U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Multiple sclerosis, susceptibility to, 5(MS5)

MedGen UID:
766642
Concept ID:
C3553728
Finding
Synonym: MS5
 
Gene (location): TNFRSF1A (12p13.31)
 
Monarch Initiative: MONDO:0013893
OMIM®: 614810

Definition

Multiple sclerosis-5 (MS5) is a chronic inflammatory disease of the central nervous system characterized by damage to axonal myelin sheaths and axons, commonly resulting in progressive neurologic disability beginning in early adulthood (summary by Xu et al., 2001). For a discussion of genetic heterogeneity of multiple sclerosis, see MS1 (126200). [from OMIM]

Professional guidelines

PubMed

An Q, Fan CH, Xu SM
Eur Rev Med Pharmacol Sci 2018 Sep;22(17):5747-5754. doi: 10.26355/eurrev_201809_15843. PMID: 30229853
Gordon PH
CNS Drugs 2011 Jan;25(1):1-15. doi: 10.2165/11586000-000000000-00000. PMID: 21128691
Costello K, Sipe JC
J Neurosci Nurs 2008 Oct;40(5):275-80. doi: 10.1097/01376517-200810000-00005. PMID: 18856248

Curated

UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

Recent clinical studies

Etiology

Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N; University of California San Francisco MS-EPIC Team, Schaefer CA, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR
Brain 2023 Feb 13;146(2):645-656. doi: 10.1093/brain/awac092. PMID: 35253861Free PMC Article
Hemond CC, Reich DS, Dundamadappa SK
AJR Am J Roentgenol 2022 Jul;219(1):120-131. Epub 2021 Dec 1 doi: 10.2214/AJR.21.26777. PMID: 34851712Free PMC Article
Voskuhl RR
Mult Scler 2020 Apr;26(5):554-560. Epub 2020 Jan 22 doi: 10.1177/1352458519892491. PMID: 31965884Free PMC Article
Zurawski J, Stankiewicz J
Am J Med 2018 May;131(5):464-472. Epub 2017 Dec 21 doi: 10.1016/j.amjmed.2017.11.044. PMID: 29274753
International Multiple Sclerosis Genetics Consortium (IMSGC), Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, Oturai A, Saarela J, Fontaine B, Hemmer B, Martin C, Zipp F, D'Alfonso S, Martinelli-Boneschi F, Taylor B, Harbo HF, Kockum I, Hillert J, Olsson T, Ban M, Oksenberg JR, Hintzen R, Barcellos LF; Wellcome Trust Case Control Consortium 2 (WTCCC2); International IBD Genetics Consortium (IIBDGC), Agliardi C, Alfredsson L, Alizadeh M, Anderson C, Andrews R, Søndergaard HB, Baker A, Band G, Baranzini SE, Barizzone N, Barrett J, Bellenguez C, Bergamaschi L, Bernardinelli L, Berthele A, Biberacher V, Binder TM, Blackburn H, Bomfim IL, Brambilla P, Broadley S, Brochet B, Brundin L, Buck D, Butzkueven H, Caillier SJ, Camu W, Carpentier W, Cavalla P, Celius EG, Coman I, Comi G, Corrado L, Cosemans L, Cournu-Rebeix I, Cree BA, Cusi D, Damotte V, Defer G, Delgado SR, Deloukas P, di Sapio A, Dilthey AT, Donnelly P, Dubois B, Duddy M, Edkins S, Elovaara I, Esposito F, Evangelou N, Fiddes B, Field J, Franke A, Freeman C, Frohlich IY, Galimberti D, Gieger C, Gourraud PA, Graetz C, Graham A, Grummel V, Guaschino C, Hadjixenofontos A, Hakonarson H, Halfpenny C, Hall G, Hall P, Hamsten A, Harley J, Harrower T, Hawkins C, Hellenthal G, Hillier C, Hobart J, Hoshi M, Hunt SE, Jagodic M, Jelčić I, Jochim A, Kendall B, Kermode A, Kilpatrick T, Koivisto K, Konidari I, Korn T, Kronsbein H, Langford C, Larsson M, Lathrop M, Lebrun-Frenay C, Lechner-Scott J, Lee MH, Leone MA, Leppä V, Liberatore G, Lie BA, Lill CM, Lindén M, Link J, Luessi F, Lycke J, Macciardi F, Männistö S, Manrique CP, Martin R, Martinelli V, Mason D, Mazibrada G, McCabe C, Mero IL, Mescheriakova J, Moutsianas L, Myhr KM, Nagels G, Nicholas R, Nilsson P, Piehl F, Pirinen M, Price SE, Quach H, Reunanen M, Robberecht W, Robertson NP, Rodegher M, Rog D, Salvetti M, Schnetz-Boutaud NC, Sellebjerg F, Selter RC, Schaefer C, Shaunak S, Shen L, Shields S, Siffrin V, Slee M, Sorensen PS, Sorosina M, Sospedra M, Spurkland A, Strange A, Sundqvist E, Thijs V, Thorpe J, Ticca A, Tienari P, van Duijn C, Visser EM, Vucic S, Westerlind H, Wiley JS, Wilkins A, Wilson JF, Winkelmann J, Zajicek J, Zindler E, Haines JL, Pericak-Vance MA, Ivinson AJ, Stewart G, Hafler D, Hauser SL, Compston A, McVean G, De Jager P, Sawcer SJ, McCauley JL
Nat Genet 2013 Nov;45(11):1353-60. Epub 2013 Sep 29 doi: 10.1038/ng.2770. PMID: 24076602Free PMC Article

