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Osteoarthritis susceptibility 5(OS5)

MedGen UID:
1674605
Concept ID:
C4759728
Finding
Synonym: OS5
 
Gene (location): GDF5 (20q11.22)
 
Monarch Initiative: MONDO:0012893
OMIM®: 612400

Definition

Any osteoarthritis in which the cause of the disease is a mutation in the GDF5 gene. [from MONDO]

Professional guidelines

PubMed

Tuerlings M, van Hoolwerff M, Houtman E, Suchiman EHED, Lakenberg N, Mei H, van der Linden EHMJ, Nelissen RRGHH, Ramos YYFM, Coutinho de Almeida R, Meulenbelt I
Arthritis Rheumatol 2021 May;73(5):789-799. Epub 2021 Mar 21 doi: 10.1002/art.41600. PMID: 33258547Free PMC Article
Georgiev T, Angelov AK
Rheumatol Int 2019 Jul;39(7):1145-1157. Epub 2019 Mar 25 doi: 10.1007/s00296-019-04290-z. PMID: 30911813
Marshall M, Watt FE, Vincent TL, Dziedzic K
Nat Rev Rheumatol 2018 Nov;14(11):641-656. doi: 10.1038/s41584-018-0095-4. PMID: 30305701

Curated

UK NICE Guideline NG226, Osteoarthritis in over 16s: diagnosis and management, 2022

Recent clinical studies

Etiology

Lorrot M, Gillet Y, Basmaci R, Bréhin C, Dommergues MA, Favier M, Jeziorski E, Panetta L, Pinquier D, Ouziel A, Grimprel E, Cohen R
Infect Dis Now 2023 Nov;53(8S):104789. Epub 2023 Sep 21 doi: 10.1016/j.idnow.2023.104789. PMID: 37741341
Aubourg G, Rice SJ, Bruce-Wootton P, Loughlin J
Osteoarthritis Cartilage 2022 May;30(5):636-649. Epub 2021 Mar 17 doi: 10.1016/j.joca.2021.03.002. PMID: 33722698Free PMC Article
Georgiev T, Angelov AK
Rheumatol Int 2019 Jul;39(7):1145-1157. Epub 2019 Mar 25 doi: 10.1007/s00296-019-04290-z. PMID: 30911813
Zeng C, Dubreuil M, LaRochelle MR, Lu N, Wei J, Choi HK, Lei G, Zhang Y
JAMA 2019 Mar 12;321(10):969-982. doi: 10.1001/jama.2019.1347. PMID: 30860559Free PMC Article
Derry S, Wiffen PJ, Kalso EA, Bell RF, Aldington D, Phillips T, Gaskell H, Moore RA
Cochrane Database Syst Rev 2017 May 12;5(5):CD008609. doi: 10.1002/14651858.CD008609.pub2. PMID: 28497473Free PMC Article

Diagnosis

Lorrot M, Gillet Y, Basmaci R, Bréhin C, Dommergues MA, Favier M, Jeziorski E, Panetta L, Pinquier D, Ouziel A, Grimprel E, Cohen R
Infect Dis Now 2023 Nov;53(8S):104789. Epub 2023 Sep 21 doi: 10.1016/j.idnow.2023.104789. PMID: 37741341
Zhang L, Zhang C, Zhang J, Liu A, Wang P, Xu J
Clin Interv Aging 2023;18:1577-1586. Epub 2023 Sep 15 doi: 10.2147/CIA.S424633. PMID: 37731961Free PMC Article
Gu Y, Jin Q, Hu J, Wang X, Yu W, Wang Z, Wang C, Liu Y, Chen Y, Yuan W
J Transl Med 2023 May 31;21(1):357. doi: 10.1186/s12967-023-04165-9. PMID: 37259122Free PMC Article
Zeng C, Dubreuil M, LaRochelle MR, Lu N, Wei J, Choi HK, Lei G, Zhang Y
JAMA 2019 Mar 12;321(10):969-982. doi: 10.1001/jama.2019.1347. PMID: 30860559Free PMC Article
Derry S, Rice AS, Cole P, Tan T, Moore RA
Cochrane Database Syst Rev 2017 Jan 13;1(1):CD007393. doi: 10.1002/14651858.CD007393.pub4. PMID: 28085183Free PMC Article

