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Elevated basal serum calcitonin

MedGen UID:
808158
•Concept ID:
CN221570
•
Disease or Syndrome

Professional guidelines

PubMed

Calcitonin screening and pentagastrin testing: predictive value for the diagnosis of medullary carcinoma in nodular thyroid disease.
Herrmann BL, Schmid KW, Goerges R, Kemen M, Mann K
Eur J Endocrinol 2010 Jun;162(6):1141-5. Epub 2010 Mar 23 doi: 10.1530/EJE-10-0111. PMID: 20332126
Latent subclinical medullary thyroid carcinoma: diagnosis and treatment.
Henry JF, Denizot A, Puccini M, Gramatica L, Kvachenyuk A, Conte Devolx B, De Micco C
World J Surg 1998 Jul;22(7):752-6; discussion 756-7. doi: 10.1007/s002689900464. PMID: 9606293
Monomeric serum calcitonin and bone turnover during anticonvulsant treatment and in congenital hypothyroidism.
Kruse K, Süss A, Büsse M, Schneider P
J Pediatr 1987 Jul;111(1):57-63. doi: 10.1016/s0022-3476(87)80342-6. PMID: 3598791

Recent clinical studies

Etiology

Medullary Thyroid Carcinoma Associated with Germline RET(K666N) Mutation.
Xu JY, Grubbs EG, Waguespack SG, Jimenez C, Gagel RF, Sosa JA, Sellin RV, Dadu R, Hu MI, Trotter CS, Jackson M, Rich TA, Hyde SM, Sherman SI, Cote GJ
Thyroid 2016 Dec;26(12):1744-1751. Epub 2016 Oct 18 doi: 10.1089/thy.2016.0374. PMID: 27673361Free PMC Article
Importance of early screening and prophylactic thyroidectomy in asymptomatic nonindex RET germline carriers.
Ukkat J, Lorenz K, Hinze R, Thomusch O, Dralle H
World J Surg 2001 Jun;25(6):713-7. doi: 10.1007/s00268-001-0020-9. PMID: 11376404

Diagnosis

The rare intracellular RET mutation p.S891A in a Chinese Han family with familial medullary thyroid carcinoma.
Qi XP, Zhang RX, Cao JL, Chen ZG, Jin HY, Yang RR
J Biosci 2014 Jun;39(3):505-12. doi: 10.1007/s12038-014-9428-x. PMID: 24845513
Evaluation of routine basal serum calcitonin measurement for early diagnosis of medullary thyroid carcinoma in seven hundred seventy-three patients with nodular goiter.
Ozgen AG, Hamulu F, Bayraktar F, Yilmaz C, Tüzün M, Yetkin E, Tunçyürek M, Kabalak T
Thyroid 1999 Jun;9(6):579-82. doi: 10.1089/thy.1999.9.579. PMID: 10411120

Therapy

Evaluation of routine basal serum calcitonin measurement for early diagnosis of medullary thyroid carcinoma in seven hundred seventy-three patients with nodular goiter.
Ozgen AG, Hamulu F, Bayraktar F, Yilmaz C, Tüzün M, Yetkin E, Tunçyürek M, Kabalak T
Thyroid 1999 Jun;9(6):579-82. doi: 10.1089/thy.1999.9.579. PMID: 10411120
Microsurgical neck dissection for occultly metastasizing medullary thyroid carcinoma. Three-year results.
Buhr HJ, Kallinowski F, Raue F, Frank-Raue K, Herfarth C
Cancer 1993 Dec 15;72(12):3685-93. doi: 10.1002/1097-0142(19931215)72:12<3685::aid-cncr2820721221>3.0.co;2-3. PMID: 8252485
Use of somatostatin analog SMS 201-995 in medullary thyroid carcinoma.
Libroia A, Verga U, Di Sacco G, Piolini M, Muratori F
Henry Ford Hosp Med J 1989;37(3-4):151-3. PMID: 2576951

Prognosis

Importance of early screening and prophylactic thyroidectomy in asymptomatic nonindex RET germline carriers.
Ukkat J, Lorenz K, Hinze R, Thomusch O, Dralle H
World J Surg 2001 Jun;25(6):713-7. doi: 10.1007/s00268-001-0020-9. PMID: 11376404
Evaluation of routine basal serum calcitonin measurement for early diagnosis of medullary thyroid carcinoma in seven hundred seventy-three patients with nodular goiter.
Ozgen AG, Hamulu F, Bayraktar F, Yilmaz C, Tüzün M, Yetkin E, Tunçyürek M, Kabalak T
Thyroid 1999 Jun;9(6):579-82. doi: 10.1089/thy.1999.9.579. PMID: 10411120

Clinical prediction guides

Evaluation of routine basal serum calcitonin measurement for early diagnosis of medullary thyroid carcinoma in seven hundred seventy-three patients with nodular goiter.
Ozgen AG, Hamulu F, Bayraktar F, Yilmaz C, Tüzün M, Yetkin E, Tunçyürek M, Kabalak T
Thyroid 1999 Jun;9(6):579-82. doi: 10.1089/thy.1999.9.579. PMID: 10411120

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