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Ebola hemorrhagic fever

MedGen UID:
129219
Concept ID:
C0282687
Disease or Syndrome
Synonym: Ebola virus disease
SNOMED CT: Viral hemorrhagic fever, Ebola (37109004); EVD - Ebola virus disease (37109004); Ebola virus disease (37109004); Ebola hemorrhagic fever (37109004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005737
Orphanet: ORPHA319218

Definition

Ebola hemorrhagic fever (EHF), caused by Ebola virus, is a severe viral hemorrhagic disease characterized by initial fever and malaise followed by gastrointestinal symptoms, bleeding, shock, and multi-organ system failure. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEbola hemorrhagic fever
Follow this link to review classifications for Ebola hemorrhagic fever in Orphanet.

Professional guidelines

PubMed

Nicastri E, Kobinger G, Vairo F, Montaldo C, Mboera LEG, Ansunama R, Zumla A, Ippolito G
Infect Dis Clin North Am 2019 Dec;33(4):953-976. doi: 10.1016/j.idc.2019.08.005. PMID: 31668200
Choi JH, Croyle MA
BioDrugs 2013 Dec;27(6):565-83. doi: 10.1007/s40259-013-0046-1. PMID: 23813435Free PMC Article
Takada A
Immunotherapy 2013 May;5(5):441-3. doi: 10.2217/imt.13.29. PMID: 23638738

Recent clinical studies

Etiology

Liu CH, Hu YT, Wong SH, Lin LT
Viruses 2022 Mar 11;14(3) doi: 10.3390/v14030579. PMID: 35336986Free PMC Article
Frieden TR
MMWR Suppl 2016 Jul 8;65(3):1-3. doi: 10.15585/mmwr.su6503a1. PMID: 27389046
Gilbert SC
Expert Rev Vaccines 2015;14(10):1347-57. Epub 2015 Aug 11 doi: 10.1586/14760584.2015.1077122. PMID: 26289977
Rougeron V, Feldmann H, Grard G, Becker S, Leroy EM
J Clin Virol 2015 Mar;64:111-9. Epub 2015 Jan 23 doi: 10.1016/j.jcv.2015.01.014. PMID: 25660265Free PMC Article
Pigott DC
Crit Care Clin 2005 Oct;21(4):765-83, vii. doi: 10.1016/j.ccc.2005.06.007. PMID: 16168314Free PMC Article

Diagnosis

Feldmann H, Sprecher A, Geisbert TW
N Engl J Med 2020 May 7;382(19):1832-1842. doi: 10.1056/NEJMra1901594. PMID: 32441897
Nicastri E, Kobinger G, Vairo F, Montaldo C, Mboera LEG, Ansunama R, Zumla A, Ippolito G
Infect Dis Clin North Am 2019 Dec;33(4):953-976. doi: 10.1016/j.idc.2019.08.005. PMID: 31668200
Richardson KJ
Adv Emerg Nurs J 2015 Apr-Jun;37(2):102-15. doi: 10.1097/TME.0000000000000063. PMID: 25929221
Zawilińska B, Kosz-Vnenchak M
Folia Med Cracov 2014;54(3):57-65. PMID: 25694096
Feldmann H, Geisbert TW
Lancet 2011 Mar 5;377(9768):849-62. doi: 10.1016/S0140-6736(10)60667-8. PMID: 21084112Free PMC Article

Therapy

Feldmann H, Sprecher A, Geisbert TW
N Engl J Med 2020 May 7;382(19):1832-1842. doi: 10.1056/NEJMra1901594. PMID: 32441897
Jacob ST, Crozier I, Fischer WA 2nd, Hewlett A, Kraft CS, Vega MA, Soka MJ, Wahl V, Griffiths A, Bollinger L, Kuhn JH
Nat Rev Dis Primers 2020 Feb 20;6(1):13. doi: 10.1038/s41572-020-0147-3. PMID: 32080199Free PMC Article
Mulangu S, Dodd LE, Davey RT Jr, Tshiani Mbaya O, Proschan M, Mukadi D, Lusakibanza Manzo M, Nzolo D, Tshomba Oloma A, Ibanda A, Ali R, Coulibaly S, Levine AC, Grais R, Diaz J, Lane HC, Muyembe-Tamfum JJ; PALM Writing Group, Sivahera B, Camara M, Kojan R, Walker R, Dighero-Kemp B, Cao H, Mukumbayi P, Mbala-Kingebeni P, Ahuka S, Albert S, Bonnett T, Crozier I, Duvenhage M, Proffitt C, Teitelbaum M, Moench T, Aboulhab J, Barrett K, Cahill K, Cone K, Eckes R, Hensley L, Herpin B, Higgs E, Ledgerwood J, Pierson J, Smolskis M, Sow Y, Tierney J, Sivapalasingam S, Holman W, Gettinger N, Vallée D, Nordwall J; PALM Consortium Study Team
N Engl J Med 2019 Dec 12;381(24):2293-2303. Epub 2019 Nov 27 doi: 10.1056/NEJMoa1910993. PMID: 31774950Free PMC Article
Furuyama W, Marzi A
Annu Rev Virol 2019 Sep 29;6(1):435-458. doi: 10.1146/annurev-virology-092818-015708. PMID: 31567063
Griffiths PD
Rev Med Virol 2014 Nov;24(6):363-4. Epub 2014 Oct 15 doi: 10.1002/rmv.1812. PMID: 25318448

