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Complex regional pain syndrome type 1

MedGen UID:
11159
•Concept ID:
C0034931
•
Disease or Syndrome
Synonym: Reflex sympathetic dystrophy
SNOMED CT: Complex regional pain syndrome type I (734947007); Complex regional pain syndrome type 1 (734947007); CRPS (complex regional pain syndrome) type I (734947007); Reflex sympathetic dystrophy (734947007)
 
Monarch Initiative: MONDO:0011441
OMIM®: 604335
Orphanet: ORPHA99995

Definition

Complex regional pain syndrome type 1 (CRPS1) is a form of complex regional pain syndrome (see this term) in which the pain is disproportionate to any known inciting event and is characterized by continuous pain, allodynia, or hyperalgesia as well as edema, coloration (changes in skin blood flow), or abnormal sudomotor activity in the region of pain. Onset of CRPS1 symptoms may occur within a few days to a month after an injury or trauma to the affected limb. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVComplex regional pain syndrome type 1
Follow this link to review classifications for Complex regional pain syndrome type 1 in Orphanet.

Professional guidelines

PubMed

Bisphosphonates in the treatment of complex regional pain syndrome: is bone the main player at early stage of the disease?
Varenna M, Crotti C
Rheumatol Int 2018 Nov;38(11):1959-1962. Epub 2018 Jul 14 doi: 10.1007/s00296-018-4101-6. PMID: 30008128
Complex Regional Pain Syndrome Type 1: Diagnosis and Management.
Lee JW, Lee SK, Choy WS
J Hand Surg Asian Pac Vol 2018 Mar;23(1):1-10. doi: 10.1142/S2424835518300013. PMID: 29409405
Stroke, complex regional pain syndrome and phantom limb pain: can commonalities direct future management?
Acerra NE, Souvlis T, Moseley GL
J Rehabil Med 2007 Mar;39(2):109-14. doi: 10.2340/16501977-0027. PMID: 17351691

Recent clinical studies

Etiology

Bisphosphonates for treatment of Complex Regional Pain Syndrome type 1: A systematic literature review and meta-analysis of randomized controlled trials versus placebo.
Chevreau M, Romand X, Gaudin P, Juvin R, Baillet A
Joint Bone Spine 2017 Jul;84(4):393-399. Epub 2017 Apr 11 doi: 10.1016/j.jbspin.2017.03.009. PMID: 28408275
Update on the effects of graded motor imagery and mirror therapy on complex regional pain syndrome type 1: A systematic review.
Méndez-Rebolledo G, Gatica-Rojas V, Torres-Cueco R, Albornoz-Verdugo M, Guzmán-Muñoz E
J Back Musculoskelet Rehabil 2017;30(3):441-449. doi: 10.3233/BMR-150500. PMID: 27858687
Thermal pain in complex regional pain syndrome type I.
Grothusen JR, Alexander G, Erwin K, Schwartzman R
Pain Physician 2014 Jan-Feb;17(1):71-9. PMID: 24452647
Graded motor imagery for pathologic pain: a randomized controlled trial.
Moseley GL
Neurology 2006 Dec 26;67(12):2129-34. Epub 2006 Nov 2 doi: 10.1212/01.wnl.0000249112.56935.32. PMID: 17082465
Graded motor imagery is effective for long-standing complex regional pain syndrome: a randomised controlled trial.
Moseley GL
Pain 2004 Mar;108(1-2):192-8. doi: 10.1016/j.pain.2004.01.006. PMID: 15109523

Diagnosis

Sensory Function and Psychological Factors in Children With Complex Regional Pain Syndrome Type 1.
Truffyn EE, Moayedi M, Brown SC, Ruskin D, Duerden EG
J Child Neurol 2021 Sep;36(10):823-830. Epub 2021 Apr 21 doi: 10.1177/08830738211007685. PMID: 33882728Free PMC Article
Complex Regional Pain Syndrome Type 1: Diagnosis and Management.
Lee JW, Lee SK, Choy WS
J Hand Surg Asian Pac Vol 2018 Mar;23(1):1-10. doi: 10.1142/S2424835518300013. PMID: 29409405
Complex Regional Pain Type 1.
Barrett MJ, Barnett PL
Pediatr Emerg Care 2016 Mar;32(3):185-9; quiz 190-1. doi: 10.1097/PEC.0000000000000731. PMID: 26928099
Thermal pain in complex regional pain syndrome type I.
Grothusen JR, Alexander G, Erwin K, Schwartzman R
Pain Physician 2014 Jan-Feb;17(1):71-9. PMID: 24452647
Graded motor imagery for pathologic pain: a randomized controlled trial.
Moseley GL
Neurology 2006 Dec 26;67(12):2129-34. Epub 2006 Nov 2 doi: 10.1212/01.wnl.0000249112.56935.32. PMID: 17082465

