U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Trimipramine response

MedGen UID:
808073
•Concept ID:
CN221259
•
Sign or Symptom
Drug:
trimipramine
MedGen UID:
21693
•Concept ID:
C0041056
•
Pharmacologic Substance
Tricyclic antidepressant similar to IMIPRAMINE, but with more antihistaminic and sedative properties. [from MeSH]
trimipramine
 
Genes (locations): CYP2C19 (10q23.33); CYP2D6 (22q13.2)

Professional guidelines

PubMed

Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.
Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Müller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC
Clin Pharmacol Ther 2017 Jul;102(1):37-44. Epub 2017 Feb 13 doi: 10.1002/cpt.597. PMID: 27997040Free PMC Article
Sleep and antidepressant treatment.
Wichniak A, Wierzbicka A, Jernajczyk W
Curr Pharm Des 2012;18(36):5802-17. doi: 10.2174/138161212803523608. PMID: 22681161
Tricyclic antidepressant poisoning: an evidence-based consensus guideline for out-of-hospital management.
Woolf AD, Erdman AR, Nelson LS, Caravati EM, Cobaugh DJ, Booze LL, Wax PM, Manoguerra AS, Scharman EJ, Olson KR, Chyka PA, Christianson G, Troutman WG
Clin Toxicol (Phila) 2007;45(3):203-33. doi: 10.1080/15563650701226192. PMID: 17453872

Suggested Reading

PubMed

Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.
Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Müller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC
Clin Pharmacol Ther 2017 Jul;102(1):37-44. Epub 2017 Feb 13 doi: 10.1002/cpt.597. PMID: 27997040Free PMC Article

Recent clinical studies

Etiology

Receptor occupancy of mirtazapine determined by PET in healthy volunteers.
Smith DF, Stork BS, Wegener G, Jakobsen S, Bender D, Audrain H, Jensen SB, Hansen SB, Rodell A, Rosenberg R
Psychopharmacology (Berl) 2007 Nov;195(1):131-8. Epub 2007 Jul 25 doi: 10.1007/s00213-007-0877-x. PMID: 17653532
Trimipramine: acute and lasting effects on sleep in healthy and major depressive subjects.
Feuillade P, Pringuey D, Belugou JL, Robert P, Darcourt G
J Affect Disord 1992 Mar;24(3):135-45. doi: 10.1016/0165-0327(92)90061-a. PMID: 1573122
Trimipramine--an atypical neuroleptic?
Eikmeier G, Berger M, Lodemann E, Muszynski K, Kaumeier S, Gastpar M
Int Clin Psychopharmacol 1991 Winter;6(3):147-53. doi: 10.1097/00004850-199100630-00003. PMID: 1806621
Plasma levels and therapeutic response with trimipramine treatment of endogenous depression.
Simpson GM, Pi EH, Gross L, Baron D, November M
J Clin Psychiatry 1988 Mar;49(3):113-6. PMID: 3279023
Lithium carbonate addition in tricyclic antidepressant-resistant unipolar depression. Correlations with the neurobiologic actions of tricyclic antidepressant drugs and lithium ion on the serotonin system.
de Montigny C, Cournoyer G, Morissette R, Langlois R, Caillé G
Arch Gen Psychiatry 1983 Dec;40(12):1327-34. doi: 10.1001/archpsyc.1983.01790110069012. PMID: 6418109

Diagnosis

A new carbon paste electrode modified with MWCNTs and nano-structured molecularly imprinted polymer for ultratrace determination of trimipramine: The crucial effect of electrode components mixing on its performance.
Akhoundian M, Alizadeh T, Ganjali MR, Rafiei F
Biosens Bioelectron 2018 Jul 15;111:27-33. Epub 2018 Mar 28 doi: 10.1016/j.bios.2018.03.061. PMID: 29631160
Trimipramine: acute and lasting effects on sleep in healthy and major depressive subjects.
Feuillade P, Pringuey D, Belugou JL, Robert P, Darcourt G
J Affect Disord 1992 Mar;24(3):135-45. doi: 10.1016/0165-0327(92)90061-a. PMID: 1573122
Trimipramine--an atypical neuroleptic?
Eikmeier G, Berger M, Lodemann E, Muszynski K, Kaumeier S, Gastpar M
Int Clin Psychopharmacol 1991 Winter;6(3):147-53. doi: 10.1097/00004850-199100630-00003. PMID: 1806621
Trimipramine, anxiety, depression and sleep.
Pecknold JC, Luthe L
Drugs 1989;38 Suppl 1:25-31; discussion 49-50. doi: 10.2165/00003495-198900381-00007. PMID: 2693052
Will amitriptyline prevent the "cheese" reaction of monoamine-oxidase inhibitors?
Pare CM, Kline N, Hallstrom C, Cooper TB
Lancet 1982 Jul 24;2(8291):183-6. doi: 10.1016/s0140-6736(82)91030-3. PMID: 6123888

