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Chlorpropamide response

MedGen UID:
1093727
•Concept ID:
CN427423
•
Sign or Symptom
Drug:
Chlorpropamide
MedGen UID:
40256
•Concept ID:
C0008287
•
Pharmacologic Substance
A long-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to other sulfonylureas, chlorpropamide has an increased risk of prolonged hypoglycemia because of its long half-life. [from NCI]
Chlorpropamide
 
Gene (location): G6PD (Xq28)

Professional guidelines

PubMed

Special considerations for treatment of type 2 diabetes mellitus in the elderly.
Fravel MA, McDanel DL, Ross MB, Moores KG, Starry MJ
Am J Health Syst Pharm 2011 Mar 15;68(6):500-9. doi: 10.2146/ajhp080085. PMID: 21378298
Position Paper on urine alkalinization.
Proudfoot AT, Krenzelok EP, Vale JA
J Toxicol Clin Toxicol 2004;42(1):1-26. doi: 10.1081/clt-120028740. PMID: 15083932
Drug-induced syndrome of inappropriate antidiuretic hormone secretion. Causes, diagnosis and management.
Chan TY
Drugs Aging 1997 Jul;11(1):27-44. doi: 10.2165/00002512-199711010-00004. PMID: 9237039

Curated

Gammal et al, Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype. 2 Sept 2022. Clin Pharmacol Ther.

DailyMed Drug Label, CHLORPROPAMIDE- Discontinued in the US, 2019

Recent clinical studies

Etiology

Kinetics-effect relations of insulin-releasing drugs in patients with type 2 diabetes: brief overview.
Melander A
Diabetes 2004 Dec;53 Suppl 3:S151-5. doi: 10.2337/diabetes.53.suppl_3.s151. PMID: 15561903
Effect of magnesium hydroxide on the absorption and efficacy of tolbutamide and chlorpropamide.
Kivistö KT, Neuvonen PJ
Eur J Clin Pharmacol 1992;42(6):675-9. doi: 10.1007/BF00265936. PMID: 1623912
Clinical pharmacology of sulfonylureas.
Melander A
Metabolism 1987 Feb;36(2 Suppl 1):12-6. doi: 10.1016/0026-0495(87)90195-8. PMID: 3543616
The genetics of diabetes mellitus, including the South African perspective.
Sandler M
S Afr Med J 1984 Sep 22;66(12):441-4. PMID: 6385308
Comparison of chlorpropamide and metformin treatment on weight and blood-glucose response of uncontrolled obese diabetics.
Clarke BF, Duncan LJ
Lancet 1968 Jan 20;1(7534):123-6. doi: 10.1016/s0140-6736(68)92726-8. PMID: 4169605

Diagnosis

Influence of genetic polymorphisms on the pharmacokinetics and pharmaco-dynamics of sulfonylurea drugs.
Xu H, Murray M, McLachlan AJ
Curr Drug Metab 2009 Jul;10(6):643-58. doi: 10.2174/138920009789375388. PMID: 19799532
Enzymes that hydrolyze adenine nucleotides in diabetes and associated pathologies.
Lunkes GI, Lunkes D, Stefanello F, Morsch A, Morsch VM, Mazzanti CM, Schetinger MR
Thromb Res 2003 Feb 15;109(4):189-94. doi: 10.1016/s0049-3848(03)00178-6. PMID: 12757773
Inhibition of ALDH3A1-catalyzed oxidation by chlorpropamide analogues.
Sládek NE, Rekha GK, Lee MJ, Nagasawa HT
Chem Biol Interact 2001 Nov 28;138(2):201-15. doi: 10.1016/s0009-2797(01)00282-4. PMID: 11672702
Diabetes insipidus in a quadriplegic patient.
Farrell CA, Staas WE Jr
Arch Phys Med Rehabil 1986 Feb;67(2):132-4. doi: 10.1016/0003-9993(86)90126-7. PMID: 3954565
Flushing reactions: consequences and mechanisms.
Wilkin JK
Ann Intern Med 1981 Oct;95(4):468-76. doi: 10.7326/0003-4819-95-4-468. PMID: 6169300

