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Abnormal trabecular meshwork morphology

MedGen UID:: 868420
•Concept ID:: C4022814
•: Anatomical Abnormality

Synonym:	Abnormality of the trabecular meshwork

HPO:	HP:0012630

Definition

An anomaly of the trabecular meshwork, which is the porelike structure surrounding the entire circumference of the anterior chamber at the base of the cornea and near the ciliary body. The trabecular mesh work is responsible for draining the aqueous humor into the canal of Schlemm. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

Abnormal trabecular meshwork morphology

Phenotypic abnormality
- Abnormality of the eye
  - Abnormal eye morphology
    - Abnormal anterior eye segment morphology
      - Abnormal anterior chamber morphology
        Abnormal trabecular meshwork morphology
        Pigment deposition in the trabecular meshwork

Professional guidelines

PubMed

PLATEAU IRIS--DIAGNOSIS AND TREATMENT.

Stefan C, Iliescu DA, Batras M, Timaru CM, De Simone A
Rom J Ophthalmol 2015 Jan-Mar;59(1):14-8. PMID: 27373109 Free PMC Article

Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: challenges of dual combination therapy with N-acetylcarnosine lubricant eye drops and oral formulation of nonhydrolyzed carnosine.

Babizhayev MA
Fundam Clin Pharmacol 2012 Feb;26(1):86-117. Epub 2011 Aug 24 doi: 10.1111/j.1472-8206.2011.00969.x. PMID: 21883446

Congenital glaucoma--diagnosis and management.

Krieglstein GK
Trans Ophthalmol Soc U K (1962) 1986;105 ( Pt 5):549-54. PMID: 3541304

See all (11)

Recent clinical studies

Etiology

Functional role of peroxiredoxin 6 in the eye.

Wahlig S, Lovatt M, Mehta JS
Free Radic Biol Med 2018 Oct;126:210-220. Epub 2018 Aug 16 doi: 10.1016/j.freeradbiomed.2018.08.017. PMID: 30120980

Oxidative stress in the trabecular meshwork (Review).

Zhao J, Wang S, Zhong W, Yang B, Sun L, Zheng Y
Int J Mol Med 2016 Oct;38(4):995-1002. Epub 2016 Aug 24 doi: 10.3892/ijmm.2016.2714. PMID: 27572245

PLATEAU IRIS SYNDROME--CASE SERIES.

Feraru CI, Pantalon AD, Chiselita D, Branisteanu D
Rom J Ophthalmol 2015 Jul-Sep;59(3):188-93. PMID: 26978890 Free PMC Article

Genetic susceptibility to primary angle closure glaucoma (PACG).

Shastry BS
Discov Med 2013 Jan;15(80):17-22. PMID: 23375010

Role of CYP1B1 in glaucoma.

Vasiliou V, Gonzalez FJ
Annu Rev Pharmacol Toxicol 2008;48:333-58. doi: 10.1146/annurev.pharmtox.48.061807.154729. PMID: 17914928

See all (53)

Diagnosis

Pigment dispersion syndrome and pigmentary glaucoma: a review and update.

Scuderi G, Contestabile MT, Scuderi L, Librando A, Fenicia V, Rahimi S
Int Ophthalmol 2019 Jul;39(7):1651-1662. Epub 2018 May 2 doi: 10.1007/s10792-018-0938-7. PMID: 29721842

PLATEAU IRIS--DIAGNOSIS AND TREATMENT.

Stefan C, Iliescu DA, Batras M, Timaru CM, De Simone A
Rom J Ophthalmol 2015 Jan-Mar;59(1):14-8. PMID: 27373109 Free PMC Article

Current concepts in pigmentary glaucoma.

Farrar SM, Shields MB
Surv Ophthalmol 1993 Jan-Feb;37(4):233-52. doi: 10.1016/0039-6257(93)90008-u. PMID: 8095105

Congenital glaucoma--diagnosis and management.

Krieglstein GK
Trans Ophthalmol Soc U K (1962) 1986;105 ( Pt 5):549-54. PMID: 3541304

Primary infantile glaucoma (congenital glaucoma).

deLuise VP, Anderson DR
Surv Ophthalmol 1983 Jul-Aug;28(1):1-19. doi: 10.1016/0039-6257(83)90174-1. PMID: 6353647

See all (70)

Therapy

NAD(+) supplementation improves mitochondrial functions and normalizes glaucomatous trabecular meshwork features.

