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Clonal hematopoiesis

MedGen UID:
1694554
•Concept ID:
C5206406
•
Finding
Synonyms: Clonal Hematopoiesis; Hematopoiesis, Clonal
SNOMED CT: Clonal hematopoiesis (1240416002)
 
Monarch Initiative: MONDO:0100542

Definition

Cellular proliferation of hematopoietic cells where a substantial proportion of the cells is derived from a single hematopoietic stem cell lineage. [from NCI]

Professional guidelines

PubMed

Childhood Cancer Treatment and Clonal Hematopoiesis.
Collord G, Behjati S
Cancer Discov 2023 Apr 3;13(4):811-813. doi: 10.1158/2159-8290.CD-23-0090. PMID: 37009705
Practical Considerations for the Use of Circulating Tumor DNA in the Treatment of Patients With Cancer: A Narrative Review.
Krebs MG, Malapelle U, André F, Paz-Ares L, Schuler M, Thomas DM, Vainer G, Yoshino T, Rolfo C
JAMA Oncol 2022 Dec 1;8(12):1830-1839. doi: 10.1001/jamaoncol.2022.4457. PMID: 36264554
Diagnosis and Treatment of Aplastic Anemia.
Peslak SA, Olson T, Babushok DV
Curr Treat Options Oncol 2017 Nov 16;18(12):70. doi: 10.1007/s11864-017-0511-z. PMID: 29143887Free PMC Article

Recent clinical studies

Etiology

Causes and consequences of clonal hematopoiesis.
Weeks LD, Ebert BL
Blood 2023 Dec 28;142(26):2235-2246. doi: 10.1182/blood.2023022222. PMID: 37931207Free PMC Article
Clonal hematopoiesis, somatic mosaicism, and age-associated disease.
Evans MA, Walsh K
Physiol Rev 2023 Jan 1;103(1):649-716. Epub 2022 Sep 1 doi: 10.1152/physrev.00004.2022. PMID: 36049115Free PMC Article
Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease.
Marnell CS, Bick A, Natarajan P
J Mol Cell Cardiol 2021 Dec;161:98-105. Epub 2021 Jul 21 doi: 10.1016/j.yjmcc.2021.07.004. PMID: 34298011Free PMC Article
Clonal hematopoiesis and nonhematologic disorders.
Jaiswal S
Blood 2020 Oct 1;136(14):1606-1614. doi: 10.1182/blood.2019000989. PMID: 32736379Free PMC Article
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.
Jaiswal S, Natarajan P, Silver AJ, Gibson CJ, Bick AG, Shvartz E, McConkey M, Gupta N, Gabriel S, Ardissino D, Baber U, Mehran R, Fuster V, Danesh J, Frossard P, Saleheen D, Melander O, Sukhova GK, Neuberg D, Libby P, Kathiresan S, Ebert BL
N Engl J Med 2017 Jul 13;377(2):111-121. Epub 2017 Jun 21 doi: 10.1056/NEJMoa1701719. PMID: 28636844Free PMC Article

Diagnosis

Genetic basis and molecular profiling in myeloproliferative neoplasms.
Luque Paz D, Kralovics R, Skoda RC
Blood 2023 Apr 20;141(16):1909-1921. doi: 10.1182/blood.2022017578. PMID: 36347013Free PMC Article
Pathogenesis of aplastic anemia.
Wang L, Liu H
Hematology 2019 Dec;24(1):559-566. doi: 10.1080/16078454.2019.1642548. PMID: 31315542
Diagnosis and Treatment of Aplastic Anemia.
Peslak SA, Olson T, Babushok DV
Curr Treat Options Oncol 2017 Nov 16;18(12):70. doi: 10.1007/s11864-017-0511-z. PMID: 29143887Free PMC Article
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes.
Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP, Ebert BL
Blood 2015 Jul 2;126(1):9-16. Epub 2015 Apr 30 doi: 10.1182/blood-2015-03-631747. PMID: 25931582Free PMC Article
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence.
Genovese G, Kähler AK, Handsaker RE, Lindberg J, Rose SA, Bakhoum SF, Chambert K, Mick E, Neale BM, Fromer M, Purcell SM, Svantesson O, Landén M, Höglund M, Lehmann S, Gabriel SB, Moran JL, Lander ES, Sullivan PF, Sklar P, Grönberg H, Hultman CM, McCarroll SA
N Engl J Med 2014 Dec 25;371(26):2477-87. Epub 2014 Nov 26 doi: 10.1056/NEJMoa1409405. PMID: 25426838Free PMC Article

Therapy

JAK: Not Just Another Kinase.
Agashe RP, Lippman SM, Kurzrock R
Mol Cancer Ther 2022 Dec 2;21(12):1757-1764. doi: 10.1158/1535-7163.MCT-22-0323. PMID: 36252553Free PMC Article
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.
Kar SP, Quiros PM, Gu M, Jiang T, Mitchell J, Langdon R, Iyer V, Barcena C, Vijayabaskar MS, Fabre MA, Carter P, Petrovski S, Burgess S, Vassiliou GS
Nat Genet 2022 Aug;54(8):1155-1166. Epub 2022 Jul 14 doi: 10.1038/s41588-022-01121-z. PMID: 35835912Free PMC Article
Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation.
Gibson CJ, Kim HT, Zhao L, Murdock HM, Hambley B, Ogata A, Madero-Marroquin R, Wang S, Green L, Fleharty M, Dougan T, Cheng CA, Blumenstiel B, Cibulskis C, Tsuji J, Duran M, Gocke CD, Antin JH, Nikiforow S, DeZern AE, Chen YB, Ho VT, Jones RJ, Lennon NJ, Walt DR, Ritz J, Soiffer RJ, Gondek LP, Lindsley RC
J Clin Oncol 2022 Jan 10;40(2):189-201. Epub 2021 Nov 18 doi: 10.1200/JCO.21.02286. PMID: 34793200Free PMC Article
MDS overlap disorders and diagnostic boundaries.
Tanaka TN, Bejar R
Blood 2019 Mar 7;133(10):1086-1095. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844670. PMID: 30670443
Diagnosis and Treatment of Aplastic Anemia.
Peslak SA, Olson T, Babushok DV
Curr Treat Options Oncol 2017 Nov 16;18(12):70. doi: 10.1007/s11864-017-0511-z. PMID: 29143887Free PMC Article

