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Metastatic malignant neoplasm in the lymph nodes

MedGen UID:
151947
•Concept ID:
C0686619
•
Neoplastic Process
Synonyms: Lymph Node Metastases; Lymph Node Metastasis; Metastasis, Lymph Node
SNOMED CT: Secondary lymph node cancer (94392001); Secondary malignant neoplasm of lymph node (94392001); Metastatic malignant neoplasm to lymph node (94392001); Cancer metastatic to lymph nodes (94392001); Metastatic malignant neoplasm of lymph node (94392001)
 
Monarch Initiative: MONDO:0005438

Definition

The spread of a malignant neoplasm from its original site of growth to lymph nodes. [from NCI]

Professional guidelines

PubMed

Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma: A Review and Multidisciplinary 2023 Update.
Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):265-272. doi: 10.1001/jamaoto.2023.4323. PMID: 38206595
Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Casali PG, Abecassis N, Aro HT, Bauer S, Biagini R, Bielack S, Bonvalot S, Boukovinas I, Bovee JVMG, Brodowicz T, Broto JM, Buonadonna A, De Álava E, Dei Tos AP, Del Muro XG, Dileo P, Eriksson M, Fedenko A, Ferraresi V, Ferrari A, Ferrari S, Frezza AM, Gasperoni S, Gelderblom H, Gil T, Grignani G, Gronchi A, Haas RL, Hassan B, Hohenberger P, Issels R, Joensuu H, Jones RL, Judson I, Jutte P, Kaal S, Kasper B, Kopeckova K, Krákorová DA, Le Cesne A, Lugowska I, Merimsky O, Montemurro M, Pantaleo MA, Piana R, Picci P, Piperno-Neumann S, Pousa AL, Reichardt P, Robinson MH, Rutkowski P, Safwat AA, Schöffski P, Sleijfer S, Stacchiotti S, Sundby Hall K, Unk M, Van Coevorden F, van der Graaf WTA, Whelan J, Wardelmann E, Zaikova O, Blay JY; ESMO Guidelines Committee and EURACAN
Ann Oncol 2018 Oct 1;29(Suppl 4):iv51-iv67. doi: 10.1093/annonc/mdy096. PMID: 29846498
Advances in diagnosis and treatment of metastatic cervical cancer.
Li H, Wu X, Cheng X
J Gynecol Oncol 2016 Jul;27(4):e43. doi: 10.3802/jgo.2016.27.e43. PMID: 27171673Free PMC Article

Recent clinical studies

Etiology

A deep-learning radiomics-based lymph node metastasis predictive model for pancreatic cancer: a diagnostic study.
Fu N, Fu W, Chen H, Chai W, Qian X, Wang W, Jiang Y, Shen B
Int J Surg 2023 Aug 1;109(8):2196-2203. doi: 10.1097/JS9.0000000000000469. PMID: 37216230Free PMC Article
Terms, definitions and measurements to describe sonographic features of lymph nodes: consensus opinion from the Vulvar International Tumor Analysis (VITA) group.
Fischerova D, Garganese G, Reina H, Fragomeni SM, Cibula D, Nanka O, Rettenbacher T, Testa AC, Epstein E, Guiggi I, Frühauf F, Manegold G, Scambia G, Valentin L
Ultrasound Obstet Gynecol 2021 Jun;57(6):861-879. doi: 10.1002/uog.23617. PMID: 34077608
Esophageal Cancer: Tumor-Node-Metastasis Staging.
Betancourt-Cuellar SL, Benveniste MFK, Palacio DP, Hofstetter WL
Radiol Clin North Am 2021 Mar;59(2):219-229. doi: 10.1016/j.rcl.2020.11.008. PMID: 33551083
Comprehensive analysis of metastatic gastric cancer tumour cells using single-cell RNA-seq.
Wang B, Zhang Y, Qing T, Xing K, Li J, Zhen T, Zhu S, Zhan X
Sci Rep 2021 Jan 13;11(1):1141. doi: 10.1038/s41598-020-80881-2. PMID: 33441952Free PMC Article
Updates in the Eighth Edition of the Tumor-Node-Metastasis Staging Classification for Urologic Cancers.
Paner GP, Stadler WM, Hansel DE, Montironi R, Lin DW, Amin MB
Eur Urol 2018 Apr;73(4):560-569. Epub 2018 Jan 9 doi: 10.1016/j.eururo.2017.12.018. PMID: 29325693

Diagnosis

Frontiers in Esophageal disease: lymph node metastatic patterns in esophageal cancer-first article in our new invited review series.
Nilsson M, Gupta N
Dis Esophagus 2023 Mar 30;36(4) doi: 10.1093/dote/doad018. PMID: 36946326
A Deep Dive into the Diagnosis and Management of Regional Lymph Node Metastases.
Wuthrick EJ, Harrison LB
Semin Radiat Oncol 2019 Apr;29(2):91-92. doi: 10.1016/j.semradonc.2018.11.009. PMID: 30827457
Updates in the Eighth Edition of the Tumor-Node-Metastasis Staging Classification for Urologic Cancers.
Paner GP, Stadler WM, Hansel DE, Montironi R, Lin DW, Amin MB
Eur Urol 2018 Apr;73(4):560-569. Epub 2018 Jan 9 doi: 10.1016/j.eururo.2017.12.018. PMID: 29325693
Pretreatment MRI of lymph nodes in rectal cancer: an opinion-based review.
Beets-Tan RG
Colorectal Dis 2013 Jul;15(7):781-4. doi: 10.1111/codi.12300. PMID: 23701484
Imaging of lymph nodes in the neck.
van den Brekel MW, Castelijns JA
Semin Roentgenol 2000 Jan;35(1):42-53. doi: 10.1016/s0037-198x(00)80031-0. PMID: 10670052