Diagnosis

Ali FHM, Smatti MK, Elrayess MA, Al Thani AA, Yassine HM
Eur Rev Med Pharmacol Sci 2023 Sep;27(18):8463-8485. doi: 10.26355/eurrev_202309_33772. PMID: 37782163
Rahmanzadeh R, Galbusera R, Lu PJ, Bahn E, Weigel M, Barakovic M, Franz J, Nguyen TD, Spincemaille P, Schiavi S, Daducci A, La Rosa F, Absinta M, Sati P, Bach Cuadra M, Radue EW, Leppert D, Kuhle J, Kappos L, Brück W, Reich DS, Stadelmann C, Wang Y, Granziera C
Ann Neurol 2022 Sep;92(3):486-502. Epub 2022 Jul 13 doi: 10.1002/ana.26441. PMID: 35713309Free PMC Article
Rodríguez-Salgado P, García-Romero MT
Gac Med Mex 2019;155(5):522-531. doi: 10.24875/GMM.18004288. PMID: 31695234
Zurawski J, Stankiewicz J
Am J Med 2018 May;131(5):464-472. Epub 2017 Dec 21 doi: 10.1016/j.amjmed.2017.11.044. PMID: 29274753
Yeh EA, Chitnis T, Krupp L, Ness J, Chabas D, Kuntz N, Waubant E; US Network of Pediatric Multiple Sclerosis Centers of Excellence
Nat Rev Neurol 2009 Nov;5(11):621-31. Epub 2009 Oct 13 doi: 10.1038/nrneurol.2009.158. PMID: 19826402

Therapy

Louis S, Carlson AK, Suresh A, Rim J, Mays M, Ontaneda D, Dhawan A
Neurology 2023 Mar 7;100(10):474-483. Epub 2022 Nov 16 doi: 10.1212/WNL.0000000000201630. PMID: 36384657Free PMC Article
Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N; University of California San Francisco MS-EPIC Team, Schaefer CA, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR
Brain 2023 Feb 13;146(2):645-656. doi: 10.1093/brain/awac092. PMID: 35253861Free PMC Article
Voskuhl RR
Mult Scler 2020 Apr;26(5):554-560. Epub 2020 Jan 22 doi: 10.1177/1352458519892491. PMID: 31965884Free PMC Article
Zurawski J, Stankiewicz J
Am J Med 2018 May;131(5):464-472. Epub 2017 Dec 21 doi: 10.1016/j.amjmed.2017.11.044. PMID: 29274753
Yeh EA, Chitnis T, Krupp L, Ness J, Chabas D, Kuntz N, Waubant E; US Network of Pediatric Multiple Sclerosis Centers of Excellence
Nat Rev Neurol 2009 Nov;5(11):621-31. Epub 2009 Oct 13 doi: 10.1038/nrneurol.2009.158. PMID: 19826402

