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Lumbar disk herniation, susceptibility to

MedGen UID:
393597
•Concept ID:
C2676840
•
Finding
Synonym: Lumbar disc herniation, susceptibility to
 
Monarch Initiative: MONDO:0100202
OMIM®: 120280; 188061; 603932

Professional guidelines

PubMed

Type IX collagen neo-deposition in degenerative discs of surgical patients whether genotyped plus or minus for COL9 risk alleles.
Zhu Y, Wu JJ, Weis MA, Mirza SK, Eyre DR
Spine (Phila Pa 1976) 2011 Nov 15;36(24):2031-8. doi: 10.1097/BRS.0b013e3181ffdd61. PMID: 21311409Free PMC Article
Association of interleukin-1 receptor antagonist gene polymorphism with response to conservative treatment of lumbar herniated nucleus pulposus.
Kim DH, Lee SH, Kim KT, Yu SD
Spine (Phila Pa 1976) 2010 Jul 15;35(16):1527-31. doi: 10.1097/BRS.0b013e3181e4efb6. PMID: 20581747
Management of deep wound infection after posterior lumbar interbody fusion with cages.
Mirovsky Y, Floman Y, Smorgick Y, Ashkenazi E, Anekstein Y, Millgram MA, Giladi M
J Spinal Disord Tech 2007 Apr;20(2):127-31. doi: 10.1097/01.bsd.0000211266.66615.e5. PMID: 17414981

Recent clinical studies

Etiology

Genetic Predisposition to Symptomatic Lumbar Disk Herniation in Pediatric and Young Adult Patients.
Theodore N, Ahmed AK, Fulton T, Mousses S, Yoo C, Goodwin CR, Danielson J, Sciubba DM, Giers MB, Kalani MYS
Spine (Phila Pa 1976) 2019 Jun 1;44(11):E640-E649. doi: 10.1097/BRS.0000000000002949. PMID: 30475332
Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis.
Wu H, Wang S, Chen W, Zhan X, Xiao Z, Jiang H, Wei Q
J Orthop Surg Res 2018 Mar 5;13(1):47. doi: 10.1186/s13018-018-0750-0. PMID: 29506578Free PMC Article
Advances in susceptibility genetics of intervertebral degenerative disc disease.
Zhang Y, Sun Z, Liu J, Guo X
Int J Biol Sci 2008 Sep 2;4(5):283-90. doi: 10.7150/ijbs.4.283. PMID: 18781226Free PMC Article
The genetics of intervertebral disc degeneration. Associated genes.
Kalichman L, Hunter DJ
Joint Bone Spine 2008 Jul;75(4):388-96. Epub 2008 May 15 doi: 10.1016/j.jbspin.2007.11.002. PMID: 18485784
Genetic risk factors for lumbar disc disease.
Ala-Kokko L
Ann Med 2002;34(1):42-7. doi: 10.1080/078538902317338634. PMID: 12014433

Diagnosis

MAS-Net:Multi-modal Assistant Segmentation Network For Lumbar Intervertebral Disc.
Qinhong D, Yue H, Wendong B, Yukun D, Huan Y, Yongming X
Phys Med Biol 2023 Aug 29;68(17) doi: 10.1088/1361-6560/acef9f. PMID: 37567228
Association between MIR31HG polymorphisms and the risk of Lumbar disc herniation in Chinese Han population.
Hu X, Hao D, Yin J, Gong F, Wang X, Wang R, Liu B
Cell Cycle 2022 Oct;21(19):2109-2120. Epub 2022 Jun 15 doi: 10.1080/15384101.2022.2087281. PMID: 35704669Free PMC Article
The interaction between aggrecan gene VNTR polymorphism and obesity in predicting incident symptomatic lumbar disc herniation.
Cong L, Zhu Y, Pang H, Guanjun TU
Connect Tissue Res 2014 Oct-Dec;55(5-6):384-90. Epub 2014 Sep 22 doi: 10.3109/03008207.2014.959117. PMID: 25188217
Evidence for an inherited predisposition to lumbar disc disease.
Patel AA, Spiker WR, Daubs M, Brodke D, Cannon-Albright LA
J Bone Joint Surg Am 2011 Feb 2;93(3):225-9. doi: 10.2106/JBJS.J.00276. PMID: 21266637Free PMC Article
Genetic risk factors for lumbar disc disease.
Ala-Kokko L
Ann Med 2002;34(1):42-7. doi: 10.1080/078538902317338634. PMID: 12014433

