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Leukemia/lymphoma, B-cell, 3

MedGen UID:
1050763
•Concept ID:
CN375896
•
Disease or Syndrome
Gene (location): BCL3 (19q13.32)

Professional guidelines

PubMed

Diagnosis and Treatment of Chronic Lymphocytic Leukemia: A Review.
Shadman M
JAMA 2023 Mar 21;329(11):918-932. doi: 10.1001/jama.2023.1946. PMID: 36943212
Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA).
Hayden PJ, Roddie C, Bader P, Basak GW, Bonig H, Bonini C, Chabannon C, Ciceri F, Corbacioglu S, Ellard R, Sanchez-Guijo F, Jäger U, Hildebrandt M, Hudecek M, Kersten MJ, Köhl U, Kuball J, Mielke S, Mohty M, Murray J, Nagler A, Rees J, Rioufol C, Saccardi R, Snowden JA, Styczynski J, Subklewe M, Thieblemont C, Topp M, Ispizua ÁU, Chen D, Vrhovac R, Gribben JG, Kröger N, Einsele H, Yakoub-Agha I
Ann Oncol 2022 Mar;33(3):259-275. Epub 2021 Dec 16 doi: 10.1016/j.annonc.2021.12.003. PMID: 34923107
Recent advances in CAR T-cell toxicity: Mechanisms, manifestations and management.
Brudno JN, Kochenderfer JN
Blood Rev 2019 Mar;34:45-55. Epub 2018 Nov 14 doi: 10.1016/j.blre.2018.11.002. PMID: 30528964Free PMC Article

Recent clinical studies

Etiology

Rituximab plus gemcitabine and oxaliplatin (R-GemOx) in refractory/relapsed diffuse large B-cell lymphoma: a real-life study in patients ineligible for autologous stem-cell transplantation.
Cazelles C, Belhadj K, Vellemans H, Camus V, Poullot E, Gaulard P, Veresezan L, Itti E, Becker S, Carvalho M, Dupuis J, Le Bras F, Lemonnier F, Roulin L, El Gnaoui T, Jardin F, Mounier N, Tilly H, Haioun C
Leuk Lymphoma 2021 Sep;62(9):2161-2168. Epub 2021 Mar 25 doi: 10.1080/10428194.2021.1901090. PMID: 33764240
Additional B-cell malignancies in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL).
Meacham PJ, Williams AM, Strawderman M, Baran AM, Archibald WJ, Wallace DS, Tschernia NP, Burack WR, Barr PM, Zent CS
Leuk Lymphoma 2020 Jul;61(7):1636-1644. Epub 2020 Mar 16 doi: 10.1080/10428194.2020.1737690. PMID: 32175786
Molecular processes involved in B cell acute lymphoblastic leukaemia.
Malouf C, Ottersbach K
Cell Mol Life Sci 2018 Feb;75(3):417-446. Epub 2017 Aug 17 doi: 10.1007/s00018-017-2620-z. PMID: 28819864Free PMC Article
Targeting the B cell receptor pathway in chronic lymphocytic leukemia.
Davids MS, Brown JR
Leuk Lymphoma 2012 Dec;53(12):2362-70. doi: 10.3109/10428194.2012.695781. PMID: 22616724Free PMC Article
Primary breast lymphoma.
Gholam D, Bibeau F, El Weshi A, Bosq J, Ribrag V
Leuk Lymphoma 2003 Jul;44(7):1173-8. doi: 10.1080/1042819031000079195. PMID: 12916870

Diagnosis

Update on Lymphoblastic Leukemia/Lymphoma.
Luca DC
Clin Lab Med 2021 Sep;41(3):405-416. doi: 10.1016/j.cll.2021.04.003. PMID: 34304772
Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia.
Gökbuget N, Zugmaier G, Dombret H, Stein A, Bonifacio M, Graux C, Faul C, Brüggemann M, Taylor K, Mergen N, Reichle A, Horst HA, Havelange V, Topp MS, Bargou RC
Leuk Lymphoma 2020 Nov;61(11):2665-2673. Epub 2020 Jul 3 doi: 10.1080/10428194.2020.1780583. PMID: 32619115
Molecular processes involved in B cell acute lymphoblastic leukaemia.
Malouf C, Ottersbach K
Cell Mol Life Sci 2018 Feb;75(3):417-446. Epub 2017 Aug 17 doi: 10.1007/s00018-017-2620-z. PMID: 28819864Free PMC Article
B-acute lymphoblastic leukemia/lymphoblastic lymphoma.
Loghavi S, Kutok JL, Jorgensen JL
Am J Clin Pathol 2015 Sep;144(3):393-410. doi: 10.1309/AJCPAN7BH5DNYWZB. PMID: 26276770
Primary breast lymphoma.
Gholam D, Bibeau F, El Weshi A, Bosq J, Ribrag V
Leuk Lymphoma 2003 Jul;44(7):1173-8. doi: 10.1080/1042819031000079195. PMID: 12916870

