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Abnormal circulating lactate dehydrogenase concentration

MedGen UID:
892640
•Concept ID:
C4073168
•
Finding
Synonym: Abnormal lactate dehydrogenase activity
 
HPO: HP:0045040

Definition

A deviation from the normal serum concentration/activity of lactate dehydrogenase (LDH), which catalyzes the reduction of pyruvate to form lactate. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Abnormal circulating lactate dehydrogenase concentration

Recent clinical studies

Etiology

Abnormalities in renal tubular phosphate handling in children with sickle cell disease.
Raj VM, Freundlich M, Hamideh D, Alvarez O, Seeherunvong W, Abitbol C, Katsoufis C, Chandar J, Ruiz P, Zilleruelo G
Pediatr Blood Cancer 2014 Dec;61(12):2267-70. Epub 2014 Aug 17 doi: 10.1002/pbc.25188. PMID: 25132581
The effectiveness of high-flow regional cerebral perfusion in Norwood stage I palliation.
Miyaji K, Miyamoto T, Kohira S, Yoshii T, Itatani K, Sato H, Inoue N
Eur J Cardiothorac Surg 2011 Nov;40(5):1215-20. Epub 2011 Apr 5 doi: 10.1016/j.ejcts.2011.02.040. PMID: 21470870
Rationale for a metabolic approach in diabetic coronary patients.
Stanley WC
Coron Artery Dis 2005 Nov;16 Suppl 1:S11-5. doi: 10.1097/00019501-200511001-00003. PMID: 16340398
Interleukin-6: a candidate mediator of human prostate cancer morbidity.
Twillie DA, Eisenberger MA, Carducci MA, Hseih WS, Kim WY, Simons JW
Urology 1995 Mar;45(3):542-9. doi: 10.1016/S0090-4295(99)80034-X. PMID: 7879350
The laboratory evaluation of hypertensive gravidas.
Magann EF, Martin JN Jr
Obstet Gynecol Surv 1995 Feb;50(2):138-45. doi: 10.1097/00006254-199502000-00026. PMID: 7731626

Diagnosis

Circulating angiogenic cytokines in multiple myeloma and related disorders.
Urba ska-Rys H, Wierzbowska A, Robak T
Eur Cytokine Netw 2003 Jan-Mar;14(1):40-51. PMID: 12799213
Troponin T concentrations 72 hours after myocardial infarction as a serological estimate of infarct size.
Licka M, Zimmermann R, Zehelein J, Dengler TJ, Katus HA, Kübler W
Heart 2002 Jun;87(6):520-4. doi: 10.1136/heart.87.6.520. PMID: 12010931Free PMC Article
Clinical and radiologic improvements in mitochondrial encephalomyelopathy following sodium dichloroacetate therapy.
Kimura S, Ohtuki N, Nezu A, Tanaka M, Takeshita S
Brain Dev 1997 Dec;19(8):535-40. doi: 10.1016/s0387-7604(97)00074-0. PMID: 9440797
The laboratory evaluation of hypertensive gravidas.
Magann EF, Martin JN Jr
Obstet Gynecol Surv 1995 Feb;50(2):138-45. doi: 10.1097/00006254-199502000-00026. PMID: 7731626
Control of glycaemia.
Gerich JE
Baillieres Clin Endocrinol Metab 1993 Jul;7(3):551-86. doi: 10.1016/s0950-351x(05)80207-1. PMID: 8379904

Therapy

Rationale for a metabolic approach in diabetic coronary patients.
Stanley WC
Coron Artery Dis 2005 Nov;16 Suppl 1:S11-5. doi: 10.1097/00019501-200511001-00003. PMID: 16340398
Clinical and radiologic improvements in mitochondrial encephalomyelopathy following sodium dichloroacetate therapy.
Kimura S, Ohtuki N, Nezu A, Tanaka M, Takeshita S
Brain Dev 1997 Dec;19(8):535-40. doi: 10.1016/s0387-7604(97)00074-0. PMID: 9440797
Dichloroacetate.
Stacpoole PW, Greene YJ
Diabetes Care 1992 Jun;15(6):785-91. doi: 10.2337/diacare.15.6.785. PMID: 1600837

Prognosis

Prognostic value of serum/plasma neurofilament light chain for COVID-19-associated mortality.
Masvekar RR, Kosa P, Jin K, Dobbs K, Stack MA, Castagnoli R, Quaresima V, Su HC, Imberti L, Notarangelo LD, Bielekova B
Ann Clin Transl Neurol 2022 May;9(5):622-632. Epub 2022 Mar 21 doi: 10.1002/acn3.51542. PMID: 35313387Free PMC Article
Abnormalities in renal tubular phosphate handling in children with sickle cell disease.
Raj VM, Freundlich M, Hamideh D, Alvarez O, Seeherunvong W, Abitbol C, Katsoufis C, Chandar J, Ruiz P, Zilleruelo G
Pediatr Blood Cancer 2014 Dec;61(12):2267-70. Epub 2014 Aug 17 doi: 10.1002/pbc.25188. PMID: 25132581
Circulating angiogenic cytokines in multiple myeloma and related disorders.
Urba ska-Rys H, Wierzbowska A, Robak T
Eur Cytokine Netw 2003 Jan-Mar;14(1):40-51. PMID: 12799213
The laboratory evaluation of hypertensive gravidas.
Magann EF, Martin JN Jr
Obstet Gynecol Surv 1995 Feb;50(2):138-45. doi: 10.1097/00006254-199502000-00026. PMID: 7731626
Quantification of wear, hemolysis and coagulation deficits in patients with Beall mitral valves.
Clark RE, Pavlovic TA, Knight BE, Joist JH, Burrows SD, McKnight RC, Brown EB
Circulation 1977 Sep;56(3 Suppl):II139-43. PMID: 884818

Clinical prediction guides

Prognostic value of serum/plasma neurofilament light chain for COVID-19-associated mortality.
Masvekar RR, Kosa P, Jin K, Dobbs K, Stack MA, Castagnoli R, Quaresima V, Su HC, Imberti L, Notarangelo LD, Bielekova B
Ann Clin Transl Neurol 2022 May;9(5):622-632. Epub 2022 Mar 21 doi: 10.1002/acn3.51542. PMID: 35313387Free PMC Article
High plasma proteasome levels are detected in patients with metastatic malignant melanoma.
Stoebner PE, Lavabre-Bertrand T, Henry L, Guiraud I, Carillo S, Dandurand M, Joujoux JM, Bureau JP, Meunier L
Br J Dermatol 2005 May;152(5):948-53. doi: 10.1111/j.1365-2133.2005.06487.x. PMID: 15888151
Clinical and radiologic improvements in mitochondrial encephalomyelopathy following sodium dichloroacetate therapy.
Kimura S, Ohtuki N, Nezu A, Tanaka M, Takeshita S
Brain Dev 1997 Dec;19(8):535-40. doi: 10.1016/s0387-7604(97)00074-0. PMID: 9440797
The laboratory evaluation of hypertensive gravidas.
Magann EF, Martin JN Jr
Obstet Gynecol Surv 1995 Feb;50(2):138-45. doi: 10.1097/00006254-199502000-00026. PMID: 7731626
Studies on the carrier state in X-linked recessive (Duchenne) muscular dystrophy.
Thomson WH, Sweetin JC, Hilditch TE
Clin Chim Acta 1975 Sep 16;63(3):383-94. doi: 10.1016/0009-8981(75)90061-3. PMID: 240524

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