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Estrogen receptor mutant, temperature-sensitive

MedGen UID:
864474
•Concept ID:
C4016037
•
Finding
Synonym: ESTROGEN RECEPTOR MUTANT, TEMPERATURE-SENSITIVE
 
OMIM®: 133430

Recent clinical studies

Diagnosis

Making stem cell lines suitable for transplantation.
Hodges H, Pollock K, Stroemer P, Patel S, Stevanato L, Reuter I, Sinden J
Cell Transplant 2007;16(2):101-15. PMID: 17474292
Resistance to p53-mediated growth arrest and apoptosis in Hep 3B hepatoma cells.
Friedman SL, Shaulian E, Littlewood T, Resnitzky D, Oren M
Oncogene 1997 Jul 3;15(1):63-70. doi: 10.1038/sj.onc.1201149. PMID: 9233778
Estrogen response in the hFOB 1.19 human fetal osteoblastic cell line stably transfected with the human estrogen receptor gene.
Harris SA, Tau KR, Enger RJ, Toft DO, Riggs BL, Spelsberg TC
J Cell Biochem 1995 Oct;59(2):193-201. doi: 10.1002/jcb.240590209. PMID: 8904314
Identification of charged residues in an N-terminal portion of the hormone-binding domain of the human estrogen receptor important in transcriptional activity of the receptor.
Pakdel F, Reese JC, Katzenellenbogen BS
Mol Endocrinol 1993 Nov;7(11):1408-17. doi: 10.1210/mend.7.11.8114756. PMID: 8114756
Characterization of a temperature-sensitive mutation in the hormone binding domain of the human estrogen receptor. Studies in cell extracts and intact cells and their implications for hormone-dependent transcriptional activation.
Reese JC, Katzenellenbogen BS
J Biol Chem 1992 May 15;267(14):9868-73. PMID: 1577818

Clinical prediction guides

Resistance to p53-mediated growth arrest and apoptosis in Hep 3B hepatoma cells.
Friedman SL, Shaulian E, Littlewood T, Resnitzky D, Oren M
Oncogene 1997 Jul 3;15(1):63-70. doi: 10.1038/sj.onc.1201149. PMID: 9233778
Characterization of a temperature-sensitive mutation in the hormone binding domain of the human estrogen receptor. Studies in cell extracts and intact cells and their implications for hormone-dependent transcriptional activation.
Reese JC, Katzenellenbogen BS
J Biol Chem 1992 May 15;267(14):9868-73. PMID: 1577818

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