Therapy

Lorrot M, Gillet Y, Basmaci R, Bréhin C, Dommergues MA, Favier M, Jeziorski E, Panetta L, Pinquier D, Ouziel A, Grimprel E, Cohen R
Infect Dis Now 2023 Nov;53(8S):104789. Epub 2023 Sep 21 doi: 10.1016/j.idnow.2023.104789. PMID: 37741341
Gu Y, Jin Q, Hu J, Wang X, Yu W, Wang Z, Wang C, Liu Y, Chen Y, Yuan W
J Transl Med 2023 May 31;21(1):357. doi: 10.1186/s12967-023-04165-9. PMID: 37259122Free PMC Article
Zeng C, Dubreuil M, LaRochelle MR, Lu N, Wei J, Choi HK, Lei G, Zhang Y
JAMA 2019 Mar 12;321(10):969-982. doi: 10.1001/jama.2019.1347. PMID: 30860559Free PMC Article
Marshall M, Watt FE, Vincent TL, Dziedzic K
Nat Rev Rheumatol 2018 Nov;14(11):641-656. doi: 10.1038/s41584-018-0095-4. PMID: 30305701
Derry S, Wiffen PJ, Kalso EA, Bell RF, Aldington D, Phillips T, Gaskell H, Moore RA
Cochrane Database Syst Rev 2017 May 12;5(5):CD008609. doi: 10.1002/14651858.CD008609.pub2. PMID: 28497473Free PMC Article

Prognosis

Peshkova M, Lychagin A, Lipina M, Di Matteo B, Anzillotti G, Ronzoni F, Kosheleva N, Shpichka A, Royuk V, Fomin V, Kalinsky E, Timashev P, Kon E
Int J Mol Sci 2022 Mar 2;23(5) doi: 10.3390/ijms23052767. PMID: 35269906Free PMC Article
Georgiev T, Angelov AK
Rheumatol Int 2019 Jul;39(7):1145-1157. Epub 2019 Mar 25 doi: 10.1007/s00296-019-04290-z. PMID: 30911813
Zeng C, Dubreuil M, LaRochelle MR, Lu N, Wei J, Choi HK, Lei G, Zhang Y
JAMA 2019 Mar 12;321(10):969-982. doi: 10.1001/jama.2019.1347. PMID: 30860559Free PMC Article
Jiang L, Xie X, Wang Y, Wang Y, Lu Y, Tian T, Chu M, Shen Y
Int J Rheum Dis 2016 Dec;19(12):1244-1254. Epub 2016 Nov 5 doi: 10.1111/1756-185X.12895. PMID: 28371440
Abhishek A
Curr Opin Rheumatol 2016 Mar;28(2):133-9. doi: 10.1097/BOR.0000000000000246. PMID: 26626724

