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Abnormal circulating enzyme concentration

MedGen UID:: 869169
•Concept ID:: C4023591
•: Finding

Synonym:	Abnormality of circulating enzyme level

HPO:	HP:0011021

Definition

The concentration or activity of an enzyme in the blood circulation is outside of the limits of the normal range. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

Abnormal circulating enzyme concentration

Phenotypic abnormality
- Abnormality of metabolism/homeostasis
  - Abnormal circulating metabolite concentration
    - Abnormal circulating protein concentration
      - Abnormal circulating enzyme concentration
        Abnormal circulating creatine kinase concentration
        Decreased circulating creatine kinase concentration
        Elevated circulating creatine kinase concentration
        Elevated creatine kinase after exercise
        Extremely elevated creatine kinase
        Highly elevated creatine kinase
        Mildly elevated creatine kinase
        Increased circulating creatine kinase BB isoform
        Increased circulating creatine kinase MB isoform
        Increased circulating creatine kinase MM isoform
        Elevated circulating Angiotensin-converting enzyme concentration
        Increased serum beta-hexosaminidase

Professional guidelines

PubMed

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.

Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495

Congenital blood coagulation factor XIII deficiency and perinatal management.

Ichinose A, Asahina T, Kobayashi T
Curr Drug Targets 2005 Aug;6(5):541-9. doi: 10.2174/1389450054545953. PMID: 16026274

Catecholamine levels and treatment in chronic heart failure.

Anker SD
Eur Heart J 1998 Jun;19 Suppl F:F56-61. PMID: 9651737

See all (9)

Recent clinical studies

Etiology

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.

Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495

The role of sulfated steroid hormones in reproductive processes.

Geyer J, Bakhaus K, Bernhardt R, Blaschka C, Dezhkam Y, Fietz D, Grosser G, Hartmann K, Hartmann MF, Neunzig J, Papadopoulos D, Sánchez-Guijo A, Scheiner-Bobis G, Schuler G, Shihan M, Wrenzycki C, Wudy SA, Bergmann M
J Steroid Biochem Mol Biol 2017 Sep;172:207-221. Epub 2016 Jul 5 doi: 10.1016/j.jsbmb.2016.07.002. PMID: 27392637

Premature adrenarche: etiology, clinical findings, and consequences.

Voutilainen R, Jääskeläinen J
J Steroid Biochem Mol Biol 2015 Jan;145:226-36. Epub 2014 Jun 9 doi: 10.1016/j.jsbmb.2014.06.004. PMID: 24923732

Eryptosis in lead-exposed workers.

Aguilar-Dorado IC, Hernández G, Quintanar-Escorza MA, Maldonado-Vega M, Rosas-Flores M, Calderón-Salinas JV
Toxicol Appl Pharmacol 2014 Dec 1;281(2):195-202. Epub 2014 Oct 27 doi: 10.1016/j.taap.2014.10.003. PMID: 25448684

Angiogenic factors and preeclampsia.

Tjoa ML, Levine RJ, Karumanchi SA
Front Biosci 2007 Jan 1;12:2395-402. doi: 10.2741/2241. PMID: 17127249

See all (274)

Diagnosis

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.

Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495

Angiogenic Biomarkers for Risk Stratification in Women with Preeclampsia.

Docheva N, Arenas G, Nieman KM, Lopes-Perdigao J, Yeo KJ, Rana S
Clin Chem 2022 Jun 1;68(6):771-781. doi: 10.1093/clinchem/hvab281. PMID: 35092286

Multifunctional Liposomes.

Aryasomayajula B, Salzano G, Torchilin VP
Methods Mol Biol 2017;1530:41-61. doi: 10.1007/978-1-4939-6646-2_3. PMID: 28150195

Angiogenic factors and preeclampsia.

Tjoa ML, Levine RJ, Karumanchi SA
Front Biosci 2007 Jan 1;12:2395-402. doi: 10.2741/2241. PMID: 17127249

The pharmacology of letrozole.

Haynes BP, Dowsett M, Miller WR, Dixon JM, Bhatnagar AS
J Steroid Biochem Mol Biol 2003 Oct;87(1):35-45. doi: 10.1016/s0960-0760(03)00384-4. PMID: 14630089

See all (173)

Therapy

Organokines and liver enzymes in adolescent girls with polycystic ovary syndrome during randomized treatments.

