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Monoclonal B-Cell Lymphocytosis

MedGen UID:
395902
Concept ID:
C2698259
Neoplastic Process
Synonyms: MBL - monoclonal B-cell lymphocytosis; Monoclonal B-cell lymphocytosis
SNOMED CT: MBL - monoclonal B-cell lymphocytosis (717780007); Monoclonal B-cell lymphocytosis (717780007); Monoclonal B-cell lymphocytosis (789740004)

Definition

A monoclonal expansion of B-lymphocytes with or without the characteristic immunophenotype of chronic lymphocytic leukemia. It precedes virtually all cases of chronic lymphocytic leukemia/small lymphocytic lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Monoclonal B-Cell Lymphocytosis

Professional guidelines

PubMed

Tang C, Shen Y, Soosapilla A, Mulligan SP
Leuk Lymphoma 2022 Dec;63(12):2795-2806. Epub 2022 Jun 29 doi: 10.1080/10428194.2022.2092857. PMID: 35767361
Shanafelt TD, Ghia P, Lanasa MC, Landgren O, Rawstron AC
Leukemia 2010 Mar;24(3):512-20. Epub 2010 Jan 21 doi: 10.1038/leu.2009.287. PMID: 20090778Free PMC Article
Marti GE, Rawstron AC, Ghia P, Hillmen P, Houlston RS, Kay N, Schleinitz TA, Caporaso N; International Familial CLL Consortium
Br J Haematol 2005 Aug;130(3):325-32. doi: 10.1111/j.1365-2141.2005.05550.x. PMID: 16042682

Recent clinical studies

Etiology

Obiorah IE, Patel BA, Groarke EM, Wang W, Trick M, Ombrello AK, Ferrada MA, Wu Z, Gutierrez-Rodrigues F, Lotter J, Wilson L, Hoffmann P, Cardona DO, Patel N, Dulau-Florea A, Kastner DL, Grayson PC, Beck DB, Young NS, Calvo KR
Blood Adv 2021 Aug 24;5(16):3203-3215. doi: 10.1182/bloodadvances.2021004976. PMID: 34427584Free PMC Article
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174
Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP, Ebert BL
Blood 2015 Jul 2;126(1):9-16. Epub 2015 Apr 30 doi: 10.1182/blood-2015-03-631747. PMID: 25931582Free PMC Article
Kalpadakis C, Pangalis GA, Sachanas S, Vassilakopoulos TP, Kyriakaki S, Korkolopoulou P, Koulieris E, Moschogiannis M, Yiakoumis X, Tsirkinidis P, Kyrtsonis MC, Levidou G, Papadaki HA, Panayiotidis P, Angelopoulou MK
Biomed Res Int 2014;2014:258917. Epub 2014 Sep 11 doi: 10.1155/2014/258917. PMID: 25295254Free PMC Article
Rawstron AC
Curr Hematol Malig Rep 2013 Mar;8(1):52-9. doi: 10.1007/s11899-012-0144-z. PMID: 23307471

Diagnosis

Nardi V, Kuo FC, Hasserjian RP
Am J Clin Pathol 2019 Aug 1;152(3):347-358. doi: 10.1093/ajcp/aqz079. PMID: 31305863
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174
Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP, Ebert BL
Blood 2015 Jul 2;126(1):9-16. Epub 2015 Apr 30 doi: 10.1182/blood-2015-03-631747. PMID: 25931582Free PMC Article
Kalpadakis C, Pangalis GA, Sachanas S, Vassilakopoulos TP, Kyriakaki S, Korkolopoulou P, Koulieris E, Moschogiannis M, Yiakoumis X, Tsirkinidis P, Kyrtsonis MC, Levidou G, Papadaki HA, Panayiotidis P, Angelopoulou MK
Biomed Res Int 2014;2014:258917. Epub 2014 Sep 11 doi: 10.1155/2014/258917. PMID: 25295254Free PMC Article
Rawstron AC
Hematology Am Soc Hematol Educ Program 2009:430-9. doi: 10.1182/asheducation-2009.1.430. PMID: 20008229

