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Empty ovarian follicle

MedGen UID:
1390749
•Concept ID:
C4476946
•
Anatomical Abnormality
Synonym: Empty follicle syndrome
 
HPO: HP:0031067

Definition

A failure to collect oocytes after an apparently normal controlled ovarian hyperstimulation cycle for in vitro fertilization. [from HPO]

Professional guidelines

PubMed

Risk factors, management, and future fertility of empty follicle syndrome: a retrospective study with real-world data.
Luo Z, Xu S, Hao G
Front Endocrinol (Lausanne) 2024;15:1424837. Epub 2024 Jul 11 doi: 10.3389/fendo.2024.1424837. PMID: 39055059Free PMC Article
Reproductive outcomes after in vitro fertilization treatment in a cohort of Danish women transplanted with cryopreserved ovarian tissue.
Dueholm Hjorth IM, Kristensen SG, Dueholm M, Humaidan P
Fertil Steril 2020 Aug;114(2):379-387. Epub 2020 Jul 2 doi: 10.1016/j.fertnstert.2020.03.035. PMID: 32624219
Empty follicle syndrome revisited: definition, incidence, aetiology, early diagnosis and treatment.
Revelli A, Carosso A, Grassi G, Gennarelli G, Canosa S, Benedetto C
Reprod Biomed Online 2017 Aug;35(2):132-138. Epub 2017 May 23 doi: 10.1016/j.rbmo.2017.04.012. PMID: 28596003

Recent clinical studies

Etiology

Prediction, assessment, and management of suboptimal GnRH agonist trigger: a systematic review.
Ganer Herman H, Horowitz E, Mizrachi Y, Farhi J, Raziel A, Weissman A
J Assist Reprod Genet 2022 Feb;39(2):291-303. Epub 2022 Mar 19 doi: 10.1007/s10815-021-02359-y. PMID: 35306603Free PMC Article
Empty follicle syndrome: Frequency and probable causes in Pakistani Population.
Jehan S, Iram Z, Syed S
J Pak Med Assoc 2020 Sep;70(9):1538-1542. doi: 10.5455/JPMA.18623. PMID: 33040104
Gonadotropin-releasing hormone agonist ovulation trigger-beyond OHSS prevention.
Castillo JC, Haahr T, Martínez-Moya M, Humaidan P
Ups J Med Sci 2020 May;125(2):138-143. Epub 2020 Mar 25 doi: 10.1080/03009734.2020.1737599. PMID: 32208810Free PMC Article
Empty follicle syndrome prevalence and management in oocyte donors.
Blazquez A, Guillén JJ, Colomé C, Coll O, Vassena R, Vernaeve V
Hum Reprod 2014 Oct 10;29(10):2221-7. Epub 2014 Aug 1 doi: 10.1093/humrep/deu203. PMID: 25085799
The empty follicle syndrome.
Kourtis A, Rousso D, Panidis D
J Endocrinol Invest 2004 Feb;27(2):187-91. doi: 10.1007/BF03346267. PMID: 15129817

Diagnosis

Novel variants in ZP1, ZP2 and ZP3 associated with empty follicle syndrome and abnormal zona pellucida.
Sun L, Tong K, Liu W, Tian Y, Liu D, Huang G, Li J
Reprod Biomed Online 2023 May;46(5):847-855. Epub 2023 Jan 16 doi: 10.1016/j.rbmo.2023.01.010. PMID: 36931917
A novel mutation in ZP3 causes empty follicle syndrome and abnormal zona pellucida formation.
Zhang D, Zhu L, Liu Z, Ren X, Yang X, Li D, Luo Y, Peng X, Zhou X, Jia W, Hou M, Li Z, Jin L, Zhang X
J Assist Reprod Genet 2021 Jan;38(1):251-259. Epub 2020 Nov 2 doi: 10.1007/s10815-020-01995-0. PMID: 33140178Free PMC Article
Empty follicle syndrome revisited: definition, incidence, aetiology, early diagnosis and treatment.
Revelli A, Carosso A, Grassi G, Gennarelli G, Canosa S, Benedetto C
Reprod Biomed Online 2017 Aug;35(2):132-138. Epub 2017 May 23 doi: 10.1016/j.rbmo.2017.04.012. PMID: 28596003
The empty follicle syndrome.
Kourtis A, Rousso D, Panidis D
J Endocrinol Invest 2004 Feb;27(2):187-91. doi: 10.1007/BF03346267. PMID: 15129817
Ovarian factor infertility.
Summaria V, Speca S, Mirk P
Rays 1998 Oct-Dec;23(4):709-26. PMID: 10191667

