Intermediate primary alphalipoproteinemia-2 is an autosomal dominant condition characterized by half-normal plasma levels of apoA-I and HDL-C (Yamakawa-Kobayashi et al., 1999). Affected individuals may develop xanthomas and corneal opacities, but most do not have increased cardiovascular risk (summary by Rader and deGoma, 2012).
For a discussion of genetic heterogeneity of hypoalphalipoproteinemia, see 604091. [from
OMIM]