Therapy

The impact of pregnancy on the pharmacokinetics of antidepressants: a systematic critical review and meta-analysis.
Schoretsanitis G, Spigset O, Stingl JC, Deligiannidis KM, Paulzen M, Westin AA
Expert Opin Drug Metab Toxicol 2020 May;16(5):431-440. Epub 2020 Apr 10 doi: 10.1080/17425255.2020.1750598. PMID: 32238008Free PMC Article
Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.
Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Müller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC
Clin Pharmacol Ther 2017 Jul;102(1):37-44. Epub 2017 Feb 13 doi: 10.1002/cpt.597. PMID: 27997040Free PMC Article
Trimipramine: acute and lasting effects on sleep in healthy and major depressive subjects.
Feuillade P, Pringuey D, Belugou JL, Robert P, Darcourt G
J Affect Disord 1992 Mar;24(3):135-45. doi: 10.1016/0165-0327(92)90061-a. PMID: 1573122
Trimipramine--an atypical neuroleptic?
Eikmeier G, Berger M, Lodemann E, Muszynski K, Kaumeier S, Gastpar M
Int Clin Psychopharmacol 1991 Winter;6(3):147-53. doi: 10.1097/00004850-199100630-00003. PMID: 1806621
Increased deep sleep after trazodone use: a double-blind placebo-controlled study in healthy young adults.
Ware JC, Pittard JT
J Clin Psychiatry 1990 Sep;51 Suppl:18-22. PMID: 2211560

Prognosis

The impact of pregnancy on the pharmacokinetics of antidepressants: a systematic critical review and meta-analysis.
Schoretsanitis G, Spigset O, Stingl JC, Deligiannidis KM, Paulzen M, Westin AA
Expert Opin Drug Metab Toxicol 2020 May;16(5):431-440. Epub 2020 Apr 10 doi: 10.1080/17425255.2020.1750598. PMID: 32238008Free PMC Article
Drug-Induced Liver Injury during Antidepressant Treatment: Results of AMSP, a Drug Surveillance Program.
Friedrich ME, Akimova E, Huf W, Konstantinidis A, Papageorgiou K, Winkler D, Toto S, Greil W, Grohmann R, Kasper S
Int J Neuropsychopharmacol 2016 Apr;19(4) Epub 2016 Apr 20 doi: 10.1093/ijnp/pyv126. PMID: 26721950Free PMC Article
Trimipramine pharmacokinetics after intravenous and oral administration in carriers of CYP2D6 genotypes predicting poor, extensive and ultrahigh activity.
Kirchheiner J, Sasse J, Meineke I, Roots I, Brockmöller J
Pharmacogenetics 2003 Dec;13(12):721-8. doi: 10.1097/00008571-200312000-00003. PMID: 14646691
Repeated administration of the combined dexamethasone-human corticotropin releasing hormone stimulation test during treatment of depression.
Holsboer-Trachsler E, Stohler R, Hatzinger M
Psychiatry Res 1991 Aug;38(2):163-71. doi: 10.1016/0165-1781(91)90041-m. PMID: 1661430
Trimipramine, anxiety, depression and sleep.
Pecknold JC, Luthe L
Drugs 1989;38 Suppl 1:25-31; discussion 49-50. doi: 10.2165/00003495-198900381-00007. PMID: 2693052

Clinical prediction guides

Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors.
Baumann P
Clin Pharmacokinet 1996 Dec;31(6):444-69. doi: 10.2165/00003088-199631060-00004. PMID: 8968657
Trimipramine--an atypical neuroleptic?
Eikmeier G, Berger M, Lodemann E, Muszynski K, Kaumeier S, Gastpar M
Int Clin Psychopharmacol 1991 Winter;6(3):147-53. doi: 10.1097/00004850-199100630-00003. PMID: 1806621
Repeated administration of the combined dexamethasone-human corticotropin releasing hormone stimulation test during treatment of depression.
Holsboer-Trachsler E, Stohler R, Hatzinger M
Psychiatry Res 1991 Aug;38(2):163-71. doi: 10.1016/0165-1781(91)90041-m. PMID: 1661430
Trimipramine, anxiety, depression and sleep.
Pecknold JC, Luthe L
Drugs 1989;38 Suppl 1:25-31; discussion 49-50. doi: 10.2165/00003495-198900381-00007. PMID: 2693052
Lithium carbonate addition in tricyclic antidepressant-resistant unipolar depression. Correlations with the neurobiologic actions of tricyclic antidepressant drugs and lithium ion on the serotonin system.
de Montigny C, Cournoyer G, Morissette R, Langlois R, Caillé G
Arch Gen Psychiatry 1983 Dec;40(12):1327-34. doi: 10.1001/archpsyc.1983.01790110069012. PMID: 6418109

Recent systematic reviews

The impact of pregnancy on the pharmacokinetics of antidepressants: a systematic critical review and meta-analysis.
Schoretsanitis G, Spigset O, Stingl JC, Deligiannidis KM, Paulzen M, Westin AA
Expert Opin Drug Metab Toxicol 2020 May;16(5):431-440. Epub 2020 Apr 10 doi: 10.1080/17425255.2020.1750598. PMID: 32238008Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...