Therapy

Complex Regional Pain Syndrome Type 1: Diagnosis and Management.
Lee JW, Lee SK, Choy WS
J Hand Surg Asian Pac Vol 2018 Mar;23(1):1-10. doi: 10.1142/S2424835518300013. PMID: 29409405
Bisphosphonates for treatment of Complex Regional Pain Syndrome type 1: A systematic literature review and meta-analysis of randomized controlled trials versus placebo.
Chevreau M, Romand X, Gaudin P, Juvin R, Baillet A
Joint Bone Spine 2017 Jul;84(4):393-399. Epub 2017 Apr 11 doi: 10.1016/j.jbspin.2017.03.009. PMID: 28408275
Update on the effects of graded motor imagery and mirror therapy on complex regional pain syndrome type 1: A systematic review.
Méndez-Rebolledo G, Gatica-Rojas V, Torres-Cueco R, Albornoz-Verdugo M, Guzmán-Muñoz E
J Back Musculoskelet Rehabil 2017;30(3):441-449. doi: 10.3233/BMR-150500. PMID: 27858687
Graded motor imagery for pathologic pain: a randomized controlled trial.
Moseley GL
Neurology 2006 Dec 26;67(12):2129-34. Epub 2006 Nov 2 doi: 10.1212/01.wnl.0000249112.56935.32. PMID: 17082465
Graded motor imagery is effective for long-standing complex regional pain syndrome: a randomised controlled trial.
Moseley GL
Pain 2004 Mar;108(1-2):192-8. doi: 10.1016/j.pain.2004.01.006. PMID: 15109523

Prognosis

The long-term effect of complex regional pain syndrome type 1 on disability and quality of life after foot injury.
Mouraux D, Lenoir C, Tuna T, Brassinne E, Sobczak S
Disabil Rehabil 2021 Apr;43(7):967-975. Epub 2019 Aug 14 doi: 10.1080/09638288.2019.1650295. PMID: 31411910
Musculoskeletal manifestations of the antiphospholipid syndrome.
Noureldine MH, Khamashta MA, Merashli M, Sabbouh T, Hughes GR, Uthman I
Lupus 2016 Apr;25(5):451-62. Epub 2016 Feb 27 doi: 10.1177/0961203316636467. PMID: 26923284
The outcome of complex regional pain syndrome type 1: a systematic review.
Bean DJ, Johnson MH, Kydd RR
J Pain 2014 Jul;15(7):677-90. Epub 2014 Feb 12 doi: 10.1016/j.jpain.2014.01.500. PMID: 24530407
Thermal pain in complex regional pain syndrome type I.
Grothusen JR, Alexander G, Erwin K, Schwartzman R
Pain Physician 2014 Jan-Feb;17(1):71-9. PMID: 24452647
Diagnosis of partial complex regional pain syndrome type 1 of the hand: retrospective study of 16 cases and literature review.
Konzelmann M, Deriaz O, Luthi F
BMC Neurol 2013 Mar 18;13:28. doi: 10.1186/1471-2377-13-28. PMID: 23506090Free PMC Article

Clinical prediction guides

Incidence and Prevalence of Pain Medication Prescriptions in Pathologies with a Potential for Chronic Pain.
Goudman L, Moens M, Pilitsis JG
Anesthesiology 2024 Mar 1;140(3):524-537. doi: 10.1097/ALN.0000000000004863. PMID: 38081041
Direct Sciatic Nerve Electrical Stimulation for Complex Regional Pain Syndrome Type 1.
Buwembo J, Munson R, Rizvi SA, Ijaz A, Gupta S
Neuromodulation 2021 Aug;24(6):1075-1082. Epub 2020 Nov 10 doi: 10.1111/ner.13294. PMID: 33171547
Complex regional pain syndrome type 1: Analysis of 108 patients.
Pendón G, Salas A, García M, Pereira D
Reumatol Clin 2017 Mar-Apr;13(2):73-77. Epub 2016 Apr 28 doi: 10.1016/j.reuma.2016.03.015. PMID: 27132482
The outcome of complex regional pain syndrome type 1: a systematic review.
Bean DJ, Johnson MH, Kydd RR
J Pain 2014 Jul;15(7):677-90. Epub 2014 Feb 12 doi: 10.1016/j.jpain.2014.01.500. PMID: 24530407
Graded motor imagery is effective for long-standing complex regional pain syndrome: a randomised controlled trial.
Moseley GL
Pain 2004 Mar;108(1-2):192-8. doi: 10.1016/j.pain.2004.01.006. PMID: 15109523

Recent systematic reviews

Effect of Perioperative Vitamin C on the Incidence of Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis.
Seth I, Bulloch G, Seth N, Siu A, Clayton S, Lower K, Roshan S, Nara N
J Foot Ankle Surg 2022 Jul-Aug;61(4):748-754. Epub 2021 Nov 21 doi: 10.1053/j.jfas.2021.11.008. PMID: 34961681
Bisphosphonates for treatment of Complex Regional Pain Syndrome type 1: A systematic literature review and meta-analysis of randomized controlled trials versus placebo.
Chevreau M, Romand X, Gaudin P, Juvin R, Baillet A
Joint Bone Spine 2017 Jul;84(4):393-399. Epub 2017 Apr 11 doi: 10.1016/j.jbspin.2017.03.009. PMID: 28408275
Update on the effects of graded motor imagery and mirror therapy on complex regional pain syndrome type 1: A systematic review.
Méndez-Rebolledo G, Gatica-Rojas V, Torres-Cueco R, Albornoz-Verdugo M, Guzmán-Muñoz E
J Back Musculoskelet Rehabil 2017;30(3):441-449. doi: 10.3233/BMR-150500. PMID: 27858687
The outcome of complex regional pain syndrome type 1: a systematic review.
Bean DJ, Johnson MH, Kydd RR
J Pain 2014 Jul;15(7):677-90. Epub 2014 Feb 12 doi: 10.1016/j.jpain.2014.01.500. PMID: 24530407
Is there an association between psychological factors and the Complex Regional Pain Syndrome type 1 (CRPS1) in adults? A systematic review.
Beerthuizen A, van 't Spijker A, Huygen FJ, Klein J, de Wit R
Pain 2009 Sep;145(1-2):52-9. Epub 2009 Jul 1 doi: 10.1016/j.pain.2009.05.003. PMID: 19573987

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