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Letrozole response

MedGen UID:
983000
Concept ID:
CN298326
Sign or Symptom
Drug:
letrozole
MedGen UID:
70064
Concept ID:
C0246421
Pharmacologic Substance
A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. [from NCI]

Professional guidelines

PubMed

Carson SA, Kallen AN
JAMA 2021 Jul 6;326(1):65-76. doi: 10.1001/jama.2021.4788. PMID: 34228062Free PMC Article
Practice Committee of the American Society for Reproductive Medicine. Electronic address: [email protected]; Practice Committee of the American Society for Reproductive Medicine
Fertil Steril 2020 Feb;113(2):305-322. doi: 10.1016/j.fertnstert.2019.10.014. PMID: 32106976
Thurston L, Abbara A, Dhillo WS
J Clin Pathol 2019 Sep;72(9):579-587. Epub 2019 Jul 11 doi: 10.1136/jclinpath-2018-205579. PMID: 31296604

Curated

DailyMed Drug Label, letrozole, 2022

Recent clinical studies

Etiology

Liu L, Mo M, Chen X, Chao D, Zhang Y, Chen X, Wang Y, Zhang N, He N, Yuan X, Chen H, Yang J
J Exp Clin Cancer Res 2023 Apr 13;42(1):85. doi: 10.1186/s13046-023-02647-8. PMID: 37055842Free PMC Article
Tripathy D, Im SA, Colleoni M, Franke F, Bardia A, Harbeck N, Hurvitz SA, Chow L, Sohn J, Lee KS, Campos-Gomez S, Villanueva Vazquez R, Jung KH, Babu KG, Wheatley-Price P, De Laurentiis M, Im YH, Kuemmel S, El-Saghir N, Liu MC, Carlson G, Hughes G, Diaz-Padilla I, Germa C, Hirawat S, Lu YS
Lancet Oncol 2018 Jul;19(7):904-915. Epub 2018 May 24 doi: 10.1016/S1470-2045(18)30292-4. PMID: 29804902
Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Petrakova K, Blackwell KL, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Mondal S, Su F, Miller M, Elmeliegy M, Germa C, O'Shaughnessy J
Ann Oncol 2018 Jul 1;29(7):1541-1547. doi: 10.1093/annonc/mdy155. PMID: 29718092
Finn RS, Martin M, Rugo HS, Jones S, Im SA, Gelmon K, Harbeck N, Lipatov ON, Walshe JM, Moulder S, Gauthier E, Lu DR, Randolph S, Diéras V, Slamon DJ
N Engl J Med 2016 Nov 17;375(20):1925-1936. doi: 10.1056/NEJMoa1607303. PMID: 27959613
Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Blackwell KL, André F, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Petrakova K, Hart LL, Villanueva C, Chan A, Jakobsen E, Nusch A, Burdaeva O, Grischke EM, Alba E, Wist E, Marschner N, Favret AM, Yardley D, Bachelot T, Tseng LM, Blau S, Xuan F, Souami F, Miller M, Germa C, Hirawat S, O'Shaughnessy J
N Engl J Med 2016 Nov 3;375(18):1738-1748. Epub 2016 Oct 7 doi: 10.1056/NEJMoa1609709. PMID: 27717303

Diagnosis

Bidard FC, Hardy-Bessard AC, Dalenc F, Bachelot T, Pierga JY, de la Motte Rouge T, Sabatier R, Dubot C, Frenel JS, Ferrero JM, Ladoire S, Levy C, Mouret-Reynier MA, Lortholary A, Grenier J, Chakiba C, Stefani L, Plaza JE, Clatot F, Teixeira L, D'Hondt V, Vegas H, Derbel O, Garnier-Tixidre C, Canon JL, Pistilli B, André F, Arnould L, Pradines A, Bièche I, Callens C, Lemonnier J, Berger F, Delaloge S; PADA-1 investigators
Lancet Oncol 2022 Nov;23(11):1367-1377. Epub 2022 Sep 29 doi: 10.1016/S1470-2045(22)00555-1. PMID: 36183733
Gershenson DM, Miller A, Brady WE, Paul J, Carty K, Rodgers W, Millan D, Coleman RL, Moore KN, Banerjee S, Connolly K, Secord AA, O'Malley DM, Dorigo O, Gaillard S, Gabra H, Slomovitz B, Hanjani P, Farley J, Churchman M, Ewing A, Hollis RL, Herrington CS, Huang HQ, Wenzel L, Gourley C
Lancet 2022 Feb 5;399(10324):541-553. doi: 10.1016/S0140-6736(21)02175-9. PMID: 35123694Free PMC Article
Llombart-Cussac A, Pérez-García JM, Bellet M, Dalenc F, Gil-Gil M, Ruíz-Borrego M, Gavilá J, Sampayo-Cordero M, Aguirre E, Schmid P, Marmé F, Di Cosimo S, Gligorov J, Schneeweiss A, Albanell J, Zamora P, Wheatley D, Martínez-de Dueñas E, Amillano K, Malfettone A, Cortés J; PARSIFAL Steering Committee and Trial Investigators
JAMA Oncol 2021 Dec 1;7(12):1791-1799. doi: 10.1001/jamaoncol.2021.4301. PMID: 34617955Free PMC Article
Ruhstaller T, Giobbie-Hurder A, Colleoni M, Jensen MB, Ejlertsen B, de Azambuja E, Neven P, Láng I, Jakobsen EH, Gladieff L, Bonnefoi H, Harvey VJ, Spazzapan S, Tondini C, Del Mastro L, Veyret C, Simoncini E, Gianni L, Rochlitz C, Kralidis E, Zaman K, Jassem J, Piccart-Gebhart M, Di Leo A, Gelber RD, Coates AS, Goldhirsch A, Thürlimann B, Regan MM; members of the BIG 1-98 Collaborative Group and the International Breast Cancer Study Group
J Clin Oncol 2019 Jan 10;37(2):105-114. Epub 2018 Nov 26 doi: 10.1200/JCO.18.00440. PMID: 30475668Free PMC Article
Baselga J, Campone M, Piccart M, Burris HA 3rd, Rugo HS, Sahmoud T, Noguchi S, Gnant M, Pritchard KI, Lebrun F, Beck JT, Ito Y, Yardley D, Deleu I, Perez A, Bachelot T, Vittori L, Xu Z, Mukhopadhyay P, Lebwohl D, Hortobagyi GN
N Engl J Med 2012 Feb 9;366(6):520-9. Epub 2011 Dec 7 doi: 10.1056/NEJMoa1109653. PMID: 22149876Free PMC Article

