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Pulmonary hypertension, neonatal, susceptibility to(PHN)

MedGen UID:: 811528
•Concept ID:: C3714958
•: Finding

Synonym:	PHN

Gene (location): Gene(s) directly associated with this condition or phenotype.	CPS1 (2q34)

Monarch Initiative:	MONDO:0014151
OMIM®:	615371

Professional guidelines

PubMed

Impact of Changes in Early Respiratory Support Management on Respiratory Outcomes of Preterm Infants.

Xie L, Luo X, Li B, Du L, Wang Z, Liu Y, Chen J, Duan S, Yan L, Gao W
Respir Care 2022 Oct;67(10):1310-1319. Epub 2022 Jun 28 doi: 10.4187/respcare.09963. PMID: 35764345

Characteristics and treatment outcomes of patients with MDR and XDR tuberculosis in a TB referral hospital in Beijing: a 13-year experience.

Liu CH, Li L, Chen Z, Wang Q, Hu YL, Zhu B, Woo PC
PLoS One 2011 Apr 29;6(4):e19399. doi: 10.1371/journal.pone.0019399. PMID: 21559362 Free PMC Article

Pathophysiology and treatment of bronchopulmonary dysplasia. Current issues.

Abman SH, Groothius JR
Pediatr Clin North Am 1994 Apr;41(2):277-315. doi: 10.1016/s0031-3955(16)38726-0. PMID: 8139877

See all (3)

Recent clinical studies

Etiology

Short- and Long-Term Complications of Bronchopulmonary Dysplasia.

Homan TD, Nayak RP
Respir Care 2021 Oct;66(10):1618-1629. doi: 10.4187/respcare.08401. PMID: 34552015

Cardiovascular impact and sequelae of bronchopulmonary dysplasia.

Yallapragada SG, Savani RC, Goss KN
Pediatr Pulmonol 2021 Nov;56(11):3453-3463. Epub 2021 Mar 23 doi: 10.1002/ppul.25370. PMID: 33756045

The COVID-19 pandemic: a global health crisis.

Pollard CA, Morran MP, Nestor-Kalinoski AL
Physiol Genomics 2020 Nov 1;52(11):549-557. Epub 2020 Sep 29 doi: 10.1152/physiolgenomics.00089.2020. PMID: 32991251 Free PMC Article

Vascular abnormalities in human newborns with pulmonary hypertension.

Sluiter I, Reiss I, Kraemer U, Krijger Rd, Tibboel D, Rottier RJ
Expert Rev Respir Med 2011 Apr;5(2):245-56. doi: 10.1586/ers.11.8. PMID: 21510734

Pathogenesis of bronchopulmonary dysplasia.

Hayes D Jr, Feola DJ, Murphy BS, Shook LA, Ballard HO
Respiration 2010;79(5):425-36. Epub 2009 Sep 25 doi: 10.1159/000242497. PMID: 19786727

See all (32)

Diagnosis

Pulmonary Hypertension in Established Bronchopulmonary Dysplasia: Physiologic Approaches to Clinical Care.

Abman SH, Lakshminrusimha S
Clin Perinatol 2024 Mar;51(1):195-216. Epub 2024 Jan 9 doi: 10.1016/j.clp.2023.12.002. PMID: 38325941

Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia.

Sun F, Wang G, Pradhan A, Xu K, Gomez-Arroyo J, Zhang Y, Kalin GT, Deng Z, Vagnozzi RJ, He H, Dunn AW, Wang Y, York AJ, Hegde RS, Woods JC, Kalin TV, Molkentin JD, Kalinichenko VV
Circulation 2021 Aug 17;144(7):539-555. Epub 2021 Jun 11 doi: 10.1161/CIRCULATIONAHA.121.053980. PMID: 34111939 Free PMC Article

Epigenetic regulation of insulin-like growth factor signaling: A novel insight into the pathophysiology of neonatal pulmonary hypertension.

Madonna R, De Caterina R, Geng YJ
Vascul Pharmacol 2015 Oct;73:4-7. Epub 2015 Aug 5 doi: 10.1016/j.vph.2015.08.002. PMID: 26254106

Pulmonary arterial hypertension in women.

Sanchez O, Marié E, Lerolle U, Wermert D, Israël-Biet D, Meyer G
Rev Mal Respir 2010 Oct;27(8):e79-87. Epub 2010 May 13 doi: 10.1016/j.rmr.2009.12.001. PMID: 20965396

Perinatal asphyxia, hypoxia, ischemia and hearing loss. An overview.

Borg E
Scand Audiol 1997;26(2):77-91. doi: 10.3109/01050399709074979. PMID: 9187000

See all (27)

Therapy

Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia.