Prognosis

Lu DY, Wu HY, Yarla NS, Lu TR, Xu B, Jian-Ding
Infect Disord Drug Targets 2019;19(1):17-29. doi: 10.2174/1871526518666180813160348. PMID: 30101721
Baseler L, Chertow DS, Johnson KM, Feldmann H, Morens DM
Annu Rev Pathol 2017 Jan 24;12:387-418. doi: 10.1146/annurev-pathol-052016-100506. PMID: 27959626
Harries J, Jacobs M, Davies SC
BMJ 2016 Jan 22;532:i178. doi: 10.1136/bmj.i178. PMID: 26801216
Gilbert SC
Expert Rev Vaccines 2015;14(10):1347-57. Epub 2015 Aug 11 doi: 10.1586/14760584.2015.1077122. PMID: 26289977
Nature 2014 Nov 27;515(7528):465-6. doi: 10.1038/515465b. PMID: 25428460

Clinical prediction guides

Jacob ST, Crozier I, Fischer WA 2nd, Hewlett A, Kraft CS, Vega MA, Soka MJ, Wahl V, Griffiths A, Bollinger L, Kuhn JH
Nat Rev Dis Primers 2020 Feb 20;6(1):13. doi: 10.1038/s41572-020-0147-3. PMID: 32080199Free PMC Article
Reynolds P, Marzi A
Virus Genes 2017 Aug;53(4):501-515. Epub 2017 Apr 26 doi: 10.1007/s11262-017-1455-x. PMID: 28447193Free PMC Article
Baseler L, Chertow DS, Johnson KM, Feldmann H, Morens DM
Annu Rev Pathol 2017 Jan 24;12:387-418. doi: 10.1146/annurev-pathol-052016-100506. PMID: 27959626
Lo TQ, Marston BJ, Dahl BA, De Cock KM
Annu Rev Med 2017 Jan 14;68:359-370. Epub 2016 Oct 21 doi: 10.1146/annurev-med-052915-015604. PMID: 27813879
Gire SK, Goba A, Andersen KG, Sealfon RS, Park DJ, Kanneh L, Jalloh S, Momoh M, Fullah M, Dudas G, Wohl S, Moses LM, Yozwiak NL, Winnicki S, Matranga CB, Malboeuf CM, Qu J, Gladden AD, Schaffner SF, Yang X, Jiang PP, Nekoui M, Colubri A, Coomber MR, Fonnie M, Moigboi A, Gbakie M, Kamara FK, Tucker V, Konuwa E, Saffa S, Sellu J, Jalloh AA, Kovoma A, Koninga J, Mustapha I, Kargbo K, Foday M, Yillah M, Kanneh F, Robert W, Massally JL, Chapman SB, Bochicchio J, Murphy C, Nusbaum C, Young S, Birren BW, Grant DS, Scheiffelin JS, Lander ES, Happi C, Gevao SM, Gnirke A, Rambaut A, Garry RF, Khan SH, Sabeti PC
Science 2014 Sep 12;345(6202):1369-72. Epub 2014 Aug 28 doi: 10.1126/science.1259657. PMID: 25214632Free PMC Article

Recent systematic reviews

Nash RK, Bhatia S, Morgenstern C, Doohan P, Jorgensen D, McCain K, McCabe R, Nikitin D, Forna A, Cuomo-Dannenburg G, Hicks JT, Sheppard RJ, Naidoo T, van Elsland S, Geismar C, Rawson T, Leuba SI, Wardle J, Routledge I, Fraser K; Pathogen Epidemiology Review Group, Imai-Eaton N, Cori A, Unwin HJT
Lancet Infect Dis 2024 Dec;24(12):e762-e773. Epub 2024 Aug 7 doi: 10.1016/S1473-3099(24)00374-8. PMID: 39127058Free PMC Article
Pollock A, Campbell P, Cheyne J, Cowie J, Davis B, McCallum J, McGill K, Elders A, Hagen S, McClurg D, Torrens C, Maxwell M
Cochrane Database Syst Rev 2020 Nov 5;11(11):CD013779. doi: 10.1002/14651858.CD013779. PMID: 33150970Free PMC Article
Schuler J, Hudson ML, Schwartz D, Samudrala R
Molecules 2017 Oct 20;22(10) doi: 10.3390/molecules22101777. PMID: 29053626Free PMC Article
Bower H, Glynn JR
Sci Data 2017 Jan 31;4:160133. doi: 10.1038/sdata.2016.133. PMID: 28140390Free PMC Article
Fung IC, Duke CH, Finch KC, Snook KR, Tseng PL, Hernandez AC, Gambhir M, Fu KW, Tse ZTH
Am J Infect Control 2016 Dec 1;44(12):1660-1671. Epub 2016 Jul 15 doi: 10.1016/j.ajic.2016.05.011. PMID: 27425009

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