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PAIN SENSITIVITY QUANTITATIVE TRAIT LOCUS 1(PAINQTL1)

MedGen UID:
1676393
•Concept ID:
C4760611
•
Finding
Synonyms: Insensitivity to pain; PAINQTL1
 
OMIM®: 618377

Professional guidelines

PubMed

Evaluating the association of TRPA1 gene polymorphisms with pain sensitivity: a protocol for an adaptive recall by genotype study.
Nickerson AP, Corbin LJ, Timpson NJ, Phillips K, Pickering AE, Dunham JP
BMC Med Genomics 2022 Jan 12;15(1):9. doi: 10.1186/s12920-022-01156-5. PMID: 35022050Free PMC Article
Palmar-plantar erythrodysesthesia syndrome following treatment with high-dose methotrexate or high-dose cytarabine.
Karol SE, Yang W, Smith C, Cheng C, Stewart CF, Baker SD, Sandlund JT, Rubnitz JE, Bishop MW, Pappo AS, Jeha S, Pui CH, Relling MV
Cancer 2017 Sep 15;123(18):3602-3608. Epub 2017 May 11 doi: 10.1002/cncr.30762. PMID: 28493546Free PMC Article

Recent clinical studies

Etiology

Association between lipid-lowering agents with intervertebral disc degeneration, sciatica and low back pain: a drug-targeted mendelian randomized study and cross-sectional observation.
Liu C, Chu X, Biao Y, Jin Q, Zhang Y, Gao Y, Feng S, Ma J, Zhang Y
Lipids Health Dis 2024 Oct 2;23(1):327. doi: 10.1186/s12944-024-02311-w. PMID: 39358768Free PMC Article
Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study.
Bi Y, Zhu Y, Tang S, Huang Y
J Headache Pain 2023 Aug 18;24(1):112. doi: 10.1186/s10194-023-01633-x. PMID: 37596566Free PMC Article
Comprehensive characterization of putative genetic influences on plasma metabolome in a pediatric cohort.
Lee IH, Smith MR, Yazdani A, Sandhu S, Walker DI, Mandl KD, Jones DP, Kong SW
Hum Genomics 2022 Dec 8;16(1):67. doi: 10.1186/s40246-022-00440-w. PMID: 36482414Free PMC Article
Detangling red hair from pain: phenotype-specific contributions from different genetic variants in melanocortin-1 receptor.
Zorina-Lichtenwalter K, Maixner W, Diatchenko L
Pain 2020 May;161(5):938-948. doi: 10.1097/j.pain.0000000000001780. PMID: 31834199Free PMC Article
Palmar-plantar erythrodysesthesia syndrome following treatment with high-dose methotrexate or high-dose cytarabine.
Karol SE, Yang W, Smith C, Cheng C, Stewart CF, Baker SD, Sandlund JT, Rubnitz JE, Bishop MW, Pappo AS, Jeha S, Pui CH, Relling MV
Cancer 2017 Sep 15;123(18):3602-3608. Epub 2017 May 11 doi: 10.1002/cncr.30762. PMID: 28493546Free PMC Article

