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Dna topoisomerase II, resistance to inhibition of, by amsacrine

MedGen UID:
1844533
•Concept ID:
CN724455
•
Disease or Syndrome

Professional guidelines

PubMed

New drugs in the treatment of acute and chronic leukemia with some emphasis on m-AMSA.
Jehn U, Heinemann V
Anticancer Res 1991 Mar-Apr;11(2):705-11. PMID: 2064323

Recent clinical studies

Etiology

Antimalarial 9-anilinoacridine compounds directed at hematin.
Auparakkitanon S, Noonpakdee W, Ralph RK, Denny WA, Wilairat P
Antimicrob Agents Chemother 2003 Dec;47(12):3708-12. doi: 10.1128/AAC.47.12.3708-3712.2003. PMID: 14638470Free PMC Article
Structure-activity studies of amsacrine analogs in drug resistant human leukemia cell lines expressing either altered DNA topoisomerase II or P-glycoprotein.
Granzen B, Graves DE, Baguley BC, Danks MK, Beck WT
Oncol Res 1992;4(11-12):489-96. PMID: 1363724
New drugs in the treatment of acute and chronic leukemia with some emphasis on m-AMSA.
Jehn U, Heinemann V
Anticancer Res 1991 Mar-Apr;11(2):705-11. PMID: 2064323

Diagnosis

Novel tetra-acridine derivatives as dual inhibitors of topoisomerase II and the human proteasome.
Vispé S, Vandenberghe I, Robin M, Annereau JP, Créancier L, Pique V, Galy JP, Kruczynski A, Barret JM, Bailly C
Biochem Pharmacol 2007 Jun 15;73(12):1863-72. Epub 2007 Mar 3 doi: 10.1016/j.bcp.2007.02.016. PMID: 17391647
N-terminal and core-domain random mutations in human topoisomerase II alpha conferring bisdioxopiperazine resistance.
Jensen LH, Wessel I, Møller M, Nitiss JL, Sehested M, Jensen PB
FEBS Lett 2000 Sep 1;480(2-3):201-7. doi: 10.1016/s0014-5793(00)01934-7. PMID: 11034329
Quantification of topoisomerase-DNA complexes in leukemia cells from patients undergoing therapy with a topoisomerase-directed agent.
Ellis AL, Nowak B, Plunkett W, Zwelling LA
Cancer Chemother Pharmacol 1994;34(3):249-56. doi: 10.1007/BF00685085. PMID: 8004759
Cross-resistance of an amsacrine-resistant human leukemia line to topoisomerase II reactive DNA intercalating agents. Evidence for two topoisomerase II directed drug actions.
Zwelling LA, Mayes J, Hinds M, Chan D, Altschuler E, Carroll B, Parker E, Deisseroth K, Radcliffe A, Seligman M
Biochemistry 1991 Apr 23;30(16):4048-55. doi: 10.1021/bi00230a032. PMID: 1850298
A restriction fragment length polymorphism for human topoisomerase II: possible relationship to drug-resistance.
Zwelling LA, Mayes J, Deisseroth K, Hinds M, Grant G, Pathak S, Ledley FD, Vyas R, Hittelman W
Cancer Commun 1990;2(11):357-61. doi: 10.3727/095535490820874047. PMID: 1978687

Therapy

N-terminal and core-domain random mutations in human topoisomerase II alpha conferring bisdioxopiperazine resistance.
Jensen LH, Wessel I, Møller M, Nitiss JL, Sehested M, Jensen PB
FEBS Lett 2000 Sep 1;480(2-3):201-7. doi: 10.1016/s0014-5793(00)01934-7. PMID: 11034329
Biochemical modulation of cytotoxic drugs by cytokines: molecular mechanisms in experimental oncology.
Kreuser ED, Wadler S, Thiel E
Recent Results Cancer Res 1995;139:371-82. doi: 10.1007/978-3-642-78771-3_28. PMID: 7597304
Quantification of topoisomerase-DNA complexes in leukemia cells from patients undergoing therapy with a topoisomerase-directed agent.
Ellis AL, Nowak B, Plunkett W, Zwelling LA
Cancer Chemother Pharmacol 1994;34(3):249-56. doi: 10.1007/BF00685085. PMID: 8004759
Laboratory and clinical studies of biochemical modulation by hydroxyurea.
Schilsky RL, Ratain MJ, Vokes EE, Vogelzang NJ, Anderson J, Peterson BA
Semin Oncol 1992 Jun;19(3 Suppl 9):84-9. PMID: 1641659
New drugs in the treatment of acute and chronic leukemia with some emphasis on m-AMSA.
Jehn U, Heinemann V
Anticancer Res 1991 Mar-Apr;11(2):705-11. PMID: 2064323

Prognosis

Studies on Non-synonymous Polymorphisms Altering Human DNA Topoisomerase II-Alpha Interaction with Amsacrine and Mitoxantrone: An In Silico Approach.
Farsani FM, Ganjalikhany MR, Vallian S
Curr Cancer Drug Targets 2017;17(7):657-668. doi: 10.2174/1568009617666161109142629. PMID: 27834128
Reduced topoisomerase II activity in multidrug-resistant human non-small cell lung cancer cell lines.
Eijdems EW, de Haas M, Timmerman AJ, Van der Schans GP, Kamst E, de Nooij J, Astaldi Ricotti GC, Borst P, Baas F
Br J Cancer 1995 Jan;71(1):40-7. doi: 10.1038/bjc.1995.9. PMID: 7819046Free PMC Article
Quantification of topoisomerase-DNA complexes in leukemia cells from patients undergoing therapy with a topoisomerase-directed agent.
Ellis AL, Nowak B, Plunkett W, Zwelling LA
Cancer Chemother Pharmacol 1994;34(3):249-56. doi: 10.1007/BF00685085. PMID: 8004759

Clinical prediction guides

Studies on Non-synonymous Polymorphisms Altering Human DNA Topoisomerase II-Alpha Interaction with Amsacrine and Mitoxantrone: An In Silico Approach.
Farsani FM, Ganjalikhany MR, Vallian S
Curr Cancer Drug Targets 2017;17(7):657-668. doi: 10.2174/1568009617666161109142629. PMID: 27834128
Quantification of topoisomerase-DNA complexes in leukemia cells from patients undergoing therapy with a topoisomerase-directed agent.
Ellis AL, Nowak B, Plunkett W, Zwelling LA
Cancer Chemother Pharmacol 1994;34(3):249-56. doi: 10.1007/BF00685085. PMID: 8004759
New drugs in the treatment of acute and chronic leukemia with some emphasis on m-AMSA.
Jehn U, Heinemann V
Anticancer Res 1991 Mar-Apr;11(2):705-11. PMID: 2064323
Multiple patterns of resistance of human leukemia cell sublines to amsacrine analogues.
Finlay GJ, Baguley BC, Snow K, Judd W
J Natl Cancer Inst 1990 Apr 18;82(8):662-7. doi: 10.1093/jnci/82.8.662. PMID: 2157028
A restriction fragment length polymorphism for human topoisomerase II: possible relationship to drug-resistance.
Zwelling LA, Mayes J, Deisseroth K, Hinds M, Grant G, Pathak S, Ledley FD, Vyas R, Hittelman W
Cancer Commun 1990;2(11):357-61. doi: 10.3727/095535490820874047. PMID: 1978687

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