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Candida glabrata infection

MedGen UID:
963707
•Concept ID:
CN281816
•
Disease or Syndrome
Synonyms: candida glabrata; candida glabrata infection; Torulopsis glabrata (formerly)
 
Monarch Initiative: MONDO:0022636

Professional guidelines

PubMed

Pharmacokinetic/Pharmacodynamic Target Attainment of Different Antifungal Agents in De-escalation Treatment in Critically Ill Patients: a Step toward Dose Optimization Using Monte Carlo Simulation.
Xie J, Yang Q, Han X, Dong Y, Zhang T, Li Y, Ji M, Liu C, Cai Y, Wang Y
Antimicrob Agents Chemother 2022 Jun 21;66(6):e0009922. Epub 2022 May 23 doi: 10.1128/aac.00099-22. PMID: 35604209Free PMC Article

Recent clinical studies

Etiology

Antifungal susceptibility, molecular epidemiology, and clinical risk factors of Candida glabrata in intensive care unit in a Chinese Tertiary Hospital.
Huang SJ, Lv G, Song YH, Zhao JT, Liu JY, Wang LL, Xiang MJ
Front Cell Infect Microbiol 2024;14:1455145. Epub 2024 Oct 7 doi: 10.3389/fcimb.2024.1455145. PMID: 39435186Free PMC Article
Candida-induced prosthetic joint infection. A literature review including 72 cases and a case report.
Cobo F, Rodríguez-Granger J, López EM, Jiménez G, Sampedro A, Aliaga-Martínez L, Navarro-Marí JM
Infect Dis (Lond) 2017 Feb;49(2):81-94. Epub 2016 Sep 1 doi: 10.1080/23744235.2016.1219456. PMID: 27586845
Drug-resistant Candida glabrata infection in cancer patients.
Farmakiotis D, Tarrand JJ, Kontoyiannis DP
Emerg Infect Dis 2014 Nov;20(11):1833-40. doi: 10.3201/eid2011.140685. PMID: 25340258Free PMC Article
Congenital Candida glabrata infection without specific nodules on the placenta and umbilical cord.
Matsuzawa S, Ohyama M, Kawataki M, Itani Y, Hashimoto S, Yamanaka M, Ijiri R, Tanaka Y
Pediatr Infect Dis J 2005 Aug;24(8):744-5. doi: 10.1097/01.inf.0000173611.59475.30. PMID: 16094238
Two cases of systemic Candida glabrata infection following in vitro fertilization and embryo transfer.
Ibara AS, Marcorelles P, Le Martelot MT, Touffet N, Moalic E, Hery-Arnaud G, Giroux JD, Le Flohic AM
Eur J Clin Microbiol Infect Dis 2004 Jan;23(1):53-6. Epub 2003 Dec 2 doi: 10.1007/s10096-003-1051-y. PMID: 14652784

Diagnosis

Dectin-1 plays an important role in host defense against systemic Candida glabrata infection.
Chen SM, Shen H, Zhang T, Huang X, Liu XQ, Guo SY, Zhao JJ, Wang CF, Yan L, Xu GT, Jiang YY, An MM
Virulence 2017 Nov 17;8(8):1643-1656. Epub 2017 Jul 31 doi: 10.1080/21505594.2017.1346756. PMID: 28658592Free PMC Article
Candida-induced prosthetic joint infection. A literature review including 72 cases and a case report.
Cobo F, Rodríguez-Granger J, López EM, Jiménez G, Sampedro A, Aliaga-Martínez L, Navarro-Marí JM
Infect Dis (Lond) 2017 Feb;49(2):81-94. Epub 2016 Sep 1 doi: 10.1080/23744235.2016.1219456. PMID: 27586845
Candida glabrata and pre-term premature rupture of membrane complicating in vitro pregnancy: case report and confirmation of mother to neonate transmission.
Alfei A, Rizzo A, Cavanna C, Lallitto F, Spinillo A
Arch Gynecol Obstet 2014 Aug;290(2):211-4. Epub 2014 Apr 2 doi: 10.1007/s00404-014-3222-8. PMID: 24691825
Intracardiac giant cells after left ventricular assist device placement.
Fenton H, Judge DP, Yuh DD, Halushka MK
J Heart Lung Transplant 2007 Apr;26(4):417-20. doi: 10.1016/j.healun.2007.01.013. PMID: 17403488
Severe vulvovaginitis associated with intravaginal nystatin therapy.
Dan M
Am J Obstet Gynecol 2001 Jul;185(1):254-5. doi: 10.1067/mob.2001.115112. PMID: 11483943

