U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Generalized weakness of limb muscles

MedGen UID:
870172
Concept ID:
C4024605
Finding
Synonym: Generalised weakness of limb muscles
 
HPO: HP:0009028

Definition

Generalized weakness of the muscles of the arms and legs. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Generalized weakness of limb muscles

Professional guidelines

PubMed

Wang C, Zeng H, Fang W, Song L
Invest New Drugs 2023 Apr;41(2):333-339. Epub 2023 Mar 29 doi: 10.1007/s10637-023-01347-6. PMID: 36988830
Morisaki K, Yamaoka T, Iwasa K, Ohmine T
J Vasc Surg 2017 Dec;66(6):1758-1764. Epub 2017 Jun 21 doi: 10.1016/j.jvs.2017.04.048. PMID: 28647199
Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society, Delgado MR, Hirtz D, Aisen M, Ashwal S, Fehlings DL, McLaughlin J, Morrison LA, Shrader MW, Tilton A, Vargus-Adams J
Neurology 2010 Jan 26;74(4):336-43. doi: 10.1212/WNL.0b013e3181cbcd2f. PMID: 20101040Free PMC Article

Recent clinical studies

Etiology

Coelho-Júnior HJ, Calvani R, Tosato M, Landi F, Picca A, Marzetti E
Ageing Res Rev 2022 Nov;81:101731. Epub 2022 Sep 8 doi: 10.1016/j.arr.2022.101731. PMID: 36087703
Morris R, Lewis A
Clin Oncol (R Coll Radiol) 2020 Sep;32(9):569-578. Epub 2020 Apr 11 doi: 10.1016/j.clon.2020.03.011. PMID: 32291190
Latronico N, Herridge M, Hopkins RO, Angus D, Hart N, Hermans G, Iwashyna T, Arabi Y, Citerio G, Ely EW, Hall J, Mehta S, Puntillo K, Van den Hoeven J, Wunsch H, Cook D, Dos Santos C, Rubenfeld G, Vincent JL, Van den Berghe G, Azoulay E, Needham DM
Intensive Care Med 2017 Sep;43(9):1270-1281. Epub 2017 Mar 13 doi: 10.1007/s00134-017-4757-5. PMID: 28289812
D'Amico A, Mercuri E, Tiziano FD, Bertini E
Orphanet J Rare Dis 2011 Nov 2;6:71. doi: 10.1186/1750-1172-6-71. PMID: 22047105Free PMC Article
Bensimon G, Lacomblez L, Meininger V
N Engl J Med 1994 Mar 3;330(9):585-91. doi: 10.1056/NEJM199403033300901. PMID: 8302340

Diagnosis

Ciafaloni E
Continuum (Minneap Minn) 2019 Dec;25(6):1767-1784. doi: 10.1212/CON.0000000000000800. PMID: 31794470
Ranjan A, Jamshed N, Aggarwal P, Upadhyay V
Am J Emerg Med 2019 Apr;37(4):798.e1-798.e2. Epub 2019 Jan 21 doi: 10.1016/j.ajem.2019.01.033. PMID: 30686539
Hehir MK, Silvestri NJ
Neurol Clin 2018 May;36(2):253-260. doi: 10.1016/j.ncl.2018.01.002. PMID: 29655448
Latronico N, Herridge M, Hopkins RO, Angus D, Hart N, Hermans G, Iwashyna T, Arabi Y, Citerio G, Ely EW, Hall J, Mehta S, Puntillo K, Van den Hoeven J, Wunsch H, Cook D, Dos Santos C, Rubenfeld G, Vincent JL, Van den Berghe G, Azoulay E, Needham DM
Intensive Care Med 2017 Sep;43(9):1270-1281. Epub 2017 Mar 13 doi: 10.1007/s00134-017-4757-5. PMID: 28289812
D'Amico A, Mercuri E, Tiziano FD, Bertini E
Orphanet J Rare Dis 2011 Nov 2;6:71. doi: 10.1186/1750-1172-6-71. PMID: 22047105Free PMC Article

Therapy

Lai X, Bo L, Zhu H, Chen B, Wu Z, Du H, Huo X
BMC Geriatr 2021 Jul 30;21(1):447. doi: 10.1186/s12877-021-02386-5. PMID: 34330211Free PMC Article
Ciafaloni E
Continuum (Minneap Minn) 2019 Dec;25(6):1767-1784. doi: 10.1212/CON.0000000000000800. PMID: 31794470
Ranjan A, Jamshed N, Aggarwal P, Upadhyay V
Am J Emerg Med 2019 Apr;37(4):798.e1-798.e2. Epub 2019 Jan 21 doi: 10.1016/j.ajem.2019.01.033. PMID: 30686539
Silvestri NJ, Wolfe GI
Semin Neurol 2012 Jul;32(3):215-26. Epub 2012 Nov 1 doi: 10.1055/s-0032-1329200. PMID: 23117946
Bensimon G, Lacomblez L, Meininger V
N Engl J Med 1994 Mar 3;330(9):585-91. doi: 10.1056/NEJM199403033300901. PMID: 8302340