Diagnosis

Association between lipid-lowering agents with intervertebral disc degeneration, sciatica and low back pain: a drug-targeted mendelian randomized study and cross-sectional observation.
Liu C, Chu X, Biao Y, Jin Q, Zhang Y, Gao Y, Feng S, Ma J, Zhang Y
Lipids Health Dis 2024 Oct 2;23(1):327. doi: 10.1186/s12944-024-02311-w. PMID: 39358768Free PMC Article
Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study.
Bi Y, Zhu Y, Tang S, Huang Y
J Headache Pain 2023 Aug 18;24(1):112. doi: 10.1186/s10194-023-01633-x. PMID: 37596566Free PMC Article
Evaluating the association of TRPA1 gene polymorphisms with pain sensitivity: a protocol for an adaptive recall by genotype study.
Nickerson AP, Corbin LJ, Timpson NJ, Phillips K, Pickering AE, Dunham JP
BMC Med Genomics 2022 Jan 12;15(1):9. doi: 10.1186/s12920-022-01156-5. PMID: 35022050Free PMC Article
Detangling red hair from pain: phenotype-specific contributions from different genetic variants in melanocortin-1 receptor.
Zorina-Lichtenwalter K, Maixner W, Diatchenko L
Pain 2020 May;161(5):938-948. doi: 10.1097/j.pain.0000000000001780. PMID: 31834199Free PMC Article
Palmar-plantar erythrodysesthesia syndrome following treatment with high-dose methotrexate or high-dose cytarabine.
Karol SE, Yang W, Smith C, Cheng C, Stewart CF, Baker SD, Sandlund JT, Rubnitz JE, Bishop MW, Pappo AS, Jeha S, Pui CH, Relling MV
Cancer 2017 Sep 15;123(18):3602-3608. Epub 2017 May 11 doi: 10.1002/cncr.30762. PMID: 28493546Free PMC Article

Therapy

Association between lipid-lowering agents with intervertebral disc degeneration, sciatica and low back pain: a drug-targeted mendelian randomized study and cross-sectional observation.
Liu C, Chu X, Biao Y, Jin Q, Zhang Y, Gao Y, Feng S, Ma J, Zhang Y
Lipids Health Dis 2024 Oct 2;23(1):327. doi: 10.1186/s12944-024-02311-w. PMID: 39358768Free PMC Article
Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study.
Bi Y, Zhu Y, Tang S, Huang Y
J Headache Pain 2023 Aug 18;24(1):112. doi: 10.1186/s10194-023-01633-x. PMID: 37596566Free PMC Article
Palmar-plantar erythrodysesthesia syndrome following treatment with high-dose methotrexate or high-dose cytarabine.
Karol SE, Yang W, Smith C, Cheng C, Stewart CF, Baker SD, Sandlund JT, Rubnitz JE, Bishop MW, Pappo AS, Jeha S, Pui CH, Relling MV
Cancer 2017 Sep 15;123(18):3602-3608. Epub 2017 May 11 doi: 10.1002/cncr.30762. PMID: 28493546Free PMC Article

Prognosis

Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study.
Bi Y, Zhu Y, Tang S, Huang Y
J Headache Pain 2023 Aug 18;24(1):112. doi: 10.1186/s10194-023-01633-x. PMID: 37596566Free PMC Article
Palmar-plantar erythrodysesthesia syndrome following treatment with high-dose methotrexate or high-dose cytarabine.
Karol SE, Yang W, Smith C, Cheng C, Stewart CF, Baker SD, Sandlund JT, Rubnitz JE, Bishop MW, Pappo AS, Jeha S, Pui CH, Relling MV
Cancer 2017 Sep 15;123(18):3602-3608. Epub 2017 May 11 doi: 10.1002/cncr.30762. PMID: 28493546Free PMC Article

Clinical prediction guides

Association between lipid-lowering agents with intervertebral disc degeneration, sciatica and low back pain: a drug-targeted mendelian randomized study and cross-sectional observation.
Liu C, Chu X, Biao Y, Jin Q, Zhang Y, Gao Y, Feng S, Ma J, Zhang Y
Lipids Health Dis 2024 Oct 2;23(1):327. doi: 10.1186/s12944-024-02311-w. PMID: 39358768Free PMC Article
Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study.
Bi Y, Zhu Y, Tang S, Huang Y
J Headache Pain 2023 Aug 18;24(1):112. doi: 10.1186/s10194-023-01633-x. PMID: 37596566Free PMC Article
Evaluating the association of TRPA1 gene polymorphisms with pain sensitivity: a protocol for an adaptive recall by genotype study.
Nickerson AP, Corbin LJ, Timpson NJ, Phillips K, Pickering AE, Dunham JP
BMC Med Genomics 2022 Jan 12;15(1):9. doi: 10.1186/s12920-022-01156-5. PMID: 35022050Free PMC Article

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