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Candidiasis, familial, 6(CANDF6)

MedGen UID:
462755
•Concept ID:
C3151405
•
Disease or Syndrome
Synonyms: CANDF6; Candidiasis, familial, 6, autosomal dominant
 
Gene (location): IL17F (6p12.2)
 
Monarch Initiative: MONDO:0013503
OMIM®: 613956

Definition

Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17F gene. [from MONDO]

Clinical features

From HPO
Chronic mucocutaneous candidiasis
MedGen UID:
2426
•Concept ID:
C0006845
•
Disease or Syndrome
Recurrent or persistent superficial Candida infections of the skin, mucous membranes, and nails.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Integrating Clinical and Microbiological Expertise to Improve Vaginal Candidiasis Management.
Karakoyun AS, Unal N, Sucu M, Bingöl O, Unal I, Ilkit M
Mycopathologia 2024 Nov 8;189(6):96. doi: 10.1007/s11046-024-00904-8. PMID: 39514006
Survey of healthcare providers' testing practices for vulvovaginal candidiasis and treatment outcomes-United States, 2021.
Benedict K, Moret R, Molinari NAM, Jackson BR
PLoS One 2022;17(12):e0278630. Epub 2022 Dec 30 doi: 10.1371/journal.pone.0278630. PMID: 36584109Free PMC Article
ACOG Practice Bulletin No. 117: Gynecologic care for women with human immunodeficiency virus.
Obstet Gynecol 2010 Dec;116(6):1492-1509. doi: 10.1097/AOG.0b013e3182054cae. PMID: 21099636

Recent clinical studies

Etiology

Global incidence and mortality of severe fungal disease.
Denning DW
Lancet Infect Dis 2024 Jul;24(7):e428-e438. Epub 2024 Jan 12 doi: 10.1016/S1473-3099(23)00692-8. PMID: 38224705
ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [II]: agents targeting interleukins, immunoglobulins and complement factors).
Winthrop KL, Mariette X, Silva JT, Benamu E, Calabrese LH, Dumusc A, Smolen JS, Aguado JM, Fernández-Ruiz M
Clin Microbiol Infect 2018 Jun;24 Suppl 2:S21-S40. Epub 2018 Feb 12 doi: 10.1016/j.cmi.2018.02.002. PMID: 29447987
Recurrent vaginal candidiasis.
Loh KY, Sivalingam N
Med J Malaysia 2003 Dec;58(5):788-92. PMID: 15190674
New and old immunodeficiencies.
Stiehm ER
Pediatr Res 1993 Jan;33(1 Suppl):S2-7; discussion S7-8. doi: 10.1203/00006450-199305001-00007. PMID: 8433870
Fungal vulvovaginitis.
Maccato ML, Kaufman RH
Curr Opin Obstet Gynecol 1991 Dec;3(6):849-52. PMID: 1818723

Diagnosis

Immunological Evaluation of Pediatric Patients with Polyautoimmunity.
Mahdavi FS, Tavakol M, Aghamahdi F, Sadri H, Chavoshzadeh Z, Jamee M, Noorian S, Alaei MR, Ashkevari P, Anaya JM, Abolhassani H, Ochs HD, Azizi G
Endocr Metab Immune Disord Drug Targets 2024;24(7):798-807. doi: 10.2174/1871530323666230912124951. PMID: 37702233
Multicenter Prospective Study of Biomarkers for Diagnosis of Invasive Candidiasis in Children and Adolescents.
Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, Yin DE, Huppler AR, Danziger-Isakov L, Muller WJ, Roilides E, Romero J, Sue PK, Berman D, Wattier RL, Halasa N, Pong A, Maron G, Soler-Palacin P, Hutto SC, Gonzalez BE, Salvatore CM, Rajan S, Green M, Doby Knackstedt E, Hauger SB, Steinbach WJ
Clin Infect Dis 2022 Aug 25;75(2):248-259. doi: 10.1093/cid/ciab928. PMID: 35134165Free PMC Article
Resistant pathogens, fungi, and viruses.
Guidry CA, Mansfield SA, Sawyer RG, Cook CH
Surg Clin North Am 2014 Dec;94(6):1195-218. Epub 2014 Oct 3 doi: 10.1016/j.suc.2014.08.010. PMID: 25440119Free PMC Article
Infectious endophthalmitis.
Pflugfelder SC, Flynn HW Jr
Infect Dis Clin North Am 1992 Dec;6(4):859-73. PMID: 1460267
Fungal vulvovaginitis.
Maccato ML, Kaufman RH
Curr Opin Obstet Gynecol 1991 Dec;3(6):849-52. PMID: 1818723