Prognosis

Alonso-Pérez J, González-Quereda L, Bruno C, Panicucci C, Alavi A, Nafissi S, Nilipour Y, Zanoteli E, Isihi LMA, Melegh B, Hadzsiev K, Muelas N, Vílchez JJ, Dourado ME, Kadem N, Kutluk G, Umair M, Younus M, Pegorano E, Bello L, Crawford TO, Suárez-Calvet X, Töpf A, Guglieri M, Marini-Bettolo C, Gallano P, Straub V, Díaz-Manera J
Brain 2022 Apr 18;145(2):596-606. doi: 10.1093/brain/awab301. PMID: 34515763Free PMC Article
Hehir MK, Silvestri NJ
Neurol Clin 2018 May;36(2):253-260. doi: 10.1016/j.ncl.2018.01.002. PMID: 29655448
D'Amico A, Mercuri E, Tiziano FD, Bertini E
Orphanet J Rare Dis 2011 Nov 2;6:71. doi: 10.1186/1750-1172-6-71. PMID: 22047105Free PMC Article
Lacomblez L, Bensimon G, Leigh PN, Guillet P, Meininger V
Lancet 1996 May 25;347(9013):1425-31. doi: 10.1016/s0140-6736(96)91680-3. PMID: 8676624
Bensimon G, Lacomblez L, Meininger V
N Engl J Med 1994 Mar 3;330(9):585-91. doi: 10.1056/NEJM199403033300901. PMID: 8302340

Clinical prediction guides

Bril V, Howard JF Jr, Karam C, De Bleecker JL, Murai H, Utsugisawa K, Ulrichts P, Brauer E, Zhao S, Mantegazza R, Vu T; ADAPT Study Group
Eur J Neurol 2024 Jan;31(1):e16098. Epub 2023 Oct 16 doi: 10.1111/ene.16098. PMID: 37843174Free PMC Article
Coelho-Júnior HJ, Calvani R, Tosato M, Landi F, Picca A, Marzetti E
Ageing Res Rev 2022 Nov;81:101731. Epub 2022 Sep 8 doi: 10.1016/j.arr.2022.101731. PMID: 36087703
Alonso-Pérez J, González-Quereda L, Bruno C, Panicucci C, Alavi A, Nafissi S, Nilipour Y, Zanoteli E, Isihi LMA, Melegh B, Hadzsiev K, Muelas N, Vílchez JJ, Dourado ME, Kadem N, Kutluk G, Umair M, Younus M, Pegorano E, Bello L, Crawford TO, Suárez-Calvet X, Töpf A, Guglieri M, Marini-Bettolo C, Gallano P, Straub V, Díaz-Manera J
Brain 2022 Apr 18;145(2):596-606. doi: 10.1093/brain/awab301. PMID: 34515763Free PMC Article
Kinugasa Y, Yamamoto K
Heart 2017 Feb;103(3):184-189. Epub 2016 Dec 9 doi: 10.1136/heartjnl-2016-309995. PMID: 27940967
Faulkner JA, Larkin LM, Claflin DR, Brooks SV
Clin Exp Pharmacol Physiol 2007 Nov;34(11):1091-6. doi: 10.1111/j.1440-1681.2007.04752.x. PMID: 17880359

Recent systematic reviews

Xie S, Li S, Shaharudin S
J Sports Sci Med 2023 Sep;22(3):541-548. Epub 2023 Sep 1 doi: 10.52082/jssm.2023.541. PMID: 37711701Free PMC Article
Coelho-Júnior HJ, Calvani R, Tosato M, Landi F, Picca A, Marzetti E
Ageing Res Rev 2022 Nov;81:101731. Epub 2022 Sep 8 doi: 10.1016/j.arr.2022.101731. PMID: 36087703
Jones RL, Paul L, Steultjens MPM, Smith SL
J Cachexia Sarcopenia Muscle 2022 Dec;13(6):2791-2806. Epub 2022 Aug 17 doi: 10.1002/jcsm.13064. PMID: 35977879Free PMC Article
Subías-Perié J, Navarrete-Villanueva D, Gómez-Cabello A, Vicente-Rodríguez G, Casajús JA
Exp Gerontol 2022 May;161:111713. Epub 2022 Jan 29 doi: 10.1016/j.exger.2022.111713. PMID: 35104563
Mañas A, Gómez-Redondo P, Valenzuela PL, Morales JS, Lucía A, Ara I
Ageing Res Rev 2021 Aug;69:101368. Epub 2021 May 19 doi: 10.1016/j.arr.2021.101368. PMID: 34022464

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...