Increased relative concentration of 4-hydroxyphenylpyruvic acid in the urine.

Increased concentration of 4-hydroxyphenylacetic acid in the urine.

The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction.

An abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age.

Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm.

Distention of the abdomen.

Accumulation of fluid in the peritoneal cavity.

Impairment of bile flow due to obstruction in bile ducts.

Yellow pigmentation of the skin due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream.

A chronic disorder of the liver in which liver tissue becomes scarred and is partially replaced by regenerative nodules and fibrotic tissue resulting in loss of liver function.

A disorder characterized by the inability of the liver to metabolize chemicals in the body. Causes include cirrhosis and drug-induced hepatotoxicity. Signs and symptoms include jaundice and encephalopathy. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin, lactic dehydrogenase, and alkaline phosphatase.

A form of hepatic steatosis characterized by the presence of small, lipid-laden vesicles in the affected hepatocytes.

A state of fatigue, either physical or mental slowness and sluggishness, with difficulties in initiating or performing simple tasks. Distinguished from apathy which implies indifference and a lack of desire or interest in the task. A person with lethargy may have the desire, but not the energy to engage in personal or socially relevant tasks.

Respiratory distress is objectively observable as the physical or emotional consequences from the experience of dyspnea. The physical presentation of respiratory distress is generally referred to as labored breathing, while the sensation of respiratory distress is called shortness of breath or dyspnea.

A decreased concentration of glucose in the blood.

Elevations of the levels of SGOT and SGPT in the serum. SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) are transaminases primarily found in the liver and heart and are released into the bloodstream as the result of liver or heart damage. SGOT and SGPT are used clinically mainly as markers of liver damage.

Reduction in the concentration of albumin in the blood.

Abnormally high level of conjugated bilirubin in the blood.

An increased amount of bilirubin in the blood.

Abnormally increased serum levels of alkaline phosphatase activity.

An increased concentration of tyrosine in the blood.

An increased concentration of methionine in the blood.

The presence of excess amniotic fluid in the uterus during pregnancy.