Prognosis

Chen L, Wang F, Zhang H, Cao B
Sci Rep 2024 Jan 18;14(1):1557. doi: 10.1038/s41598-024-51903-0. PMID: 38238429Free PMC Article
Zurawski J, Stankiewicz J
Am J Med 2018 May;131(5):464-472. Epub 2017 Dec 21 doi: 10.1016/j.amjmed.2017.11.044. PMID: 29274753
Zostawa J, Adamczyk J, Sowa P, Adamczyk-Sowa M
Neurol Sci 2017 Mar;38(3):389-398. Epub 2017 Jan 11 doi: 10.1007/s10072-016-2802-8. PMID: 28078565Free PMC Article
Goodin DS
Handb Clin Neurol 2016;138:173-206. doi: 10.1016/B978-0-12-802973-2.00011-2. PMID: 27637959
Chitnis T, Krupp L, Yeh A, Rubin J, Kuntz N, Strober JB, Chabas D, Weinstock-Guttmann B, Ness J, Rodriguez M, Waubant E
Neurol Clin 2011 May;29(2):481-505. doi: 10.1016/j.ncl.2011.01.004. PMID: 21439455

Clinical prediction guides

Chen L, Wang F, Zhang H, Cao B
Sci Rep 2024 Jan 18;14(1):1557. doi: 10.1038/s41598-024-51903-0. PMID: 38238429Free PMC Article
Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N; University of California San Francisco MS-EPIC Team, Schaefer CA, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR
Brain 2023 Feb 13;146(2):645-656. doi: 10.1093/brain/awac092. PMID: 35253861Free PMC Article
Voskuhl RR
Mult Scler 2020 Apr;26(5):554-560. Epub 2020 Jan 22 doi: 10.1177/1352458519892491. PMID: 31965884Free PMC Article
Patsopoulos NA, De Jager PL
Mult Scler 2020 Apr;26(5):576-581. Epub 2020 Jan 22 doi: 10.1177/1352458519898332. PMID: 31965883
Goodin DS
Handb Clin Neurol 2016;138:173-206. doi: 10.1016/B978-0-12-802973-2.00011-2. PMID: 27637959

Recent systematic reviews

Reeves JA, Mohebbi M, Zivadinov R, Bergsland N, Dwyer MG, Salman F, Schweser F, Jakimovski D
Mult Scler Relat Disord 2023 Nov;79:104968. Epub 2023 Sep 14 doi: 10.1016/j.msard.2023.104968. PMID: 37716210Free PMC Article
De Silvestri A, Capittini C, Mallucci G, Bergamaschi R, Rebuffi C, Pasi A, Martinetti M, Tinelli C
Dis Markers 2019;2019:1409069. Epub 2019 Nov 6 doi: 10.1155/2019/1409069. PMID: 31781296Free PMC Article
Zhang Y, Zhang J, Liu H, He F, Chen A, Yang H, Pi B
Medicine (Baltimore) 2019 Sep;98(38):e17224. doi: 10.1097/MD.0000000000017224. PMID: 31567981Free PMC Article
Zhao S, Wang J, Liu Y, Luo L, Zhu Z, Li E, Zhao Z
J Sex Med 2018 Dec;15(12):1716-1727. Epub 2018 Nov 2 doi: 10.1016/j.jsxm.2018.09.016. PMID: 30393105
Belbasis L, Bellou V, Evangelou E, Ioannidis JP, Tzoulaki I
Lancet Neurol 2015 Mar;14(3):263-73. Epub 2015 Feb 4 doi: 10.1016/S1474-4422(14)70267-4. PMID: 25662901

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...