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clopidogrel response - Efficacy

MedGen UID:
1002723
•Concept ID:
CN322727
•
Sign or Symptom

Professional guidelines

PubMed

Pharmacogenomics for Primary Care: An Overview.
Rollinson V, Turner R, Pirmohamed M
Genes (Basel) 2020 Nov 12;11(11) doi: 10.3390/genes11111337. PMID: 33198260Free PMC Article
Genotype-based clinical trials in cardiovascular disease.
Pereira NL, Sargent DJ, Farkouh ME, Rihal CS
Nat Rev Cardiol 2015 Aug;12(8):475-87. Epub 2015 May 5 doi: 10.1038/nrcardio.2015.64. PMID: 25940926Free PMC Article
Efficacy of clopidogrel treatment and platelet responsiveness in peripheral arterial procedures.
Spiliopoulos S, Pastromas G, Diamantopoulos A, Katsanos K
Expert Opin Pharmacother 2014 Oct;15(15):2205-17. Epub 2014 Aug 27 doi: 10.1517/14656566.2014.953054. PMID: 25162471

Recent clinical studies

Etiology

Do patients benefit from omega-3 fatty acids?
Sherratt SCR, Mason RP, Libby P, Steg PG, Bhatt DL
Cardiovasc Res 2024 Feb 17;119(18):2884-2901. doi: 10.1093/cvr/cvad188. PMID: 38252923Free PMC Article
Safety and efficacy of factor XIa inhibition with milvexian for secondary stroke prevention (AXIOMATIC-SSP): a phase 2, international, randomised, double-blind, placebo-controlled, dose-finding trial.
Sharma M, Molina CA, Toyoda K, Bereczki D, Bangdiwala SI, Kasner SE, Lutsep HL, Tsivgoulis G, Ntaios G, Czlonkowska A, Shuaib A, Amarenco P, Endres M, Yoon BW, Tanne D, Toni D, Yperzeele L, von Weitzel-Mudersbach P, Sampaio Silva G, Avezum A, Dawson J, Strbian D, Tatlisumak T, Eckstein J, Ameriso SF, Weber JR, Sandset EC, Goar Pogosova N, Lavados PM, Arauz A, Gailani D, Diener HC, Bernstein RA, Cordonnier C, Kahl A, Abelian G, Donovan M, Pachai C, Li D, Hankey GJ
Lancet Neurol 2024 Jan;23(1):46-59. doi: 10.1016/S1474-4422(23)00403-9. PMID: 38101902Free PMC Article
Applied pharmacogenomics in cardiovascular medicine.
Weeke P, Roden DM
Annu Rev Med 2014;65:81-94. Epub 2013 Oct 2 doi: 10.1146/annurev-med-101712-122545. PMID: 24111889Free PMC Article
Prasugrel.
Tello-Montoliu A, Tomasello SD, Angiolillo DJ
Adv Cardiol 2012;47:39-63. Epub 2012 Aug 9 doi: 10.1159/000338044. PMID: 22906902
Antiplatelet agents.
Varon D, Spectre G
Hematology Am Soc Hematol Educ Program 2009:267-72. doi: 10.1182/asheducation-2009.1.267. PMID: 20008209

Diagnosis

Do patients benefit from omega-3 fatty acids?
Sherratt SCR, Mason RP, Libby P, Steg PG, Bhatt DL
Cardiovasc Res 2024 Feb 17;119(18):2884-2901. doi: 10.1093/cvr/cvad188. PMID: 38252923Free PMC Article
Pharmacogenetics in Cardiovascular Medicine.
Weeke PE
Adv Pharmacol 2018;83:333-360. doi: 10.1016/bs.apha.2018.04.002. PMID: 29801582
Review of aspirin and clopidogrel resistance in peripheral arterial disease.
Guirgis M, Thompson P, Jansen S
J Vasc Surg 2017 Nov;66(5):1576-1586. doi: 10.1016/j.jvs.2017.07.065. PMID: 28893489
Use of genetic data to guide therapy in arterial disease.
Ross S, Nejat S, Paré G
J Thromb Haemost 2015 Jun;13 Suppl 1:S281-9. doi: 10.1111/jth.12924. PMID: 26149037
Aspirin and stroke prevention.
van Gijn J, Algra A
Thromb Res 2003 Jun 15;110(5-6):349-53. doi: 10.1016/s0049-3848(03)00414-6. PMID: 14592561