Liu Y, Bu Q, Hu D, Chen C, Zhu J, Zhou Q, Li Z, Pan X
Exp Cell Res 2024 Jul 1;440(1):114137. Epub 2024 Jun 17 doi: 10.1016/j.yexcr.2024.114137. PMID: 38897410

Oxidative stress in the trabecular meshwork (Review).

Zhao J, Wang S, Zhong W, Yang B, Sun L, Zheng Y
Int J Mol Med 2016 Oct;38(4):995-1002. Epub 2016 Aug 24 doi: 10.3892/ijmm.2016.2714. PMID: 27572245

Babizhayev MA
Fundam Clin Pharmacol 2012 Feb;26(1):86-117. Epub 2011 Aug 24 doi: 10.1111/j.1472-8206.2011.00969.x. PMID: 21883446

Current concepts in pigmentary glaucoma.

Farrar SM, Shields MB
Surv Ophthalmol 1993 Jan-Feb;37(4):233-52. doi: 10.1016/0039-6257(93)90008-u. PMID: 8095105

Experimental models of anterior segment dysgenesis.

Cook CS
Ophthalmic Paediatr Genet 1989 Mar;10(1):33-46. doi: 10.3109/13816818909083771. PMID: 2662095

See all (18)

Prognosis

Primary congenital glaucoma: An iridotrabeculodysgenesis?

Sihota R, Mahalingam K, Maurya AK, Sharma A, Bukke AN, Dada T
Indian J Ophthalmol 2024 Mar 1;72(3):328-334. Epub 2023 Dec 15 doi: 10.4103/IJO.IJO_370_23. PMID: 38099353 Free PMC Article

Surgical site characteristics after CLASS followed by ultrasound biomicroscopy and clinical grading scale: a 2-year follow-up.

Yan X, Zhang H, Li F, Ma L, Geng Y, Tang G
Eye (Lond) 2021 Aug;35(8):2283-2293. Epub 2020 Nov 2 doi: 10.1038/s41433-020-01235-w. PMID: 33139873 Free PMC Article

Pigment dispersion syndrome and pigmentary glaucoma: a review and update.

Scuderi G, Contestabile MT, Scuderi L, Librando A, Fenicia V, Rahimi S
Int Ophthalmol 2019 Jul;39(7):1651-1662. Epub 2018 May 2 doi: 10.1007/s10792-018-0938-7. PMID: 29721842

Congenital glaucoma--diagnosis and management.

Krieglstein GK
Trans Ophthalmol Soc U K (1962) 1986;105 ( Pt 5):549-54. PMID: 3541304

Primary infantile glaucoma (congenital glaucoma).

deLuise VP, Anderson DR
Surv Ophthalmol 1983 Jul-Aug;28(1):1-19. doi: 10.1016/0039-6257(83)90174-1. PMID: 6353647

See all (26)

Clinical prediction guides

Primary congenital glaucoma: An iridotrabeculodysgenesis?

Sihota R, Mahalingam K, Maurya AK, Sharma A, Bukke AN, Dada T
Indian J Ophthalmol 2024 Mar 1;72(3):328-334. Epub 2023 Dec 15 doi: 10.4103/IJO.IJO_370_23. PMID: 38099353 Free PMC Article

Comparisons of Schlemm's canal and trabecular meshwork morphologies between juvenile and primary open angle glaucoma.

Hamanaka T, Sakurai T, Fuse N, Ishida N, Kumasaka T, Tanito M
Exp Eye Res 2021 Sep;210:108711. Epub 2021 Aug 2 doi: 10.1016/j.exer.2021.108711. PMID: 34352267

Oxidative stress in the trabecular meshwork (Review).

Zhao J, Wang S, Zhong W, Yang B, Sun L, Zheng Y
Int J Mol Med 2016 Oct;38(4):995-1002. Epub 2016 Aug 24 doi: 10.3892/ijmm.2016.2714. PMID: 27572245

Axenfeld-Rieger syndrome. A spectrum of developmental disorders.

Shields MB, Buckley E, Klintworth GK, Thresher R
Surv Ophthalmol 1985 May-Jun;29(6):387-409. doi: 10.1016/0039-6257(85)90205-x. PMID: 3892740

Primary infantile glaucoma (congenital glaucoma).

deLuise VP, Anderson DR
Surv Ophthalmol 1983 Jul-Aug;28(1):1-19. doi: 10.1016/0039-6257(83)90174-1. PMID: 6353647

See all (58)