The COVID-19 pandemic: a global health crisis.

Pollard CA, Morran MP, Nestor-Kalinoski AL
Physiol Genomics 2020 Nov 1;52(11):549-557. Epub 2020 Sep 29 doi: 10.1152/physiolgenomics.00089.2020. PMID: 32991251 Free PMC Article

Pulmonary arterial hypertension in children after neonatal arterial switch operation.

Zijlstra WM, Elmasry O, Pepplinkhuizen S, Ivy DD, Bonnet D, Luijendijk P, Lévy M, Gavilan JL, Torrent-Vernetta A, Mendoza A, Del Cerro MJ, Moledina S, Berger RM
Heart 2017 Aug;103(16):1244-1249. Epub 2017 Jan 23 doi: 10.1136/heartjnl-2016-310624. PMID: 28115472

Pulmonary arterial hypertension in women.

Sanchez O, Marié E, Lerolle U, Wermert D, Israël-Biet D, Meyer G
Rev Mal Respir 2010 Oct;27(8):e79-87. Epub 2010 May 13 doi: 10.1016/j.rmr.2009.12.001. PMID: 20965396

Pathogenesis of bronchopulmonary dysplasia.

Hayes D Jr, Feola DJ, Murphy BS, Shook LA, Ballard HO
Respiration 2010;79(5):425-36. Epub 2009 Sep 25 doi: 10.1159/000242497. PMID: 19786727

See all (21)

Prognosis

Pulmonary Hypertension in Established Bronchopulmonary Dysplasia: Physiologic Approaches to Clinical Care.

Abman SH, Lakshminrusimha S
Clin Perinatol 2024 Mar;51(1):195-216. Epub 2024 Jan 9 doi: 10.1016/j.clp.2023.12.002. PMID: 38325941

Pulmonary arterial hypertension in children after neonatal arterial switch operation.

Epigenetic regulation of insulin-like growth factor signaling: A novel insight into the pathophysiology of neonatal pulmonary hypertension.

Madonna R, De Caterina R, Geng YJ
Vascul Pharmacol 2015 Oct;73:4-7. Epub 2015 Aug 5 doi: 10.1016/j.vph.2015.08.002. PMID: 26254106

Developmental and genetic aspects of congenital diaphragmatic hernia.

Veenma DC, de Klein A, Tibboel D
Pediatr Pulmonol 2012 Jun;47(6):534-45. Epub 2012 Mar 29 doi: 10.1002/ppul.22553. PMID: 22467525

Pulmonary arterial hypertension in women.

Sanchez O, Marié E, Lerolle U, Wermert D, Israël-Biet D, Meyer G
Rev Mal Respir 2010 Oct;27(8):e79-87. Epub 2010 May 13 doi: 10.1016/j.rmr.2009.12.001. PMID: 20965396

See all (24)

Clinical prediction guides

Vascular Disorders of Pregnancy Increase Susceptibility to Neonatal Pulmonary Hypertension in High-Altitude Populations.

Heath-Freudenthal A, Toledo-Jaldin L, von Alvensleben I, Lazo-Vega L, Mizutani R, Stalker M, Yasini H, Mendizabal F, Dorado Madera J, Mundo W, Castro-Monrroy M, Houck JA, Moreno-Aramayo A, Miranda-Garrido V, Su EJ, Giussani DA, Abman SH, Moore LG, Julian CG
Hypertension 2022 Jun;79(6):1286-1296. Epub 2022 Apr 19 doi: 10.1161/HYPERTENSIONAHA.122.19078. PMID: 35437031 Free PMC Article

Short- and Long-Term Complications of Bronchopulmonary Dysplasia.

Homan TD, Nayak RP
Respir Care 2021 Oct;66(10):1618-1629. doi: 10.4187/respcare.08401. PMID: 34552015

Sex and Gender Differences in Lung Disease.

Silveyra P, Fuentes N, Rodriguez Bauza DE
Adv Exp Med Biol 2021;1304:227-258. doi: 10.1007/978-3-030-68748-9_14. PMID: 34019273 Free PMC Article

EDN1 Gene Variant is Associated with Neonatal Persistent Pulmonary Hypertension.

Mei M, Cheng G, Sun B, Yang L, Wang H, Sun J, Zhou W
Sci Rep 2016 Jul 18;6:29877. doi: 10.1038/srep29877. PMID: 27425626 Free PMC Article

Developmental and genetic aspects of congenital diaphragmatic hernia.

Veenma DC, de Klein A, Tibboel D
Pediatr Pulmonol 2012 Jun;47(6):534-45. Epub 2012 Mar 29 doi: 10.1002/ppul.22553. PMID: 22467525

See all (18)