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Fasting plasma glucose level quantitative trait locus 5(FGQTL5)

MedGen UID:
462064
•Concept ID:
C3150714
•
Finding
Synonym: FGQTL5
 
Gene (location): GCKR (2p23.3)
 
OMIM®: 613463

Professional guidelines

PubMed

Genome-wide interaction of genotype by erythrocyte n-3 fatty acids contributes to phenotypic variance of diabetes-related traits.
Zheng JS, Lai CQ, Parnell LD, Lee YC, Shen J, Smith CE, Casas-Agustench P, Richardson K, Li D, Noel SE, Tucker KL, Arnett DK, Borecki IB, Ordovás JM
BMC Genomics 2014 Sep 11;15(1):781. doi: 10.1186/1471-2164-15-781. PMID: 25213455Free PMC Article

Recent clinical studies

Etiology

Novel association between a transient receptor potential cation channel subfamily M member 5 expression quantitative trait locus rs35197079 and decreased susceptibility of gestational diabetes mellitus in a Chinese population.
Li X, Lai L, Su J, Chen S, Lin S, Wang B, Gao J, Zhang L, Yao K, Duan S
J Diabetes Investig 2021 Nov;12(11):2062-2070. Epub 2021 Jun 10 doi: 10.1111/jdi.13572. PMID: 33979016Free PMC Article
Association of 48 type 2 diabetes susceptibility loci with fasting plasma glucose and lipid levels in Chinese Hans.
Liu J, Wang L, Qian Y, Dai J, Shen C, Jin G, Hu Z, Shen H
Diabetes Res Clin Pract 2018 May;139:114-121. Epub 2018 Mar 6 doi: 10.1016/j.diabres.2018.02.039. PMID: 29518490
Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study.
Sohani ZN, Anand SS, Robiou-du-Pont S, Morrison KM, McDonald SD, Atkinson SA, Teo KK, Meyre D
PLoS One 2016;11(4):e0152107. Epub 2016 Apr 6 doi: 10.1371/journal.pone.0152107. PMID: 27049325Free PMC Article
Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci.
Service SK, Teslovich TM, Fuchsberger C, Ramensky V, Yajnik P, Koboldt DC, Larson DE, Zhang Q, Lin L, Welch R, Ding L, McLellan MD, O'Laughlin M, Fronick C, Fulton LL, Magrini V, Swift A, Elliott P, Jarvelin MR, Kaakinen M, McCarthy MI, Peltonen L, Pouta A, Bonnycastle LL, Collins FS, Narisu N, Stringham HM, Tuomilehto J, Ripatti S, Fulton RS, Sabatti C, Wilson RK, Boehnke M, Freimer NB
PLoS Genet 2014 Jan;10(1):e1004147. Epub 2014 Jan 30 doi: 10.1371/journal.pgen.1004147. PMID: 24497850Free PMC Article
Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice.
Zhang Z, Rowlan JS, Wang Q, Shi W
Circ Cardiovasc Genet 2012 Apr 1;5(2):190-201. Epub 2012 Jan 31 doi: 10.1161/CIRCGENETICS.111.961649. PMID: 22294616Free PMC Article

Diagnosis

The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals.
Grarup N, Overvad M, Sparsø T, Witte DR, Pisinger C, Jørgensen T, Yamauchi T, Hara K, Maeda S, Kadowaki T, Hansen T, Pedersen O
Diabetologia 2011 Apr;54(4):789-94. Epub 2011 Jan 20 doi: 10.1007/s00125-010-2031-2. PMID: 21249489

Therapy

The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals.
Grarup N, Overvad M, Sparsø T, Witte DR, Pisinger C, Jørgensen T, Yamauchi T, Hara K, Maeda S, Kadowaki T, Hansen T, Pedersen O
Diabetologia 2011 Apr;54(4):789-94. Epub 2011 Jan 20 doi: 10.1007/s00125-010-2031-2. PMID: 21249489

Prognosis

Cross-sectional and longitudinal replication analyses of genome-wide association loci of type 2 diabetes in Han Chinese.
Zhao Q, Xiao J, He J, Zhang X, Hong J, Kong X, Mills KT, Weng J, Jia W, Yang W
PLoS One 2014;9(3):e91790. Epub 2014 Mar 17 doi: 10.1371/journal.pone.0091790. PMID: 24637646Free PMC Article
Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study.
Hivert MF, Manning AK, McAteer JB, Florez JC, Dupuis J, Fox CS, O'Donnell CJ, Cupples LA, Meigs JB
Diabetes 2008 Dec;57(12):3353-9. Epub 2008 Sep 5 doi: 10.2337/db08-0700. PMID: 18776141Free PMC Article

Clinical prediction guides

Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study.
Sohani ZN, Anand SS, Robiou-du-Pont S, Morrison KM, McDonald SD, Atkinson SA, Teo KK, Meyre D
PLoS One 2016;11(4):e0152107. Epub 2016 Apr 6 doi: 10.1371/journal.pone.0152107. PMID: 27049325Free PMC Article
Cross-sectional and longitudinal replication analyses of genome-wide association loci of type 2 diabetes in Han Chinese.
Zhao Q, Xiao J, He J, Zhang X, Hong J, Kong X, Mills KT, Weng J, Jia W, Yang W
PLoS One 2014;9(3):e91790. Epub 2014 Mar 17 doi: 10.1371/journal.pone.0091790. PMID: 24637646Free PMC Article

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    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

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