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Apolipoprotein A-II deficiency

MedGen UID:
854810
•Concept ID:
C3888202
•
Disease or Syndrome
Synonym: APOLIPOPROTEIN A-II DEFICIENCY
 
OMIM®: 107670

Professional guidelines

PubMed

The saga of the discovery of IL-1 and TNF and their specific inhibitors in the pathogenesis and treatment of rheumatoid arthritis.
Dayer JM
Joint Bone Spine 2002 Mar;69(2):123-32. doi: 10.1016/s1297-319x(02)00363-9. PMID: 12027302
Genotype/phenotype relationships in HNF-4alpha/MODY1: haploinsufficiency is associated with reduced apolipoprotein (AII), apolipoprotein (CIII), lipoprotein(a), and triglyceride levels.
Shih DQ, Dansky HM, Fleisher M, Assmann G, Fajans SS, Stoffel M
Diabetes 2000 May;49(5):832-7. doi: 10.2337/diabetes.49.5.832. PMID: 10905494
HDL metabolism in HDL deficiency associated with familial hypertriglyceridemia: effect of treatment with gemfibrozil.
Kashyap ML, Saku K
Adv Exp Med Biol 1991;285:233-6. doi: 10.1007/978-1-4684-5904-3_28. PMID: 1907081

Recent clinical studies

Etiology

Nosocomial infections after severe trauma are associated with lower apolipoproteins B and AII.
Femling JK, West SD, Hauswald EK, Gresham HD, Hall PR
J Trauma Acute Care Surg 2013 Apr;74(4):1067-73. doi: 10.1097/TA.0b013e3182826be0. PMID: 23511146Free PMC Article
Lipoprotein abnormalities in compound heterozygous lipoprotein lipase deficiency after treatment with a low-fat diet and orlistat.
Blackett P, Tryggestad J, Krishnan S, Li S, Xu W, Alaupovic P, Quiroga C, Copeland K
J Clin Lipidol 2013 Mar-Apr;7(2):132-9. Epub 2012 Dec 12 doi: 10.1016/j.jacl.2012.11.006. PMID: 23415432
ApoA-II maintains HDL levels in part by inhibition of hepatic lipase. Studies In apoA-II and hepatic lipase double knockout mice.
Weng W, Brandenburg NA, Zhong S, Halkias J, Wu L, Jiang XC, Tall A, Breslow JL
J Lipid Res 1999 Jun;40(6):1064-70. PMID: 10357838
ApoA-IHelsinki (Lys107-->0) associated with reduced HDL cholesterol and LpA-I:A-II deficiency.
Tilly-Kiesi M, Zhang Q, Ehnholm S, Kahri J, Lahdenperä S, Ehnholm C, Taskinen MR
Arterioscler Thromb Vasc Biol 1995 Sep;15(9):1294-306. doi: 10.1161/01.atv.15.9.1294. PMID: 7670941

Diagnosis

Lipoprotein abnormalities in compound heterozygous lipoprotein lipase deficiency after treatment with a low-fat diet and orlistat.
Blackett P, Tryggestad J, Krishnan S, Li S, Xu W, Alaupovic P, Quiroga C, Copeland K
J Clin Lipidol 2013 Mar-Apr;7(2):132-9. Epub 2012 Dec 12 doi: 10.1016/j.jacl.2012.11.006. PMID: 23415432
Acquired hypolipoproteinemia.
De Buyzere M, Delanghe J, Labeur C, Noens L, Benoit Y, Baert J, Rosseneu M
Clin Chem 1992 May;38(5):776-81. PMID: 1582035

Therapy

Lipoprotein abnormalities in compound heterozygous lipoprotein lipase deficiency after treatment with a low-fat diet and orlistat.
Blackett P, Tryggestad J, Krishnan S, Li S, Xu W, Alaupovic P, Quiroga C, Copeland K
J Clin Lipidol 2013 Mar-Apr;7(2):132-9. Epub 2012 Dec 12 doi: 10.1016/j.jacl.2012.11.006. PMID: 23415432
Apolipoprotein A-II suppressed concanavalin A-induced hepatitis via the inhibition of CD4 T cell function.
Yamashita J, Iwamura C, Sasaki T, Mitsumori K, Ohshima K, Hada K, Hara N, Takahashi M, Kaneshiro Y, Tanaka H, Kaneko K, Nakayama T
J Immunol 2011 Mar 15;186(6):3410-20. Epub 2011 Feb 7 doi: 10.4049/jimmunol.1002924. PMID: 21300819

Prognosis

Nosocomial infections after severe trauma are associated with lower apolipoproteins B and AII.
Femling JK, West SD, Hauswald EK, Gresham HD, Hall PR
J Trauma Acute Care Surg 2013 Apr;74(4):1067-73. doi: 10.1097/TA.0b013e3182826be0. PMID: 23511146Free PMC Article

Clinical prediction guides

Depletion in LpA-I:A-II particles enhances HDL-mediated endothelial protection in familial LCAT deficiency.
Gomaraschi M, Ossoli A, Castelnuovo S, Simonelli S, Pavanello C, Balzarotti G, Arca M, Di Costanzo A, Sampietro T, Vaudo G, Baldassarre D, Veglia F, Franceschini G, Calabresi L
J Lipid Res 2017 May;58(5):994-1001. Epub 2017 Mar 28 doi: 10.1194/jlr.P072371. PMID: 28351888Free PMC Article
Nosocomial infections after severe trauma are associated with lower apolipoproteins B and AII.
Femling JK, West SD, Hauswald EK, Gresham HD, Hall PR
J Trauma Acute Care Surg 2013 Apr;74(4):1067-73. doi: 10.1097/TA.0b013e3182826be0. PMID: 23511146Free PMC Article
Apolipoprotein A-II suppressed concanavalin A-induced hepatitis via the inhibition of CD4 T cell function.
Yamashita J, Iwamura C, Sasaki T, Mitsumori K, Ohshima K, Hada K, Hara N, Takahashi M, Kaneshiro Y, Tanaka H, Kaneko K, Nakayama T
J Immunol 2011 Mar 15;186(6):3410-20. Epub 2011 Feb 7 doi: 10.4049/jimmunol.1002924. PMID: 21300819
ApoA-II maintains HDL levels in part by inhibition of hepatic lipase. Studies In apoA-II and hepatic lipase double knockout mice.
Weng W, Brandenburg NA, Zhong S, Halkias J, Wu L, Jiang XC, Tall A, Breslow JL
J Lipid Res 1999 Jun;40(6):1064-70. PMID: 10357838
ApoA-IHelsinki (Lys107-->0) associated with reduced HDL cholesterol and LpA-I:A-II deficiency.
Tilly-Kiesi M, Zhang Q, Ehnholm S, Kahri J, Lahdenperä S, Ehnholm C, Taskinen MR
Arterioscler Thromb Vasc Biol 1995 Sep;15(9):1294-306. doi: 10.1161/01.atv.15.9.1294. PMID: 7670941

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