Therapy

ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [II]: agents targeting interleukins, immunoglobulins and complement factors).
Winthrop KL, Mariette X, Silva JT, Benamu E, Calabrese LH, Dumusc A, Smolen JS, Aguado JM, Fernández-Ruiz M
Clin Microbiol Infect 2018 Jun;24 Suppl 2:S21-S40. Epub 2018 Feb 12 doi: 10.1016/j.cmi.2018.02.002. PMID: 29447987
Recurrent vulvovaginal candidiasis.
Belayneh M, Sehn E, Korownyk C
Can Fam Physician 2017 Jun;63(6):455. PMID: 28615397Free PMC Article
Resistant pathogens, fungi, and viruses.
Guidry CA, Mansfield SA, Sawyer RG, Cook CH
Surg Clin North Am 2014 Dec;94(6):1195-218. Epub 2014 Oct 3 doi: 10.1016/j.suc.2014.08.010. PMID: 25440119Free PMC Article
Infectious endophthalmitis.
Pflugfelder SC, Flynn HW Jr
Infect Dis Clin North Am 1992 Dec;6(4):859-73. PMID: 1460267
Fungal vulvovaginitis.
Maccato ML, Kaufman RH
Curr Opin Obstet Gynecol 1991 Dec;3(6):849-52. PMID: 1818723

Prognosis

Global incidence and mortality of severe fungal disease.
Denning DW
Lancet Infect Dis 2024 Jul;24(7):e428-e438. Epub 2024 Jan 12 doi: 10.1016/S1473-3099(23)00692-8. PMID: 38224705
Multicenter Prospective Study of Biomarkers for Diagnosis of Invasive Candidiasis in Children and Adolescents.
Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, Yin DE, Huppler AR, Danziger-Isakov L, Muller WJ, Roilides E, Romero J, Sue PK, Berman D, Wattier RL, Halasa N, Pong A, Maron G, Soler-Palacin P, Hutto SC, Gonzalez BE, Salvatore CM, Rajan S, Green M, Doby Knackstedt E, Hauger SB, Steinbach WJ
Clin Infect Dis 2022 Aug 25;75(2):248-259. doi: 10.1093/cid/ciab928. PMID: 35134165Free PMC Article
Oral Candida Predicts Streptococcus mutans Emergence in Underserved US Infants.
Alkhars N, Zeng Y, Alomeir N, Al Jallad N, Wu TT, Aboelmagd S, Youssef M, Jang H, Fogarty C, Xiao J
J Dent Res 2022 Jan;101(1):54-62. Epub 2021 May 21 doi: 10.1177/00220345211012385. PMID: 34018817Free PMC Article
Recurrent vaginal candidiasis.
Loh KY, Sivalingam N
Med J Malaysia 2003 Dec;58(5):788-92. PMID: 15190674
Infectious endophthalmitis.
Pflugfelder SC, Flynn HW Jr
Infect Dis Clin North Am 1992 Dec;6(4):859-73. PMID: 1460267

Clinical prediction guides

Multicenter Prospective Study of Biomarkers for Diagnosis of Invasive Candidiasis in Children and Adolescents.
Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, Yin DE, Huppler AR, Danziger-Isakov L, Muller WJ, Roilides E, Romero J, Sue PK, Berman D, Wattier RL, Halasa N, Pong A, Maron G, Soler-Palacin P, Hutto SC, Gonzalez BE, Salvatore CM, Rajan S, Green M, Doby Knackstedt E, Hauger SB, Steinbach WJ
Clin Infect Dis 2022 Aug 25;75(2):248-259. doi: 10.1093/cid/ciab928. PMID: 35134165Free PMC Article
Vulvovaginal candidiasis: species distribution of Candida and their antifungal susceptibility pattern.
Bitew A, Abebaw Y
BMC Womens Health 2018 Jun 15;18(1):94. doi: 10.1186/s12905-018-0607-z. PMID: 29902998Free PMC Article
ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [II]: agents targeting interleukins, immunoglobulins and complement factors).
Winthrop KL, Mariette X, Silva JT, Benamu E, Calabrese LH, Dumusc A, Smolen JS, Aguado JM, Fernández-Ruiz M
Clin Microbiol Infect 2018 Jun;24 Suppl 2:S21-S40. Epub 2018 Feb 12 doi: 10.1016/j.cmi.2018.02.002. PMID: 29447987
Prevalence and risk factors of trichomoniasis, bacterial vaginosis, and candidiasis for married women of child-bearing age in rural Shandong.
Fang X, Zhou Y, Yang Y, Diao Y, Li H
Jpn J Infect Dis 2007 Sep;60(5):257-61. PMID: 17881863
New and old immunodeficiencies.
Stiehm ER
Pediatr Res 1993 Jan;33(1 Suppl):S2-7; discussion S7-8. doi: 10.1203/00006450-199305001-00007. PMID: 8433870

Recent systematic reviews

Candida parapsilosis: A systematic review to inform the World Health Organization fungal priority pathogens list.
Asogan M, Kim HY, Kidd S, Alastruey-Izquierdo A, Govender NP, Dao A, Shin JH, Heim J, Ford NP, Gigante V, Sati H, Morrissey CO, Alffenaar JW, Beardsley J
Med Mycol 2024 Jun 27;62(6) doi: 10.1093/mmy/myad131. PMID: 38935912Free PMC Article
Screening for Bacterial Vaginosis in Pregnant Adolescents and Women to Prevent Preterm Delivery: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
Kahwati LC, Clark R, Berkman N, Urrutia R, Patel SV, Zeng J, Viswanathan M
JAMA 2020 Apr 7;323(13):1293-1309. doi: 10.1001/jama.2020.0233. PMID: 32259235

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