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Trimipramine response

MedGen UID:
808073
•Concept ID:
CN221259
•
Sign or Symptom
Drug:
trimipramine
MedGen UID:
21693
•Concept ID:
C0041056
•
Pharmacologic Substance
Tricyclic antidepressant similar to IMIPRAMINE, but with more antihistaminic and sedative properties. [from MeSH]
trimipramine
 
Genes (locations): CYP2C19 (10q23.33); CYP2D6 (22q13.2)

Professional guidelines

PubMed

Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.
Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Müller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC
Clin Pharmacol Ther 2017 Jul;102(1):37-44. Epub 2017 Feb 13 doi: 10.1002/cpt.597. PMID: 27997040Free PMC Article
Sleep and antidepressant treatment.
Wichniak A, Wierzbicka A, Jernajczyk W
Curr Pharm Des 2012;18(36):5802-17. doi: 10.2174/138161212803523608. PMID: 22681161
Tricyclic antidepressant poisoning: an evidence-based consensus guideline for out-of-hospital management.
Woolf AD, Erdman AR, Nelson LS, Caravati EM, Cobaugh DJ, Booze LL, Wax PM, Manoguerra AS, Scharman EJ, Olson KR, Chyka PA, Christianson G, Troutman WG
Clin Toxicol (Phila) 2007;45(3):203-33. doi: 10.1080/15563650701226192. PMID: 17453872

Suggested Reading

PubMed

Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.
Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Müller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC
Clin Pharmacol Ther 2017 Jul;102(1):37-44. Epub 2017 Feb 13 doi: 10.1002/cpt.597. PMID: 27997040Free PMC Article

Recent clinical studies

Etiology

Metabolism in adipose tissue in response to citalopram and trimipramine treatment--an in situ microdialysis study.
Flechtner-Mors M, Jenkinson CP, Alt A, Adler G, Ditschuneit HH
J Psychiatr Res 2008 Jun;42(7):578-86. Epub 2007 Aug 9 doi: 10.1016/j.jpsychires.2007.06.003. PMID: 17692337
Trimipramine pharmacokinetics after intravenous and oral administration in carriers of CYP2D6 genotypes predicting poor, extensive and ultrahigh activity.
Kirchheiner J, Sasse J, Meineke I, Roots I, Brockmöller J
Pharmacogenetics 2003 Dec;13(12):721-8. doi: 10.1097/00008571-200312000-00003. PMID: 14646691
Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors.
Baumann P
Clin Pharmacokinet 1996 Dec;31(6):444-69. doi: 10.2165/00003088-199631060-00004. PMID: 8968657
Trimipramine--an atypical neuroleptic?
Eikmeier G, Berger M, Lodemann E, Muszynski K, Kaumeier S, Gastpar M
Int Clin Psychopharmacol 1991 Winter;6(3):147-53. doi: 10.1097/00004850-199100630-00003. PMID: 1806621
Treatment of affective illness in the elderly with drugs and electroconvulsive therapy.
Jenike MA
J Geriatr Psychiatry 1989;22(1):77-112; discussion 113-20. PMID: 2691555

Diagnosis

High performance liquid chromatographic determination of ultra traces of two tricyclic antidepressant drugs imipramine and trimipramine in urine samples after their dispersive liquid-liquid microextraction coupled with response surface optimization.
Shamsipur M, Mirmohammadi M
J Pharm Biomed Anal 2014 Nov;100:271-278. Epub 2014 Aug 13 doi: 10.1016/j.jpba.2014.08.008. PMID: 25178259
Simultaneous determination of trimipramine and desmethyl- and hydroxytrimipramine in plasma and red blood cells by capillary gas chromatography with nitrogen-selective detection.
Jourdil N, Pinteur B, Vincent F, Marka C, Bessard G
J Chromatogr 1993 Mar 5;613(1):59-65. doi: 10.1016/0378-4347(93)80197-c. PMID: 8458903
Trimipramine--an atypical neuroleptic?
Eikmeier G, Berger M, Lodemann E, Muszynski K, Kaumeier S, Gastpar M
Int Clin Psychopharmacol 1991 Winter;6(3):147-53. doi: 10.1097/00004850-199100630-00003. PMID: 1806621
Trimipramine, anxiety, depression and sleep.
Pecknold JC, Luthe L
Drugs 1989;38 Suppl 1:25-31; discussion 49-50. doi: 10.2165/00003495-198900381-00007. PMID: 2693052
Tricyclic use in the cognitively impaired elderly.
Cole JO, Branconnier R, Salomon M, Dessain E
J Clin Psychiatry 1983 Sep;44(9 Pt 2):14-9. PMID: 6355072

