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Schizophrenia 18(SCZD18)

MedGen UID:
815243
•Concept ID:
C3808913
•
Mental or Behavioral Dysfunction
Synonym: SCZD18
 
Gene (location): SLC1A1 (9p24.2)
 
Monarch Initiative: MONDO:0014092
OMIM®: 615232

Definition

A schizophrenia that has material basis in a mutation of SLC1A1 on chromosome 9p24.2. [from MONDO]

Professional guidelines

PubMed

Altered effect of dopamine transporter 3'UTR VNTR genotype on prefrontal and striatal function in schizophrenia.
Prata DP, Mechelli A, Picchioni MM, Fu CH, Toulopoulou T, Bramon E, Walshe M, Murray RM, Collier DA, McGuire P
Arch Gen Psychiatry 2009 Nov;66(11):1162-72. doi: 10.1001/archgenpsychiatry.2009.147. PMID: 19884604
Problems in the recognition and treatment of patients with dual diagnoses.
Milling RN, Faulkner LR, Craig JM
J Subst Abuse Treat 1994 May-Jun;11(3):267-71. doi: 10.1016/0740-5472(94)90085-x. PMID: 8072056

Recent clinical studies

Etiology

Identification and treatment of individuals with childhood-onset and early-onset schizophrenia.
Correll CU, Arango C, Fagerlund B, Galderisi S, Kas MJ, Leucht S
Eur Neuropsychopharmacol 2024 May;82:57-71. Epub 2024 Mar 15 doi: 10.1016/j.euroneuro.2024.02.005. PMID: 38492329
The Economic Burden of Schizophrenia in the United States.
Kadakia A, Catillon M, Fan Q, Williams GR, Marden JR, Anderson A, Kirson N, Dembek C
J Clin Psychiatry 2022 Oct 10;83(6) doi: 10.4088/JCP.22m14458. PMID: 36244006
Cigarette smoking and schizophrenia: Mendelian randomisation study.
Chen J, Chen R, Xiang S, Li N, Gao C, Wu C, Zhang Q, Zhao Y, Liao Y, Stewart R, Xu Y, Shi Y, Li Z
Br J Psychiatry 2021 Feb;218(2):98-103. doi: 10.1192/bjp.2020.116. PMID: 32552923
Global Epidemiology and Burden of Schizophrenia: Findings From the Global Burden of Disease Study 2016.
Charlson FJ, Ferrari AJ, Santomauro DF, Diminic S, Stockings E, Scott JG, McGrath JJ, Whiteford HA
Schizophr Bull 2018 Oct 17;44(6):1195-1203. doi: 10.1093/schbul/sby058. PMID: 29762765Free PMC Article
Menopause and schizophrenia.
Gupta R, Assalman I, Bottlender R
Menopause Int 2012 Mar;18(1):10-4. Epub 2012 Feb 3 doi: 10.1258/mi.2012.011116. PMID: 22308532

Diagnosis

Identification and treatment of individuals with childhood-onset and early-onset schizophrenia.
Correll CU, Arango C, Fagerlund B, Galderisi S, Kas MJ, Leucht S
Eur Neuropsychopharmacol 2024 May;82:57-71. Epub 2024 Mar 15 doi: 10.1016/j.euroneuro.2024.02.005. PMID: 38492329
What is obsession? Differentiating obsessive-compulsive disorder and the schizophrenia spectrum.
Rasmussen AR, Parnas J
Schizophr Res 2022 May;243:1-8. Epub 2022 Feb 23 doi: 10.1016/j.schres.2022.02.014. PMID: 35219003
Cystine/Glutamate Antiporter in Schizophrenia: From Molecular Mechanism to Novel Biomarker and Treatment.
Hung CC, Lin CH, Lane HY
Int J Mol Sci 2021 Sep 8;22(18) doi: 10.3390/ijms22189718. PMID: 34575878Free PMC Article
Cigarette smoking and schizophrenia: Mendelian randomisation study.
Chen J, Chen R, Xiang S, Li N, Gao C, Wu C, Zhang Q, Zhao Y, Liao Y, Stewart R, Xu Y, Shi Y, Li Z
Br J Psychiatry 2021 Feb;218(2):98-103. doi: 10.1192/bjp.2020.116. PMID: 32552923
Schizophrenia.
Marder SR, Cannon TD
N Engl J Med 2019 Oct 31;381(18):1753-1761. doi: 10.1056/NEJMra1808803. PMID: 31665579