Therapy

Changes in Intervertebral Disc Properties after Intradiscal Injection of Condoliase for Painful Lumbar Disc Herniation.
Ohtonari T, Sakai K, Furukawa Y, Takeda Y
Neurol Med Chir (Tokyo) 2024 Jun 15;64(6):222-229. Epub 2024 May 8 doi: 10.2176/jns-nmc.2023-0302. PMID: 38719578Free PMC Article
Degenerate-disc infection study with contaminant control (DISC): a multicenter prospective case-control trial.
Rao PJ, Maharaj M, Chau C, Taylor P, Phan K, Choy WJ, Scherman D, Mews P, Scholsem M, Coughlan M, Mobbs R
Spine J 2020 Oct;20(10):1544-1553. Epub 2020 Apr 25 doi: 10.1016/j.spinee.2020.03.013. PMID: 32339766
Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation.
Bjornsdottir G, Benonisdottir S, Sveinbjornsson G, Styrkarsdottir U, Thorleifsson G, Walters GB, Bjornsson A, Olafsson IH, Ulfarsson E, Vikingsson A, Hansdottir R, Karlsson KO, Rafnar T, Jonsdottir I, Frigge ML, Kong A, Oddsson A, Masson G, Magnusson OT, Gudbjartsson T, Stefansson H, Sulem P, Gudbjartsson D, Thorsteinsdottir U, Thorgeirsson TE, Stefansson K
Nat Commun 2017 Feb 22;8:14265. doi: 10.1038/ncomms14265. PMID: 28223688Free PMC Article
A short report comparing outcomes between L4/L5 and L5/S1 single-level discectomy surgery.
Okoro T, Sell P
J Spinal Disord Tech 2010 Feb;23(1):40-2. doi: 10.1097/BSD.0b013e3181b38537. PMID: 20134287
Significant spinal injury resulting from low-level accelerations: a case series of roller coaster injuries.
Freeman MD, Croft AC, Nicodemus CN, Centeno CJ, Elkins WL
Arch Phys Med Rehabil 2005 Nov;86(11):2126-30. doi: 10.1016/j.apmr.2005.05.017. PMID: 16271559

Prognosis

The role of ADAMTS6 and ADAMTS17 polymorphisms in susceptibility to lumbar disc herniation in Chinese Han population.
Han P, Jiang F, Zhang L
Eur Spine J 2023 Apr;32(4):1106-1114. Epub 2023 Feb 21 doi: 10.1007/s00586-023-07586-8. PMID: 36810712
Association between MIR31HG polymorphisms and the risk of Lumbar disc herniation in Chinese Han population.
Hu X, Hao D, Yin J, Gong F, Wang X, Wang R, Liu B
Cell Cycle 2022 Oct;21(19):2109-2120. Epub 2022 Jun 15 doi: 10.1080/15384101.2022.2087281. PMID: 35704669Free PMC Article
Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation.
Bjornsdottir G, Benonisdottir S, Sveinbjornsson G, Styrkarsdottir U, Thorleifsson G, Walters GB, Bjornsson A, Olafsson IH, Ulfarsson E, Vikingsson A, Hansdottir R, Karlsson KO, Rafnar T, Jonsdottir I, Frigge ML, Kong A, Oddsson A, Masson G, Magnusson OT, Gudbjartsson T, Stefansson H, Sulem P, Gudbjartsson D, Thorsteinsdottir U, Thorgeirsson TE, Stefansson K
Nat Commun 2017 Feb 22;8:14265. doi: 10.1038/ncomms14265. PMID: 28223688Free PMC Article
The interaction between aggrecan gene VNTR polymorphism and obesity in predicting incident symptomatic lumbar disc herniation.
Cong L, Zhu Y, Pang H, Guanjun TU
Connect Tissue Res 2014 Oct-Dec;55(5-6):384-90. Epub 2014 Sep 22 doi: 10.3109/03008207.2014.959117. PMID: 25188217
The genetics of intervertebral disc degeneration. Associated genes.
Kalichman L, Hunter DJ
Joint Bone Spine 2008 Jul;75(4):388-96. Epub 2008 May 15 doi: 10.1016/j.jbspin.2007.11.002. PMID: 18485784

