.
Shiohara T, Mizukawa Y
Allergol Int 2019 Jul;68(3):301-308. Epub 2019 Apr 16 doi: 10.1016/j.alit.2019.03.006. PMID: 31000444
Vaccination and allergy: EAACI position paper, practical aspects.
Nilsson L, Brockow K, Alm J, Cardona V, Caubet JC, Gomes E, Jenmalm MC, Lau S, Netterlid E, Schwarze J, Sheikh A, Storsaeter J, Skevaki C, Terreehorst I, Zanoni G
Pediatr Allergy Immunol 2017 Nov;28(7):628-640. Epub 2017 Oct 10 doi: 10.1111/pai.12762. PMID: 28779496
Food allergies: the basics.
Valenta R, Hochwallner H, Linhart B, Pahr S
Gastroenterology 2015 May;148(6):1120-31.e4. Epub 2015 Feb 11 doi: 10.1053/j.gastro.2015.02.006. PMID: 25680669Free PMC Article
Pulmonary aspergillosis: a clinical review.
Kousha M, Tadi R, Soubani AO
Eur Respir Rev 2011 Sep 1;20(121):156-74. doi: 10.1183/09059180.00001011. PMID: 21881144Free PMC Article

Recent systematic reviews

Systematic review and meta-analyses on the accuracy of diagnostic tests for IgE-mediated food allergy.
Riggioni C, Ricci C, Moya B, Wong D, van Goor E, Bartha I, Buyuktiryaki B, Giovannini M, Jayasinghe S, Jaumdally H, Marques-Mejias A, Piletta-Zanin A, Berbenyuk A, Andreeva M, Levina D, Iakovleva E, Roberts G, Chu D, Peters R, du Toit G, Skypala I, Santos AF
Allergy 2024 Feb;79(2):324-352. Epub 2023 Nov 27 doi: 10.1111/all.15939. PMID: 38009299
Vernal Keratoconjunctivitis: A Systematic Review.
Bruschi G, Ghiglioni DG, Cozzi L, Osnaghi S, Viola F, Marchisio P
Clin Rev Allergy Immunol 2023 Aug;65(2):277-329. Epub 2023 Sep 2 doi: 10.1007/s12016-023-08970-4. PMID: 37658939Free PMC Article
Indoor Air Pollution and the Health of Vulnerable Groups: A Systematic Review Focused on Particulate Matter (PM), Volatile Organic Compounds (VOCs) and Their Effects on Children and People with Pre-Existing Lung Disease.
Maung TZ, Bishop JE, Holt E, Turner AM, Pfrang C
Int J Environ Res Public Health 2022 Jul 19;19(14) doi: 10.3390/ijerph19148752. PMID: 35886604Free PMC Article
Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis.
Fritz D, van de Beek D, Brouwer MC
BMC Neurol 2016 Nov 15;16(1):220. doi: 10.1186/s12883-016-0741-x. PMID: 27846819Free PMC Article
Mycoplasma pneumoniae-induced rash and mucositis as a syndrome distinct from Stevens-Johnson syndrome and erythema multiforme: a systematic review.
Canavan TN, Mathes EF, Frieden I, Shinkai K
J Am Acad Dermatol 2015 Feb;72(2):239-45. doi: 10.1016/j.jaad.2014.06.026. PMID: 25592340

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