Therapy

Identification and treatment of individuals with childhood-onset and early-onset schizophrenia.
Correll CU, Arango C, Fagerlund B, Galderisi S, Kas MJ, Leucht S
Eur Neuropsychopharmacol 2024 May;82:57-71. Epub 2024 Mar 15 doi: 10.1016/j.euroneuro.2024.02.005. PMID: 38492329
Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis.
Pillinger T, McCutcheon RA, Vano L, Mizuno Y, Arumuham A, Hindley G, Beck K, Natesan S, Efthimiou O, Cipriani A, Howes OD
Lancet Psychiatry 2020 Jan;7(1):64-77. Epub 2019 Dec 17 doi: 10.1016/S2215-0366(19)30416-X. PMID: 31860457Free PMC Article
Schizophrenia.
Marder SR, Cannon TD
N Engl J Med 2019 Oct 31;381(18):1753-1761. doi: 10.1056/NEJMra1808803. PMID: 31665579
Music therapy for people with schizophrenia and schizophrenia-like disorders.
Geretsegger M, Mössler KA, Bieleninik Ł, Chen XJ, Heldal TO, Gold C
Cochrane Database Syst Rev 2017 May 29;5(5):CD004025. doi: 10.1002/14651858.CD004025.pub4. PMID: 28553702Free PMC Article
Phenylethylamine and schizophrenia.
O'Reilly RL, Davis BA
Prog Neuropsychopharmacol Biol Psychiatry 1994 Jan;18(1):63-75. doi: 10.1016/0278-5846(94)90024-8. PMID: 7906896

Prognosis

Clinical Recovery and Long-Term Association of Specialized Early Intervention Services vs Treatment as Usual Among Individuals With First-Episode Schizophrenia Spectrum Disorder: 20-Year Follow-up of the OPUS Trial.
Hansen HG, Starzer M, Nilsson SF, Hjorthøj C, Albert N, Nordentoft M
JAMA Psychiatry 2023 Apr 1;80(4):371-379. doi: 10.1001/jamapsychiatry.2022.5164. PMID: 36811902Free PMC Article
Multimodal Machine Learning Workflows for Prediction of Psychosis in Patients With Clinical High-Risk Syndromes and Recent-Onset Depression.
Koutsouleris N, Dwyer DB, Degenhardt F, Maj C, Urquijo-Castro MF, Sanfelici R, Popovic D, Oeztuerk O, Haas SS, Weiske J, Ruef A, Kambeitz-Ilankovic L, Antonucci LA, Neufang S, Schmidt-Kraepelin C, Ruhrmann S, Penzel N, Kambeitz J, Haidl TK, Rosen M, Chisholm K, Riecher-Rössler A, Egloff L, Schmidt A, Andreou C, Hietala J, Schirmer T, Romer G, Walger P, Franscini M, Traber-Walker N, Schimmelmann BG, Flückiger R, Michel C, Rössler W, Borisov O, Krawitz PM, Heekeren K, Buechler R, Pantelis C, Falkai P, Salokangas RKR, Lencer R, Bertolino A, Borgwardt S, Noethen M, Brambilla P, Wood SJ, Upthegrove R, Schultze-Lutter F, Theodoridou A, Meisenzahl E; PRONIA Consortium
JAMA Psychiatry 2021 Feb 1;78(2):195-209. doi: 10.1001/jamapsychiatry.2020.3604. PMID: 33263726Free PMC Article
Theranostic Biomarkers for Schizophrenia.
Perkovic MN, Erjavec GN, Strac DS, Uzun S, Kozumplik O, Pivac N
Int J Mol Sci 2017 Mar 30;18(4) doi: 10.3390/ijms18040733. PMID: 28358316Free PMC Article
Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis.
Hjorthøj C, Stürup AE, McGrath JJ, Nordentoft M
Lancet Psychiatry 2017 Apr;4(4):295-301. Epub 2017 Feb 22 doi: 10.1016/S2215-0366(17)30078-0. PMID: 28237639
Differences in diagnosis and long-term course and outcome between monosymptomatic and other delusional disorders.
Retterstøl N, Opjordsmoen S
Psychopathology 1994;27(3-5):240-6. doi: 10.1159/000284876. PMID: 7846244