Therapy

Do patients benefit from omega-3 fatty acids?
Sherratt SCR, Mason RP, Libby P, Steg PG, Bhatt DL
Cardiovasc Res 2024 Feb 17;119(18):2884-2901. doi: 10.1093/cvr/cvad188. PMID: 38252923Free PMC Article
Safety and efficacy of factor XIa inhibition with milvexian for secondary stroke prevention (AXIOMATIC-SSP): a phase 2, international, randomised, double-blind, placebo-controlled, dose-finding trial.
Sharma M, Molina CA, Toyoda K, Bereczki D, Bangdiwala SI, Kasner SE, Lutsep HL, Tsivgoulis G, Ntaios G, Czlonkowska A, Shuaib A, Amarenco P, Endres M, Yoon BW, Tanne D, Toni D, Yperzeele L, von Weitzel-Mudersbach P, Sampaio Silva G, Avezum A, Dawson J, Strbian D, Tatlisumak T, Eckstein J, Ameriso SF, Weber JR, Sandset EC, Goar Pogosova N, Lavados PM, Arauz A, Gailani D, Diener HC, Bernstein RA, Cordonnier C, Kahl A, Abelian G, Donovan M, Pachai C, Li D, Hankey GJ
Lancet Neurol 2024 Jan;23(1):46-59. doi: 10.1016/S1474-4422(23)00403-9. PMID: 38101902Free PMC Article
Antiplatelet Therapy in Flow Diversion.
Tonetti DA, Jankowitz BT, Gross BA
Neurosurgery 2020 Jan 1;86(Suppl 1):S47-S52. doi: 10.1093/neuros/nyz391. PMID: 31838537
Antiplatelet agents.
Varon D, Spectre G
Hematology Am Soc Hematol Educ Program 2009:267-72. doi: 10.1182/asheducation-2009.1.267. PMID: 20008209
Prasugrel.
Tantry US, Bliden KP, Gurbel PA
Expert Opin Investig Drugs 2006 Dec;15(12):1627-33. doi: 10.1517/13543784.15.12.1627. PMID: 17107286

Prognosis

Drug-drug interactions between clopidogrel and novel cardiovascular drugs.
Pelliccia F, Rollini F, Marazzi G, Greco C, Gaudio C, Angiolillo DJ
Eur J Pharmacol 2015 Oct 15;765:332-6. Epub 2015 Sep 2 doi: 10.1016/j.ejphar.2015.08.059. PMID: 26341013
Use of genetic data to guide therapy in arterial disease.
Ross S, Nejat S, Paré G
J Thromb Haemost 2015 Jun;13 Suppl 1:S281-9. doi: 10.1111/jth.12924. PMID: 26149037
Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial.
Dewilde WJ, Oirbans T, Verheugt FW, Kelder JC, De Smet BJ, Herrman JP, Adriaenssens T, Vrolix M, Heestermans AA, Vis MM, Tijsen JG, van 't Hof AW, ten Berg JM; WOEST study investigators
Lancet 2013 Mar 30;381(9872):1107-15. Epub 2013 Feb 13 doi: 10.1016/S0140-6736(12)62177-1. PMID: 23415013
The pharmacogenetics of antiplatelet agents: towards personalized therapy?
Ahmad T, Voora D, Becker RC
Nat Rev Cardiol 2011 Aug 9;8(10):560-71. doi: 10.1038/nrcardio.2011.111. PMID: 21826075
Comparison of ticagrelor, the first reversible oral P2Y(12) receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial.
James S, Akerblom A, Cannon CP, Emanuelsson H, Husted S, Katus H, Skene A, Steg PG, Storey RF, Harrington R, Becker R, Wallentin L
Am Heart J 2009 Apr;157(4):599-605. doi: 10.1016/j.ahj.2009.01.003. PMID: 19332184