Therapy

Risk factors for poor oocyte yield and oocyte immaturity after GnRH agonist triggering.
Gambini S, Sonigo C, Robin G, Cedrin-Durnerin I, Vinolas C, Sifer C, Boumerdassi Y, Mayeur A, Gallot V, Grynberg M, Peigné M
Hum Reprod 2024 May 2;39(5):963-973. doi: 10.1093/humrep/deae041. PMID: 38452353
Prediction, assessment, and management of suboptimal GnRH agonist trigger: a systematic review.
Ganer Herman H, Horowitz E, Mizrachi Y, Farhi J, Raziel A, Weissman A
J Assist Reprod Genet 2022 Feb;39(2):291-303. Epub 2022 Mar 19 doi: 10.1007/s10815-021-02359-y. PMID: 35306603Free PMC Article
Gonadotropin-releasing hormone agonist ovulation trigger-beyond OHSS prevention.
Castillo JC, Haahr T, Martínez-Moya M, Humaidan P
Ups J Med Sci 2020 May;125(2):138-143. Epub 2020 Mar 25 doi: 10.1080/03009734.2020.1737599. PMID: 32208810Free PMC Article
Empty follicle syndrome revisited: definition, incidence, aetiology, early diagnosis and treatment.
Revelli A, Carosso A, Grassi G, Gennarelli G, Canosa S, Benedetto C
Reprod Biomed Online 2017 Aug;35(2):132-138. Epub 2017 May 23 doi: 10.1016/j.rbmo.2017.04.012. PMID: 28596003
Empty follicle syndrome: the reality of a controversial syndrome, a systematic review.
Stevenson TL, Lashen H
Fertil Steril 2008 Sep;90(3):691-8. Epub 2007 Nov 26 doi: 10.1016/j.fertnstert.2007.07.1312. PMID: 18023430

Prognosis

Prediction, assessment, and management of suboptimal GnRH agonist trigger: a systematic review.
Ganer Herman H, Horowitz E, Mizrachi Y, Farhi J, Raziel A, Weissman A
J Assist Reprod Genet 2022 Feb;39(2):291-303. Epub 2022 Mar 19 doi: 10.1007/s10815-021-02359-y. PMID: 35306603Free PMC Article
The critical role of ZP genes in female infertility characterized by empty follicle syndrome and oocyte degeneration.
Yang P, Chen T, Liu Y, Hou Z, Wu K, Cao Y, Zhang J, Wang Z, Zhao H
Fertil Steril 2021 May;115(5):1259-1269. Epub 2020 Dec 4 doi: 10.1016/j.fertnstert.2020.11.003. PMID: 33272616
Empty follicle syndrome revisited: definition, incidence, aetiology, early diagnosis and treatment.
Revelli A, Carosso A, Grassi G, Gennarelli G, Canosa S, Benedetto C
Reprod Biomed Online 2017 Aug;35(2):132-138. Epub 2017 May 23 doi: 10.1016/j.rbmo.2017.04.012. PMID: 28596003
The empty follicle syndrome.
Kourtis A, Rousso D, Panidis D
J Endocrinol Invest 2004 Feb;27(2):187-91. doi: 10.1007/BF03346267. PMID: 15129817
Empty follicle syndrome.
Coulam CB, Bustillo M, Schulman JD
Fertil Steril 1986 Dec;46(6):1153-5. doi: 10.1016/s0015-0282(16)49898-5. PMID: 3781029

Clinical prediction guides

Prediction, assessment, and management of suboptimal GnRH agonist trigger: a systematic review.
Ganer Herman H, Horowitz E, Mizrachi Y, Farhi J, Raziel A, Weissman A
J Assist Reprod Genet 2022 Feb;39(2):291-303. Epub 2022 Mar 19 doi: 10.1007/s10815-021-02359-y. PMID: 35306603Free PMC Article
Combined ovulation triggering with GnRH agonist and hCG in IVF patients.
Kasum M, Kurdija K, Orešković S, Čehić E, Pavičić-Baldani D, Škrgatić L
Gynecol Endocrinol 2016 Nov;32(11):861-865. Epub 2016 Jun 8 doi: 10.1080/09513590.2016.1193141. PMID: 27275861
The empty follicle syndrome.
Kourtis A, Rousso D, Panidis D
J Endocrinol Invest 2004 Feb;27(2):187-91. doi: 10.1007/BF03346267. PMID: 15129817
Ovarian factor infertility.
Summaria V, Speca S, Mirk P
Rays 1998 Oct-Dec;23(4):709-26. PMID: 10191667
Empty follicle syndrome.
Coulam CB, Bustillo M, Schulman JD
Fertil Steril 1986 Dec;46(6):1153-5. doi: 10.1016/s0015-0282(16)49898-5. PMID: 3781029

Recent systematic reviews

A systematic review and standardized clinical validity assessment of genes involved in female reproductive failure.
Volozonoka L, Miskova A, Kornejeva L, Kempa I, Bargatina V, Gailite L
Reproduction 2022 Apr 22;163(6):351-363. doi: 10.1530/REP-21-0486. PMID: 35451369Free PMC Article
Prediction, assessment, and management of suboptimal GnRH agonist trigger: a systematic review.
Ganer Herman H, Horowitz E, Mizrachi Y, Farhi J, Raziel A, Weissman A
J Assist Reprod Genet 2022 Feb;39(2):291-303. Epub 2022 Mar 19 doi: 10.1007/s10815-021-02359-y. PMID: 35306603Free PMC Article
Ovarian stimulation and assisted reproductive technology outcomes in women transplanted with cryopreserved ovarian tissue: a systematic review.
Andersen ST, Pors SE, Poulsen LC, Colmorn LB, Macklon KT, Ernst E, Humaidan P, Andersen CY, Kristensen SG
Fertil Steril 2019 Nov;112(5):908-921. Epub 2019 Oct 6 doi: 10.1016/j.fertnstert.2019.07.008. PMID: 31594631
Empty follicle syndrome: the reality of a controversial syndrome, a systematic review.
Stevenson TL, Lashen H
Fertil Steril 2008 Sep;90(3):691-8. Epub 2007 Nov 26 doi: 10.1016/j.fertnstert.2007.07.1312. PMID: 18023430

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