Therapy

Wen YK
Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1502-1505. doi: 10.4103/1319-2442.248281. PMID: 30588987
Svenningsen M, Herborg LL, Hokland P, Ludvigsen M
Dan Med J 2017 Dec;64(12) PMID: 29206098
Wiernik PH
Curr Treat Options Oncol 2015 Feb;16(2):8. doi: 10.1007/s11864-014-0323-3. PMID: 25762123
Rawstron AC
Hematology Am Soc Hematol Educ Program 2009:430-9. doi: 10.1182/asheducation-2009.1.430. PMID: 20008229
Vogt RF, Shim YK, Middleton DC, Buffler PA, Campolucci SS, Lybarger JA, Marti GE
Br J Haematol 2007 Dec;139(5):690-700. doi: 10.1111/j.1365-2141.2007.06861.x. PMID: 18021083

Prognosis

Obiorah IE, Patel BA, Groarke EM, Wang W, Trick M, Ombrello AK, Ferrada MA, Wu Z, Gutierrez-Rodrigues F, Lotter J, Wilson L, Hoffmann P, Cardona DO, Patel N, Dulau-Florea A, Kastner DL, Grayson PC, Beck DB, Young NS, Calvo KR
Blood Adv 2021 Aug 24;5(16):3203-3215. doi: 10.1182/bloodadvances.2021004976. PMID: 34427584Free PMC Article
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174
Wiernik PH
Curr Treat Options Oncol 2015 Feb;16(2):8. doi: 10.1007/s11864-014-0323-3. PMID: 25762123
Siddon AJ, Rinder HM; Education Committee of the Academy of Clinical Laboratory Physicians and Scientists
Am J Clin Pathol 2013 Jun;139(6):708-12. doi: 10.1309/AJCPLIR4GZWX3XKA. PMID: 23690112
Rawstron AC
Hematology Am Soc Hematol Educ Program 2009:430-9. doi: 10.1182/asheducation-2009.1.430. PMID: 20008229

Clinical prediction guides

Oliva-Ariza G, Fuentes-Herrero B, Lecrevisse Q, Carbonell C, Pérez-Pons A, Torres-Valle A, Pozo J, Martín-Oterino JÁ, González-López Ó, López-Bernús A, Bernal-Ribes M, Belhassen-García M, Pérez-Escurza O, Pérez-Andrés M, Vazquez L, Hernández-Pérez G, García Palomo FJ, Leoz P, Costa-Alba P, Pérez-Losada E, Yeguas A, Santos Sánchez M, García-Blázquez M, Morán-Plata FJ, Damasceno D, Botafogo V, Muñoz-García N, Fluxa R, van Dongen JJM, Marcos M, Almeida J, Orfao A; ECRIN-M3 Consortium
Am J Hematol 2023 Dec;98(12):1909-1922. Epub 2023 Oct 4 doi: 10.1002/ajh.27119. PMID: 37792579
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174
Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP, Ebert BL
Blood 2015 Jul 2;126(1):9-16. Epub 2015 Apr 30 doi: 10.1182/blood-2015-03-631747. PMID: 25931582Free PMC Article
Goldin LR, McMaster ML, Caporaso NE
Cancer Epidemiol Biomarkers Prev 2013 Apr;22(4):533-9. doi: 10.1158/1055-9965.EPI-12-1348. PMID: 23549397Free PMC Article
Scarfò L, Dagklis A, Scielzo C, Fazi C, Ghia P
Semin Cancer Biol 2010 Dec;20(6):384-90. Epub 2010 Sep 15 doi: 10.1016/j.semcancer.2010.08.005. PMID: 20816789

Recent systematic reviews

Hodgson K, Ferrer G, Montserrat E, Moreno C
Haematologica 2011 May;96(5):752-61. Epub 2011 Jan 17 doi: 10.3324/haematol.2010.036152. PMID: 21242190Free PMC Article
Shim YK, Middleton DC, Caporaso NE, Rachel JM, Landgren O, Abbasi F, Raveche ES, Rawstron AC, Orfao A, Marti GE, Vogt RF
Cytometry B Clin Cytom 2010;78 Suppl 1(Suppl 1):S10-8. doi: 10.1002/cyto.b.20538. PMID: 20839330Free PMC Article

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