Clinical prediction guides

The role of ADAMTS6 and ADAMTS17 polymorphisms in susceptibility to lumbar disc herniation in Chinese Han population.
Han P, Jiang F, Zhang L
Eur Spine J 2023 Apr;32(4):1106-1114. Epub 2023 Feb 21 doi: 10.1007/s00586-023-07586-8. PMID: 36810712
Association between MIR31HG polymorphisms and the risk of Lumbar disc herniation in Chinese Han population.
Hu X, Hao D, Yin J, Gong F, Wang X, Wang R, Liu B
Cell Cycle 2022 Oct;21(19):2109-2120. Epub 2022 Jun 15 doi: 10.1080/15384101.2022.2087281. PMID: 35704669Free PMC Article
Interactions between the MMP-3 gene rs591058 polymorphism and occupational risk factors contribute to the increased risk for lumbar disk herniation: A case-control study.
Luo Y, Wang J, Pei J, Rong Y, Liu W, Tang P, Cai W, Yin G
J Clin Lab Anal 2020 Jul;34(7):e23273. Epub 2020 Mar 10 doi: 10.1002/jcla.23273. PMID: 32157746Free PMC Article
Genetic Predisposition to Symptomatic Lumbar Disk Herniation in Pediatric and Young Adult Patients.
Theodore N, Ahmed AK, Fulton T, Mousses S, Yoo C, Goodwin CR, Danielson J, Sciubba DM, Giers MB, Kalani MYS
Spine (Phila Pa 1976) 2019 Jun 1;44(11):E640-E649. doi: 10.1097/BRS.0000000000002949. PMID: 30475332
The genetics of intervertebral disc degeneration. Associated genes.
Kalichman L, Hunter DJ
Joint Bone Spine 2008 Jul;75(4):388-96. Epub 2008 May 15 doi: 10.1016/j.jbspin.2007.11.002. PMID: 18485784

Recent systematic reviews

Gene polymorphisms and expression levels of interleukin-6 and interleukin-10 in lumbar disc disease: a meta-analysis and immunohistochemical study.
Guan Y, Wang S, Wang J, Meng D, Wu H, Wei Q, Jiang H
J Orthop Surg Res 2020 Feb 18;15(1):54. doi: 10.1186/s13018-020-01588-8. PMID: 32070384Free PMC Article
Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis.
Wu H, Wang S, Chen W, Zhan X, Xiao Z, Jiang H, Wei Q
J Orthop Surg Res 2018 Mar 5;13(1):47. doi: 10.1186/s13018-018-0750-0. PMID: 29506578Free PMC Article
Genetic association studies in lumbar disc degeneration: a systematic review.
Eskola PJ, Lemmelä S, Kjaer P, Solovieva S, Männikkö M, Tommerup N, Lind-Thomsen A, Husgafvel-Pursiainen K, Cheung KM, Chan D, Samartzis D, Karppinen J
PLoS One 2012;7(11):e49995. Epub 2012 Nov 21 doi: 10.1371/journal.pone.0049995. PMID: 23185509Free PMC Article

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