Prognosis

Pathophysiology of Acute Myeloid Leukemia.
Wachter F, Pikman Y
Acta Haematol 2024;147(2):229-246. Epub 2024 Feb 16 doi: 10.1159/000536152. PMID: 38228114
Causes and consequences of clonal hematopoiesis.
Weeks LD, Ebert BL
Blood 2023 Dec 28;142(26):2235-2246. doi: 10.1182/blood.2023022222. PMID: 37931207Free PMC Article
Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease.
Marnell CS, Bick A, Natarajan P
J Mol Cell Cardiol 2021 Dec;161:98-105. Epub 2021 Jul 21 doi: 10.1016/j.yjmcc.2021.07.004. PMID: 34298011Free PMC Article
Cardiovascular Disease, Aging, and Clonal Hematopoiesis.
Evans MA, Sano S, Walsh K
Annu Rev Pathol 2020 Jan 24;15:419-438. Epub 2019 Nov 5 doi: 10.1146/annurev-pathmechdis-012419-032544. PMID: 31689371Free PMC Article
Diagnosis and Treatment of Aplastic Anemia.
Peslak SA, Olson T, Babushok DV
Curr Treat Options Oncol 2017 Nov 16;18(12):70. doi: 10.1007/s11864-017-0511-z. PMID: 29143887Free PMC Article

Clinical prediction guides

Causes and consequences of clonal hematopoiesis.
Weeks LD, Ebert BL
Blood 2023 Dec 28;142(26):2235-2246. doi: 10.1182/blood.2023022222. PMID: 37931207Free PMC Article
Fundamental Pathobiology of Coronary Atherosclerosis and Clinical Implications for Chronic Ischemic Heart Disease Management-The Plaque Hypothesis: A Narrative Review.
Stone PH, Libby P, Boden WE
JAMA Cardiol 2023 Feb 1;8(2):192-201. doi: 10.1001/jamacardio.2022.3926. PMID: 36515941Free PMC Article
JAK: Not Just Another Kinase.
Agashe RP, Lippman SM, Kurzrock R
Mol Cancer Ther 2022 Dec 2;21(12):1757-1764. doi: 10.1158/1535-7163.MCT-22-0323. PMID: 36252553Free PMC Article
Cardiovascular Disease, Aging, and Clonal Hematopoiesis.
Evans MA, Sano S, Walsh K
Annu Rev Pathol 2020 Jan 24;15:419-438. Epub 2019 Nov 5 doi: 10.1146/annurev-pathmechdis-012419-032544. PMID: 31689371Free PMC Article
Age-related clonal hematopoiesis associated with adverse outcomes.
Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kuo FC, Kluk MJ, Henderson B, Kinnunen L, Koistinen HA, Ladenvall C, Getz G, Correa A, Banahan BF, Gabriel S, Kathiresan S, Stringham HM, McCarthy MI, Boehnke M, Tuomilehto J, Haiman C, Groop L, Atzmon G, Wilson JG, Neuberg D, Altshuler D, Ebert BL
N Engl J Med 2014 Dec 25;371(26):2488-98. Epub 2014 Nov 26 doi: 10.1056/NEJMoa1408617. PMID: 25426837Free PMC Article

Recent systematic reviews

Effects of donor-engrafted clonal hematopoiesis in allogeneic and autologous stem cell transplantation: a systematic review and meta-analysis.
Xie Y, Kazakova V, Weeks LD, Gerber JM, Tai J, Zhang TY, Lowsky R, Wu X, Yang C, Patel SA
Bone Marrow Transplant 2024 Nov;59(11):1585-1593. Epub 2024 Aug 25 doi: 10.1038/s41409-024-02403-2. PMID: 39183321Free PMC Article
Clonal hematopoiesis of indeterminate potential as a prognostic factor: a systematic review and meta-analysis.
Singh J, Li N, Ashrafi E, Thao LTP, Curtis DJ, Wood EM, McQuilten ZK
Blood Adv 2024 Jul 23;8(14):3771-3784. doi: 10.1182/bloodadvances.2024013228. PMID: 38838228Free PMC Article
Accuracy of digital implant impressions obtained using intraoral scanners: a systematic review and meta-analysis of in vivo studies.
Ma J, Zhang B, Song H, Wu D, Song T
Int J Implant Dent 2023 Dec 6;9(1):48. doi: 10.1186/s40729-023-00517-8. PMID: 38055096Free PMC Article
Association between genetically determined telomere length and health-related outcomes: A systematic review and meta-analysis of Mendelian randomization studies.
Chen B, Yan Y, Wang H, Xu J
Aging Cell 2023 Jul;22(7):e13874. Epub 2023 May 26 doi: 10.1111/acel.13874. PMID: 37232505Free PMC Article
Association of clonal hematopoiesis mutations with clinical outcomes: A systematic review and meta-analysis.
Nowakowska MK, Kim T, Thompson MT, Bolton KL, Deswal A, Lin SH, Scheet P, Wehner MR, Nead KT
Am J Hematol 2022 Apr;97(4):411-420. Epub 2022 Jan 19 doi: 10.1002/ajh.26465. PMID: 35015316Free PMC Article

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