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Abnormal brainstem MRI signal intensity

MedGen UID:
868355
Concept ID:
C4022749
Finding
HPO: HP:0012747

Definition

A deviation from normal signal on magnetic resonance imaging (MRI) of the brainstem. [from HPO]

Professional guidelines

PubMed

Yoon DL, Kim YJ, Koo BS, Kim YG, Lee CK, Yoo B
Int J Rheum Dis 2014 May;17(4):453-8. Epub 2014 Feb 8 doi: 10.1111/1756-185X.12265. PMID: 24506839
O'Brien DF, Farrell M, Delanty N, Traunecker H, Perrin R, Smyth MD, Park TS; Children's Cancer and Leukaemia Group
Br J Neurosurg 2007 Dec;21(6):539-49. doi: 10.1080/02688690701594817. PMID: 18071981
Berry-Kravis E, Abrams L, Coffey SM, Hall DA, Greco C, Gane LW, Grigsby J, Bourgeois JA, Finucane B, Jacquemont S, Brunberg JA, Zhang L, Lin J, Tassone F, Hagerman PJ, Hagerman RJ, Leehey MA
Mov Disord 2007 Oct 31;22(14):2018-30, quiz 2140. doi: 10.1002/mds.21493. PMID: 17618523

Recent clinical studies

Etiology

Calvez S, Levy R, Calvez R, Roux CJ, Grévent D, Purcell Y, Beccaria K, Blauwblomme T, Grill J, Dufour C, Bourdeaut F, Doz F, Robert MP, Boddaert N, Dangouloff-Ros V
AJNR Am J Neuroradiol 2020 Sep;41(9):1733-1739. Epub 2020 Aug 13 doi: 10.3174/ajnr.A6740. PMID: 32816766Free PMC Article
Lombardo F, De Cori S, Aghakhanyan G, Montanaro D, De Marchi D, Frijia F, Fortunato S, Forli F, Chiappino D, Berrettini S, Canapicchi R
Eur Radiol 2016 Oct;26(10):3744-51. Epub 2016 Jan 8 doi: 10.1007/s00330-015-4170-9. PMID: 26747254
Tuttolomondo A, Pecoraro R, Simonetta I, Miceli S, Arnao V, Licata G, Pinto A
Curr Pharm Des 2013;19(33):6014-30. doi: 10.2174/13816128113199990387. PMID: 23448452
Tokumaru AM, Saito Y, Murayama S, Kazutomi K, Sakiyama Y, Toyoda M, Yamakawa M, Terada H
AJNR Am J Neuroradiol 2009 Nov;30(10):1884-92. Epub 2009 Oct 15 doi: 10.3174/ajnr.A1721. PMID: 19833793Free PMC Article
Barkovich AJ, Peck WW
AJNR Am J Neuroradiol 1997 Jun-Jul;18(6):1163-70. PMID: 9194444Free PMC Article

Diagnosis

Resende LL, de Paiva ARB, Kok F, da Costa Leite C, Lucato LT
Radiographics 2019 Jan-Feb;39(1):153-168. doi: 10.1148/rg.2019180081. PMID: 30620693
Tuttolomondo A, Pecoraro R, Simonetta I, Miceli S, Arnao V, Licata G, Pinto A
Curr Pharm Des 2013;19(33):6014-30. doi: 10.2174/13816128113199990387. PMID: 23448452
Correa GG, Amaral LF, Vedolin LM
Top Magn Reson Imaging 2011 Dec;22(6):303-12. doi: 10.1097/RMR.0b013e3182a2ca77. PMID: 24132069
Laothamatas J, Sungkarat W, Hemachudha T
Adv Virus Res 2011;79:309-27. doi: 10.1016/B978-0-12-387040-7.00014-7. PMID: 21601052
O'Brien DF, Farrell M, Delanty N, Traunecker H, Perrin R, Smyth MD, Park TS; Children's Cancer and Leukaemia Group
Br J Neurosurg 2007 Dec;21(6):539-49. doi: 10.1080/02688690701594817. PMID: 18071981