Clinical prediction guides

Gu Y, Jin Q, Hu J, Wang X, Yu W, Wang Z, Wang C, Liu Y, Chen Y, Yuan W
J Transl Med 2023 May 31;21(1):357. doi: 10.1186/s12967-023-04165-9. PMID: 37259122Free PMC Article
Rahmioglu N, Mortlock S, Ghiasi M, Møller PL, Stefansdottir L, Galarneau G, Turman C, Danning R, Law MH, Sapkota Y, Christofidou P, Skarp S, Giri A, Banasik K, Krassowski M, Lepamets M, Marciniak B, Nõukas M, Perro D, Sliz E, Sobalska-Kwapis M, Thorleifsson G, Topbas-Selcuki NF, Vitonis A, Westergaard D, Arnadottir R, Burgdorf KS, Campbell A, Cheuk CSK, Clementi C, Cook J, De Vivo I, DiVasta A, Dorien O, Donoghue JF, Edwards T, Fontanillas P, Fung JN, Geirsson RT, Girling JE, Harkki P, Harris HR, Healey M, Heikinheimo O, Holdsworth-Carson S, Hostettler IC, Houlden H, Houshdaran S, Irwin JC, Jarvelin MR, Kamatani Y, Kennedy SH, Kepka E, Kettunen J, Kubo M, Kulig B, Kurra V, Laivuori H, Laufer MR, Lindgren CM, MacGregor S, Mangino M, Martin NG, Matalliotaki C, Matalliotakis M, Murray AD, Ndungu A, Nezhat C, Olsen CM, Opoku-Anane J, Padmanabhan S, Paranjpe M, Peters M, Polak G, Porteous DJ, Rabban J, Rexrode KM, Romanowicz H, Saare M, Saavalainen L, Schork AJ, Sen S, Shafrir AL, Siewierska-Górska A, Słomka M, Smith BH, Smolarz B, Szaflik T, Szyłło K, Takahashi A, Terry KL, Tomassetti C, Treloar SA, Vanhie A, Vincent K, Vo KC, Werring DJ, Zeggini E, Zervou MI; DBDS Genomic Consortium; FinnGen Study; FinnGen Endometriosis Taskforce; Celmatix Research Team; 23andMe Research Team, Adachi S, Buring JE, Ridker PM, D'Hooghe T, Goulielmos GN, Hapangama DK, Hayward C, Horne AW, Low SK, Martikainen H, Chasman DI, Rogers PAW, Saunders PT, Sirota M, Spector T, Strapagiel D, Tung JY, Whiteman DC, Giudice LC, Velez-Edwards DR, Uimari O, Kraft P, Salumets A, Nyholt DR, Mägi R, Stefansson K, Becker CM, Yurttas-Beim P, Steinthorsdottir V, Nyegaard M, Missmer SA, Montgomery GW, Morris AP, Zondervan KT
Nat Genet 2023 Mar;55(3):423-436. Epub 2023 Mar 13 doi: 10.1038/s41588-023-01323-z. PMID: 36914876Free PMC Article
O'Connor D, Johnston RV, Brignardello-Petersen R, Poolman RW, Cyril S, Vandvik PO, Buchbinder R
Cochrane Database Syst Rev 2022 Mar 3;3(3):CD014328. doi: 10.1002/14651858.CD014328. PMID: 35238404Free PMC Article
Zeng C, Dubreuil M, LaRochelle MR, Lu N, Wei J, Choi HK, Lei G, Zhang Y
JAMA 2019 Mar 12;321(10):969-982. doi: 10.1001/jama.2019.1347. PMID: 30860559Free PMC Article
Marshall M, Watt FE, Vincent TL, Dziedzic K
Nat Rev Rheumatol 2018 Nov;14(11):641-656. doi: 10.1038/s41584-018-0095-4. PMID: 30305701

Recent systematic reviews

O'Connor D, Johnston RV, Brignardello-Petersen R, Poolman RW, Cyril S, Vandvik PO, Buchbinder R
Cochrane Database Syst Rev 2022 Mar 3;3(3):CD014328. doi: 10.1002/14651858.CD014328. PMID: 35238404Free PMC Article
Derry S, Wiffen PJ, Kalso EA, Bell RF, Aldington D, Phillips T, Gaskell H, Moore RA
Cochrane Database Syst Rev 2017 May 12;5(5):CD008609. doi: 10.1002/14651858.CD008609.pub2. PMID: 28497473Free PMC Article
Derry S, Rice AS, Cole P, Tan T, Moore RA
Cochrane Database Syst Rev 2017 Jan 13;1(1):CD007393. doi: 10.1002/14651858.CD007393.pub4. PMID: 28085183Free PMC Article
Jiang L, Tian W, Wang Y, Rong J, Bao C, Liu Y, Zhao Y, Wang C
Joint Bone Spine 2012 May;79(3):291-7. Epub 2011 Jul 30 doi: 10.1016/j.jbspin.2011.05.015. PMID: 21803633
Jiang L, Rong J, Wang Y, Hu F, Bao C, Li X, Zhao Y
Joint Bone Spine 2011 Mar;78(2):150-5. Epub 2010 Jun 30 doi: 10.1016/j.jbspin.2010.04.011. PMID: 20580591

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG226, Osteoarthritis in over 16s: diagnosis and management, 2022

    Consumer resources

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