Therapy

Tripathy D, Im SA, Colleoni M, Franke F, Bardia A, Harbeck N, Hurvitz SA, Chow L, Sohn J, Lee KS, Campos-Gomez S, Villanueva Vazquez R, Jung KH, Babu KG, Wheatley-Price P, De Laurentiis M, Im YH, Kuemmel S, El-Saghir N, Liu MC, Carlson G, Hughes G, Diaz-Padilla I, Germa C, Hirawat S, Lu YS
Lancet Oncol 2018 Jul;19(7):904-915. Epub 2018 May 24 doi: 10.1016/S1470-2045(18)30292-4. PMID: 29804902
Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Petrakova K, Blackwell KL, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Mondal S, Su F, Miller M, Elmeliegy M, Germa C, O'Shaughnessy J
Ann Oncol 2018 Jul 1;29(7):1541-1547. doi: 10.1093/annonc/mdy155. PMID: 29718092
Goetz MP, Toi M, Campone M, Sohn J, Paluch-Shimon S, Huober J, Park IH, Trédan O, Chen SC, Manso L, Freedman OC, Garnica Jaliffe G, Forrester T, Frenzel M, Barriga S, Smith IC, Bourayou N, Di Leo A
J Clin Oncol 2017 Nov 10;35(32):3638-3646. Epub 2017 Oct 2 doi: 10.1200/JCO.2017.75.6155. PMID: 28968163
Finn RS, Martin M, Rugo HS, Jones S, Im SA, Gelmon K, Harbeck N, Lipatov ON, Walshe JM, Moulder S, Gauthier E, Lu DR, Randolph S, Diéras V, Slamon DJ
N Engl J Med 2016 Nov 17;375(20):1925-1936. doi: 10.1056/NEJMoa1607303. PMID: 27959613
Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Blackwell KL, André F, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Petrakova K, Hart LL, Villanueva C, Chan A, Jakobsen E, Nusch A, Burdaeva O, Grischke EM, Alba E, Wist E, Marschner N, Favret AM, Yardley D, Bachelot T, Tseng LM, Blau S, Xuan F, Souami F, Miller M, Germa C, Hirawat S, O'Shaughnessy J
N Engl J Med 2016 Nov 3;375(18):1738-1748. Epub 2016 Oct 7 doi: 10.1056/NEJMoa1609709. PMID: 27717303

