U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

46,XY ovotesticular disorder of sex development

MedGen UID:
394582
Concept ID:
C2697358
Congenital Abnormality
Synonym: 46,XY TRUE HERMAPHRODITISM
SNOMED CT: 46,XY ovotesticular disorder of sex development (763683004)
 
Monarch Initiative: MONDO:0017968
OMIM®: 480000
Orphanet: ORPHA325345

Definition

A rare genetic disorder of sex development with either the coexistence of both male and female reproductive gonads or, more frequently, the presence of one or both gonads containing a mixture of both testicular and ovarian tissue (ovotestes) in an individual with a normal male 46, XY karyotype. External genitalia are usually ambiguous, but can range from normal male to normal female and if a uterus and/or fallopian tubes are present, they are generally hypoplastic. Cryptorchidism, hypospadias, infertility and increased risk of gonadal neoplasm are frequently associated. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGV46,XY ovotesticular disorder of sex development

Professional guidelines

PubMed

Jaruratanasirikul S, Engchaun V
World J Pediatr 2014 May;10(2):168-74. Epub 2013 Jun 17 doi: 10.1007/s12519-013-0418-0. PMID: 23775676

Recent clinical studies

Etiology

Kim HI, Lee I, Kim SH, Lee YS, Han SW, Yun BH
J Pediatr Adolesc Gynecol 2021 Oct;34(5):626-630. Epub 2021 Mar 2 doi: 10.1016/j.jpag.2021.02.105. PMID: 33667640
Ren Š, Harmaš V, Stará M, Laštůvkováj, Čejnová V
Ceska Gynekol 2020 Winter;85(4):259-262. PMID: 33562981
Kremen J, Chan YM, Swartz JM
Curr Opin Urol 2017 Jan;27(1):1-6. doi: 10.1097/MOU.0000000000000353. PMID: 27798415Free PMC Article
Mouriquand PD, Gorduza DB, Gay CL, Meyer-Bahlburg HF, Baker L, Baskin LS, Bouvattier C, Braga LH, Caldamone AC, Duranteau L, El Ghoneimi A, Hensle TW, Hoebeke P, Kaefer M, Kalfa N, Kolon TF, Manzoni G, Mure PY, Nordenskjöld A, Pippi Salle JL, Poppas DP, Ransley PG, Rink RC, Rodrigo R, Sann L, Schober J, Sibai H, Wisniewski A, Wolffenbuttel KP, Lee P
J Pediatr Urol 2016 Jun;12(3):139-49. Epub 2016 Apr 9 doi: 10.1016/j.jpurol.2016.04.001. PMID: 27132944
Sircili MH, Denes FT, Costa EM, Machado MG, Inacio M, Silva RB, Srougi M, Mendonca BB, Domenice S
J Urol 2014 May;191(5 Suppl):1532-6. Epub 2014 Mar 26 doi: 10.1016/j.juro.2013.10.037. PMID: 24679863

Diagnosis

Kim HI, Lee I, Kim SH, Lee YS, Han SW, Yun BH
J Pediatr Adolesc Gynecol 2021 Oct;34(5):626-630. Epub 2021 Mar 2 doi: 10.1016/j.jpag.2021.02.105. PMID: 33667640
Ren Š, Harmaš V, Stará M, Laštůvkováj, Čejnová V
Ceska Gynekol 2020 Winter;85(4):259-262. PMID: 33562981
Ahmad A, Ayub F, Saleem I, Ahmad N
J Pak Med Assoc 2019 May;69(5):711-717. PMID: 31105293
Kremen J, Chan YM, Swartz JM
Curr Opin Urol 2017 Jan;27(1):1-6. doi: 10.1097/MOU.0000000000000353. PMID: 27798415Free PMC Article
Khadilkar KS, Budyal SR, Kasaliwal R, Sathe PA, Kandalkar B, Sanghvi BV, Parelkar SV, Lila AR, Bandgar T, Shah NS
Endocr Pract 2015 Jul;21(7):770-6. Epub 2015 Mar 18 doi: 10.4158/EP15606.OR. PMID: 25786559

