MedGen

The Emm red blood cell antigen is assigned number 901008 in the International Society of Blood Transfusion (ISBY) 901 series of high incidence antigens. Emm has been designated the 42nd blood group system. Rare individuals have an Emm- phenotype due to homozygous loss-of-function mutations in the PIGG gene. These individuals often have naturally occurring anti-Emm antibodies that are identified during routine blood type and crossing. These antibodies have the potential to cause acute hemolytic transfusion reactions (summary by Lane et al., 2021). [from OMIM]

Sudden loss of renal function, as manifested by decreased urine production, and a rise in serum creatinine or blood urea nitrogen concentration (azotemia). [from HPO]

Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis. [from ORDO]

Any of the several infectious disorders caused by members of streptococcus, a genus of gram positive bacteria belonging to the family Streptococcaceae. Streptococcal infections are classified into Groups A, B, C, D and G. [from NCI]

Inflammation of the renal glomeruli. [from HPO]