Garcia-Beltran C, Peyrou M, Navarro-Gascon A, López-Bermejo A, de Zegher F, Villarroya F, Ibáñez L
Front Endocrinol (Lausanne) 2024;15:1325230. Epub 2024 May 16 doi: 10.3389/fendo.2024.1325230. PMID: 38818508 Free PMC Article

Multifunctional Liposomes.

Aryasomayajula B, Salzano G, Torchilin VP
Methods Mol Biol 2017;1530:41-61. doi: 10.1007/978-1-4939-6646-2_3. PMID: 28150195

The pharmacology of letrozole.

Haynes BP, Dowsett M, Miller WR, Dixon JM, Bhatnagar AS
J Steroid Biochem Mol Biol 2003 Oct;87(1):35-45. doi: 10.1016/s0960-0760(03)00384-4. PMID: 14630089

Obstructive nephropathy.

Klahr S
Intern Med 2000 May;39(5):355-61. doi: 10.2169/internalmedicine.39.355. PMID: 10830173

Dichloroacetate.

Stacpoole PW, Greene YJ
Diabetes Care 1992 Jun;15(6):785-91. doi: 10.2337/diacare.15.6.785. PMID: 1600837

See all (137)

Prognosis

Angiogenic Biomarkers for Risk Stratification in Women with Preeclampsia.

Docheva N, Arenas G, Nieman KM, Lopes-Perdigao J, Yeo KJ, Rana S
Clin Chem 2022 Jun 1;68(6):771-781. doi: 10.1093/clinchem/hvab281. PMID: 35092286

Trimethylamine oxide: a potential target for heart failure therapy.

Lv S, Wang Y, Zhang W, Shang H
Heart 2022 May 25;108(12):917-922. doi: 10.1136/heartjnl-2021-320054. PMID: 34611047

Impact of Tissue Enolase 1 Protein Overexpression in Esophageal Cancer Progression.

Hoang AT, Vizio B, Chiusa L, Cimino A, Solerio D, Do NH, Pileci S, Camandona M, Bellone G
Int J Med Sci 2021;18(6):1406-1414. Epub 2021 Jan 26 doi: 10.7150/ijms.52688. PMID: 33628097 Free PMC Article

Premature and multiple births in IVF are associated with pretreatment circulating LH/hCG receptor concentration.

Chambers A, Fairbairn C, Gaudoin M, Mills W, Banerjee S
Hum Fertil (Camb) 2017 Dec;20(4):279-284. Epub 2016 Nov 30 doi: 10.1080/14647273.2016.1260169. PMID: 27900886

Angiogenic factors and preeclampsia.

Tjoa ML, Levine RJ, Karumanchi SA
Front Biosci 2007 Jan 1;12:2395-402. doi: 10.2741/2241. PMID: 17127249

See all (101)

Clinical prediction guides

Organokines and liver enzymes in adolescent girls with polycystic ovary syndrome during randomized treatments.

SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells.

Iida H, Kono T, Lee CC, Krishnan P, Arvin MC, Weaver SA, Jarvela TS, Branco RCS, McLaughlin MR, Bone RN, Tong X, Arvan P, Lindberg I, Evans-Molina C
Diabetologia 2023 Nov;66(11):2042-2061. Epub 2023 Aug 4 doi: 10.1007/s00125-023-05979-4. PMID: 37537395 Free PMC Article

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.

Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495

Angiogenic Biomarkers for Risk Stratification in Women with Preeclampsia.

Docheva N, Arenas G, Nieman KM, Lopes-Perdigao J, Yeo KJ, Rana S
Clin Chem 2022 Jun 1;68(6):771-781. doi: 10.1093/clinchem/hvab281. PMID: 35092286

Angiogenic factors and preeclampsia.

Tjoa ML, Levine RJ, Karumanchi SA
Front Biosci 2007 Jan 1;12:2395-402. doi: 10.2741/2241. PMID: 17127249

See all (194)

Recent systematic reviews

Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis.

Murri M, Luque-Ramírez M, Insenser M, Ojeda-Ojeda M, Escobar-Morreale HF
Hum Reprod Update 2013 May-Jun;19(3):268-88. Epub 2013 Jan 9 doi: 10.1093/humupd/dms059. PMID: 23303572

See all (1)

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Abnormal circulating enzyme concentration

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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