Clinical prediction guides

Do patients benefit from omega-3 fatty acids?
Sherratt SCR, Mason RP, Libby P, Steg PG, Bhatt DL
Cardiovasc Res 2024 Feb 17;119(18):2884-2901. doi: 10.1093/cvr/cvad188. PMID: 38252923Free PMC Article
Safety and efficacy of factor XIa inhibition with milvexian for secondary stroke prevention (AXIOMATIC-SSP): a phase 2, international, randomised, double-blind, placebo-controlled, dose-finding trial.
Sharma M, Molina CA, Toyoda K, Bereczki D, Bangdiwala SI, Kasner SE, Lutsep HL, Tsivgoulis G, Ntaios G, Czlonkowska A, Shuaib A, Amarenco P, Endres M, Yoon BW, Tanne D, Toni D, Yperzeele L, von Weitzel-Mudersbach P, Sampaio Silva G, Avezum A, Dawson J, Strbian D, Tatlisumak T, Eckstein J, Ameriso SF, Weber JR, Sandset EC, Goar Pogosova N, Lavados PM, Arauz A, Gailani D, Diener HC, Bernstein RA, Cordonnier C, Kahl A, Abelian G, Donovan M, Pachai C, Li D, Hankey GJ
Lancet Neurol 2024 Jan;23(1):46-59. doi: 10.1016/S1474-4422(23)00403-9. PMID: 38101902Free PMC Article
Antithrombotic dose: Some observations from published clinical trials.
Dimmitt SB, Floyd CN, Ferner RE
Br J Clin Pharmacol 2019 Oct;85(10):2194-2197. Epub 2019 Jul 1 doi: 10.1111/bcp.13968. PMID: 31050833Free PMC Article
Antiplatelet agents.
Varon D, Spectre G
Hematology Am Soc Hematol Educ Program 2009:267-72. doi: 10.1182/asheducation-2009.1.267. PMID: 20008209
Aspirin and clopidogrel: efficacy and resistance in diabetes mellitus.
Angiolillo DJ, Suryadevara S
Best Pract Res Clin Endocrinol Metab 2009 Jun;23(3):375-88. doi: 10.1016/j.beem.2008.12.001. PMID: 19520310

Recent systematic reviews

Role of genetic polymorphisms in clopidogrel response variability: a systematic review.
Lopez J, Mark J, Duarte GJ, Shaban M, Sosa F, Mishra R, Jain S, Tran A, Khizar A, Karpel D, Acosta G, Rodriguez-Guerra M
Open Heart 2023 Nov;10(2) doi: 10.1136/openhrt-2023-002436. PMID: 37963685Free PMC Article
Efficacy and safety of low dose ticagrelor in patients with acute coronary syndrome: a systematic review and meta-analysis.
Chen Q, Zhang Y, Wang Z, Wang S, Zhang H, Wang Y, Lu C, Xuan H, Wang C, Li D, Xu T
Postgrad Med J 2020 Nov;96(1141):693-702. Epub 2020 Jun 19 doi: 10.1136/postgradmedj-2019-137180. PMID: 32561595
The impact of smoking on clinical efficacy and pharmacodynamic effects of clopidogrel: a systematic review and meta-analysis.
Zhao ZG, Chen M, Peng Y, Chai H, Liu W, Li Q, Ren X, Wang XQ, Luo XL, Zhang C, Huang DJ
Heart 2014 Feb;100(3):192-9. Epub 2013 Jun 8 doi: 10.1136/heartjnl-2013-304138. PMID: 23749792
High-maintenance-dose clopidogrel in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis.
Chen Y, Zhang Y, Tang Y, Huang X, Xie Y
PLoS One 2013;8(10):e78549. Epub 2013 Oct 23 doi: 10.1371/journal.pone.0078549. PMID: 24194947Free PMC Article
Impact of clopidogrel loading dose on clinical outcome in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis.
Siller-Matula JM, Huber K, Christ G, Schrör K, Kubica J, Herkner H, Jilma B
Heart 2011 Jan;97(2):98-105. Epub 2010 Aug 23 doi: 10.1136/hrt.2010.195438. PMID: 20736210

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