Therapy

A matching-adjusted indirect comparison of the efficacy of elranatamab versus teclistamab in patients with triple-class exposed/refractory multiple myeloma.
Mol I, Hu Y, LeBlanc TW, Cappelleri JC, Chu H, Nador G, Aydin D, Schepart A, Hlavacek P
Leuk Lymphoma 2024 May;65(5):660-668. Epub 2024 Feb 12 doi: 10.1080/10428194.2024.2313628. PMID: 38347747
Rituximab plus gemcitabine and oxaliplatin (R-GemOx) in refractory/relapsed diffuse large B-cell lymphoma: a real-life study in patients ineligible for autologous stem-cell transplantation.
Cazelles C, Belhadj K, Vellemans H, Camus V, Poullot E, Gaulard P, Veresezan L, Itti E, Becker S, Carvalho M, Dupuis J, Le Bras F, Lemonnier F, Roulin L, El Gnaoui T, Jardin F, Mounier N, Tilly H, Haioun C
Leuk Lymphoma 2021 Sep;62(9):2161-2168. Epub 2021 Mar 25 doi: 10.1080/10428194.2021.1901090. PMID: 33764240
Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia.
Gökbuget N, Zugmaier G, Dombret H, Stein A, Bonifacio M, Graux C, Faul C, Brüggemann M, Taylor K, Mergen N, Reichle A, Horst HA, Havelange V, Topp MS, Bargou RC
Leuk Lymphoma 2020 Nov;61(11):2665-2673. Epub 2020 Jul 3 doi: 10.1080/10428194.2020.1780583. PMID: 32619115
Blinatumomab, a bispecific B-cell and T-cell engaging antibody, in the treatment of B-cell malignancies.
Burt R, Warcel D, Fielding AK
Hum Vaccin Immunother 2019;15(3):594-602. Epub 2018 Nov 20 doi: 10.1080/21645515.2018.1540828. PMID: 30380973Free PMC Article
Primary breast lymphoma.
Gholam D, Bibeau F, El Weshi A, Bosq J, Ribrag V
Leuk Lymphoma 2003 Jul;44(7):1173-8. doi: 10.1080/1042819031000079195. PMID: 12916870

Prognosis

Update on Lymphoblastic Leukemia/Lymphoma.
Luca DC
Clin Lab Med 2021 Sep;41(3):405-416. doi: 10.1016/j.cll.2021.04.003. PMID: 34304772
Rituximab plus gemcitabine and oxaliplatin (R-GemOx) in refractory/relapsed diffuse large B-cell lymphoma: a real-life study in patients ineligible for autologous stem-cell transplantation.
Cazelles C, Belhadj K, Vellemans H, Camus V, Poullot E, Gaulard P, Veresezan L, Itti E, Becker S, Carvalho M, Dupuis J, Le Bras F, Lemonnier F, Roulin L, El Gnaoui T, Jardin F, Mounier N, Tilly H, Haioun C
Leuk Lymphoma 2021 Sep;62(9):2161-2168. Epub 2021 Mar 25 doi: 10.1080/10428194.2021.1901090. PMID: 33764240
Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia.
Gökbuget N, Zugmaier G, Dombret H, Stein A, Bonifacio M, Graux C, Faul C, Brüggemann M, Taylor K, Mergen N, Reichle A, Horst HA, Havelange V, Topp MS, Bargou RC
Leuk Lymphoma 2020 Nov;61(11):2665-2673. Epub 2020 Jul 3 doi: 10.1080/10428194.2020.1780583. PMID: 32619115
Primary breast lymphoma.
Gholam D, Bibeau F, El Weshi A, Bosq J, Ribrag V
Leuk Lymphoma 2003 Jul;44(7):1173-8. doi: 10.1080/1042819031000079195. PMID: 12916870
T-cell associated antigen-positive B-cell lymphoma.
Inaba T, Shimazaki C, Sumikuma T, Nakagawa M
Leuk Lymphoma 2001 Nov-Dec;42(6):1161-71. doi: 10.3109/10428190109097741. PMID: 11911397

