MedGen

Gingival fibromatosis-5 (GINGF5) is an autosomal dominant benign overgrowth disorder characterized by slowly progressive fibrous enlargement of the keratinized gingival tissues. Affected individuals may have diastema, malposition of the teeth, and prolonged retention of primary teeth. Onset is in the first decade. Treatment by surgical resection is generally followed by regrowth of the gingival tissues (summary by Pehlivan et al., 2009). For a general phenotypic description and a discussion of genetic heterogeneity of hereditary gingival fibromatosis, see GINGF1 (135300). [from OMIM]

Wilms tumor is the most common renal tumor of childhood, occurring with an incidence of 1 in 10,000. It is often described as an embryonal tumor, as it arises from embryonal cells in which growth and/or differentiation have become dysregulated during development (summary by Mahamdallie et al., 2015). For a general phenotypic description and discussion of genetic heterogeneity of Wilms tumor, see WT1 (194070). [from OMIM]

DFNA27 is characterized by postlingual progressive moderate to profound sensorineural hearing loss (Peters et al., 2008). [from OMIM]