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Eculizumab, poor response to

MedGen UID:
816732
Concept ID:
C3810402
Disease or Syndrome
Synonym: ECULIZUMAB, POOR RESPONSE TO
 
Gene (location): C5 (9q33.2)
 
OMIM®: 615749

Professional guidelines

PubMed

Vaisbich MH, Braga A, Gabrielle M, Bueno C, Piazzon F, Kok F
Pediatr Nephrol 2017 Jun;32(6):1089-1092. Epub 2017 Feb 16 doi: 10.1007/s00467-017-3615-6. PMID: 28210839

Recent clinical studies

Etiology

Keller MD, Hanley PJ, Chi YY, Aguayo-Hiraldo P, Dvorak CC, Verneris MR, Kohn DB, Pai SY, Dávila Saldaña BJ, Hanisch B, Quigg TC, Adams RH, Dahlberg A, Chandrakasan S, Hasan H, Malvar J, Jensen-Wachspress MA, Lazarski CA, Sani G, Idso JM, Lang H, Chansky P, McCann CD, Tanna J, Abraham AA, Webb JL, Shibli A, Keating AK, Satwani P, Muranski P, Hall E, Eckrich MJ, Shereck E, Miller H, Mamcarz E, Agarwal R, De Oliveira SN, Vander Lugt MT, Ebens CL, Aquino VM, Bednarski JJ, Chu J, Parikh S, Whangbo J, Lionakis M, Zambidis ET, Gourdine E, Bollard CM, Pulsipher MA
Nat Commun 2024 Apr 18;15(1):3258. doi: 10.1038/s41467-024-47057-2. PMID: 38637498Free PMC Article
Benítez Carabante MI, Bueno D, Alonso García L, López Torija I, Marsal J, Fernandez Navarro JM, Uria Oficialdegui ML, Panesso M, Molina B, Beléndez Bieler C, Palomo P, Pérez Martínez A, Diaz-de-Heredia C
Transplant Cell Ther 2024 Jun;30(6):601.e1-601.e13. Epub 2024 Mar 21 doi: 10.1016/j.jtct.2024.03.019. PMID: 38521410
Svec P, Elfeky R, Galimard JE, Higham CS, Dalissier A, Quigg TC, Bueno Sanchez D, Han Lum S, Faraci M, Cole T, Pichler H, Benítez-Carabante MI, Horakova J, Gonzalez-Vicent M, Yanir A, Fagioli F, Wölfl M, von der Weid N, Protheroe R, Krivan G, Speckmann C, James B, Avcin SL, Bertrand Y, Verna M, Riha P, Patrick K, Cesaro S, Kalwak K, Bierings M, Büchner J, Mellgren K, Prohászka Z, Neven B, Lankester A, Corbacioglu S
Bone Marrow Transplant 2023 Feb;58(2):129-141. Epub 2022 Nov 4 doi: 10.1038/s41409-022-01852-x. PMID: 36333550
Vaisbich MH, Braga A, Gabrielle M, Bueno C, Piazzon F, Kok F
Pediatr Nephrol 2017 Jun;32(6):1089-1092. Epub 2017 Feb 16 doi: 10.1007/s00467-017-3615-6. PMID: 28210839
Dhakal P, Bhatt VR
Bone Marrow Transplant 2017 Mar;52(3):352-356. Epub 2016 Oct 24 doi: 10.1038/bmt.2016.253. PMID: 27775697