Clinical prediction guides

Durable Responses and Low Toxicity After Fast Off-Rate CD19 Chimeric Antigen Receptor-T Therapy in Adults With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia.
Roddie C, Dias J, O'Reilly MA, Abbasian M, Cadinanos-Garai A, Vispute K, Bosshard-Carter L, Mitsikakou M, Mehra V, Roddy H, Hartley JA, Spanswick V, Lowe H, Popova B, Clifton-Hadley L, Wheeler G, Olejnik J, Bloor A, Irvine D, Wood L, Marzolini MAV, Domning S, Farzaneh F, Lowdell MW, Linch DC, Pule MA, Peggs KS
J Clin Oncol 2021 Oct 20;39(30):3352-3363. Epub 2021 Aug 31 doi: 10.1200/JCO.21.00917. PMID: 34464155Free PMC Article
Rituximab plus gemcitabine and oxaliplatin (R-GemOx) in refractory/relapsed diffuse large B-cell lymphoma: a real-life study in patients ineligible for autologous stem-cell transplantation.
Cazelles C, Belhadj K, Vellemans H, Camus V, Poullot E, Gaulard P, Veresezan L, Itti E, Becker S, Carvalho M, Dupuis J, Le Bras F, Lemonnier F, Roulin L, El Gnaoui T, Jardin F, Mounier N, Tilly H, Haioun C
Leuk Lymphoma 2021 Sep;62(9):2161-2168. Epub 2021 Mar 25 doi: 10.1080/10428194.2021.1901090. PMID: 33764240
Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia.
Gökbuget N, Zugmaier G, Dombret H, Stein A, Bonifacio M, Graux C, Faul C, Brüggemann M, Taylor K, Mergen N, Reichle A, Horst HA, Havelange V, Topp MS, Bargou RC
Leuk Lymphoma 2020 Nov;61(11):2665-2673. Epub 2020 Jul 3 doi: 10.1080/10428194.2020.1780583. PMID: 32619115
The molecular pathogenesis of mantle cell lymphoma.
Vogt N, Dai B, Erdmann T, Berdel WE, Lenz G
Leuk Lymphoma 2017 Jul;58(7):1530-1537. Epub 2016 Nov 28 doi: 10.1080/10428194.2016.1248965. PMID: 27894215
Primary breast lymphoma.
Gholam D, Bibeau F, El Weshi A, Bosq J, Ribrag V
Leuk Lymphoma 2003 Jul;44(7):1173-8. doi: 10.1080/1042819031000079195. PMID: 12916870

Recent systematic reviews

Efficacy and Safety of Blinatumomab for the Treatment of Relapsed/Refractory Acute Lymphoblastic Leukemia: A Systemic Review and Meta-Analysis.
Liu H, Xi R, Mao D, Zhao X, Wu T
Clin Lymphoma Myeloma Leuk 2023 Mar;23(3):e139-e149. Epub 2022 Dec 17 doi: 10.1016/j.clml.2022.12.009. PMID: 36593170
Clinical Presentation, Risk Factors, and Outcomes of Immune Effector Cell-Associated Neurotoxicity Syndrome Following Chimeric Antigen Receptor T Cell Therapy: A Systematic Review.
Grant SJ, Grimshaw AA, Silberstein J, Murdaugh D, Wildes TM, Rosko AE, Giri S
Transplant Cell Ther 2022 Jun;28(6):294-302. Epub 2022 Mar 11 doi: 10.1016/j.jtct.2022.03.006. PMID: 35288347Free PMC Article
Systematic Review and Meta-analysis of CD19-Specific CAR-T Cell Therapy in Relapsed/Refractory Acute Lymphoblastic Leukemia in the Pediatric and Young Adult Population: Safety and Efficacy Outcomes.
Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE
Clin Lymphoma Myeloma Leuk 2021 Apr;21(4):e334-e347. Epub 2020 Dec 17 doi: 10.1016/j.clml.2020.12.010. PMID: 33573914
Risks and Benefits of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in Cancer: A Systematic Review and Meta-Analysis.
Grigor EJM, Fergusson D, Kekre N, Montroy J, Atkins H, Seftel MD, Daugaard M, Presseau J, Thavorn K, Hutton B, Holt RA, Lalu MM
Transfus Med Rev 2019 Apr;33(2):98-110. Epub 2019 Feb 14 doi: 10.1016/j.tmrv.2019.01.005. PMID: 30948292
A systematic review of p53 regulation of oxidative stress in skeletal muscle.
Beyfuss K, Hood DA
Redox Rep 2018 Dec;23(1):100-117. Epub 2018 Jan 3 doi: 10.1080/13510002.2017.1416773. PMID: 29298131Free PMC Article

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