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Early repolarization associated with ventricular fibrillation

MedGen UID:: 462202
•Concept ID:: C3150852
•: Disease or Syndrome

Synonyms:	EARLY REPOLARIZATION ASSOCIATED WITH VENTRICULAR FIBRILLATION; EARLY REPOLARIZATION SYNDROME

Monarch Initiative:	MONDO:0013318
OMIM®:	613601

Definition

Electrocardiographic (ECG) early repolarization, defined as an elevation of the QRS-ST junction (J-point) of at least 1.0 mm (0.1 mV) from baseline in the inferior or lateral lead, manifest as QRS slurring or notching, is a common ECG finding that is generally considered to be benign but may be associated with ventricular fibrillation in some patients (summary by Haissaguerre et al., 2008). [from OMIM]

Professional guidelines

PubMed

Management of ventricular electrical storm: a contemporary appraisal.

Kowlgi GN, Cha YM
Europace 2020 Dec 23;22(12):1768-1780. doi: 10.1093/europace/euaa232. PMID: 32984880

Diagnosis and management of patients with inherited arrhythmia syndromes in Europe: results of the European Heart Rhythm Association Survey.

Hocini M, Pison L, Proclemer A, Larsen TB, Madrid A, Blomström-Lundqvist C; Scientific Initiative Committee, European Heart Rhythm Association
Europace 2014 Apr;16(4):600-3. doi: 10.1093/europace/euu074. PMID: 24711616

ECG repolarization syndrome abnormalities (J wave syndromes) and idiopathic ventricular fibrillation: diagnostic and management.

Lévy S, Sbragia P
J Interv Card Electrophysiol 2011 Dec;32(3):181-6. Epub 2011 Jul 21 doi: 10.1007/s10840-011-9597-6. PMID: 21833514

See all (6)

Recent clinical studies

Etiology

Clinical aspects of inherited J-wave syndromes.

Huikuri HV, Juhani Junttila M
Trends Cardiovasc Med 2015 Jan;25(1):24-30. Epub 2014 Sep 6 doi: 10.1016/j.tcm.2014.08.008. PMID: 25442737

A practical guide to early repolarization.

Adler A, Gollob MH
Curr Opin Cardiol 2015 Jan;30(1):8-16. doi: 10.1097/HCO.0000000000000126. PMID: 25389652

Early repolarization pattern: its ECG characteristics, arrhythmogeneity and heritability.

Mizusawa Y, Bezzina CR
J Interv Card Electrophysiol 2014 Apr;39(3):185-92. Epub 2014 Feb 16 doi: 10.1007/s10840-013-9870-y. PMID: 24532112

Early repolarization syndrome: electrocardiographic signs and clinical implications.

Rezus C, Floria M, Moga VD, Sirbu O, Dima N, Ionescu SD, Ambarus V
Ann Noninvasive Electrocardiol 2014 Jan;19(1):15-22. Epub 2013 Sep 30 doi: 10.1111/anec.12113. PMID: 24118137 Free PMC Article

J wave syndromes.

Antzelevitch C, Yan GX
Heart Rhythm 2010 Apr;7(4):549-58. Epub 2009 Dec 11 doi: 10.1016/j.hrthm.2009.12.006. PMID: 20153265 Free PMC Article

See all (142)

Diagnosis

Nogami A, Komatsu Y, Talib AK, Phanthawimol W, Naeemah QJ, Haruna T, Morishima I
JACC Clin Electrophysiol 2023 Oct;9(10):2172-2196. Epub 2023 Jul 26 doi: 10.1016/j.jacep.2023.05.040. PMID: 37498247

Diagnostic and prognostic role of electrocardiogram in acute myocarditis: A comprehensive review.

Buttà C, Zappia L, Laterra G, Roberto M
Ann Noninvasive Electrocardiol 2020 May;25(3) Epub 2019 Nov 28 doi: 10.1111/anec.12726. PMID: 31778001 Free PMC Article

Arrhythmias due to Inherited and Acquired Abnormalities of Ventricular Repolarization.

Locati ET, Bagliani G, Cecchi F, Johny H, Lunati M, Pappone C
Card Electrophysiol Clin 2019 Jun;11(2):345-362. Epub 2019 Apr 10 doi: 10.1016/j.ccep.2019.02.009. PMID: 31084855

Clinical aspects of inherited J-wave syndromes.

Huikuri HV, Juhani Junttila M
Trends Cardiovasc Med 2015 Jan;25(1):24-30. Epub 2014 Sep 6 doi: 10.1016/j.tcm.2014.08.008. PMID: 25442737

J wave syndromes.

Antzelevitch C, Yan GX
Heart Rhythm 2010 Apr;7(4):549-58. Epub 2009 Dec 11 doi: 10.1016/j.hrthm.2009.12.006. PMID: 20153265 Free PMC Article

See all (108)

Therapy

Androgens, QT, sex and ventricular repolarization-a double-edged sword: A case series.