Prognosis

Liu L, Mo M, Chen X, Chao D, Zhang Y, Chen X, Wang Y, Zhang N, He N, Yuan X, Chen H, Yang J
J Exp Clin Cancer Res 2023 Apr 13;42(1):85. doi: 10.1186/s13046-023-02647-8. PMID: 37055842Free PMC Article
Tripathy D, Im SA, Colleoni M, Franke F, Bardia A, Harbeck N, Hurvitz SA, Chow L, Sohn J, Lee KS, Campos-Gomez S, Villanueva Vazquez R, Jung KH, Babu KG, Wheatley-Price P, De Laurentiis M, Im YH, Kuemmel S, El-Saghir N, Liu MC, Carlson G, Hughes G, Diaz-Padilla I, Germa C, Hirawat S, Lu YS
Lancet Oncol 2018 Jul;19(7):904-915. Epub 2018 May 24 doi: 10.1016/S1470-2045(18)30292-4. PMID: 29804902
Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Petrakova K, Blackwell KL, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Mondal S, Su F, Miller M, Elmeliegy M, Germa C, O'Shaughnessy J
Ann Oncol 2018 Jul 1;29(7):1541-1547. doi: 10.1093/annonc/mdy155. PMID: 29718092
Goetz MP, Toi M, Campone M, Sohn J, Paluch-Shimon S, Huober J, Park IH, Trédan O, Chen SC, Manso L, Freedman OC, Garnica Jaliffe G, Forrester T, Frenzel M, Barriga S, Smith IC, Bourayou N, Di Leo A
J Clin Oncol 2017 Nov 10;35(32):3638-3646. Epub 2017 Oct 2 doi: 10.1200/JCO.2017.75.6155. PMID: 28968163
Slomovitz BM, Jiang Y, Yates MS, Soliman PT, Johnston T, Nowakowski M, Levenback C, Zhang Q, Ring K, Munsell MF, Gershenson DM, Lu KH, Coleman RL
J Clin Oncol 2015 Mar 10;33(8):930-6. Epub 2015 Jan 26 doi: 10.1200/JCO.2014.58.3401. PMID: 25624430Free PMC Article

Clinical prediction guides

Lu YS, Mahidin EIBM, Azim H, Eralp Y, Yap YS, Im SA, Rihani J, Gokmen E, El Bastawisy A, Karadurmus N, Lim YN, Lim CS, Duc LT, Chung WP, Babu KG, Penkov K, Bowles J, Alfaro TD, Wu J, Gao M, Slimane K, El Saghir NS
J Clin Oncol 2024 Aug 10;42(23):2812-2821. Epub 2024 May 21 doi: 10.1200/JCO.24.00144. PMID: 38771995Free PMC Article
Liu L, Mo M, Chen X, Chao D, Zhang Y, Chen X, Wang Y, Zhang N, He N, Yuan X, Chen H, Yang J
J Exp Clin Cancer Res 2023 Apr 13;42(1):85. doi: 10.1186/s13046-023-02647-8. PMID: 37055842Free PMC Article
Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Petrakova K, Blackwell KL, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Mondal S, Su F, Miller M, Elmeliegy M, Germa C, O'Shaughnessy J
Ann Oncol 2018 Jul 1;29(7):1541-1547. doi: 10.1093/annonc/mdy155. PMID: 29718092
Slomovitz BM, Jiang Y, Yates MS, Soliman PT, Johnston T, Nowakowski M, Levenback C, Zhang Q, Ring K, Munsell MF, Gershenson DM, Lu KH, Coleman RL
J Clin Oncol 2015 Mar 10;33(8):930-6. Epub 2015 Jan 26 doi: 10.1200/JCO.2014.58.3401. PMID: 25624430Free PMC Article
Baselga J, Campone M, Piccart M, Burris HA 3rd, Rugo HS, Sahmoud T, Noguchi S, Gnant M, Pritchard KI, Lebrun F, Beck JT, Ito Y, Yardley D, Deleu I, Perez A, Bachelot T, Vittori L, Xu Z, Mukhopadhyay P, Lebwohl D, Hortobagyi GN
N Engl J Med 2012 Feb 9;366(6):520-9. Epub 2011 Dec 7 doi: 10.1056/NEJMoa1109653. PMID: 22149876Free PMC Article

Recent systematic reviews

Scudeler MM, Manóchio C, Braga Pinto AJ, Santos Cirino HD, da Silva CS, Rodrigues-Soares F
Pharmacogenomics 2023 Jan;24(2):107-122. Epub 2022 Dec 8 doi: 10.2217/pgs-2022-0144. PMID: 36475975
De Rocco S, Buca D, Oronzii L, Petrillo M, Fanfani F, Nappi L, Liberati M, D'Antonio F, Scambia G, Leombroni M, Dessole M, Lucidi A
Eur J Obstet Gynecol Reprod Biol 2022 Jun;273:90-97. Epub 2022 Apr 25 doi: 10.1016/j.ejogrb.2022.04.019. PMID: 35526471
Zhang Y, Zhang C, Shu J, Guo J, Chang HM, Leung PCK, Sheng JZ, Huang H
Hum Reprod Update 2020 Feb 28;26(2):247-263. doi: 10.1093/humupd/dmz046. PMID: 32045470
Giuliano M, Schettini F, Rognoni C, Milani M, Jerusalem G, Bachelot T, De Laurentiis M, Thomas G, De Placido P, Arpino G, De Placido S, Cristofanilli M, Giordano A, Puglisi F, Pistilli B, Prat A, Del Mastro L, Venturini S, Generali D
Lancet Oncol 2019 Oct;20(10):1360-1369. Epub 2019 Sep 4 doi: 10.1016/S1470-2045(19)30420-6. PMID: 31494037
Bechtejew TN, Nadai MN, Nastri CO, Martins WP
Ultrasound Obstet Gynecol 2017 Sep;50(3):315-323. Epub 2017 Aug 10 doi: 10.1002/uog.17442. PMID: 28236310

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