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Superoxide dismutase, elevated extracellular

MedGen UID:
855959
•Concept ID:
C3891298
•
Finding
Synonym: SUPEROXIDE DISMUTASE, ELEVATED EXTRACELLULAR
 
OMIM®: 185490

Professional guidelines

PubMed

Crocin treatment promotes the oxidative stress and apoptosis in human thyroid cancer cells FTC-133 through the inhibition of STAT/JAK signaling pathway.
Zhang Y, Zhu M, Krishna Mohan S, Hao Z
J Biochem Mol Toxicol 2021 Jan;35(1):e22608. Epub 2020 Sep 4 doi: 10.1002/jbt.22608. PMID: 32886819
Diabetes mellitus: novel insights, analysis and interpretation of pathophysiology and complications management with imidazole-containing peptidomimetic antioxidants.
Babizhayev MA, Lankin VZ, Savel'Yeva EL, Deyev AI, Yegorov YE
Recent Pat Drug Deliv Formul 2013 Dec;7(3):216-56. doi: 10.2174/1872211307666131117121058. PMID: 24236935
Molecular changes evoked by triethylenetetramine treatment in the extracellular matrix of the heart and aorta in diabetic rats.
Gong D, Lu J, Chen X, Choong SY, Zhang S, Chan YK, Glyn-Jones S, Gamble GD, Phillips AR, Cooper GJ
Mol Pharmacol 2006 Dec;70(6):2045-51. Epub 2006 Sep 14 doi: 10.1124/mol.106.028605. PMID: 16973718

Recent clinical studies

Etiology

Diverse cellular and organismal functions of the lysosomal thiol reductase GILT.
Rausch MP, Hastings KT
Mol Immunol 2015 Dec;68(2 Pt A):124-8. Epub 2015 Jun 23 doi: 10.1016/j.molimm.2015.06.008. PMID: 26116226Free PMC Article
Role of advanced glycation end products in cellular signaling.
Ott C, Jacobs K, Haucke E, Navarrete Santos A, Grune T, Simm A
Redox Biol 2014;2:411-29. Epub 2014 Jan 9 doi: 10.1016/j.redox.2013.12.016. PMID: 24624331Free PMC Article
Extracellular superoxide dismutase, a potential extracellular biomarker candidate for prolactinoma.
Yang J, Zhang C, Zhang W, Shi R, Zhang Z
West Indian Med J 2012 Oct;61(7):665-9. PMID: 23620962
Extracellular superoxide dismutase (EC-SOD) quenches free radicals and attenuates age-related cognitive decline: opportunities for novel drug development in aging.
Levin ED
Curr Alzheimer Res 2005 Apr;2(2):191-6. doi: 10.2174/1567205053585710. PMID: 15974918
Influence of hyperhomocysteinemia on the cellular redox state--impact on homocysteine-induced endothelial dysfunction.
Weiss N, Heydrick SJ, Postea O, Keller C, Keaney JF Jr, Loscalzo J
Clin Chem Lab Med 2003 Nov;41(11):1455-61. doi: 10.1515/CCLM.2003.223. PMID: 14656025

Diagnosis

Biomimetic Nanozyme-Decorated Smart Hydrogel for Promoting Chronic Refractory Wound Healing.
Feng S, Peng X, Deng Y, Luo Y, Shi S, Wei X, Pu X, Yu X
ACS Appl Mater Interfaces 2024 Nov 6;16(44):59862-59879. Epub 2024 Oct 23 doi: 10.1021/acsami.4c13220. PMID: 39441846
Endoplasmic Reticulum Stress Promotes the Expression of TNF-α in THP-1 Cells by Mechanisms Involving ROS/CHOP/HIF-1α and MAPK/NF-κB Pathways.
Akhter N, Wilson A, Arefanian H, Thomas R, Kochumon S, Al-Rashed F, Abu-Farha M, Al-Madhoun A, Al-Mulla F, Ahmad R, Sindhu S
Int J Mol Sci 2023 Oct 14;24(20) doi: 10.3390/ijms242015186. PMID: 37894865Free PMC Article
Extracellular superoxide dismutase, a potential extracellular biomarker candidate for prolactinoma.
Yang J, Zhang C, Zhang W, Shi R, Zhang Z
West Indian Med J 2012 Oct;61(7):665-9. PMID: 23620962
Smoking and COPD increase sputum levels of extracellular superoxide dismutase.
Regan EA, Mazur W, Meoni E, Toljamo T, Millar J, Vuopala K, Bowler RP, Rahman I, Nicks ME, Crapo JD, Kinnula VL
Free Radic Biol Med 2011 Aug 1;51(3):726-32. Epub 2011 May 14 doi: 10.1016/j.freeradbiomed.2011.05.008. PMID: 21621610
Relationship between homocysteine and superoxide dismutase in homocystinuria: possible relevance to cardiovascular risk.
Wilcken DE, Wang XL, Adachi T, Hara H, Duarte N, Green K, Wilcken B
Arterioscler Thromb Vasc Biol 2000 May;20(5):1199-202. doi: 10.1161/01.atv.20.5.1199. PMID: 10807733

