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Abnormal mitral valve physiology

MedGen UID:
1624687
•Concept ID:
C4531094
•
Anatomical Abnormality
HPO: HP:0031481

Definition

Any functional anomaly of the mitral valve. [from HPO]

Professional guidelines

PubMed

The MAP3K7 gene: Further delineation of clinical characteristics and genotype/phenotype correlations.
van Woerden GM, Senden R, de Konink C, Trezza RA, Baban A, Bassetti JA, van Bever Y, Bird LM, van Bon BW, Brooks AS, Guan Q, Klee EW, Marcelis C, Rosado JM, Schimmenti LA, Shikany AR, Terhal PA, Nicole Weaver K, Wessels MW, van Wieringen H, Hurst AC, Gooch CF, Steindl K, Joset P, Rauch A, Tartaglia M, Niceta M, Elgersma Y, Demirdas S
Hum Mutat 2022 Oct;43(10):1377-1395. Epub 2022 Jul 29 doi: 10.1002/humu.24425. PMID: 35730652Free PMC Article
Floppy mitral valve/mitral valve prolapse: A complex entity with multiple genotypes and phenotypes.
Boudoulas KD, Pitsis AA, Mazzaferri EL, Gumina RJ, Triposkiadis F, Boudoulas H
Prog Cardiovasc Dis 2020 May-Jun;63(3):308-326. Epub 2020 Mar 19 doi: 10.1016/j.pcad.2020.03.004. PMID: 32201287
Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Whitlock RP, Sun JC, Fremes SE, Rubens FD, Teoh KH
Chest 2012 Feb;141(2 Suppl):e576S-e600S. doi: 10.1378/chest.11-2305. PMID: 22315272Free PMC Article

Recent clinical studies

Etiology

Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.
Grayburn PA, Sannino A, Packer M
JACC Cardiovasc Imaging 2019 Feb;12(2):353-362. Epub 2018 Dec 12 doi: 10.1016/j.jcmg.2018.11.006. PMID: 30553663
Mitral Valve Prolapse: Multimodality Imaging and Genetic Insights.
Parwani P, Avierinos JF, Levine RA, Delling FN
Prog Cardiovasc Dis 2017 Nov-Dec;60(3):361-369. Epub 2017 Nov 6 doi: 10.1016/j.pcad.2017.10.007. PMID: 29122631Free PMC Article
Mitral Annulus Calcification.
Abramowitz Y, Jilaihawi H, Chakravarty T, Mack MJ, Makkar RR
J Am Coll Cardiol 2015 Oct 27;66(17):1934-41. doi: 10.1016/j.jacc.2015.08.872. PMID: 26493666
Mitral regurgitation.
Ahmed MI, McGiffin DC, O'Rourke RA, Dell'Italia LJ
Curr Probl Cardiol 2009 Mar;34(3):93-136. doi: 10.1016/j.cpcardiol.2008.11.002. PMID: 19232244
Ischemic mitral regurgitation.
Le HC, Thys DM
Semin Cardiothorac Vasc Anesth 2006 Mar;10(1):73-7. doi: 10.1177/108925320601000113. PMID: 16703238

Diagnosis

Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.
Grayburn PA, Sannino A, Packer M
JACC Cardiovasc Imaging 2019 Feb;12(2):353-362. Epub 2018 Dec 12 doi: 10.1016/j.jcmg.2018.11.006. PMID: 30553663
Mitral Valve Prolapse: Multimodality Imaging and Genetic Insights.
Parwani P, Avierinos JF, Levine RA, Delling FN
Prog Cardiovasc Dis 2017 Nov-Dec;60(3):361-369. Epub 2017 Nov 6 doi: 10.1016/j.pcad.2017.10.007. PMID: 29122631Free PMC Article
Mitral Annulus Calcification.
Abramowitz Y, Jilaihawi H, Chakravarty T, Mack MJ, Makkar RR
J Am Coll Cardiol 2015 Oct 27;66(17):1934-41. doi: 10.1016/j.jacc.2015.08.872. PMID: 26493666
Mitral valve and papillary muscle abnormalities in hypertrophic obstructive cardiomyopathy.
Teo EP, Teoh JG, Hung J
Curr Opin Cardiol 2015 Sep;30(5):475-82. doi: 10.1097/HCO.0000000000000200. PMID: 26192489
Mitral regurgitation.
Ahmed MI, McGiffin DC, O'Rourke RA, Dell'Italia LJ
Curr Probl Cardiol 2009 Mar;34(3):93-136. doi: 10.1016/j.cpcardiol.2008.11.002. PMID: 19232244

Therapy

Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.
Grayburn PA, Sannino A, Packer M
JACC Cardiovasc Imaging 2019 Feb;12(2):353-362. Epub 2018 Dec 12 doi: 10.1016/j.jcmg.2018.11.006. PMID: 30553663
Cor triatriatum sinister.
Kadner A, Meszaros K, Mueller C, Schoenhoff F, Hutter D, Carrel T
Multimed Man Cardiothorac Surg 2014;2014 Epub 2014 May 30 doi: 10.1093/mmcts/mmu005. PMID: 24878580
Genetics of valvular heart disease.
LaHaye S, Lincoln J, Garg V
Curr Cardiol Rep 2014;16(6):487. doi: 10.1007/s11886-014-0487-2. PMID: 24743897Free PMC Article
Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Whitlock RP, Sun JC, Fremes SE, Rubens FD, Teoh KH
Chest 2012 Feb;141(2 Suppl):e576S-e600S. doi: 10.1378/chest.11-2305. PMID: 22315272Free PMC Article
Mitral regurgitation.
Ahmed MI, McGiffin DC, O'Rourke RA, Dell'Italia LJ
Curr Probl Cardiol 2009 Mar;34(3):93-136. doi: 10.1016/j.cpcardiol.2008.11.002. PMID: 19232244