Therapy

Candida-induced prosthetic joint infection. A literature review including 72 cases and a case report.
Cobo F, Rodríguez-Granger J, López EM, Jiménez G, Sampedro A, Aliaga-Martínez L, Navarro-Marí JM
Infect Dis (Lond) 2017 Feb;49(2):81-94. Epub 2016 Sep 1 doi: 10.1080/23744235.2016.1219456. PMID: 27586845
Intracardiac giant cells after left ventricular assist device placement.
Fenton H, Judge DP, Yuh DD, Halushka MK
J Heart Lung Transplant 2007 Apr;26(4):417-20. doi: 10.1016/j.healun.2007.01.013. PMID: 17403488
Candida glabrata periprosthetic infection: a case report and literature review.
Gaston G, Ogden J
J Arthroplasty 2004 Oct;19(7):927-30. doi: 10.1016/j.arth.2004.04.012. PMID: 15483812
Severe vulvovaginitis associated with intravaginal nystatin therapy.
Dan M
Am J Obstet Gynecol 2001 Jul;185(1):254-5. doi: 10.1067/mob.2001.115112. PMID: 11483943
Candida glabrata infection after total hip arthroplasty.
Ramamohan N, Zeineh N, Grigoris P, Butcher I
J Infect 2001 Jan;42(1):74-6. doi: 10.1053/jinf.2000.0763. PMID: 11243760

Prognosis

Biofilm formation is a risk factor for mortality in patients with Candida albicans bloodstream infection-Scotland, 2012-2013.
Rajendran R, Sherry L, Nile CJ, Sherriff A, Johnson EM, Hanson MF, Williams C, Munro CA, Jones BJ, Ramage G
Clin Microbiol Infect 2016 Jan;22(1):87-93. Epub 2015 Sep 30 doi: 10.1016/j.cmi.2015.09.018. PMID: 26432192Free PMC Article
Drug-resistant Candida glabrata infection in cancer patients.
Farmakiotis D, Tarrand JJ, Kontoyiannis DP
Emerg Infect Dis 2014 Nov;20(11):1833-40. doi: 10.3201/eid2011.140685. PMID: 25340258Free PMC Article
Pharmacodynamics of echinocandins against Candida glabrata: requirement for dosage escalation to achieve maximal antifungal activity in neutropenic hosts.
Howard SJ, Livermore J, Sharp A, Goodwin J, Gregson L, Alastruey-Izquierdo A, Perlin DS, Warn PA, Hope WW
Antimicrob Agents Chemother 2011 Oct;55(10):4880-7. Epub 2011 Aug 1 doi: 10.1128/AAC.00621-11. PMID: 21807969Free PMC Article
Reduced Candida glabrata susceptibility secondary to an FKS1 mutation developed during candidemia treatment.
Cleary JD, Garcia-Effron G, Chapman SW, Perlin DS
Antimicrob Agents Chemother 2008 Jun;52(6):2263-5. Epub 2008 Mar 31 doi: 10.1128/AAC.01568-07. PMID: 18378714Free PMC Article
Two cases of systemic Candida glabrata infection following in vitro fertilization and embryo transfer.
Ibara AS, Marcorelles P, Le Martelot MT, Touffet N, Moalic E, Hery-Arnaud G, Giroux JD, Le Flohic AM
Eur J Clin Microbiol Infect Dis 2004 Jan;23(1):53-6. Epub 2003 Dec 2 doi: 10.1007/s10096-003-1051-y. PMID: 14652784

Clinical prediction guides

Antifungal susceptibility, molecular epidemiology, and clinical risk factors of Candida glabrata in intensive care unit in a Chinese Tertiary Hospital.
Huang SJ, Lv G, Song YH, Zhao JT, Liu JY, Wang LL, Xiang MJ
Front Cell Infect Microbiol 2024;14:1455145. Epub 2024 Oct 7 doi: 10.3389/fcimb.2024.1455145. PMID: 39435186Free PMC Article
Pharmacodynamics of echinocandins against Candida glabrata: requirement for dosage escalation to achieve maximal antifungal activity in neutropenic hosts.
Howard SJ, Livermore J, Sharp A, Goodwin J, Gregson L, Alastruey-Izquierdo A, Perlin DS, Warn PA, Hope WW
Antimicrob Agents Chemother 2011 Oct;55(10):4880-7. Epub 2011 Aug 1 doi: 10.1128/AAC.00621-11. PMID: 21807969Free PMC Article
In vivo pharmacodynamic characterization of anidulafungin in a neutropenic murine candidiasis model.
Andes D, Diekema DJ, Pfaller MA, Prince RA, Marchillo K, Ashbeck J, Hou J
Antimicrob Agents Chemother 2008 Feb;52(2):539-50. Epub 2007 Dec 10 doi: 10.1128/AAC.01061-07. PMID: 18070979Free PMC Article

Recent systematic reviews

Candida-induced prosthetic joint infection. A literature review including 72 cases and a case report.
Cobo F, Rodríguez-Granger J, López EM, Jiménez G, Sampedro A, Aliaga-Martínez L, Navarro-Marí JM
Infect Dis (Lond) 2017 Feb;49(2):81-94. Epub 2016 Sep 1 doi: 10.1080/23744235.2016.1219456. PMID: 27586845

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