Therapy

Protective effect of astaxanthin on ANCA-associated vasculitis.
Sun RL, Shang JC, Han RH, Xing GQ
Int Immunopharmacol 2024 May 10;132:111928. Epub 2024 Mar 26 doi: 10.1016/j.intimp.2024.111928. PMID: 38537540
Interleukin-1β triggers muscle-derived extracellular superoxide dismutase expression and protects muscles from doxorubicin-induced atrophy.
Yamada M, Okutsu M
J Physiol 2023 Nov;601(21):4699-4721. Epub 2023 Oct 10 doi: 10.1113/JP285174. PMID: 37815420
Role of advanced glycation end products in cellular signaling.
Ott C, Jacobs K, Haucke E, Navarrete Santos A, Grune T, Simm A
Redox Biol 2014;2:411-29. Epub 2014 Jan 9 doi: 10.1016/j.redox.2013.12.016. PMID: 24624331Free PMC Article
Loss of extracellular superoxide dismutase induces severe IL-23-mediated skin inflammation in mice.
Lee YS, Cheon IS, Kim BH, Kwon MJ, Lee HW, Kim TY
J Invest Dermatol 2013 Mar;133(3):732-741. Epub 2012 Dec 6 doi: 10.1038/jid.2012.406. PMID: 23223134
Smoking and COPD increase sputum levels of extracellular superoxide dismutase.
Regan EA, Mazur W, Meoni E, Toljamo T, Millar J, Vuopala K, Bowler RP, Rahman I, Nicks ME, Crapo JD, Kinnula VL
Free Radic Biol Med 2011 Aug 1;51(3):726-32. Epub 2011 May 14 doi: 10.1016/j.freeradbiomed.2011.05.008. PMID: 21621610

Prognosis

Modulation of reactive oxygen species via ERK and STAT3 dependent signalling are involved in the response of mesothelioma cells to exemestane.
Nuvoli B, Camera E, Mastrofrancesco A, Briganti S, Galati R
Free Radic Biol Med 2018 Feb 1;115:266-277. Epub 2017 Dec 9 doi: 10.1016/j.freeradbiomed.2017.12.008. PMID: 29229551
Galectin-3 in patients with chronic heart failure: association with oxidative stress, inflammation, renal dysfunction and prognosis.
Medvedeva EA, Berezin II, Surkova EA, Yaranov DM, Shchukin YV
Minerva Cardioangiol 2016 Dec;64(6):595-602. Epub 2016 Apr 27 PMID: 27119370
Identification of differentially expressed serum proteins in gastric adenocarcinoma.
Subbannayya Y, Mir SA, Renuse S, Manda SS, Pinto SM, Puttamallesh VN, Solanki HS, Manju HC, Syed N, Sharma R, Christopher R, Vijayakumar M, Veerendra Kumar KV, Keshava Prasad TS, Ramaswamy G, Kumar RV, Chatterjee A, Pandey A, Gowda H
J Proteomics 2015 Sep 8;127(Pt A):80-8. Epub 2015 May 5 doi: 10.1016/j.jprot.2015.04.021. PMID: 25952687Free PMC Article
Superoxide dismutase isoenzyme activities in plasma and tissues of Iraqi patients with breast cancer.
Hasan HR, Mathkor TH, Al-Habal MH
Asian Pac J Cancer Prev 2012;13(6):2571-6. doi: 10.7314/apjcp.2012.13.6.2571. PMID: 22938422
Demonstration of a hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation: quantitative comparisons between the biology of copper and eight other nutritionally essential elements in normal and diabetic individuals.
Cooper GJ, Chan YK, Dissanayake AM, Leahy FE, Keogh GF, Frampton CM, Gamble GD, Brunton DH, Baker JR, Poppitt SD
Diabetes 2005 May;54(5):1468-76. doi: 10.2337/diabetes.54.5.1468. PMID: 15855335

Clinical prediction guides

Protective effect of astaxanthin on ANCA-associated vasculitis.
Sun RL, Shang JC, Han RH, Xing GQ
Int Immunopharmacol 2024 May 10;132:111928. Epub 2024 Mar 26 doi: 10.1016/j.intimp.2024.111928. PMID: 38537540
Salvianolic Acid A Protects against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Neutrophil NETosis.
Liu Q, Zhu CL, Li HR, Xie J, Guo Y, Li P, Zhao ZZ, Wang JF, Deng XM
Oxid Med Cell Longev 2022;2022:7411824. Epub 2022 Jul 21 doi: 10.1155/2022/7411824. PMID: 35910849Free PMC Article
Manganese superoxide dismutase promotes anoikis resistance and tumor metastasis.
Kamarajugadda S, Cai Q, Chen H, Nayak S, Zhu J, He M, Jin Y, Zhang Y, Ai L, Martin SS, Tan M, Lu J
Cell Death Dis 2013 Feb 21;4(2):e504. doi: 10.1038/cddis.2013.20. PMID: 23429290Free PMC Article
Superoxide dismutase isoenzyme activities in plasma and tissues of Iraqi patients with breast cancer.
Hasan HR, Mathkor TH, Al-Habal MH
Asian Pac J Cancer Prev 2012;13(6):2571-6. doi: 10.7314/apjcp.2012.13.6.2571. PMID: 22938422
Excitotoxicity effects of glutamate on human neuroblastoma SH-SY5Y cells via oxidative damage.
Sun ZW, Zhang L, Zhu SJ, Chen WC, Mei B
Neurosci Bull 2010 Feb;26(1):8-16. doi: 10.1007/s12264-010-0813-7. PMID: 20101268Free PMC Article

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