Therapy

The impact of pregnancy on the pharmacokinetics of antidepressants: a systematic critical review and meta-analysis.
Schoretsanitis G, Spigset O, Stingl JC, Deligiannidis KM, Paulzen M, Westin AA
Expert Opin Drug Metab Toxicol 2020 May;16(5):431-440. Epub 2020 Apr 10 doi: 10.1080/17425255.2020.1750598. PMID: 32238008Free PMC Article
Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.
Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Müller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC
Clin Pharmacol Ther 2017 Jul;102(1):37-44. Epub 2017 Feb 13 doi: 10.1002/cpt.597. PMID: 27997040Free PMC Article
Metabolism in adipose tissue in response to citalopram and trimipramine treatment--an in situ microdialysis study.
Flechtner-Mors M, Jenkinson CP, Alt A, Adler G, Ditschuneit HH
J Psychiatr Res 2008 Jun;42(7):578-86. Epub 2007 Aug 9 doi: 10.1016/j.jpsychires.2007.06.003. PMID: 17692337
Trimipramine--an atypical neuroleptic?
Eikmeier G, Berger M, Lodemann E, Muszynski K, Kaumeier S, Gastpar M
Int Clin Psychopharmacol 1991 Winter;6(3):147-53. doi: 10.1097/00004850-199100630-00003. PMID: 1806621
Trimipramine, anxiety, depression and sleep.
Pecknold JC, Luthe L
Drugs 1989;38 Suppl 1:25-31; discussion 49-50. doi: 10.2165/00003495-198900381-00007. PMID: 2693052

Prognosis

The impact of pregnancy on the pharmacokinetics of antidepressants: a systematic critical review and meta-analysis.
Schoretsanitis G, Spigset O, Stingl JC, Deligiannidis KM, Paulzen M, Westin AA
Expert Opin Drug Metab Toxicol 2020 May;16(5):431-440. Epub 2020 Apr 10 doi: 10.1080/17425255.2020.1750598. PMID: 32238008Free PMC Article
Drug-Induced Liver Injury during Antidepressant Treatment: Results of AMSP, a Drug Surveillance Program.
Friedrich ME, Akimova E, Huf W, Konstantinidis A, Papageorgiou K, Winkler D, Toto S, Greil W, Grohmann R, Kasper S
Int J Neuropsychopharmacol 2016 Apr;19(4) Epub 2016 Apr 20 doi: 10.1093/ijnp/pyv126. PMID: 26721950Free PMC Article
Trimipramine pharmacokinetics after intravenous and oral administration in carriers of CYP2D6 genotypes predicting poor, extensive and ultrahigh activity.
Kirchheiner J, Sasse J, Meineke I, Roots I, Brockmöller J
Pharmacogenetics 2003 Dec;13(12):721-8. doi: 10.1097/00008571-200312000-00003. PMID: 14646691
Trimipramine, anxiety, depression and sleep.
Pecknold JC, Luthe L
Drugs 1989;38 Suppl 1:25-31; discussion 49-50. doi: 10.2165/00003495-198900381-00007. PMID: 2693052
Pain infirmity and psychotropic drugs in oncology.
Bourhis A, Boudouresque G, Pellet W, Fondarai J, Ponzio J, Spitalier JM
Pain 1978 Oct;5(3):263-274. doi: 10.1016/0304-3959(78)90013-1. PMID: 724279

Clinical prediction guides

Trimipramine pharmacokinetics after intravenous and oral administration in carriers of CYP2D6 genotypes predicting poor, extensive and ultrahigh activity.
Kirchheiner J, Sasse J, Meineke I, Roots I, Brockmöller J
Pharmacogenetics 2003 Dec;13(12):721-8. doi: 10.1097/00008571-200312000-00003. PMID: 14646691
Antipsychotic efficacy of the antidepressant trimipramine: a randomized, double-blind comparison with the phenothiazine perazine.
Bender S, Olbrich HM, Fischer W, Hornstein C, Schoene W, Falkai P, Haarmann C, Berger M, Gastpar M; Trimipramine Study Group
Pharmacopsychiatry 2003 Mar-Apr;36(2):61-9. doi: 10.1055/s-2003-39043. PMID: 12734763
Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors.
Baumann P
Clin Pharmacokinet 1996 Dec;31(6):444-69. doi: 10.2165/00003088-199631060-00004. PMID: 8968657
Trimipramine--an atypical neuroleptic?
Eikmeier G, Berger M, Lodemann E, Muszynski K, Kaumeier S, Gastpar M
Int Clin Psychopharmacol 1991 Winter;6(3):147-53. doi: 10.1097/00004850-199100630-00003. PMID: 1806621
Trimipramine, anxiety, depression and sleep.
Pecknold JC, Luthe L
Drugs 1989;38 Suppl 1:25-31; discussion 49-50. doi: 10.2165/00003495-198900381-00007. PMID: 2693052

Recent systematic reviews

The impact of pregnancy on the pharmacokinetics of antidepressants: a systematic critical review and meta-analysis.
Schoretsanitis G, Spigset O, Stingl JC, Deligiannidis KM, Paulzen M, Westin AA
Expert Opin Drug Metab Toxicol 2020 May;16(5):431-440. Epub 2020 Apr 10 doi: 10.1080/17425255.2020.1750598. PMID: 32238008Free PMC Article

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