Therapy

García-Acero M, Moreno-Niño O, Suárez-Obando F, Molina M, Manotas MC, Prieto JC, Forero C, Céspedes C, Pérez J, Fernandez N, Rojas A
Mol Med Rep 2020 Jan;21(1):97-106. Epub 2019 Nov 12 doi: 10.3892/mmr.2019.10819. PMID: 31746433Free PMC Article
Abd Wahab AV, Lim LM, Mohamed Tarmizi MH
J Pediatr Adolesc Gynecol 2019 Feb;32(1):74-77. Epub 2018 Sep 21 doi: 10.1016/j.jpag.2018.09.006. PMID: 30248506
Kristesashvili J, Chipashvili M, Jorbenadze T, Greydanus DE
Int J Adolesc Med Health 2012;24(2):181-90. Epub 2011 Nov 29 doi: 10.1515/ijamh.2012.027. PMID: 22909928
Nebesio TD, Torres-Martinez W, Rink RC, Eugster EA
Endocr Pract 2011 Mar-Apr;17(2):e1-3. doi: 10.4158/EP10242.CR. PMID: 21041165

Prognosis

Ganie Y, Aldous C, Balakrishna Y, Wiersma R
J Pediatr Endocrinol Metab 2017 Jan 1;30(1):11-18. doi: 10.1515/jpem-2016-0152. PMID: 27754965
Şimşek E, Binay Ç, Demiral M, Tokar B, Kabukçuoğlu S, Üstün M
J Clin Res Pediatr Endocrinol 2016 Sep 1;8(3):351-5. Epub 2016 Apr 18 doi: 10.4274/jcrpe.2705. PMID: 27087521Free PMC Article
Hyon C, Chantot-Bastaraud S, Harbuz R, Bhouri R, Perrot N, Peycelon M, Sibony M, Rojo S, Piguel X, Bilan F, Gilbert-Dussardier B, Kitzis A, McElreavey K, Siffroi JP, Bashamboo A
Am J Med Genet A 2015 Aug;167A(8):1851-8. Epub 2015 Apr 21 doi: 10.1002/ajmg.a.37101. PMID: 25900885
Sircili MH, Denes FT, Costa EM, Machado MG, Inacio M, Silva RB, Srougi M, Mendonca BB, Domenice S
J Urol 2014 May;191(5 Suppl):1532-6. Epub 2014 Mar 26 doi: 10.1016/j.juro.2013.10.037. PMID: 24679863
Matsui F, Shimada K, Matsumoto F, Itesako T, Nara K, Ida S, Nakayama M
Int J Urol 2011 Mar;18(3):231-6. Epub 2011 Jan 23 doi: 10.1111/j.1442-2042.2010.02700.x. PMID: 21255100

Clinical prediction guides

Peng L, Chen Y, Hu J, Zhao Y, Qin F
J Pediatr Urol 2024 Aug;20(4):696-702. Epub 2024 Mar 7 doi: 10.1016/j.jpurol.2024.03.002. PMID: 38555233
Eser M, Ayaz A
Balkan Med J 2018 May 29;35(3):272-274. Epub 2017 Dec 8 doi: 10.4274/balkanmedj.2017.0378. PMID: 29219112Free PMC Article
Baetens D, Stoop H, Peelman F, Todeschini AL, Rosseel T, Coppieters F, Veitia RA, Looijenga LH, De Baere E, Cools M
Genet Med 2017 Apr;19(4):367-376. Epub 2016 Aug 4 doi: 10.1038/gim.2016.118. PMID: 27490115Free PMC Article
Şimşek E, Binay Ç, Demiral M, Tokar B, Kabukçuoğlu S, Üstün M
J Clin Res Pediatr Endocrinol 2016 Sep 1;8(3):351-5. Epub 2016 Apr 18 doi: 10.4274/jcrpe.2705. PMID: 27087521Free PMC Article
Hyon C, Chantot-Bastaraud S, Harbuz R, Bhouri R, Perrot N, Peycelon M, Sibony M, Rojo S, Piguel X, Bilan F, Gilbert-Dussardier B, Kitzis A, McElreavey K, Siffroi JP, Bashamboo A
Am J Med Genet A 2015 Aug;167A(8):1851-8. Epub 2015 Apr 21 doi: 10.1002/ajmg.a.37101. PMID: 25900885

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...