Moey MYY, Wilkin M, Gandjbakhch E, Bachelot A, Abbar B, Pinna B, Simon JM, Funck-Brentano C, Salem JE
Therapie 2022 May-Jun;77(3):265-271. Epub 2021 Oct 24 doi: 10.1016/j.therap.2021.10.008. PMID: 34895755

Pharmacotherapy in inherited and acquired ventricular arrhythmia in structurally normal adult hearts.

Ortmans S, Daval C, Aguilar M, Compagno P, Cadrin-Tourigny J, Dyrda K, Rivard L, Tadros R
Expert Opin Pharmacother 2019 Dec;20(17):2101-2114. Epub 2019 Sep 30 doi: 10.1080/14656566.2019.1669561. PMID: 31566420

Clinical aspects of inherited J-wave syndromes.

Huikuri HV, Juhani Junttila M
Trends Cardiovasc Med 2015 Jan;25(1):24-30. Epub 2014 Sep 6 doi: 10.1016/j.tcm.2014.08.008. PMID: 25442737

A practical guide to early repolarization.

Adler A, Gollob MH
Curr Opin Cardiol 2015 Jan;30(1):8-16. doi: 10.1097/HCO.0000000000000126. PMID: 25389652

A clinical approach to early repolarization.

Obeyesekere MN, Klein GJ, Nattel S, Leong-Sit P, Gula LJ, Skanes AC, Yee R, Krahn AD
Circulation 2013 Apr 16;127(15):1620-9. doi: 10.1161/CIRCULATIONAHA.112.143149. PMID: 23588960

See all (43)

Prognosis

Diagnostic and prognostic role of electrocardiogram in acute myocarditis: A comprehensive review.

Buttà C, Zappia L, Laterra G, Roberto M
Ann Noninvasive Electrocardiol 2020 May;25(3) Epub 2019 Nov 28 doi: 10.1111/anec.12726. PMID: 31778001 Free PMC Article

Early repolarization is involved in ventricular fibrillation in patients with variant angina.

Shinohara T, Kondo H, Fukui A, Akioka H, Teshima Y, Yufu K, Nakagawa M, Takahashi N
Pacing Clin Electrophysiol 2018 Jul;41(7):734-740. Epub 2018 May 22 doi: 10.1111/pace.13355. PMID: 29667218

A practical guide to early repolarization.

Adler A, Gollob MH
Curr Opin Cardiol 2015 Jan;30(1):8-16. doi: 10.1097/HCO.0000000000000126. PMID: 25389652

Early repolarization pattern: its ECG characteristics, arrhythmogeneity and heritability.

Mizusawa Y, Bezzina CR
J Interv Card Electrophysiol 2014 Apr;39(3):185-92. Epub 2014 Feb 16 doi: 10.1007/s10840-013-9870-y. PMID: 24532112

Early repolarization patterns and the role of additional proarrhythmic triggers.

Barra S, Providência R, Paiva L, Nascimento J
Europace 2013 Apr;15(4):482-5. Epub 2012 Dec 28 doi: 10.1093/europace/eus421. PMID: 23275475

See all (89)

Clinical prediction guides

Outcome of patients with early repolarization pattern and syncope.

Kamakura T, Gourraud JB, Clementy N, Maury P, Mansourati J, Klug D, Da Costa A, Pasquie JL, Mabo P, Chavernac P, Laurent G, Defaye P, Laborderie J, Leenhardt A, Sadoul N, Deharo JC, Giraudeau C, Quentin A, Jesel L, Thollet A, Tixier R, Derval N, Haissaguerre M, Probst V, Sacher F
Heart Rhythm 2022 Aug;19(8):1306-1314. Epub 2022 Apr 5 doi: 10.1016/j.hrthm.2022.03.1233. PMID: 35395407

Early repolarization is associated with a significantly increased risk of ventricular arrhythmias and sudden cardiac death in patients with structural heart diseases.

Cheng YJ, Li ZY, Yao FJ, Xu XJ, Ji CC, Chen XM, Liu LJ, Lin XX, Yao H, Wu SH
Heart Rhythm 2017 Aug;14(8):1157-1164. Epub 2017 Apr 14 doi: 10.1016/j.hrthm.2017.04.022. PMID: 28416467

Early repolarization syndrome: electrocardiographic signs and clinical implications.

Rezus C, Floria M, Moga VD, Sirbu O, Dima N, Ionescu SD, Ambarus V
Ann Noninvasive Electrocardiol 2014 Jan;19(1):15-22. Epub 2013 Sep 30 doi: 10.1111/anec.12113. PMID: 24118137 Free PMC Article

Early repolarization patterns and the role of additional proarrhythmic triggers.

Barra S, Providência R, Paiva L, Nascimento J
Europace 2013 Apr;15(4):482-5. Epub 2012 Dec 28 doi: 10.1093/europace/eus421. PMID: 23275475

ECG repolarization syndrome abnormalities (J wave syndromes) and idiopathic ventricular fibrillation: diagnostic and management.

Lévy S, Sbragia P
J Interv Card Electrophysiol 2011 Dec;32(3):181-6. Epub 2011 Jul 21 doi: 10.1007/s10840-011-9597-6. PMID: 21833514

See all (82)