Clinical prediction guides

Identification and diagnosis of schizophrenia based on multichannel EEG and CNN deep learning model.
Latreche I, Slatnia S, Kazar O, Harous S, Khelili MA
Schizophr Res 2024 Sep;271:28-35. Epub 2024 Jul 14 doi: 10.1016/j.schres.2024.07.015. PMID: 39002527
Associations of the Gut Microbiome With Treatment Resistance in Schizophrenia.
Vasileva SS, Yang Y, Baker A, Siskind D, Gratten J, Eyles D
JAMA Psychiatry 2024 Mar 1;81(3):292-302. doi: 10.1001/jamapsychiatry.2023.5371. PMID: 38294805Free PMC Article
Multigenetic Pharmacogenomics-Guided Treatment vs Treatment As Usual Among Hospitalized Men With Schizophrenia: A Randomized Clinical Trial.
Kang Z, Qin Y, Sun Y, Lu Z, Sun Y, Chen H, Feng X, Zhang Y, Guo H, Yan H, Yue W
JAMA Netw Open 2023 Oct 2;6(10):e2335518. doi: 10.1001/jamanetworkopen.2023.35518. PMID: 37801319Free PMC Article
Treatment resistance in schizophrenia: a meta-analysis of prevalence and correlates.
Diniz E, Fonseca L, Rocha D, Trevizol A, Cerqueira R, Ortiz B, Brunoni AR, Bressan R, Correll CU, Gadelha A
Braz J Psychiatry 2023 Sep-Oct;45(5):448-458. Epub 2023 Sep 17 doi: 10.47626/1516-4446-2023-3126. PMID: 37718484Free PMC Article
Global Epidemiology and Burden of Schizophrenia: Findings From the Global Burden of Disease Study 2016.
Charlson FJ, Ferrari AJ, Santomauro DF, Diminic S, Stockings E, Scott JG, McGrath JJ, Whiteford HA
Schizophr Bull 2018 Oct 17;44(6):1195-1203. doi: 10.1093/schbul/sby058. PMID: 29762765Free PMC Article

Recent systematic reviews

A systematic review of physical activity and quality of life and well-being.
Marquez DX, Aguiñaga S, Vásquez PM, Conroy DE, Erickson KI, Hillman C, Stillman CM, Ballard RM, Sheppard BB, Petruzzello SJ, King AC, Powell KE
Transl Behav Med 2020 Oct 12;10(5):1098-1109. doi: 10.1093/tbm/ibz198. PMID: 33044541Free PMC Article
Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis.
Pillinger T, McCutcheon RA, Vano L, Mizuno Y, Arumuham A, Hindley G, Beck K, Natesan S, Efthimiou O, Cipriani A, Howes OD
Lancet Psychiatry 2020 Jan;7(1):64-77. Epub 2019 Dec 17 doi: 10.1016/S2215-0366(19)30416-X. PMID: 31860457Free PMC Article
Long-term outcomes of childhood sexual abuse: an umbrella review.
Hailes HP, Yu R, Danese A, Fazel S
Lancet Psychiatry 2019 Oct;6(10):830-839. Epub 2019 Sep 10 doi: 10.1016/S2215-0366(19)30286-X. PMID: 31519507Free PMC Article
New WHO prevalence estimates of mental disorders in conflict settings: a systematic review and meta-analysis.
Charlson F, van Ommeren M, Flaxman A, Cornett J, Whiteford H, Saxena S
Lancet 2019 Jul 20;394(10194):240-248. Epub 2019 Jun 12 doi: 10.1016/S0140-6736(19)30934-1. PMID: 31200992Free PMC Article
Schizophrenia and violence: systematic review and meta-analysis.
Fazel S, Gulati G, Linsell L, Geddes JR, Grann M
PLoS Med 2009 Aug;6(8):e1000120. Epub 2009 Aug 11 doi: 10.1371/journal.pmed.1000120. PMID: 19668362Free PMC Article

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