Diagnosis

Benítez Carabante MI, Bueno D, Alonso García L, López Torija I, Marsal J, Fernandez Navarro JM, Uria Oficialdegui ML, Panesso M, Molina B, Beléndez Bieler C, Palomo P, Pérez Martínez A, Diaz-de-Heredia C
Transplant Cell Ther 2024 Jun;30(6):601.e1-601.e13. Epub 2024 Mar 21 doi: 10.1016/j.jtct.2024.03.019. PMID: 38521410
Svec P, Elfeky R, Galimard JE, Higham CS, Dalissier A, Quigg TC, Bueno Sanchez D, Han Lum S, Faraci M, Cole T, Pichler H, Benítez-Carabante MI, Horakova J, Gonzalez-Vicent M, Yanir A, Fagioli F, Wölfl M, von der Weid N, Protheroe R, Krivan G, Speckmann C, James B, Avcin SL, Bertrand Y, Verna M, Riha P, Patrick K, Cesaro S, Kalwak K, Bierings M, Büchner J, Mellgren K, Prohászka Z, Neven B, Lankester A, Corbacioglu S
Bone Marrow Transplant 2023 Feb;58(2):129-141. Epub 2022 Nov 4 doi: 10.1038/s41409-022-01852-x. PMID: 36333550
Nakamura M, Abe T, Ochiai H
Am J Case Rep 2022 Jun 7;23:e936116. doi: 10.12659/AJCR.936116. PMID: 35671252Free PMC Article
Vaisbich MH, Braga A, Gabrielle M, Bueno C, Piazzon F, Kok F
Pediatr Nephrol 2017 Jun;32(6):1089-1092. Epub 2017 Feb 16 doi: 10.1007/s00467-017-3615-6. PMID: 28210839
Dhakal P, Bhatt VR
Bone Marrow Transplant 2017 Mar;52(3):352-356. Epub 2016 Oct 24 doi: 10.1038/bmt.2016.253. PMID: 27775697

Therapy

Keller MD, Hanley PJ, Chi YY, Aguayo-Hiraldo P, Dvorak CC, Verneris MR, Kohn DB, Pai SY, Dávila Saldaña BJ, Hanisch B, Quigg TC, Adams RH, Dahlberg A, Chandrakasan S, Hasan H, Malvar J, Jensen-Wachspress MA, Lazarski CA, Sani G, Idso JM, Lang H, Chansky P, McCann CD, Tanna J, Abraham AA, Webb JL, Shibli A, Keating AK, Satwani P, Muranski P, Hall E, Eckrich MJ, Shereck E, Miller H, Mamcarz E, Agarwal R, De Oliveira SN, Vander Lugt MT, Ebens CL, Aquino VM, Bednarski JJ, Chu J, Parikh S, Whangbo J, Lionakis M, Zambidis ET, Gourdine E, Bollard CM, Pulsipher MA
Nat Commun 2024 Apr 18;15(1):3258. doi: 10.1038/s41467-024-47057-2. PMID: 38637498Free PMC Article
Benítez Carabante MI, Bueno D, Alonso García L, López Torija I, Marsal J, Fernandez Navarro JM, Uria Oficialdegui ML, Panesso M, Molina B, Beléndez Bieler C, Palomo P, Pérez Martínez A, Diaz-de-Heredia C
Transplant Cell Ther 2024 Jun;30(6):601.e1-601.e13. Epub 2024 Mar 21 doi: 10.1016/j.jtct.2024.03.019. PMID: 38521410
Riedl Khursigara M, Chung E, Tjon J, Noone D, Chami R, Licht C, Teoh CW
Pediatr Nephrol 2023 Oct;38(10):3483-3487. Epub 2023 Mar 8 doi: 10.1007/s00467-023-05927-9. PMID: 36884075
Dhakal P, Bhatt VR
Bone Marrow Transplant 2017 Mar;52(3):352-356. Epub 2016 Oct 24 doi: 10.1038/bmt.2016.253. PMID: 27775697
Nishimura J, Yamamoto M, Hayashi S, Ohyashiki K, Ando K, Brodsky AL, Noji H, Kitamura K, Eto T, Takahashi T, Masuko M, Matsumoto T, Wano Y, Shichishima T, Shibayama H, Hase M, Li L, Johnson K, Lazarowski A, Tamburini P, Inazawa J, Kinoshita T, Kanakura Y
N Engl J Med 2014 Feb 13;370(7):632-9. doi: 10.1056/NEJMoa1311084. PMID: 24521109