Prognosis

Accessory mitral valve tissue: anatomical and clinical perspectives.
Yetkin E, Cuglan B, Turhan H, Yalta K
Cardiovasc Pathol 2021 Jan-Feb;50:107277. Epub 2020 Aug 31 doi: 10.1016/j.carpath.2020.107277. PMID: 32882373
Atrial functional mitral regurgitation.
Hoit BD
Curr Opin Cardiol 2020 Sep;35(5):474-481. doi: 10.1097/HCO.0000000000000761. PMID: 32649349
Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.
Grayburn PA, Sannino A, Packer M
JACC Cardiovasc Imaging 2019 Feb;12(2):353-362. Epub 2018 Dec 12 doi: 10.1016/j.jcmg.2018.11.006. PMID: 30553663
Assessment of the severity of native mitral valve regurgitation.
El-Tallawi KC, Messika-Zeitoun D, Zoghbi WA
Prog Cardiovasc Dis 2017 Nov-Dec;60(3):322-333. Epub 2017 Nov 22 doi: 10.1016/j.pcad.2017.11.005. PMID: 29174559
Mitral Valve Prolapse: Multimodality Imaging and Genetic Insights.
Parwani P, Avierinos JF, Levine RA, Delling FN
Prog Cardiovasc Dis 2017 Nov-Dec;60(3):361-369. Epub 2017 Nov 6 doi: 10.1016/j.pcad.2017.10.007. PMID: 29122631Free PMC Article

Clinical prediction guides

Accessory mitral valve tissue: anatomical and clinical perspectives.
Yetkin E, Cuglan B, Turhan H, Yalta K
Cardiovasc Pathol 2021 Jan-Feb;50:107277. Epub 2020 Aug 31 doi: 10.1016/j.carpath.2020.107277. PMID: 32882373
Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.
Grayburn PA, Sannino A, Packer M
JACC Cardiovasc Imaging 2019 Feb;12(2):353-362. Epub 2018 Dec 12 doi: 10.1016/j.jcmg.2018.11.006. PMID: 30553663
Assessment of the severity of native mitral valve regurgitation.
El-Tallawi KC, Messika-Zeitoun D, Zoghbi WA
Prog Cardiovasc Dis 2017 Nov-Dec;60(3):322-333. Epub 2017 Nov 22 doi: 10.1016/j.pcad.2017.11.005. PMID: 29174559
Mitral Valve Prolapse: Multimodality Imaging and Genetic Insights.
Parwani P, Avierinos JF, Levine RA, Delling FN
Prog Cardiovasc Dis 2017 Nov-Dec;60(3):361-369. Epub 2017 Nov 6 doi: 10.1016/j.pcad.2017.10.007. PMID: 29122631Free PMC Article
Interventional imaging: the role of echocardiography.
Maragiannis D, Little SH
Methodist Debakey Cardiovasc J 2014 Jul-Sep;10(3):172-7. doi: 10.14797/mdcj-10-3-172. PMID: 25574345Free PMC Article

Recent systematic reviews

The relationship between mitral valve prolapse and thoracic skeletal abnormalities in clinical practice: a systematic review.
Sonaglioni A, Nicolosi GL, Lombardo M
J Cardiovasc Med (Hagerstown) 2024 May 1;25(5):353-363. Epub 2024 Mar 19 doi: 10.2459/JCM.0000000000001614. PMID: 38526955
Clinical features and complications of Loeys-Dietz syndrome: A systematic review.
Gouda P, Kay R, Habib M, Aziz A, Aziza E, Welsh R
Int J Cardiol 2022 Sep 1;362:158-167. Epub 2022 Jun 1 doi: 10.1016/j.ijcard.2022.05.065. PMID: 35662564
Mitral valve prolapse and sudden cardiac death: a systematic review and meta-analysis.
Nalliah CJ, Mahajan R, Elliott AD, Haqqani H, Lau DH, Vohra JK, Morton JB, Semsarian C, Marwick T, Kalman JM, Sanders P
Heart 2019 Jan;105(2):144-151. Epub 2018 Sep 21 doi: 10.1136/heartjnl-2017-312932. PMID: 30242141
Genomic analysis in patients with myxomatous mitral valve prolapse: current state of knowledge.
Gasser S, Reichenspurner H, Girdauskas E
BMC Cardiovasc Disord 2018 Feb 27;18(1):41. doi: 10.1186/s12872-018-0755-y. PMID: 29486707Free PMC Article
Risk Factors for Coarctation of the Aorta on Prenatal Ultrasound: A Systematic Review and Meta-Analysis.
Familiari A, Morlando M, Khalil A, Sonesson SE, Scala C, Rizzo G, Del Sordo G, Vassallo C, Elena Flacco M, Manzoli L, Lanzone A, Scambia G, Acharya G, D'Antonio F
Circulation 2017 Feb 21;135(8):772-785. Epub 2016 Dec 29 doi: 10.1161/CIRCULATIONAHA.116.024068. PMID: 28034902

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