Therapy

The use of sulphonylureas in the elderly.
Graal MB, Wolffenbuttel BH
Drugs Aging 1999 Dec;15(6):471-81. doi: 10.2165/00002512-199915060-00007. PMID: 10641958
Roles of chlorpropamide, alcohol and acetaldehyde in determining the chlorpropamide-alcohol flush.
Groop L, Eriksson CJ, Huupponen R, Ylikahri R, Pelkonen R
Diabetologia 1984 Jan;26(1):34-8. doi: 10.1007/BF00252260. PMID: 6706043
The chlorpropamide alcohol flush.
Wiles PG, Pyke DA
Clin Sci (Lond) 1984 Oct;67(4):375-81. doi: 10.1042/cs0670375. PMID: 6380892
Flushing reactions: consequences and mechanisms.
Wilkin JK
Ann Intern Med 1981 Oct;95(4):468-76. doi: 10.7326/0003-4819-95-4-468. PMID: 6169300
Oral hypoglycemic agent update.
Krall LP, Chabot VA
Med Clin North Am 1978 Jul;62(4):681-94. doi: 10.1016/s0025-7125(16)31765-5. PMID: 98675

Prognosis

Prescribing of antidiabetic medicines to older diabetes type 2 patients in Lagos, Nigeria.
Erah PO, Eroje HI
Nig Q J Hosp Med 2013 Jan-Mar;23(1):12-6. PMID: 24579487
United Kingdom Prospective Diabetes Study 24: a 6-year, randomized, controlled trial comparing sulfonylurea, insulin, and metformin therapy in patients with newly diagnosed type 2 diabetes that could not be controlled with diet therapy. United Kingdom Prospective Diabetes Study Group.
Ann Intern Med 1998 Feb 1;128(3):165-75. doi: 10.7326/0003-4819-128-3-199802010-00001. PMID: 9454524
Non-insulin-dependent diabetes: 10-year outcome in relation to initial response to diet and subsequent sulfonylurea therapy.
Sönksen PH, Lowy C, Perkins JR, Lim HS
Diabetes Care 1984 May-Jun;7 Suppl 1:59-66. PMID: 6376030
Alcohol in asthma and the bronchoconstrictor effect of chlorpropamide.
Ayres J, Clark TJ
Br J Dis Chest 1982 Jan;76(1):79-87. PMID: 7059489
Influence of sulfonylureas on the secretion, disposal and effect of insulin.
Almér LO, Johansson E, Melander A, Wåhlin-Boll E
Eur J Clin Pharmacol 1982;22(1):27-32. doi: 10.1007/BF00606421. PMID: 7047169

Clinical prediction guides

Consensus guidelines for oral dosing of primarily renally cleared medications in older adults.
Hanlon JT, Aspinall SL, Semla TP, Weisbord SD, Fried LF, Good CB, Fine MJ, Stone RA, Pugh MJ, Rossi MI, Handler SM
J Am Geriatr Soc 2009 Feb;57(2):335-40. Epub 2008 Dec 10 doi: 10.1111/j.1532-5415.2008.02098.x. PMID: 19170784Free PMC Article
Effect of magnesium hydroxide on the absorption and efficacy of tolbutamide and chlorpropamide.
Kivistö KT, Neuvonen PJ
Eur J Clin Pharmacol 1992;42(6):675-9. doi: 10.1007/BF00265936. PMID: 1623912
Chlorpropamide alcohol flushing: a normal response?
Hoskins PJ, Wiles PG, Volkmann HP, Pyke DA
Clin Sci (Lond) 1987 Jul;73(1):77-80. doi: 10.1042/cs0730077. PMID: 3608379
Roles of chlorpropamide, alcohol and acetaldehyde in determining the chlorpropamide-alcohol flush.
Groop L, Eriksson CJ, Huupponen R, Ylikahri R, Pelkonen R
Diabetologia 1984 Jan;26(1):34-8. doi: 10.1007/BF00252260. PMID: 6706043
Comparison of metformin and chlorpropamide in non-obese, maturity-onset diabetics uncontrolled by diet.
Clarke BF, Campbell IW
Br Med J 1977 Dec 17;2(6102):1576-8. doi: 10.1136/bmj.2.6102.1576. PMID: 589351Free PMC Article

Supplemental Content

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    Clinical resources

    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • CPIC, 2022
      Gammal et al, Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype. 2 Sept 2022. Clin Pharmacol Ther.
    • DailyMed Drug Label, 2019
      DailyMed Drug Label, CHLORPROPAMIDE- Discontinued in the US, 2019

    Consumer resources

    Reviews

    Related information

    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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