Prognosis

Nakamura M, Abe T, Ochiai H
Am J Case Rep 2022 Jun 7;23:e936116. doi: 10.12659/AJCR.936116. PMID: 35671252Free PMC Article
Rassner M, Baur R, Wäsch R, Schiffer M, Schneider J, Mackensen A, Engelhardt M
BMC Nephrol 2021 Jan 18;22(1):32. doi: 10.1186/s12882-020-02226-5. PMID: 33461512Free PMC Article
Mittal A, Dijoo M, Aggarwal S, Gulati S
Iran J Kidney Dis 2019 Mar;13(2):134-138. PMID: 30988252
Neave L, Wilson AJ, Lissack M, Scully M
BMJ Case Rep 2018 Dec 13;11(1) doi: 10.1136/bcr-2018-226429. PMID: 30567234Free PMC Article
Nishimura J, Yamamoto M, Hayashi S, Ohyashiki K, Ando K, Brodsky AL, Noji H, Kitamura K, Eto T, Takahashi T, Masuko M, Matsumoto T, Wano Y, Shichishima T, Shibayama H, Hase M, Li L, Johnson K, Lazarowski A, Tamburini P, Inazawa J, Kinoshita T, Kanakura Y
N Engl J Med 2014 Feb 13;370(7):632-9. doi: 10.1056/NEJMoa1311084. PMID: 24521109

Clinical prediction guides

Chen C, Li Y, Shi P, Qian S
Blood Cancer J 2024 Nov 7;14(1):196. doi: 10.1038/s41408-024-01182-9. PMID: 39511171Free PMC Article
Schoettler ML, French K, Harris A, Bryson E, Deeb L, Hudson Z, Obordo J, Chandrakasan S, Parikh S, Watkins B, Stenger E, Qayed M, Chonat S, Westbrook A, Switchenko J, Williams KM
Am J Hematol 2024 Mar;99(3):370-379. Epub 2024 Jan 2 doi: 10.1002/ajh.27186. PMID: 38164997
Svec P, Elfeky R, Galimard JE, Higham CS, Dalissier A, Quigg TC, Bueno Sanchez D, Han Lum S, Faraci M, Cole T, Pichler H, Benítez-Carabante MI, Horakova J, Gonzalez-Vicent M, Yanir A, Fagioli F, Wölfl M, von der Weid N, Protheroe R, Krivan G, Speckmann C, James B, Avcin SL, Bertrand Y, Verna M, Riha P, Patrick K, Cesaro S, Kalwak K, Bierings M, Büchner J, Mellgren K, Prohászka Z, Neven B, Lankester A, Corbacioglu S
Bone Marrow Transplant 2023 Feb;58(2):129-141. Epub 2022 Nov 4 doi: 10.1038/s41409-022-01852-x. PMID: 36333550
Jodele S, Dandoy CE, Sabulski A, Koo J, Lane A, Myers KC, Wallace G, Chima RS, Teusink-Cross A, Hirsch R, Ryan TD, Benoit S, Davies SM
Transplant Cell Ther 2022 Jul;28(7):392.e1-392.e9. Epub 2022 Apr 29 doi: 10.1016/j.jtct.2022.04.019. PMID: 35490975Free PMC Article
Nishimura J, Yamamoto M, Hayashi S, Ohyashiki K, Ando K, Brodsky AL, Noji H, Kitamura K, Eto T, Takahashi T, Masuko M, Matsumoto T, Wano Y, Shichishima T, Shibayama H, Hase M, Li L, Johnson K, Lazarowski A, Tamburini P, Inazawa J, Kinoshita T, Kanakura Y
N Engl J Med 2014 Feb 13;370(7):632-9. doi: 10.1056/NEJMoa1311084. PMID: 24521109

Recent systematic reviews

Chen C, Li Y, Shi P, Qian S
Blood Cancer J 2024 Nov 7;14(1):196. doi: 10.1038/s41408-024-01182-9. PMID: 39511171Free PMC Article

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