Therapy

Zeng H, Wen F, Huang W, Gan Y, Zeng W, Chen R, He Y, Wang Y, Liu Z, Liang C, Wong KK
PLoS One 2016;11(10):e0162877. Epub 2016 Oct 31 doi: 10.1371/journal.pone.0162877. PMID: 27798639Free PMC Article
Sumida K, Inoue K, Takanashi J, Sasaki M, Watanabe K, Suzuki M, Kurahashi H, Omata T, Tanaka M, Yokochi K, Iio J, Iyoda K, Kurokawa T, Matsuo M, Sato T, Iwaki A, Osaka H, Kurosawa K, Yamamoto T, Matsumoto N, Maikusa N, Matsuda H, Sato N
Brain Dev 2016 Jun;38(6):571-80. Epub 2016 Jan 13 doi: 10.1016/j.braindev.2015.12.007. PMID: 26774704
Simao GN, Zarei Mahmoodabadi S, Snead OC, Go C, Widjaja E
AJNR Am J Neuroradiol 2011 Jan;32(1):199-203. Epub 2010 Aug 26 doi: 10.3174/ajnr.A2224. PMID: 20801762Free PMC Article
Dracopoulos A, Widjaja E, Raybaud C, Westall CA, Snead OC 3rd
Epilepsia 2010 Jul;51(7):1297-304. Epub 2010 Apr 2 doi: 10.1111/j.1528-1167.2010.02564.x. PMID: 20384718
Dousset V, Gomez C, Petry KG, Delalande C, Caille JM
MAGMA 1999 Aug;8(3):185-9. doi: 10.1007/BF02594597. PMID: 10504046

Prognosis

Calvez S, Levy R, Calvez R, Roux CJ, Grévent D, Purcell Y, Beccaria K, Blauwblomme T, Grill J, Dufour C, Bourdeaut F, Doz F, Robert MP, Boddaert N, Dangouloff-Ros V
AJNR Am J Neuroradiol 2020 Sep;41(9):1733-1739. Epub 2020 Aug 13 doi: 10.3174/ajnr.A6740. PMID: 32816766Free PMC Article
Tuttolomondo A, Pecoraro R, Simonetta I, Miceli S, Arnao V, Licata G, Pinto A
Curr Pharm Des 2013;19(33):6014-30. doi: 10.2174/13816128113199990387. PMID: 23448452
Laothamatas J, Sungkarat W, Hemachudha T
Adv Virus Res 2011;79:309-27. doi: 10.1016/B978-0-12-387040-7.00014-7. PMID: 21601052
Adamsbaum C, Moutard ML, André C, Merzoug V, Ferey S, Quéré MP, Lewin F, Fallet-Bianco C
Pediatr Radiol 2005 Feb;35(2):124-40. Epub 2004 Nov 23 doi: 10.1007/s00247-004-1316-3. PMID: 15565345
Roh JK, Lee TG, Wie BA, Lee SB, Park SH, Chang KH
Neurology 1994 Jun;44(6):1064-8. doi: 10.1212/wnl.44.6.1064. PMID: 8208401

Clinical prediction guides

Dusek P, Lescinskij A, Ruzicka F, Acosta-Cabronero J, Bruha R, Sieger T, Hajek M, Dezortova M
Radiology 2021 Jun;299(3):662-672. Epub 2021 Mar 23 doi: 10.1148/radiol.2021202846. PMID: 33754827
Majovska J, Nestrasil I, Paulson A, Nascene D, Jurickova K, Hlavata A, Lund T, Orchard PJ, Vaneckova M, Zeman J, Magner M, Dusek P
Mol Genet Metab 2021 Mar;132(3):189-197. Epub 2020 Dec 3 doi: 10.1016/j.ymgme.2020.11.008. PMID: 33317989
Calvez S, Levy R, Calvez R, Roux CJ, Grévent D, Purcell Y, Beccaria K, Blauwblomme T, Grill J, Dufour C, Bourdeaut F, Doz F, Robert MP, Boddaert N, Dangouloff-Ros V
AJNR Am J Neuroradiol 2020 Sep;41(9):1733-1739. Epub 2020 Aug 13 doi: 10.3174/ajnr.A6740. PMID: 32816766Free PMC Article
Resende LL, de Paiva ARB, Kok F, da Costa Leite C, Lucato LT
Radiographics 2019 Jan-Feb;39(1):153-168. doi: 10.1148/rg.2019180081. PMID: 30620693
Zouaoui A, Maillard JC, Dormont D, Chiras J, Marsault C
J Neuroradiol 1992 Dec;19(4):271-84. PMID: 1464779

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