Therapy

Primary Liver Cancers: Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma.
Mejia JC, Pasko J
Surg Clin North Am 2020 Jun;100(3):535-549. Epub 2020 Apr 16 doi: 10.1016/j.suc.2020.02.013. PMID: 32402299
Breast cancer and the NSABP-B32 sentinel node trial.
Krag D, Harlow S, Julian T
Breast Cancer 2004;11(3):221-4; discussion 264-6. doi: 10.1007/BF02984541. PMID: 15550839
Treatment of breast cancer.
Zurrida S, Veronesi U
Ann Chir Gynaecol 2000;89(3):187-90. PMID: 11079786
Adjuvant therapy for breast cancer.
Budman DR, Citron ML
Clin Obstet Gynecol 1994 Dec;37(4):978-87. doi: 10.1097/00003081-199412000-00025. PMID: 7842566
Axillary lymph nodes in carcinoma of the breast.
Göksel HA
Turk J Pediatr 1964 Oct;6(4):249-56. PMID: 5322349

Prognosis

Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice.
Brown M, Assen FP, Leithner A, Abe J, Schachner H, Asfour G, Bago-Horvath Z, Stein JV, Uhrin P, Sixt M, Kerjaschki D
Science 2018 Mar 23;359(6382):1408-1411. doi: 10.1126/science.aal3662. PMID: 29567714
Overdiagnosis of thyroid cancer.
Davies L
BMJ 2016 Nov 30;355:i6312. doi: 10.1136/bmj.i6312. PMID: 27903502
Elastography: the next step.
Das D, Gupta M, Kaur H, Kalucha A
J Oral Sci 2011 Jun;53(2):137-41. doi: 10.2334/josnusd.53.137. PMID: 21712616
Cervical adenocarcinoma.
Kudo R
Curr Top Pathol 1992;85:81-111. doi: 10.1007/978-3-642-75941-3_4. PMID: 1321028
Carcinoma of the breast--the significance of supraclavicular lymph node metastases.
Jackson SM
Clin Radiol 1966 Apr;17(2):107-14. doi: 10.1016/s0009-9260(66)80066-1. PMID: 5931305

Clinical prediction guides

Partial Thyroidectomy With Incidental Metastatic Lymph Nodes.
Alameer E, Eagan A, Scholfield DW, Woods RSR, Tuttle RM, Wong RJ, Patel SG, Ganly I
JAMA Otolaryngol Head Neck Surg 2024 Jan 1;150(1):49-56. doi: 10.1001/jamaoto.2023.3668. PMID: 37971746Free PMC Article
Considerations on 18FDG PET/CT and sentinel lymph node biopsy in AJCC stages I and II of melanoma.
Veronesi G, Ravaioli GM, Lambertini M, Zannetti G, Diodato S, Gardini A, Patrizi A, Fanti S, Dika E
G Ital Dermatol Venereol 2020 Dec;155(6):784-786. Epub 2018 Jul 10 doi: 10.23736/S0392-0488.18.06108-4. PMID: 29998716
Impact of Deep Learning Assistance on the Histopathologic Review of Lymph Nodes for Metastatic Breast Cancer.
Steiner DF, MacDonald R, Liu Y, Truszkowski P, Hipp JD, Gammage C, Thng F, Peng L, Stumpe MC
Am J Surg Pathol 2018 Dec;42(12):1636-1646. doi: 10.1097/PAS.0000000000001151. PMID: 30312179Free PMC Article
Future trends in lung cancer diagnosis.
Christensen JD, Patz EF Jr
Radiol Clin North Am 2012 Sep;50(5):1001-8. doi: 10.1016/j.rcl.2012.06.002. PMID: 22974783
The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM.
Edge SB, Compton CC
Ann Surg Oncol 2010 Jun;17(6):1471-4. doi: 10.1245/s10434-010-0985-4. PMID: 20180029

Recent systematic reviews

Efficacy and safety of ultrasound-guided radiofrequency, microwave and laser ablation for the treatment of T1N0M0 papillary thyroid carcinoma on a large scale: a systematic review and meta-analysis.
Gao X, Yang Y, Wang Y, Huang Y
Int J Hyperthermia 2023 Dec;40(1):2244713. doi: 10.1080/02656736.2023.2244713. PMID: 37604507
Risk and Prognostic Factors for BRAF(V600E) Mutations in Papillary Thyroid Carcinoma.
Wei X, Wang X, Xiong J, Li C, Liao Y, Zhu Y, Mao J
Biomed Res Int 2022;2022:9959649. Epub 2022 May 18 doi: 10.1155/2022/9959649. PMID: 35647194Free PMC Article
Artificial intelligence in gynecologic cancers: Current status and future challenges - A systematic review.
Akazawa M, Hashimoto K
Artif Intell Med 2021 Oct;120:102164. Epub 2021 Sep 3 doi: 10.1016/j.artmed.2021.102164. PMID: 34629152
Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article
Axillary Nodal Evaluation in Breast Cancer: State of the Art.
Chang JM, Leung JWT, Moy L, Ha SM, Moon WK
Radiology 2020 Jun;295(3):500-515. Epub 2020 Apr 21 doi: 10.1148/radiol.2020192534. PMID: 32315268

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